Celastrol (BioDeep_00000017269)

Main id: BioDeep_00000329100

 

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs BioNovoGene_Lab2019 natural product


代谢物信息卡片


2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, (2R,4aS,6aS,12bR,14aS,14bR)-

化学式: C29H38O4 (450.277)
中文名称: 雷公藤红素, 苦瓜皂甙, 南蛇藤素, 南蛇藤醇, 苦瓜苷, 苦瓜甙, 苦瓜素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(=O)O)O
InChI: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

描述信息

Celastrol, a plant-derived triterpene, has antioxidant and anti-inflammatory activity that may prevent neuronal degeneration in Alzheimers disease (AD). In the brains of patients with AD signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production. Celastrol suppresses adjuvant arthritis in the rat, demonstrating in vivo anti-inflammatory activity. Low doses of celastrol administered to rats significantly improved their performance in memory, learning and psychomotor activity tests. The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. (PMID: 11513350) [HMDB]
Celastrol, a plant-derived triterpene, has antioxidant and anti-inflammatory activity that may prevent neuronal degeneration in Alzheimers disease (AD). In the brains of patients with AD signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production. Celastrol suppresses adjuvant arthritis in the rat, demonstrating in vivo anti-inflammatory activity. Low doses of celastrol administered to rats significantly improved their performance in memory, learning and psychomotor activity tests. The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD. (PMID: 11513350).
Celastrol is a pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM). It has a role as an antioxidant, an anti-inflammatory drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antineoplastic agent, a Hsp90 inhibitor and a metabolite. It is a pentacyclic triterpenoid and a monocarboxylic acid.
Celastrol is a natural product found in Reissantia buchananii, Crossopetalum gaumeri, and other organisms with data available.
A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

同义名列表

49 个代谢物同义名

2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-, (2R,4aS,6aS,12bR,14aS,14bR)-; (2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; (2R,4AS,6as,12BR,14as,14BR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylate; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; 24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID, 3-HYDROXY-9,13-DIMETHYL-2-OXO-, (9.BETA.,13.ALPHA.,14.BETA.,20.ALPHA.)-; 1,2,3,4,4a,5,6,6a, 11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b, 14a-hexamethyl-11-oxo-2-Picenecarboxylic acid; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid; 2-Picenecarboxylic acid,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-; 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid,3-hydroxy-9,13-dimethyl-2-oxo-, (9b,13a,14b,20a)-; (9?,13?,14?,20?)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid; 10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; 3-Hydroxy-9.beta.,13.alpha.-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid; 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid; 3-Hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-Oate; D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-; 3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-Oic acid; 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-Oic acid; 3-Hydroxy-9b,13a-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-Oate; 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-Oate; (20alpha)-3-hydroxy-2-oxo-D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid; (20alpha)-3-hydroxy-2-oxo-D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oate; 24-NOR-D:A-FRIEDOOLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID, 3-HYDROXY-2-OXO-; 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid; 11-alpha-hydroxyandrostenedione; Celastrol, >=98\\% (HPLC), solid; Celastrol, Celastrus scandens; compound 2 [PMID: 28621943]; KQJSQWZMSAGSHN-JJWQIEBTSA-N; Spectrum2_000150; Spectrum4_001966; Spectrum5_000805; Spectrum3_000233; UNII-L8GG98663L; CELASTROL [MI]; DivK1c_000718; NCI60_038570; KBio2_003383; KBio3_001405; KBio2_005951; KBio2_000815; KBio1_000718; IDI1_000718; triterpene; tripterine; L8GG98663L; Celastrol; tripterin; C29H38O4



数据库引用编号

18 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

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PlantCyc(0)

