sparstolonin B (BioDeep_00000183908)
human metabolite blood metabolite
代谢物信息卡片
化学式: C15H8O5 (268.0371718)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=C1O)C3=COC(=C4C3=C(O2)C=CC4=O)O
InChI: InChI=1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16,18H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haiwei Ma, Chenglong Xie, Gaolu He, Zhengtai Chen, Hongwei Lu, Hongqiang Wu, Hancheng Cai, Zihan Dai, Baolong Li, Cong Xu, Enxing Xue. Sparstolonin B suppresses free fatty acid palmitate-induced chondrocyte inflammation and mitigates post-traumatic arthritis in obese mice.
Journal of cellular and molecular medicine.
2022 02; 26(3):725-735. doi:
10.1111/jcmm.17099. [PMID: 34953038] - Diptadip Dattaroy, Ratanesh Kumar Seth, Suvarthi Das, Firas Alhasson, Varun Chandrashekaran, Gregory Michelotti, Daping Fan, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation.
American journal of physiology. Gastrointestinal and liver physiology.
2016 04; 310(7):G510-25. doi:
10.1152/ajpgi.00259.2015. [PMID: 26718771] - Ming Wang, Liangchang Xiu, Jianxin Diao, Lianbo Wei, Jia Sun. Sparstolonin B inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes.
European journal of pharmacology.
2015 Dec; 769(?):79-85. doi:
10.1016/j.ejphar.2015.10.050. [PMID: 26522926] - Muobarak J Tuorkey. Cancer Therapy with Phytochemicals: Present and Future Perspectives.
Biomedical and environmental sciences : BES.
2015 Nov; 28(11):808-19. doi:
10.3967/bes2015.112. [PMID: 26695359] - Nuo-Shu Zou, Qiao-Li Liang, Ping Li, Jie Liu, Xiao Liu, An Kang, Hai-Shan Deng. Determination of sparstolonin B by ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry: application to pharmacokinetic study of sparstolonin B in rat plasma.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1486-91. doi:
10.1002/bmc.3447. [PMID: 25731641] - Qing Liu, Jianping Li, Qiaoli Liang, Dawei Wang, Yi Luo, Fang Yu, Joseph S Janicki, Daping Fan. Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation.
Vascular pharmacology.
2015 Apr; 67-69(?):59-66. doi:
10.1016/j.vph.2015.03.015. [PMID: 25869499] - Ambrish Kumar, Daping Fan, Donald J Dipette, Ugra S Singh. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells.
PloS one.
2014; 9(5):e96343. doi:
10.1371/journal.pone.0096343. [PMID: 24788776] - Qiaoli Liang, Fang Yu, Xiaodong Cui, Jin'ao Duan, Qinan Wu, Prakash Nagarkatti, Daping Fan. Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells.
Archives of pharmacal research.
2013 Jul; 36(7):890-6. doi:
10.1007/s12272-013-0120-8. [PMID: 23604718] - Henry R Bateman, Qiaoli Liang, Daping Fan, Vanessa Rodriguez, Susan M Lessner. Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells.
PloS one.
2013; 8(8):e70500. doi:
10.1371/journal.pone.0070500. [PMID: 23940584]