Celastrol (BioDeep_00000329100)

 

Secondary id: BioDeep_00000017269

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


(2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-11-keto-2,4a,6a,6a,9,14a-hexamethyl-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid

化学式: C29H38O4 (450.2769948)
中文名称: 雷公藤红素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.92%

分子结构信息

SMILES: CC1=C(C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(=O)O)O
InChI: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

描述信息

同义名列表

32 个代谢物同义名

(2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-11-keto-2,4a,6a,6a,9,14a-hexamethyl-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; 2-Picenecarboxylic acid, 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-; (2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-; 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid; Celastrol, i>Celastrus scandens; Spectrum2_000150; Spectrum4_001966; Spectrum5_000805; Spectrum3_000233; Spectrum_000335; SPECTRUM201664; KBioGR_002436; KBioSS_000815; DivK1c_000718; BSPBio_001905; NCI60_038570; SPBio_000260; KBio2_003383; NINDS_000718; KBio3_001405; KBio2_005951; KBio2_000815; KBio1_000718; IDI1_000718; tripterine; 34157-83-0; Celastrol; tripterin; NSC 70931; NSC70931; 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dong-Xiao Cui, Ze-Chen Niu, Xi Tang, Chun-Zhou Cai, Ding-Qiao Xu, Rui-Jia Fu, Wen-Juan Liu, Yu-Wei Wang, Yu-Ping Tang. Celastrol induced the autophagy of spermatogonia cells contributed to tripterygium glycosides-related testicular injury. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108604. doi: 10.1016/j.reprotox.2024.108604. [PMID: 38703919]
  • Wenyuan Shen, Chuanhao Li, Quan Liu, Jun Cai, Zhishuo Wang, Yilin Pang, Guangzhi Ning, Xue Yao, Xiaohong Kong, Shiqing Feng. Celastrol inhibits oligodendrocyte and neuron ferroptosis to promote spinal cord injury recovery. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155380. doi: 10.1016/j.phymed.2024.155380. [PMID: 38507854]
  • Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding. Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry. 2024 May; 67(9):7176-7196. doi: 10.1021/acs.jmedchem.4c00023. [PMID: 38679872]
  • Jia-Jia Liu, Xue Zhang, Bang-Lan Cai, Man-Man Qi, Yong-Bin Chi, Bin Peng, Deng-Hai Zhang. Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells. Journal of integrative medicine. 2024 May; 22(3):286-294. doi: 10.1016/j.joim.2024.03.007. [PMID: 38565435]
  • Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar. Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach. Medical oncology (Northwood, London, England). 2024 Mar; 41(5):97. doi: 10.1007/s12032-024-02340-6. [PMID: 38532150]
  • Tianhong Xie, Hongliang Rui, Huiqiang Liu, Xin Liu, Xiang Liu, Ping Li. Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice. Lupus science & medicine. 2024 Mar; 11(1):. doi: 10.1136/lupus-2023-001057. [PMID: 38471722]
  • Baoye Yang, Decheng Wang, Shi Yu, Chengwei Zhang, Jing Ai, Xiang Yu. Breaking CHIPS-Mediated immune evasion with tripterin to promote neutrophil chemotaxis against MRSA infection. International immunopharmacology. 2024 Mar; 129(?):111597. doi: 10.1016/j.intimp.2024.111597. [PMID: 38295543]
