Exact Mass: 443.1856

Dathf

C21H25N5O6 (443.1805)

Lucitanib

C26H25N3O4 (443.1845)

C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C93259 - VEGFR Tyrosine Kinase Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163953 - VEGFR-targeting Agent C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor

Asteromycin

C16H25N7O8 (443.1765)

platencin A4

C24H29NO7 (443.1944)

1-Hydroxy-3-[(2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-yl)carbonyl]-4-hydroxy-5-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]heptane-2-yl)-2(1H)-pyridone

C24H29NO7 (443.1944)

(2R)-N-(2phenylethyl)-N-methylcinnamamide2-O-beta-D-glucopyranoside

C24H29NO7 (443.1944)

pGlu-Gln-Trp

C21H25N5O6 (443.1805)

Cohrisitine

C24H29NO7 (443.1944)

1-{4-[(N-methyl-glycyl)-amino]-2-oxo-2H-pyrimidin-1-yl}-3-(seryl-amino)-beta-D-1,3-dideoxy-allopyranuronic acid amide|Gougerotin

C16H25N7O8 (443.1765)

N-methylasimilobine-2-O-beta-D-glucopyranoside

C24H29NO7 (443.1944)

Phe Phe Met

C23H29N3O4S (443.1879)

Met Phe Phe

C23H29N3O4S (443.1879)

N2-Methylisoeugenolyl-deoxyguanosine

C21H25N5O6 (443.1805)

Cys Gly His Lys

C17H29N7O5S (443.1951)

Cys Gly Lys His

C17H29N7O5S (443.1951)

Cys His Gly Lys

C17H29N7O5S (443.1951)

Cys His Lys Gly

C17H29N7O5S (443.1951)

Cys Lys Gly His

C17H29N7O5S (443.1951)

Cys Lys His Gly

C17H29N7O5S (443.1951)

Cys Pro Pro Gln

C18H29N5O6S (443.1838)

Cys Pro Gln Pro

C18H29N5O6S (443.1838)

Cys Gln Pro Pro

C18H29N5O6S (443.1838)

Gly Cys His Lys

C17H29N7O5S (443.1951)

Gly Cys Lys His

C17H29N7O5S (443.1951)

Gly His Cys Lys

C17H29N7O5S (443.1951)

Gly His Lys Cys

C17H29N7O5S (443.1951)

Gly Lys Cys His

C17H29N7O5S (443.1951)

Gly Lys His Cys

C17H29N7O5S (443.1951)

His Cys Gly Lys

C17H29N7O5S (443.1951)

His Cys Lys Gly

C17H29N7O5S (443.1951)

His Gly Cys Lys

C17H29N7O5S (443.1951)

His Gly Lys Cys

C17H29N7O5S (443.1951)

His Lys Cys Gly

C17H29N7O5S (443.1951)

His Lys Gly Cys

C17H29N7O5S (443.1951)

His Asn Ser Ser

C16H25N7O8 (443.1765)

Met Phe Phe

C23H29N3O4S1 (443.1879)

His Ser Asn Ser

C16H25N7O8 (443.1765)

His Ser Ser Asn

C16H25N7O8 (443.1765)

Lys Cys Gly His

C17H29N7O5S (443.1951)

Lys Cys His Gly

C17H29N7O5S (443.1951)

Lys Gly Cys His

C17H29N7O5S (443.1951)

Lys Gly His Cys

C17H29N7O5S (443.1951)

Lys His Cys Gly

C17H29N7O5S (443.1951)

Lys His Gly Cys

C17H29N7O5S (443.1951)

Phe Phe Met

C23H29N3O4S1 (443.1879)

Asn His Ser Ser

C16H25N7O8 (443.1765)

Asn Ser His Ser

C16H25N7O8 (443.1765)

Asn Ser Ser His

C16H25N7O8 (443.1765)

Pro Cys Pro Gln

C18H29N5O6S (443.1838)

Pro Cys Gln Pro

C18H29N5O6S (443.1838)

Pro Pro Cys Gln

C18H29N5O6S (443.1838)

Pro Pro Gln Cys

C18H29N5O6S (443.1838)

Pro Gln Cys Pro

C18H29N5O6S (443.1838)

Pro Gln Pro Cys

C18H29N5O6S (443.1838)

Gln Cys Pro Pro

C18H29N5O6S (443.1838)

Phe Met Phe

C23H29N3O4S1 (443.1879)

Gln Pro Cys Pro

C18H29N5O6S (443.1838)

Gln Pro Pro Cys

C18H29N5O6S (443.1838)

Ser His Asn Ser

C16H25N7O8 (443.1765)

Ser His Ser Asn

C16H25N7O8 (443.1765)

Ser Asn His Ser

C16H25N7O8 (443.1765)

Ser Asn Ser His

C16H25N7O8 (443.1765)

Ser Ser His Asn

C16H25N7O8 (443.1765)

Ser Ser Asn His

C16H25N7O8 (443.1765)

Lometrexol

C21H25N5O6 (443.1805)

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite C471 - Enzyme Inhibitor > C2692 - Glycinamide Ribonucleotide Formyltransferase Inhibitor D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists D009676 - Noxae > D000963 - Antimetabolites D000970 - Antineoplastic Agents

Fmoc-NH-PEG3-CH2CH2COOH

C24H29NO7 (443.1944)

S 14506

C24H27ClFN3O2 (443.1776)

S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].

