Chemical Formula: C15H8O5

Chemical Formula C15H8O5

Found 26 metabolite its formula value is C15H8O5

Coumesterol

5,14-dihydroxy-8,17-dioxatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-9-one

C15H8O5 (268.0372)


Cumoesterol (or coumestrol), a coumestan isoflavone, has estrogenic properties (phytoestrogens are compounds structurally and functionally similar to 17-estradiol) and is an isoflavonoid phytoalexin produced by soybeans, a low molecular weight antimicrobial compound that is synthesized de novo and accumulates in plants after exposure to microorganisms (i.e.: phytoalexin induction and accumulation in soybean cotyledon tissue is observed with four species of Aspergillus: A. sojae, A. oryzae, A. niger, and A. flavus) (PMID: 10888516). Coumestrol is a naturally occurring plant coumarin that displays high affinity for the hormone-binding site of the human estrogen receptor (hER), for which it serves as a potent non-steroidal agonist. Coumestrol emits intense blue fluorescence when bound to this protein, making it ideally suited for use as a cytological stain to detect ER in fixed and intact cells. Such observations illustrate the potential for using coumestrol to investigate real-time effects of a variety of physiological stimuli on the subcellular distribution of hER in living cells (PMID: 8315272). Coumestrol is a member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9. It has a role as an anti-inflammatory agent, an antioxidant and a plant metabolite. It is a member of coumestans, a delta-lactone and a polyphenol. It is functionally related to a coumestan. Coumestrol is a natural product found in Campylotropis hirtella, Melilotus messanensis, and other organisms with data available. A daidzein derivative occurring naturally in forage crops which has some estrogenic activity. See also: Medicago sativa whole (part of). Isolated from Medicago subspecies, Glycine max (soybean), Pisum sativum (pea), Spinacia oleracea (spinach), Brassica oleracea (cabbage), Dolichos biflorus (papadi), Melilotus alba (white melilot), Phaseolus subspecies (inc. lima beans, pinto beans) and Vigna unguiculata (all Leguminosae). Potential nutriceutical D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

   

sparstolonin B

4,14-dihydroxy-8,15-dioxatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,9(17),10,13-heptaen-12-one

C15H8O5 (268.0372)


   

Ophiohayatone C

Ophiohayatone C

C15H8O5 (268.0372)


   

Nordamnacanthal

Nordamnacanthal

C15H8O5 (268.0372)


   

Cumestrol

3,9-Dihydroxycoumestan

C15H8O5 (268.0372)


Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

   

CHEMBL2338661

CHEMBL2338661

C15H8O5 (268.0372)


   

Pachybasic acid

Pachybasic acid

C15H8O5 (268.0372)


   

Acuminol B

Acuminol B

C15H8O5 (268.0372)


   

Ayamenin B

Ayamenin B

C15H8O5 (268.0372)


   

3-hydroxymethylfuro[3,2-b]naphtho[2,3-d]furan-5,10-dione

3-hydroxymethylfuro[3,2-b]naphtho[2,3-d]furan-5,10-dione

C15H8O5 (268.0372)


   

CHEMBL520325

CHEMBL520325

C15H8O5 (268.0372)


   

6,7-dehydrobaicalein

6,7-dehydrobaicalein

C15H8O5 (268.0372)


   

Coumestrol

Coumestrol

C15H8O5 (268.0372)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

   

Coumesterol

Coumesterol

C15H8O5 (268.0372)


   

Coumestan base + 2O

Coumestan base + 2O

C15H8O5 (268.0372)


Annotation level-2

   

9-fluorenone-2,7-dicarboxylic acid

9-fluorenone-2,7-dicarboxylic acid

C15H8O5 (268.0372)


   

Cumostrol

3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, delta-lactone (6CI)

C15H8O5 (268.0372)


D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

   

6,11-dihydroxyfuro[3,2-b]xanthen-5-one

6,11-dihydroxyfuro[3,2-b]xanthen-5-one

C15H8O5 (268.0372)


   

4,5-dihydroxyanthraquinone-2-carboxylic acid; aldehyde

NA

C15H8O5 (268.0372)


{"Ingredient_id": "HBIN010019","Ingredient_name": "4,5-dihydroxyanthraquinone-2-carboxylic acid; aldehyde","Alias": "NA","Ingredient_formula": "C15H8O5","Ingredient_Smile": "NA","Ingredient_weight": "0","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "7915","PubChem_id": "NA","DrugBank_id": "NA"}

   

4-hydroxy-2-carboxyanthraquinone

NA

C15H8O5 (268.0372)


{"Ingredient_id": "HBIN010449","Ingredient_name": "4-hydroxy-2-carboxyanthraquinone","Alias": "NA","Ingredient_formula": "C15H8O5","Ingredient_Smile": "C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3)C(=O)O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "9890","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}

   

7-hydroxy-2h-anthra[1,2-d][1,3]dioxole-6,11-dione

7-hydroxy-2h-anthra[1,2-d][1,3]dioxole-6,11-dione

C15H8O5 (268.0372)


   

5,7-dihydroxy-2,17-dioxatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),3,5,7,11(16),12,14-heptaen-9-one

5,7-dihydroxy-2,17-dioxatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),3,5,7,11(16),12,14-heptaen-9-one

C15H8O5 (268.0372)


   

4-hydroxy-9,10-dioxoanthracene-2-carboxylic acid

4-hydroxy-9,10-dioxoanthracene-2-carboxylic acid

C15H8O5 (268.0372)


   

1,3-dihydroxy-9,10-dioxoanthracene-2-carbaldehyde

1,3-dihydroxy-9,10-dioxoanthracene-2-carbaldehyde

C15H8O5 (268.0372)


   

3-hydroxy-9,10-dioxoanthracene-2-carboxylic acid

3-hydroxy-9,10-dioxoanthracene-2-carboxylic acid

C15H8O5 (268.0372)


   

14-(hydroxymethyl)-12,16-dioxatetracyclo[8.6.0.0³,⁸.0¹¹,¹⁵]hexadeca-1(10),3,5,7,11(15),13-hexaene-2,9-dione

14-(hydroxymethyl)-12,16-dioxatetracyclo[8.6.0.0³,⁸.0¹¹,¹⁵]hexadeca-1(10),3,5,7,11(15),13-hexaene-2,9-dione

C15H8O5 (268.0372)