  • Xin Zhang, Yao Chen, Xiao Li, Hong Xu, Jirui Yang, Chuanqi Wang, Chaozheng Zhang, Yun Deng, Aiping Lu, Chuan Zheng, Jun Lu. Carrier-free self-assembled nanomedicine based on celastrol and galactose for targeting therapy of hepatocellular carcinoma via inducing ferroptosis. European journal of medicinal chemistry. 2024 Mar; 267(?):116183. doi: 10.1016/j.ejmech.2024.116183. [PMID: 38354520]
  • Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu. Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis. Cell communication and signaling : CCS. 2024 02; 22(1):139. doi: 10.1186/s12964-023-01409-5. [PMID: 38378659]
  • Jin-Yu Ning, Bo Ma, Jing-Yi Huang, Liang Han, Yan-Hua Shao, Feng-Yun Wang. Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115883. doi: 10.1016/j.jpba.2023.115883. [PMID: 38044218]
  • Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment. ACS applied bio materials. 2024 Feb; ?(?):. doi: 10.1021/acsabm.3c01216. [PMID: 38315869]
  • Yun Lu, Yuan Liu, Yifeng Zhang, Haiyun Gao, Xiaochao Chen, Lichan Tu, Yunfeng Luo, Zhouqian Jiang, Yan Yin, Jiawei Zhou, Tianyuan Hu, Xiaoyi Wu, Jiadian Wang, Wei Gao, Luqi Huang. Characterization of the Cytochrome P450 CYP716C52 in Celastrol Biosynthesis and Its Applications in Engineered Saccharomyces cerevisiae. Journal of natural products. 2024 Jan; ?(?):. doi: 10.1021/acs.jnatprod.3c00674. [PMID: 38277488]
  • Liuting Zeng, Ganpeng Yu, Kailin Yang, Qi He, Wensa Hao, Wang Xiang, Zhiyong Long, Hua Chen, Xiaojun Tang, Lingyun Sun. Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics. Scientific reports. 2024 01; 14(1):1604. doi: 10.1038/s41598-023-48248-5. [PMID: 38238321]
  • Fang Huang, Enjing Zhang, Yan Lei, Qiong Yan, Chengbin Xue. Tripterine Inhibits Proliferation and Promotes Apoptosis of Keloid Fibroblasts by Targeting ROS/JNK Signaling. Journal of burn care & research : official publication of the American Burn Association. 2024 01; 45(1):104-111. doi: 10.1093/jbcr/irad106. [PMID: 37436955]
  • Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun. Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil. International journal of nanomedicine. 2024; 19(?):727-742. doi: 10.2147/ijn.s446895. [PMID: 38288265]
  • Fan Wen, Dandan Liu, Mingming Wang, Shujie Zhang, Wenhua Kuang, Lixia Yuan, Jigang Wang, Gang Liu. Celastrol induces premature ovarian insufficiency by inducing apoptosis in granulosa cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115815. doi: 10.1016/j.biopha.2023.115815. [PMID: 37956480]
  • Nuria Vilaboa, Richard Voellmy. Withaferin A and Celastrol Overwhelm Proteostasis. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010367. [PMID: 38203539]
  • Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen. The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery. Drug delivery. 2023 Dec; 30(1):2162156. doi: 10.1080/10717544.2022.2162156. [PMID: 36600637]
  • Shuhan Jin, Bo Li, Bibo Zhang, Xuejie Gao, Xinyan Jia, Li Xu, Shuaikang Chang, Ke Hu, Guanli Wang, Zhijian Xu, Ting Zhang, Dongliang Song, Guang Yang, Xiaosong Wu, Huabin Zhu, Cheng Huang, Yumeng Lu, Jumei Shi, Weiliang Zhu, Gege Chen. Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation. Acta biochimica et biophysica Sinica. 2023 Nov; 55(12):1884-1891. doi: 10.3724/abbs.2023260. [PMID: 38009004]
  • Yi Pan, Yunxiao Zhang, Hongling Ouyang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Targeted Delivery of Celastrol via Chondroitin Sulfate Derived Hybrid Micelles for Alleviating Symptoms in Nonalcoholic Fatty Liver Disease. ACS applied bio materials. 2023 Oct; ?(?):. doi: 10.1021/acsabm.3c00612. [PMID: 37890075]