Fmoc-L-Glutamic acid-O-tert-butyl ester hydrate

C24H29NO7 (443.1944)

C26H25N3O4

C26H25N3O4 (443.1845)

Ningnanmycin

C16H25N7O8 (443.1765)

N-(4-{2-[(6s)-2-Amino-4-Oxo-1,4,5,6,7,8-Hexahydropyrido[2,3-D]pyrimidin-6-Yl]ethyl}benzoyl)-L-Glutamic Acid

C21H25N5O6 (443.1805)

3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid

C24H29NO7 (443.1944)

Lucitanib

C26H25N3O4 (443.1845)

C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C93259 - VEGFR Tyrosine Kinase Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163953 - VEGFR-targeting Agent C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor

Gougerotin

C16H25N7O8 (443.1765)

Ddathf

C21H25N5O6 (443.1805)

[3-Carboxy-2-[3-[(2-hydroxy-3,3-dimethyl-4-phosphonooxybutanoyl)amino]propanoyloxy]propyl]-trimethylazanium

C16H32N2O10P+ (443.1794)

Platensin A4

C24H29NO7 (443.1944)

A polycyclic cage that is the 3-hydroxy derivative of platencin. It is isolated from Streptomyces platensis.

8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

C27H26ClN3O (443.1764)

N-[5-methyl-2-(4-methylphenyl)-3-pyrazolyl]-2-[(7-methyl-4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-9-yl)oxy]acetamide

C26H25N3O4 (443.1845)

3-[7-(3,4-dimethoxyphenyl)-8-imino-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-9(8H)-yl]propan-1-ol

C26H25N3O4 (443.1845)

1-(2-Methyl-2,3-dihydroindol-1-yl)-2-[4-[5-(trifluoromethyl)-1-benzotriazolyl]-1-piperidinyl]ethanone

C23H24F3N5O (443.1933)

(E)-3-[4-(diethylsulfamoyl)phenyl]-N-(4-morpholin-4-ylphenyl)prop-2-enamide

C23H29N3O4S (443.1879)

3-(1,3-Benzodioxol-5-yl)-1-(2,6-dimethyl-4-morpholinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone

C24H29NO7 (443.1944)

(2R)-2-[(4S,5R)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

Met-Phe-Phe

C23H29N3O4S (443.1879)

(2R)-2-[(4S,5S)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

(2S)-2-[(4S,5S)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

(2S)-2-[(4R,5R)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

(2R)-2-[(4R,5R)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

2-[(1R,3R,4aR,9aS)-6-[(4-fluorophenyl)carbamoylamino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b][1]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

(2R)-2-[(4R,5S)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

(2S)-2-[(4R,5S)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

(2S)-2-[(4S,5R)-5-[(dimethylamino)methyl]-4-methyl-1,1-dioxo-8-[2-(2-pyridinyl)ethynyl]-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-2-yl]-1-propanol

C23H29N3O4S (443.1879)

2-[(1R,3S,4aR,9aS)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3S,4aR,9aS)-6-[(4-fluorophenyl)carbamoylamino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b][1]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

3-[(4S,5S)-5-[(dimethylamino)methyl]-2-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-8-yl]benzonitrile

C23H29N3O4S (443.1879)

N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-oxo-2-(4-phenylanilino)ethyl]-3,6-dihydro-2H-pyran-3-yl]-4-pyridinecarboxamide

C26H25N3O4 (443.1845)

N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-oxo-2-(4-phenylanilino)ethyl]-3,6-dihydro-2H-pyran-3-yl]-4-pyridinecarboxamide

C26H25N3O4 (443.1845)

2-[(1R,3R,4aS,9aR)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3R,4aR,9aS)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1R,3S,4aR,9aS)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1R,3R,4aS,9aR)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1R,3S,4aS,9aR)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

1-[(1S,2aR,8bR)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(3-pyridinyl)ethanone

C26H25N3O4 (443.1845)

(1R,2aS,8bS)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-N-phenyl-1,2a,3,8b-tetrahydroazeto[2,3-c]quinoline-2-carboxamide

C26H25N3O4 (443.1845)

1-[(1S,2aS,8bS)-1-(hydroxymethyl)-4-[(4-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(2-pyridinyl)ethanone

C26H25N3O4 (443.1845)

