Chemical Formula: C16H10N2O2
Chemical Formula C16H10N2O2
Found 20 metabolite its formula value is C16H10N2O2
Indigo
Indigo (indigo dye or indigotin) is an organic compound with a distinctive blue color. It is an oxindole dimer consisting of two fused oxindole rings. Indoles are compounds which consist of a pyrrole ring fused to benzene to form 2,3-benzopyrrole. Indigo is found in both plants and animals and has been detected in human urine and human tissues (PMID: 11076521; PMID: 8667928). The natural precursor to indigo is indican, a colorless, water-soluble derivative of the amino acid tryptophan. Indican readily hydrolyzes to release β-D-glucose and indoxyl. Oxidation of indoxyl by CYP450 enzymes in the liver or kidneys can convert indoxyl to indigo (PMID: 11076521). Likewise, exposure to air can convert indoxyl to indigo. In addition to the mammalian production of minute amounts of indigo, this chemical can also be recovered in far larger amounts from plants. Historically, indigo has been extracted from the leaves of certain plants of the Indigofera genus, in particular Indigofera tinctoria. Indigofera plants were commonly grown and used throughout the world for the production of indigo dyestuff. This was economically important due to the previous rarity of some blue dyestuffs historically. India was the primary supplier of indigo to Europe as early as the Greco-Roman era. The association of India with indigo is reflected in the Greek word for the dye, indikón. The Romans latinized the term to indicum, which passed into Italian dialect and eventually into English as the word indigo. Most indigo dye produced today is synthetic, constituting several thousand tons each year. It is most commonly associated with the production of denim cloth and blue jeans.
Indirubin
Indirubin or indigo red is an organic compound with a distinctive deep red/orange color. It is an oxindole dimer consisting of two fused oxindole rings. Indoles are compounds which consist of a pyrrole ring fused to benzene to form 2,3-benzopyrrole. Indirubin is found in both plants and animals and has been detected in human urine and human tissues (PMID: 11076521; PMID: 8667928). The precursor to indirubin is indican, a colorless, water-soluble derivative of the amino acid tryptophan which is converted to indole via microbial metabolism. Indican readily hydrolyzes to release β-D-glucose and indoxyl. Oxidation of indoxyl by CYP450 enzymes in the liver or kidneys can convert indoxyl to indirubin (PMID: 11076521). Likewise, exposure to air can convert indoxyl to indirubin. In addition to the mammalian production of minute amounts of indirubin, this chemical can also be recovered in far larger amounts from plants. Historically, indirubin has been extracted from the leaves of certain plants of the Indigofera genus, in particular Indigofera tinctoria. Indigofera plants were commonly grown and used throughout the world for the production of dyes. Indirubin is a chemical constituent of indigo naturalis (also known as qing dai), which has been used for hundreds of years in traditional Chinese medicine. It is produced by collecting the waste products from the bacterial degradation of specific forms of vegetation. Indirubin has shown anti-inflammatory and anti-angiogenesis properties in vitro (PMID: 21207415). It has also been studied for potential use in the treatment of ulcerative colitis (PMID: 23674882). D000970 - Antineoplastic Agents D004396 - Coloring Agents Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2]. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2].
Indirubin
A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia. Indirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment). Indirubin is a natural product found in Isatis tinctoria, Couroupita guianensis, and Calanthe discolor with data available. D000970 - Antineoplastic Agents D004396 - Coloring Agents Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2]. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2].
Indigo_dye
C.i. vat blue 1 is a dark blue powder with coppery luster. Occurs in isomeric forms (cis and trans). In solid state it is in the trans form. (NTP, 1992) Indigo dye is a member of hydroxyindoles. Indigo is a natural product found in Isatis tinctoria and Couroupita guianensis with data available. Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk. D004396 - Coloring Agents
Isoindigotin
Isoindigo is the acceptor of donor-acceptor (D-A) conjugated polymer, as well as an Indigo series dye. Isoindigo equips two lactam rings and strong electron-withdrawing character. Isoindigo can be used for dyeing and pigment preparation. Isoindigo shows high mobility and good ambient stability in FETs[1].