Exact Mass: 489.3219
Exact Mass Matches: 489.3219
Found 488 metabolites which its exact mass value is equals to given mass value 489.3219
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Borrelidin
A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.
Chenodeoxycholylproline
Chenodeoxycholylproline belongs to a class of molecules known as bile acid-amino acid conjugates. These are bile acid conjugates that consist of a primary bile acid such as cholic acid, doxycholic acid and chenodeoxycholic acid, conjugated to an amino acid. Chenodeoxycholylproline consists of the bile acid chenodeoxycholic acid conjugated to the amino acid Proline conjugated at the C24 acyl site.Bile acids play an important role in regulating various physiological systems, such as fat digestion, cholesterol metabolism, vitamin absorption, liver function, and enterohepatic circulation through their combined signaling, detergent, and antimicrobial mechanisms (PMID: 34127070). Bile acids also act as detergents in the gut and support the absorption of fats through the intestinal membrane. These same properties allow for the disruption of bacterial membranes, thereby allowing them to serve a bacteriocidal or bacteriostatic function. In humans (and other mammals) bile acids are normally conjugated with the amino acids glycine and taurine by the liver. This conjugation catalyzed by two liver enzymes, bile acid CoA ligase (BAL) and bile acid CoA: amino acid N-acyltransferase (BAT). Glycine and taurine bound BAs are also referred to as bile salts due to their decreased pKa and complete ionization resulting in these compounds being present as anions in vivo. Unlike glycine and taurine-conjugated bile acids, these recently discovered bile acids, such as Chenodeoxycholylproline, are produced by the gut microbiota, making them secondary bile acids (PMID: 32103176) or microbially conjugated bile acids (MCBAs) (PMID: 34127070). Evidence suggests that these bile acid-amino acid conjugates are produced by microbes belonging to Clostridia species (PMID: 32103176). These unusual bile acid-amino acid conjugates are found in higher frequency in patients with inflammatory bowel disease (IBD), cystic fibrosis (CF) and in infants (PMID: 32103176). Chenodeoxycholylproline appears to act as an agonist for the farnesoid X receptor (FXR) and it can also lead to reduced expression of bile acid synthesis genes (PMID: 32103176). It currently appears that microbially conjugated bile acids (MCBAs) or amino acid-bile acid conjugates are only conjugated to cholic acid, deoxycholic acid and chenodeoxycholic acid (PMID: 34127070). It has been estimated that if microbial conjugation of bile acids is very promiscuous and occurs for all potential oxidized, epimerized, and dehydroxylated states of each hydroxyl group present on cholic acid (C3, C7, C12) in addition to ring orientation, the total number of potential human bile acid conjugates could be over 2800 (PMID: 34127070).
Deoxycholylproline
Deoxycholylproline belongs to a class of molecules known as bile acid-amino acid conjugates. These are bile acid conjugates that consist of a primary bile acid such as cholic acid, doxycholic acid and chenodeoxycholic acid, conjugated to an amino acid. Deoxycholylproline consists of the bile acid deoxycholic acid conjugated to the amino acid Proline conjugated at the C24 acyl site.Bile acids play an important role in regulating various physiological systems, such as fat digestion, cholesterol metabolism, vitamin absorption, liver function, and enterohepatic circulation through their combined signaling, detergent, and antimicrobial mechanisms (PMID: 34127070). Bile acids also act as detergents in the gut and support the absorption of fats through the intestinal membrane. These same properties allow for the disruption of bacterial membranes, thereby allowing them to serve a bacteriocidal or bacteriostatic function. In humans (and other mammals) bile acids are normally conjugated with the amino acids glycine and taurine by the liver. This conjugation catalyzed by two liver enzymes, bile acid CoA ligase (BAL) and bile acid CoA: amino acid N-acyltransferase (BAT). Glycine and taurine bound BAs are also referred to as bile salts due to their decreased pKa and complete ionization resulting in these compounds being present as anions in vivo. Unlike glycine and taurine-conjugated bile acids, these recently discovered bile acids, such as Deoxycholylproline, are produced by the gut microbiota, making them secondary bile acids (PMID: 32103176) or microbially conjugated bile acids (MCBAs) (PMID: 34127070). Evidence suggests that these bile acid-amino acid conjugates are produced by microbes belonging to Clostridia species (PMID: 32103176). These unusual bile acid-amino acid conjugates are found in higher frequency in patients with inflammatory bowel disease (IBD), cystic fibrosis (CF) and in infants (PMID: 32103176). Deoxycholylproline appears to act as an agonist for the farnesoid X receptor (FXR) and it can also lead to reduced expression of bile acid synthesis genes (PMID: 32103176). It currently appears that microbially conjugated bile acids (MCBAs) or amino acid-bile acid conjugates are only conjugated to cholic acid, deoxycholic acid and chenodeoxycholic acid (PMID: 34127070). It has been estimated that if microbial conjugation of bile acids is very promiscuous and occurs for all potential oxidized, epimerized, and dehydroxylated states of each hydroxyl group present on cholic acid (C3, C7, C12) in addition to ring orientation, the total number of potential human bile acid conjugates could be over 2800 (PMID: 34127070).