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102 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Dong-Xiao Cui, Ze-Chen Niu, Xi Tang, Chun-Zhou Cai, Ding-Qiao Xu, Rui-Jia Fu, Wen-Juan Liu, Yu-Wei Wang, Yu-Ping Tang. Celastrol induced the autophagy of spermatogonia cells contributed to tripterygium glycosides-related testicular injury. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108604. doi: 10.1016/j.reprotox.2024.108604. [PMID: 38703919]
  • Wenyuan Shen, Chuanhao Li, Quan Liu, Jun Cai, Zhishuo Wang, Yilin Pang, Guangzhi Ning, Xue Yao, Xiaohong Kong, Shiqing Feng. Celastrol inhibits oligodendrocyte and neuron ferroptosis to promote spinal cord injury recovery. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155380. doi: 10.1016/j.phymed.2024.155380. [PMID: 38507854]
  • Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding. Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry. 2024 May; 67(9):7176-7196. doi: 10.1021/acs.jmedchem.4c00023. [PMID: 38679872]
  • Jia-Jia Liu, Xue Zhang, Bang-Lan Cai, Man-Man Qi, Yong-Bin Chi, Bin Peng, Deng-Hai Zhang. Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells. Journal of integrative medicine. 2024 May; 22(3):286-294. doi: 10.1016/j.joim.2024.03.007. [PMID: 38565435]
  • Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar. Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach. Medical oncology (Northwood, London, England). 2024 Mar; 41(5):97. doi: 10.1007/s12032-024-02340-6. [PMID: 38532150]
  • Tianhong Xie, Hongliang Rui, Huiqiang Liu, Xin Liu, Xiang Liu, Ping Li. Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice. Lupus science & medicine. 2024 Mar; 11(1):. doi: 10.1136/lupus-2023-001057. [PMID: 38471722]
  • Baoye Yang, Decheng Wang, Shi Yu, Chengwei Zhang, Jing Ai, Xiang Yu. Breaking CHIPS-Mediated immune evasion with tripterin to promote neutrophil chemotaxis against MRSA infection. International immunopharmacology. 2024 Mar; 129(?):111597. doi: 10.1016/j.intimp.2024.111597. [PMID: 38295543]
  • Xin Zhang, Yao Chen, Xiao Li, Hong Xu, Jirui Yang, Chuanqi Wang, Chaozheng Zhang, Yun Deng, Aiping Lu, Chuan Zheng, Jun Lu. Carrier-free self-assembled nanomedicine based on celastrol and galactose for targeting therapy of hepatocellular carcinoma via inducing ferroptosis. European journal of medicinal chemistry. 2024 Mar; 267(?):116183. doi: 10.1016/j.ejmech.2024.116183. [PMID: 38354520]
  • Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu. Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis. Cell communication and signaling : CCS. 2024 02; 22(1):139. doi: 10.1186/s12964-023-01409-5. [PMID: 38378659]
  • Jin-Yu Ning, Bo Ma, Jing-Yi Huang, Liang Han, Yan-Hua Shao, Feng-Yun Wang. Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115883. doi: 10.1016/j.jpba.2023.115883. [PMID: 38044218]
  • Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment. ACS applied bio materials. 2024 Feb; ?(?):. doi: 10.1021/acsabm.3c01216. [PMID: 38315869]
  • Yun Lu, Yuan Liu, Yifeng Zhang, Haiyun Gao, Xiaochao Chen, Lichan Tu, Yunfeng Luo, Zhouqian Jiang, Yan Yin, Jiawei Zhou, Tianyuan Hu, Xiaoyi Wu, Jiadian Wang, Wei Gao, Luqi Huang. Characterization of the Cytochrome P450 CYP716C52 in Celastrol Biosynthesis and Its Applications in Engineered Saccharomyces cerevisiae. Journal of natural products. 2024 Jan; ?(?):. doi: 10.1021/acs.jnatprod.3c00674. [PMID: 38277488]