  • Yun-Chao Liu, Ying Zhang, Shu-Cun Qin, Jun-Li Xue. [Research progress of celastrol on the prevention and treatment of metabolic associated fatty liver disease]. Sheng li xue bao : [Acta physiologica Sinica]. 2023 Oct; 75(5):682-690. doi: ". [PMID: 37909139]
  • Hongwen Liu, Lei Xu, Yiyang Zhang, Yiqiong Xie, Lishan Wang, Yue Zhou, Zhangding Wang, Yani Pan, Wenying Li, Lu Xu, Xinyun Xu, Ting Wang, Kui Meng, Jian He, Yudong Qiu, Guifang Xu, Weihong Ge, Yun Zhu, Lei Wang. Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation. Advanced healthcare materials. 2023 10; 12(26):e2300913. doi: 10.1002/adhm.202300913. [PMID: 37119498]
  • Tomoya Nakayama, Fuka Hirano, Yuki Okushi, Kosuke Matsuura, Miki Ohashi, Akiko Matsumiya, Takashi Yoshimura. Orphan nuclear receptor nr4a1 regulates winter depression-like behavior in medaka. Neuroscience letters. 2023 09; 814(?):137469. doi: 10.1016/j.neulet.2023.137469. [PMID: 37669713]
  • Manyun Dai, Wan Peng, Lisha Lin, Zhanxuan E Wu, Ting Zhang, Qi Zhao, Yan Cheng, Qiuxia Lin, Binbin Zhang, Aiming Liu, Qianru Rao, Jianfeng Huang, Jinhua Zhao, Frank J Gonzalez, Fei Li. Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155054. doi: 10.1016/j.phymed.2023.155054. [PMID: 37738906]
  • Yong Zhao, Nikolaj L Hansen, Yao-Tao Duan, Meera Prasad, Mohammed S Motawia, Birger L Møller, Irini Pateraki, Dan Staerk, Søren Bak, Karel Miettinen, Sotirios C Kampranis. Biosynthesis and biotechnological production of the anti-obesity agent celastrol. Nature chemistry. 2023 09; 15(9):1236-1246. doi: 10.1038/s41557-023-01245-7. [PMID: 37365337]
  • Senyu Zhang, Lumei Liu, Bangwen Yue, Xinyuan Wu, Hongyan Ji, Jianhuan Wang, Zhibo Jiang, Cheng Liu, Xiuli Wu. Seven lower toxicity celastrol derivatives by biotransformation of Pestalotiopsis sp. LGT-1. Phytochemistry. 2023 Sep; 213(?):113750. doi: 10.1016/j.phytochem.2023.113750. [PMID: 37279870]
  • Minling Pan, Zhen Wang, Yiyi Wang, Xianqin Jiang, Yali Fan, Fanghua Gong, Yunpeng Sun, Dezhong Wang. Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115333. doi: 10.1016/j.biopha.2023.115333. [PMID: 37598476]
  • Jia Gu, Ya-Ning Shi, Neng Zhu, Hong-Fang Li, Chan-Juan Zhang, Li Qin. Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 164(?):114981. doi: 10.1016/j.biopha.2023.114981. [PMID: 37285754]
  • Jiwen Fan, Meng Ren, Weiwei Chen, Haodong Wang, Yuquan He. Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats. International immunopharmacology. 2023 Aug; 121(?):110511. doi: 10.1016/j.intimp.2023.110511. [PMID: 37343368]
  • Shao-Ru Chen, Zheng-Qing Li, Jun Xu, Mo-Yu Ding, Ya-Ming Shan, Yung-Chi Cheng, Gao-Xiao Zhang, Ye-Wei Sun, Yu-Qiang Wang, Ying Wang. Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β. Acta pharmacologica Sinica. 2023 Aug; 44(8):1637-1648. doi: 10.1038/s41401-023-01067-w. [PMID: 36882503]
  • Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang. Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt/β-catenin signaling. International immunopharmacology. 2023 Jul; 122(?):110584. doi: 10.1016/j.intimp.2023.110584. [PMID: 37454630]