Vertilmicin
Nirogacestat
D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid
7,8-dihydro-8-hydroxyircinialactam A|8-Hydroxyircinialactam A
Lys Ser Gln Lys
Thr Ile Lys Glu
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid_2.4\\%
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid_major
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid_91.8\\%
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid_1.2\\%
(2E,6E,11E,13E)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid_1.3\\%
Ala Ile Met Arg
Ala Ile Arg Met
Ala Leu Met Arg
Ala Leu Arg Met
Ala Met Ile Arg
Ala Met Leu Arg
Ala Met Arg Ile
Ala Met Arg Leu
Ala Arg Ile Met
Ala Arg Leu Met
Ala Arg Met Ile
Ala Arg Met Leu
Cys Ile Arg Val
Cys Ile Val Arg
Cys Leu Arg Val
Cys Leu Val Arg
Cys Arg Ile Val
Cys Arg Leu Val
Cys Arg Val Ile
Cys Arg Val Leu
Cys Val Ile Arg
Cys Val Leu Arg
Cys Val Arg Ile
Cys Val Arg Leu
Glu Ile Lys Thr
Glu Ile Thr Lys
Glu Lys Ile Thr
Glu Lys Leu Thr
Glu Lys Thr Ile
Glu Lys Thr Leu
Glu Leu Lys Thr
Glu Leu Thr Lys
Glu Thr Ile Lys
Glu Thr Lys Ile
Glu Thr Lys Leu
Glu Thr Leu Lys
Phe Lys Pro Val
Phe Lys Val Pro
Phe Pro Lys Val
Phe Pro Val Lys
Phe Val Lys Pro
Phe Val Pro Lys
Ile Ala Met Arg
Ile Ala Arg Met
Ile Cys Arg Val
Ile Cys Val Arg
Ile Glu Lys Thr
Ile Glu Thr Lys
Ile Lys Glu Thr
Ile Lys Met Val
Ile Lys Thr Glu
Ile Lys Val Met
Ile Met Ala Arg
Ile Met Lys Val
Ile Met Arg Ala
Ile Met Val Lys
Ile Arg Ala Met
Ile Arg Cys Val
Ile Arg Met Ala
Ile Arg Thr Thr
Ile Arg Val Cys
Ile Thr Glu Lys
Ile Thr Lys Glu
Ile Thr Arg Thr
Ile Thr Thr Arg
Ile Val Cys Arg
Ile Val Lys Met
Ile Val Met Lys
Ile Val Arg Cys
Lys Glu Ile Thr
Lys Glu Leu Thr
Lys Glu Thr Ile
Lys Glu Thr Leu
Lys Phe Pro Val
Lys Phe Val Pro
Lys Ile Glu Thr
Lys Ile Met Val
Lys Ile Thr Glu
Lys Ile Val Met
Lys Lys Lys Ser
Lys Lys Asn Thr
Lys Lys Gln Ser
Lys Lys Ser Lys
Lys Lys Ser Gln
Lys Lys Thr Asn
Lys Leu Glu Thr
Lys Leu Met Val
Lys Leu Thr Glu
Lys Leu Val Met
Lys Met Ile Val
Lys Met Leu Val
Lys Met Val Ile
Lys Met Val Leu
Lys Asn Lys Thr
Lys Asn Thr Lys
Lys Pro Phe Val
Lys Pro Val Phe
Lys Gln Lys Ser
Lys Gln Ser Lys
Lys Ser Lys Lys
Lys Ser Lys Gln
Lys Thr Glu Ile
Lys Thr Glu Leu
Lys Thr Ile Glu
Lys Thr Lys Asn
Lys Thr Leu Glu
Lys Thr Asn Lys
Lys Val Phe Pro
Lys Val Ile Met
Lys Val Leu Met
Lys Val Met Ile
Lys Val Met Leu
Lys Val Pro Phe
Leu Ala Met Arg
Leu Ala Arg Met
Leu Cys Arg Val
Leu Cys Val Arg
Leu Glu Lys Thr
Leu Glu Thr Lys
Leu Lys Glu Thr
Leu Lys Met Val
Leu Lys Thr Glu
Leu Lys Val Met
Leu Met Ala Arg
Leu Met Lys Val
Leu Met Arg Ala
Leu Met Val Lys
Leu Arg Ala Met
Leu Arg Cys Val
Leu Arg Met Ala
Leu Arg Thr Thr
Leu Arg Val Cys