  • Liuting Zeng, Ganpeng Yu, Kailin Yang, Qi He, Wensa Hao, Wang Xiang, Zhiyong Long, Hua Chen, Xiaojun Tang, Lingyun Sun. Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics. Scientific reports. 2024 01; 14(1):1604. doi: 10.1038/s41598-023-48248-5. [PMID: 38238321]
  • Fang Huang, Enjing Zhang, Yan Lei, Qiong Yan, Chengbin Xue. Tripterine Inhibits Proliferation and Promotes Apoptosis of Keloid Fibroblasts by Targeting ROS/JNK Signaling. Journal of burn care & research : official publication of the American Burn Association. 2024 01; 45(1):104-111. doi: 10.1093/jbcr/irad106. [PMID: 37436955]
  • Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun. Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil. International journal of nanomedicine. 2024; 19(?):727-742. doi: 10.2147/ijn.s446895. [PMID: 38288265]
  • Fan Wen, Dandan Liu, Mingming Wang, Shujie Zhang, Wenhua Kuang, Lixia Yuan, Jigang Wang, Gang Liu. Celastrol induces premature ovarian insufficiency by inducing apoptosis in granulosa cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115815. doi: 10.1016/j.biopha.2023.115815. [PMID: 37956480]
  • Nuria Vilaboa, Richard Voellmy. Withaferin A and Celastrol Overwhelm Proteostasis. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010367. [PMID: 38203539]
  • Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen. The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery. Drug delivery. 2023 Dec; 30(1):2162156. doi: 10.1080/10717544.2022.2162156. [PMID: 36600637]
  • Shuhan Jin, Bo Li, Bibo Zhang, Xuejie Gao, Xinyan Jia, Li Xu, Shuaikang Chang, Ke Hu, Guanli Wang, Zhijian Xu, Ting Zhang, Dongliang Song, Guang Yang, Xiaosong Wu, Huabin Zhu, Cheng Huang, Yumeng Lu, Jumei Shi, Weiliang Zhu, Gege Chen. Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation. Acta biochimica et biophysica Sinica. 2023 Nov; 55(12):1884-1891. doi: 10.3724/abbs.2023260. [PMID: 38009004]
  • Yi Pan, Yunxiao Zhang, Hongling Ouyang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Targeted Delivery of Celastrol via Chondroitin Sulfate Derived Hybrid Micelles for Alleviating Symptoms in Nonalcoholic Fatty Liver Disease. ACS applied bio materials. 2023 Oct; ?(?):. doi: 10.1021/acsabm.3c00612. [PMID: 37890075]
  • Yun-Chao Liu, Ying Zhang, Shu-Cun Qin, Jun-Li Xue. [Research progress of celastrol on the prevention and treatment of metabolic associated fatty liver disease]. Sheng li xue bao : [Acta physiologica Sinica]. 2023 Oct; 75(5):682-690. doi: ". [PMID: 37909139]
  • Hongwen Liu, Lei Xu, Yiyang Zhang, Yiqiong Xie, Lishan Wang, Yue Zhou, Zhangding Wang, Yani Pan, Wenying Li, Lu Xu, Xinyun Xu, Ting Wang, Kui Meng, Jian He, Yudong Qiu, Guifang Xu, Weihong Ge, Yun Zhu, Lei Wang. Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation. Advanced healthcare materials. 2023 10; 12(26):e2300913. doi: 10.1002/adhm.202300913. [PMID: 37119498]
  • Tomoya Nakayama, Fuka Hirano, Yuki Okushi, Kosuke Matsuura, Miki Ohashi, Akiko Matsumiya, Takashi Yoshimura. Orphan nuclear receptor nr4a1 regulates winter depression-like behavior in medaka. Neuroscience letters. 2023 09; 814(?):137469. doi: 10.1016/j.neulet.2023.137469. [PMID: 37669713]
  • Manyun Dai, Wan Peng, Lisha Lin, Zhanxuan E Wu, Ting Zhang, Qi Zhao, Yan Cheng, Qiuxia Lin, Binbin Zhang, Aiming Liu, Qianru Rao, Jianfeng Huang, Jinhua Zhao, Frank J Gonzalez, Fei Li. Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155054. doi: 10.1016/j.phymed.2023.155054. [PMID: 37738906]