  • Shu Chen, Li Liu, Hong-Xia Jiang, Qun Sun, Liang Zhang, Jian-Qun Liu, Li-Fang Liu. UPLC-Q-TOF-MS/MS-based urine metabolomics studies on the toxicity and detoxication of Tripterygium wilfordii Hook. f. after roasting. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 234(?):115573. doi: 10.1016/j.jpba.2023.115573. [PMID: 37459834]
  • Cheng Wang, Shu Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li. Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114882. doi: 10.1016/j.biopha.2023.114882. [PMID: 37196541]
  • Ting Zhang, Qianru Rao, Manyun Dai, Zhanxuan E Wu, Qi Zhao, Fei Li. Tripterygium wilfordii protects against an animal model of autoimmune hepatitis. Journal of ethnopharmacology. 2023 Jun; 309(?):116365. doi: 10.1016/j.jep.2023.116365. [PMID: 36907478]
  • Jing Song, Guan-Nan He, Long Dai. A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114705. doi: 10.1016/j.biopha.2023.114705. [PMID: 37062220]
  • Anna Radajewska, Helena Moreira, Dorota Bęben, Oliwia Siwiela, Anna Szyjka, Katarzyna Gębczak, Paulina Nowak, Jakub Frąszczak, Fathi Emhemmed, Christian D Muller, Ewa Barg. Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119544. [PMID: 37298495]
  • Hongfang Li, Changfeng Deng, Neng Zhu, Chanjuan Zhang, Qing Zeng, Li Qin. An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis. Bioorganic chemistry. 2023 05; 134(?):106454. doi: 10.1016/j.bioorg.2023.106454. [PMID: 36889199]
  • Jing Xian, Xuemei Zhong, Qi Huang, Huan Gu, Yixuan Feng, Jiayi Sun, Di Wang, Jingjing Li, Chen Zhang, Yihan Wu, Jinming Zhang. N-Trimethylated chitosan coating white adipose tissue vascular-targeting oral nano-system for the enhanced anti-obesity effects of celastrol. International journal of biological macromolecules. 2023 May; 236(?):124023. doi: 10.1016/j.ijbiomac.2023.124023. [PMID: 36924876]
  • Chanjuan Zhang, Yan Qin, Changfeng Deng, Neng Zhu, Yaning Shi, Wei Wang, Li Qin. GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics. Analytica chimica acta. 2023 Apr; 1248(?):340933. doi: 10.1016/j.aca.2023.340933. [PMID: 36813462]
  • Tianyuan Yang, Shuping Zhao, Ning Sun, Yuan Zhao, Hui Wang, Yuntong Zhang, Xiaoyu Hou, Yulin Tang, Xiang Gao, Honggang Fan. Network pharmacology and in vivo studies reveal the pharmacological effects and molecular mechanisms of Celastrol against acute hepatic injury induced by LPS. International immunopharmacology. 2023 Apr; 117(?):109898. doi: 10.1016/j.intimp.2023.109898. [PMID: 36827925]
  • Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B Wing, Daron M Standley, Junichi Takagi, Kazuhiro Suzuki. Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Science immunology. 2023 03; 8(81):eadc9324. doi: 10.1126/sciimmunol.adc9324. [PMID: 37000855]
  • Jinhui Bian, Yi Ding, Song Wang, Yefan Jiang, Mingyan Wang, Ke Wei, Linjie Si, Xin Zhao, Yongfeng Shao. Celastrol confers ferroptosis resistance via AKT/GSK3β signaling in high-fat diet-induced cardiac injury. Free radical biology & medicine. 2023 Mar; 200(?):36-46. doi: 10.1016/j.freeradbiomed.2023.03.004. [PMID: 36906189]
  • Xue Zhang, Xueya Xu, Xiaoying Wang, Yajuan Lin, Yaling Zheng, Wen Xu, Jian Liu, Wei Xu. Hepatoma-targeting and reactive oxygen species-responsive chitosan-based polymeric micelles for delivery of celastrol. Carbohydrate polymers. 2023 Mar; 303(?):120439. doi: 10.1016/j.carbpol.2022.120439. [PMID: 36657834]