Leu Thr Glu Lys
Leu Thr Lys Glu
Leu Thr Arg Thr
Leu Thr Thr Arg
Leu Val Cys Arg
Leu Val Lys Met
Leu Val Met Lys
Leu Val Arg Cys
Met Ala Ile Arg
Met Ala Leu Arg
Met Ala Arg Ile
Met Ala Arg Leu
Met Ile Ala Arg
Met Ile Lys Val
Met Ile Arg Ala
Met Ile Val Lys
Met Lys Ile Val
Met Lys Leu Val
Met Lys Val Ile
Met Lys Val Leu
Met Leu Ala Arg
Met Leu Lys Val
Met Leu Arg Ala
Met Leu Val Lys
Met Arg Ala Ile
Met Arg Ala Leu
Met Arg Ile Ala
Met Arg Leu Ala
Met Val Ile Lys
Met Val Lys Ile
Met Val Lys Leu
Met Val Leu Lys
Asn Lys Lys Thr
Asn Lys Thr Lys
Asn Thr Lys Lys
Pro Phe Lys Val
Pro Phe Val Lys
Pro Lys Phe Val
Pro Lys Val Phe
Pro Val Phe Lys
Pro Val Lys Phe
Gln Lys Lys Ser
Gln Lys Ser Lys
Gln Ser Lys Lys
Arg Ala Ile Met
Arg Ala Leu Met
Arg Ala Met Ile
Arg Ala Met Leu
Arg Cys Ile Val
Arg Cys Leu Val
Arg Cys Val Ile
Arg Cys Val Leu
Arg Ile Ala Met
Arg Ile Cys Val
Arg Ile Met Ala
Arg Ile Thr Thr
Arg Ile Val Cys
Arg Leu Ala Met
Arg Leu Cys Val
Arg Leu Met Ala
Arg Leu Thr Thr
Arg Leu Val Cys
Arg Met Ala Ile
Arg Met Ala Leu
Arg Met Ile Ala
Arg Met Leu Ala
Arg Thr Ile Thr
Arg Thr Leu Thr
Arg Thr Thr Ile
Arg Thr Thr Leu
Arg Val Cys Ile
Arg Val Cys Leu
Arg Val Ile Cys
Arg Val Leu Cys
Ser Lys Lys Lys
Ser Lys Lys Gln
Ser Lys Gln Lys
Ser Gln Lys Lys
Thr Glu Ile Lys
Thr Glu Lys Ile
Thr Glu Lys Leu
Thr Glu Leu Lys
Thr Ile Glu Lys
Thr Ile Arg Thr
Thr Ile Thr Arg
Thr Lys Glu Ile
Thr Lys Glu Leu
Thr Lys Ile Glu
Thr Lys Lys Asn
Thr Lys Leu Glu
Thr Lys Asn Lys
Thr Leu Glu Lys
Thr Leu Lys Glu
Thr Leu Arg Thr
Thr Leu Thr Arg
Thr Asn Lys Lys
Thr Arg Ile Thr
Thr Arg Leu Thr
Thr Arg Thr Ile
Thr Arg Thr Leu
Thr Thr Ile Arg
Thr Thr Leu Arg
Thr Thr Arg Ile
Thr Thr Arg Leu
Val Cys Ile Arg
Val Cys Leu Arg
Val Cys Arg Ile
Val Cys Arg Leu
Val Phe Lys Pro
Val Phe Pro Lys
Val Ile Cys Arg
Val Ile Lys Met
Val Ile Met Lys
Val Ile Arg Cys
Val Lys Phe Pro
Val Lys Ile Met
Val Lys Leu Met
Val Lys Met Ile
Val Lys Met Leu
Val Lys Pro Phe
Val Leu Cys Arg
Val Leu Lys Met
Val Leu Met Lys
Val Leu Arg Cys
Val Met Ile Lys
Val Met Lys Ile
Val Met Lys Leu
Val Met Leu Lys
Val Pro Phe Lys
Val Pro Lys Phe
Val Arg Cys Ile
Val Arg Cys Leu
Val Arg Ile Cys
Val Arg Leu Cys
Carboprost tromethamine
D012102 - Reproductive Control Agents > D010120 - Oxytocics C78568 - Prostaglandin Analogue
2-[bis(2-hydroxyethyl)amino]ethanol,4-tridecan-3-ylbenzenesulfonic acid
Nirogacestat
D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators C471 - Enzyme Inhibitor
Migrastatin
A 14-membered macrolide which is isolated from Streptomyces sp.MK929-43F1 and inhibits cell migration of human esophageal cancer EC17 cells and mouse melanona B16 cells.