NCBI Taxonomy: 55952

Streptomyces toyocaensis (ncbi_taxid: 55952)

found 22 associated metabolites at species taxonomy rank level.

Ancestor: Streptomyces

Child Taxonomies: none taxonomy data.

   

Toyocamycin

Toyocamycin

C12H13N5O4 (291.09674980000005)


An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group. D009676 - Noxae > D000963 - Antimetabolites D000970 - Antineoplastic Agents Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM[1][2][3].

   

(1r,2r,19r,22r,34s,37r,40r,52s)-22-amino-43,63,65-trichloro-2,21,31,35,38,44,47,49,54,56,59,64-dodecahydroxy-26-(sulfooxy)-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2³,⁶.2¹⁴,¹⁷.2¹⁹,³⁴.1⁸,¹².1²³,²⁷.1²⁹,³³.1⁴¹,⁴⁵.0¹⁰,³⁷.0⁴⁶,⁵¹]hexahexaconta-3,5,8(64),9,11,14,16,20,23,25,27(61),29(60),30,32,35,38,41,43,45(57),46,48,50,53,55,58,62,65-heptacosaene-52-carboxylic acid

(1r,2r,19r,22r,34s,37r,40r,52s)-22-amino-43,63,65-trichloro-2,21,31,35,38,44,47,49,54,56,59,64-dodecahydroxy-26-(sulfooxy)-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2³,⁶.2¹⁴,¹⁷.2¹⁹,³⁴.1⁸,¹².1²³,²⁷.1²⁹,³³.1⁴¹,⁴⁵.0¹⁰,³⁷.0⁴⁶,⁵¹]hexahexaconta-3,5,8(64),9,11,14,16,20,23,25,27(61),29(60),30,32,35,38,41,43,45(57),46,48,50,53,55,58,62,65-heptacosaene-52-carboxylic acid

C58H44Cl3N7O21S (1311.1376464)


   

(1s,2r,19r,22r,37r,40r,52r)-22-amino-43,63,65-trichloro-2,21,31,35,38,44,47,49,54,56,59,64-dodecahydroxy-26-(sulfooxy)-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2³,⁶.2¹⁴,¹⁷.2¹⁹,³⁴.1⁸,¹².1²³,²⁷.1²⁹,³³.1⁴¹,⁴⁵.0¹⁰,³⁷.0⁴⁶,⁵¹]hexahexaconta-3,5,8(64),9,11,14,16,20,23,25,27(61),29(60),30,32,35,38,41,43,45(57),46,48,50,53,55,58,62,65-heptacosaene-52-carboxylic acid

(1s,2r,19r,22r,37r,40r,52r)-22-amino-43,63,65-trichloro-2,21,31,35,38,44,47,49,54,56,59,64-dodecahydroxy-26-(sulfooxy)-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.2³,⁶.2¹⁴,¹⁷.2¹⁹,³⁴.1⁸,¹².1²³,²⁷.1²⁹,³³.1⁴¹,⁴⁵.0¹⁰,³⁷.0⁴⁶,⁵¹]hexahexaconta-3,5,8(64),9,11,14,16,20,23,25,27(61),29(60),30,32,35,38,41,43,45(57),46,48,50,53,55,58,62,65-heptacosaene-52-carboxylic acid

C58H44Cl3N7O21S (1311.1376464)