  • Céline Mias, Marie Dominique Thouvenin, Eleonore Gravier, Sandrine Dalmon, Karine Bouyer, Sandrine Alvarez, Valerie Mengeaud, Virginie Ribet, Sandrine Bessou-Touya, Hélène Duplan. Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris. Journal of the European Academy of Dermatology and Venereology : JEADV. 2023 Mar; 37 Suppl 2(?):20-25. doi: 10.1111/jdv.18792. [PMID: 36729402]
  • Tao-Lin Qing, Lang Yan, Shao-Kang Wang, Xiao-Yu Dai, Li-Jun Ren, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Mei-Tang Wang, Ji-Kuai Chen, Jiang-Bo Zhu. Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway. Ecotoxicology and environmental safety. 2023 Mar; 252(?):114623. doi: 10.1016/j.ecoenv.2023.114623. [PMID: 36774793]
  • Céline Mias, Nathalie Chansard, Martine Maitre, Marie Florence Galliano, Lucile Garidou, Valerie Mengeaud, Sandrine Bessou-Touya, Hélène Duplan. Myrtus communis and Celastrol enriched plant cell culture extracts control together the pivotal role of Cutibacterium acnes and inflammatory pathways in acne. Journal of the European Academy of Dermatology and Venereology : JEADV. 2023 Mar; 37 Suppl 2(?):12-19. doi: 10.1111/jdv.18793. [PMID: 36729401]
  • Jiaqi Xin, Ting Yang, Xiaoyi Wu, Yingting Wu, Yi Liu, Xuan Liu, Mengxi Jiang, Wei Gao. Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model. Communications biology. 2023 02; 6(1):194. doi: 10.1038/s42003-023-04564-0. [PMID: 36804628]
  • Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy. 2023 02; 8(1):51. doi: 10.1038/s41392-022-01231-4. [PMID: 36732502]
  • Yansong Zhang, Lijuan Ding, Ting Wang, Xiangtao Wang, Bo Yu, Fei Jia, Meihua Han, Yifei Guo. A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031040. [PMID: 36770710]
  • Meng Li, Qiong Luo, Xi Chen, Furong Qiu, Yanyan Tao, Xin Sun, Chenghai Liu. Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns. BMC complementary medicine and therapies. 2023 Jan; 23(1):9. doi: 10.1186/s12906-023-03836-w. [PMID: 36627617]
  • Chunhong Liu, Jiahui Gu, Yingli Yu. Celastrol assuages oxygen-glucose deprivation and reoxygenation-induced damage in human brain microvascular endothelial cells through the circDLGAP4/miR-6085/GDF11 pathway. Metabolic brain disease. 2023 01; 38(1):255-267. doi: 10.1007/s11011-022-01106-1. [PMID: 36445630]
  • Shiping Zhu, Qiubo Liu, Yuling Chang, Chunhua Luo, Xingwang Zhang, Shengyun Sun. Integrated Network Pharmacology and Cellular Assay to Explore the Mechanisms of Selenized Tripterine Phytosomes (Se@Tri-PTs) Alleviating Podocyte Injury in Diabetic Nephropathy. Current pharmaceutical design. 2023; 29(38):3073-3086. doi: 10.2174/0113816128275079231102071508. [PMID: 37961864]
  • Ciyu Yao, Wenzhen Ye, Mengxue Chen. Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2. Disease markers. 2023; 2023(?):9049256. doi: 10.1155/2023/9049256. [PMID: 36712922]
  • Haiying Que, Weiqi Hong, Tianxia Lan, Hao Zeng, Li Chen, Dandan Wan, Zhenfei Bi, Wenyan Ren, Min Luo, Jingyun Yang, Cai He, Ailing Zhong, Xiawei Wei. Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment. Signal transduction and targeted therapy. 2022 12; 7(1):399. doi: 10.1038/s41392-022-01283-6. [PMID: 36566328]
  • Xiaohu Zeng, Xin Zhu, Qikang Tian, Xiaoke Tan, Ning Sun, Min Yan, Junwei Zhao, Xiangxiang Wu, Ruiqin Li, Zhenqiang Zhang, Huahui Zeng. Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer. Drug delivery. 2022 Dec; 29(1):89-98. doi: 10.1080/10717544.2021.2018521. [PMID: 34964425]
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