Exact Mass: 450.2746258
Exact Mass Matches: 450.2746258
Found 63 metabolites which its exact mass value is equals to given mass value 450.2746258,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Celastrol
Celastrol, a plant-derived triterpene, has antioxidant and anti-inflammatory activity that may prevent neuronal degeneration in Alzheimers disease (AD). In the brains of patients with AD signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production. Celastrol suppresses adjuvant arthritis in the rat, demonstrating in vivo anti-inflammatory activity. Low doses of celastrol administered to rats significantly improved their performance in memory, learning and psychomotor activity tests. The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. (PMID: 11513350) [HMDB] Celastrol, a plant-derived triterpene, has antioxidant and anti-inflammatory activity that may prevent neuronal degeneration in Alzheimers disease (AD). In the brains of patients with AD signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production. Celastrol suppresses adjuvant arthritis in the rat, demonstrating in vivo anti-inflammatory activity. Low doses of celastrol administered to rats significantly improved their performance in memory, learning and psychomotor activity tests. The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. (PMID: 11513350). Celastrol is a pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). It has a role as an antioxidant, an anti-inflammatory drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antineoplastic agent, a Hsp90 inhibitor and a metabolite. It is a pentacyclic triterpenoid and a monocarboxylic acid. Celastrol is a natural product found in Reissantia buchananii, Crossopetalum gaumeri, and other organisms with data available. A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
3-Me ether-2,3-Dihydroxy-24,29-dinor-1,3,5(10),7-friedelatetraene-6,21-dione|3-methyl-6-oxo-tingenol|3-O-methyl-6-oxotingenol
16-(2-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl)-17-nor-coryn-19-ene|Usambarin
18-O-(Z)-p-coumaroylbeyer-15-ene-11beta,18-diol|obtsurin D
(Z)-Cinnamoyl-(ent-13E)-15-Hydroxy-1(10),13-halimadien-18-oic acid
Celastrol
wilforol B
A pentacyclic triterpenoid with formula C29H38O4, originally isolated from the root bark of Tripterygium wilfordii.
25(9>8),26(13->14)abeo-24-nor-8,14-seco-friedelan-2,3-dihydroxy-1,3,5(10),6,8-pentaen-29(13)-olide
25(9->8)abeo-24-nor-8,14-seco-friedelan-2,3-dihydroxy-1,3,5(10),6,8,14(27)-hexaen-29-oic acid
2-hydroxy-3-methyl-21-oxo-12,24-dinor-D:B-friedoleane-1,3,5(10),7-tetraen-29-oic acid|rel-(2R,4aR,6aR,12bR,13aR,13bS)-2,3,4,4a,5,6,6a,8,12b,13,13a,13b-dodecahydro-11-hydroxy-2,4a,6a,9,10,12b,13a-heptamethyl-3-oxo-1H-dibenzo[a,i]fluorene-2-carboxylic acid
Naluzotan
C23H38N4O3S (450.26644780000004)
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
Seldomycin 5
An aminoglycoside antibiotic that is part of an antimicrobial complex consisting of factors 1,2,3,5 from a soil isolate named Streptomyces hofunensis.
(2-hydroxy-3-phosphonooxypropyl) (Z)-nonadec-9-enoate
LPMe(18:1)
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