Chemical Formula: C28H38O6
Chemical Formula C28H38O6
Found 90 metabolite its formula value is C28H38O6
Withaferin_A
Withaferin A is a withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity. It has a role as an antineoplastic agent and an apoptosis inducer. It is a delta-lactone, a 4-hydroxy steroid, an enone, an ergostanoid, a secondary alcohol, a withanolide, a 27-hydroxy steroid, a primary alcohol and an epoxy steroid. Ashwagandha is a popular Ayurvedic herb used as a general tonic, to increase energy and reduce stress. Ashwagandha has not been implicated in causing serum enzyme elevations during therapy, but recently has been implicated in rare cases of clinically apparent liver injury. Withaferin A is a natural product found in Vassobia breviflora, Withania somnifera, and other organisms with data available. A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
Withanolide
Withanolides, which are extracted from Withania somnifera, are employed in the treatment of arthritis and are known to be potent inhibitors of angiogenesis, inflammation and oxidative stress. Withanolides can indeed inhibit the activation of NF-κB and NF-κB-regulated gene expression, which could explain their anti-arthritic actions. W. somnifera root powder has suppressive effect on arthritis by reducing amplification and propagation of the inflammatory response, without causing any gastric damage. (PMID: 17475558, 3248848, 17084827).
Withanolide A
Withanolide A is found in herbs and spices. Withanolide A is isolated from Lycium chinense (Chinese boxthorn Isolated from Lycium chinense (Chinese boxthorn). Withanolide A is found in tea and herbs and spices.
Methyl lucidenate F
Methyl lucidenate F is found in mushrooms. Methyl lucidenate F is a constituent of Ganoderma lucidum (reishi).
Desisobutyrylciclesonide
Withaferin A
CID 92044470
Ingenol-5,20-acetonide-3-O-angelate is a natural compound.
5,7alpha-epoxy-6alpha,20alpha-dihydroxy-1-oxowitha-2,24-dienolide
(4beta,17alphaOH,22R)-4,17,27-Trihydroxy1-oxowitha-2,5,24-trienolide
5alpha,14alpha,20alphaF(R)-trihydroxy-1-oxowitha-2,7,24-trienolide|withasomniferol C
(17R,20S,22R)-5beta,6beta-epoxy-4beta,18-dihydroxy-1-oxowitha-2,24-dienolide|18-deacetylwithacnistine
(17R)-14,17,20-trihydroxy-22,26-epoxyergosta-2,5,24-triene-1,26-dione|Withanolide J
(17R,20S,22R)-5beta,6beta-epoxy-4beta,16alpha-dihydroxy-1-oxowitha-2,24-dienolide|16-deacetyliochromolide
Baimantuoluoside C
12-deoxywithastramonolide is a withanolide. 12-Deoxywithastramonolide is a natural product found in Withania somnifera and Datura metel with data available. 12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects[1]. 12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects[1].
2beta-(angeloyloxy)-6alpha-(p-anisoyloxy)-4beta-hydroxydauc-8-ene|tunetanin A
(20R,22R)-14alpha,17alpha,19-trihydroxy-1-oxowitha-2,5,24-trien-22,26-olide|cinerolide
6alpha,7alpha-epoxy-5alpha-hydroxy-17alpha-[(1R,4R,5R,7R)-4-hydroxy-4,5-dimethyl-3-oxo-2-oxabicyclo[3.2.1]octan-7-yl]androst-2-en-1-one|mandragorolide A
2-(1-oxo-2-hydroxyethyl)-3-hydroxy-5-(3-methyl-2-butenyloxy)-6-(3-methyl-2-butenyl)-6(S)-(3,7-dimethyl-8-oxo-2E,6E-octadienyl)-2,4-cyclohexadien-1-one|coodeanone C
(14S,17R,20S,22R)-14,17,20,22-tetrahydroxy-1-oxoergosta-3,5,24-trien-26-oic acid 22,26-lactone|withacoagulin I
(20R,22R)-14,20alpha,27-trihydroxy-1-oxowitha-3,5,24-trienolide|1-oxo-14,20alphaF,27-trihydroxy-20R,22R-witha-3,5,24-trienolide|14alpha,20alphaF,27-trihydroxy-1-oxo-(22R)-witha-3,5,24-trienolide
Withanolide A
Withanolide A is a withanolide. withanolide A is a natural product found in Withania somnifera, Withania coagulans, and Discopodium penninervium with data available.
3beta,17beta-dihydroxy-14,20-epoxy-1-oxo-(22R)-witha-5,24-dienolide|3beta,17beta-dihydroxy-14,20-epoxy-1-oxo-22R-witha-5,24-dienolide|ajugin|coagulin R
17-hydroxy,27-deoxy-withaferin A|17-hydroxy-27-deoxy withaferin A|17-hydroxy-27-deoxywithaferin A|27-deoxy-17-hydroxywithaferin A
3beta,17beta,20-Trihydroxy-1-oxo-(20R,22R)-witha-5,14,24-trienolide
3-(4-O-acetyl-6-deoxy-beta-galactopyranosyloxy)-19-norpregna-1,3,5(10),20-tetrae-ne
4-desmethoxy-16-dehydrowithangulatin E|withangulatin F
Withanone
Annotation level-1 Withanone is a natural product found in Withania somnifera, Physalis philadelphica, and Discopodium penninervium with data available.
Withaferin A
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
Methyl lucidenate F
Withanolide
A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 22 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum and Withania somnifera, it exhibits cytotoxic activity. Withanolides, which are extracted from Withania somnifera, are employed in the treatment of arthritis and are known to be potent inhibitors of angiogenesis, inflammation and oxidative stress. Withanolides can indeed inhibit the activation of NF-κB and NF-κB-regulated gene expression, which could explain their anti-arthritic actions. W. somnifera root powder has suppressive effect on arthritis by reducing amplification and propagation of the inflammatory response, without causing any gastric damage. (PMID: 17475558, 3248848, 17084827) [HMDB]
Withanolide
Withalongolide B
A withanolide that is 27-deoxywithaferin A substituted by a hydroxy group at position 19. Isolated from Physalis longifolia, it exhibits antineoplastic activity.
[1-(Furan-3-yl)-8-hydroxy-4b,7,7,10a,12a-pentamethyl-3-oxo-1,5,6,6a,8,9,10,10b,11,12-decahydronaphtho[2,1-f]isochromen-5-yl] acetate
(1S,2S,4S,5R,10R,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]-1-hydroxyethyl]-5-hydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one
Tubocapsanolide F
A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 17 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity.