(-)-borrelidin (BioDeep_00001031390)

   

Volatile Flavor Compounds


代谢物信息卡片


(1R,2R)-2-[(2R,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid

化学式: C28H43NO6 (489.30902180000004)
中文名称: 抗螺旋體鏈絲菌素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
InChI: InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25+,27+/m0/s1

描述信息

同义名列表

3 个代谢物同义名

(1R,2R)-2-[(2R,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid; (-)-borrelidin; Borrelidin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ferial Aslani, Tim Sebastian, Miguel Keidel, Suada Fröhlich, Hans-Peter Elsässer, Hans-Christian Schuppe, Jörg Klug, Poornima Mahavadi, Monika Fijak, Martin Bergmann, Andreas Meinhardt, Sudhanshu Bhushan. Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells. Molecular human reproduction. 2017 06; 23(6):370-380. doi: 10.1093/molehr/gax022. [PMID: 28379541]
  • Hirotaka Matsuo, Yoshiyuki Kondo, Takashi Kawasaki, Shinji Tokuyama, Nobutaka Imamura. Borrelidin Isolated from Streptomyces sp. Inhibited Adipocyte Differentiation in 3T3-L1 Cells via Several Factors Including GATA-Binding Protein 3. Biological & pharmaceutical bulletin. 2015; 38(10):1504-11. doi: 10.1248/bpb.b15-00257. [PMID: 26424016]
  • Andrew Hagen, Sean Poust, Tristan de Rond, Satoshi Yuzawa, Leonard Katz, Paul D Adams, Christopher J Petzold, Jay D Keasling. In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase. Biochemistry. 2014 Sep; 53(38):5975-7. doi: 10.1021/bi500951c. [PMID: 25188840]
  • Ming Li, Ji Zhang, Chongxi Liu, Baozhu Fang, Xiangjing Wang, Wensheng Xiang. Identification of borrelidin binding site on threonyl-tRNA synthetase. Biochemical and biophysical research communications. 2014 Sep; 451(4):485-90. doi: 10.1016/j.bbrc.2014.07.100. [PMID: 25128830]
  • D R D Bignell, J K Fyans, Z Cheng. Phytotoxins produced by plant pathogenic Streptomyces species. Journal of applied microbiology. 2014 Feb; 116(2):223-35. doi: 10.1111/jam.12369. [PMID: 24131731]
  • I G Azcárate, P Marín-García, N Camacho, S Pérez-Benavente, A Puyet, A Diez, L Ribas de Pouplana, J M Bautista. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin. British journal of pharmacology. 2013 Jun; 169(3):645-58. doi: 10.1111/bph.12156. [PMID: 23488671]
  • Chongxi Liu, Xiangjing Wang, Yijun Yan, Jidong Wang, Bo Zhang, Ji Zhang, Wensheng Xiang. Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean [Glycine max (L.) Merr]. International journal of systematic and evolutionary microbiology. 2013 Mar; 63(Pt 3):1030-1036. doi: 10.1099/ijs.0.041483-0. [PMID: 22707527]
  • Zhisheng Cao, Gholam Khodakaramian, Kenji Arakawa, Haruyasu Kinashi. Isolation of borrelidin as a phytotoxic compound from a potato pathogenic streptomyces strain. Bioscience, biotechnology, and biochemistry. 2012; 76(2):353-7. doi: 10.1271/bbb.110799. [PMID: 22313786]