  • Yong Zhao, Nikolaj L Hansen, Yao-Tao Duan, Meera Prasad, Mohammed S Motawia, Birger L Møller, Irini Pateraki, Dan Staerk, Søren Bak, Karel Miettinen, Sotirios C Kampranis. Biosynthesis and biotechnological production of the anti-obesity agent celastrol. Nature chemistry. 2023 09; 15(9):1236-1246. doi: 10.1038/s41557-023-01245-7. [PMID: 37365337]
  • Senyu Zhang, Lumei Liu, Bangwen Yue, Xinyuan Wu, Hongyan Ji, Jianhuan Wang, Zhibo Jiang, Cheng Liu, Xiuli Wu. Seven lower toxicity celastrol derivatives by biotransformation of Pestalotiopsis sp. LGT-1. Phytochemistry. 2023 Sep; 213(?):113750. doi: 10.1016/j.phytochem.2023.113750. [PMID: 37279870]
  • Minling Pan, Zhen Wang, Yiyi Wang, Xianqin Jiang, Yali Fan, Fanghua Gong, Yunpeng Sun, Dezhong Wang. Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115333. doi: 10.1016/j.biopha.2023.115333. [PMID: 37598476]
  • Jia Gu, Ya-Ning Shi, Neng Zhu, Hong-Fang Li, Chan-Juan Zhang, Li Qin. Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 164(?):114981. doi: 10.1016/j.biopha.2023.114981. [PMID: 37285754]
  • Jiwen Fan, Meng Ren, Weiwei Chen, Haodong Wang, Yuquan He. Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats. International immunopharmacology. 2023 Aug; 121(?):110511. doi: 10.1016/j.intimp.2023.110511. [PMID: 37343368]
  • Shao-Ru Chen, Zheng-Qing Li, Jun Xu, Mo-Yu Ding, Ya-Ming Shan, Yung-Chi Cheng, Gao-Xiao Zhang, Ye-Wei Sun, Yu-Qiang Wang, Ying Wang. Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β. Acta pharmacologica Sinica. 2023 Aug; 44(8):1637-1648. doi: 10.1038/s41401-023-01067-w. [PMID: 36882503]
  • Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang. Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt/β-catenin signaling. International immunopharmacology. 2023 Jul; 122(?):110584. doi: 10.1016/j.intimp.2023.110584. [PMID: 37454630]
  • Shu Chen, Li Liu, Hong-Xia Jiang, Qun Sun, Liang Zhang, Jian-Qun Liu, Li-Fang Liu. UPLC-Q-TOF-MS/MS-based urine metabolomics studies on the toxicity and detoxication of Tripterygium wilfordii Hook. f. after roasting. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 234(?):115573. doi: 10.1016/j.jpba.2023.115573. [PMID: 37459834]
  • Cheng Wang, Shu Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li. Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114882. doi: 10.1016/j.biopha.2023.114882. [PMID: 37196541]
  • Ting Zhang, Qianru Rao, Manyun Dai, Zhanxuan E Wu, Qi Zhao, Fei Li. Tripterygium wilfordii protects against an animal model of autoimmune hepatitis. Journal of ethnopharmacology. 2023 Jun; 309(?):116365. doi: 10.1016/j.jep.2023.116365. [PMID: 36907478]
  • Jing Song, Guan-Nan He, Long Dai. A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114705. doi: 10.1016/j.biopha.2023.114705. [PMID: 37062220]
  • Anna Radajewska, Helena Moreira, Dorota Bęben, Oliwia Siwiela, Anna Szyjka, Katarzyna Gębczak, Paulina Nowak, Jakub Frąszczak, Fathi Emhemmed, Christian D Muller, Ewa Barg. Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119544. [PMID: 37298495]
  • Hongfang Li, Changfeng Deng, Neng Zhu, Chanjuan Zhang, Qing Zeng, Li Qin. An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis. Bioorganic chemistry. 2023 05; 134(?):106454. doi: 10.1016/j.bioorg.2023.106454. [PMID: 36889199]
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