1-[(1S,2aR,8bR)-1-(hydroxymethyl)-4-[(4-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(2-pyridinyl)ethanone

C26H25N3O4 (443.1845)

3-[4-[(2R,3R)-6-acetyl-2-(hydroxymethyl)-1-(3,3,3-trifluoropropyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile

C24H24F3N3O2 (443.1821)

(6R,7R,8S)-8-(hydroxymethyl)-7-[4-(3-methoxyphenyl)phenyl]-4-[oxo(3-pyridinyl)methyl]-1,4-diazabicyclo[4.2.0]octan-2-one

C26H25N3O4 (443.1845)

(6S,7S,8S)-8-(hydroxymethyl)-7-[4-(3-methoxyphenyl)phenyl]-4-[oxo(3-pyridinyl)methyl]-1,4-diazabicyclo[4.2.0]octan-2-one

C26H25N3O4 (443.1845)

(6R,7S,8S)-8-(hydroxymethyl)-7-[4-(3-methoxyphenyl)phenyl]-4-[oxo(3-pyridinyl)methyl]-1,4-diazabicyclo[4.2.0]octan-2-one

C26H25N3O4 (443.1845)

3-[(4S,5S)-5-[(dimethylamino)methyl]-2-[(2R)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-8-yl]benzonitrile

C23H29N3O4S (443.1879)

N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-oxo-2-(4-phenylanilino)ethyl]-3,6-dihydro-2H-pyran-3-yl]-4-pyridinecarboxamide

C26H25N3O4 (443.1845)

N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-oxo-2-(4-phenylanilino)ethyl]-3,6-dihydro-2H-pyran-3-yl]-4-pyridinecarboxamide

C26H25N3O4 (443.1845)

N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-oxo-2-(4-phenylanilino)ethyl]-3,6-dihydro-2H-pyran-3-yl]-4-pyridinecarboxamide

C26H25N3O4 (443.1845)

2-[(1S,3S,4aS,9aR)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3R,4aS,9aR)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1R,3S,4aS,9aR)-6-[[(4-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1R,3R,4aR,9aS)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3S,4aS,9aR)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3R,4aS,9aR)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3S,4aR,9aS)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

2-[(1S,3R,4aR,9aS)-6-[[(2-fluoroanilino)-oxomethyl]amino]-1-(hydroxymethyl)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide

C23H26FN3O5 (443.1856)

1-[(1R,2aS,8bS)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(3-pyridinyl)ethanone

C26H25N3O4 (443.1845)

1-[(1R,2aR,8bR)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(3-pyridinyl)ethanone

C26H25N3O4 (443.1845)

(1S,2aS,8bS)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-N-phenyl-1,2a,3,8b-tetrahydroazeto[2,3-c]quinoline-2-carboxamide

C26H25N3O4 (443.1845)

(1R,2aR,8bR)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-N-phenyl-1,2a,3,8b-tetrahydroazeto[2,3-c]quinoline-2-carboxamide

C26H25N3O4 (443.1845)

(1S,2aR,8bR)-1-(hydroxymethyl)-4-[(2-methoxyphenyl)-oxomethyl]-N-phenyl-1,2a,3,8b-tetrahydroazeto[2,3-c]quinoline-2-carboxamide

C26H25N3O4 (443.1845)

1-[(1R,2aR,8bR)-1-(hydroxymethyl)-4-[(4-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(2-pyridinyl)ethanone

C26H25N3O4 (443.1845)

1-[(1R,2aS,8bS)-1-(hydroxymethyl)-4-[(4-methoxyphenyl)-oxomethyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-2-yl]-2-(2-pyridinyl)ethanone

C26H25N3O4 (443.1845)

(1S,5R)-N-(1,3-benzodioxol-5-yl)-7-[4-(3-methoxyphenyl)phenyl]-3,6-diazabicyclo[3.1.1]heptane-6-carboxamide

C26H25N3O4 (443.1845)

3-[4-[(2S,3S)-6-acetyl-2-(hydroxymethyl)-1-(3,3,3-trifluoropropyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile

C24H24F3N3O2 (443.1821)

3-[4-[(2S,3R)-6-acetyl-2-(hydroxymethyl)-1-(3,3,3-trifluoropropyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile

C24H24F3N3O2 (443.1821)

(6S,7R,8R)-8-(hydroxymethyl)-7-[4-(3-methoxyphenyl)phenyl]-4-[oxo(3-pyridinyl)methyl]-1,4-diazabicyclo[4.2.0]octan-2-one

C26H25N3O4 (443.1845)

Phe-Met-Phe

C23H29N3O4S (443.1879)

Phe-Phe-Met

C23H29N3O4S (443.1879)

5-[[4-[4-(3-Hydroxy-2,4,5-trimethyl-6-oxocyclohexa-1,4-dien-1-yl)-2-methylbutoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

C24H29NO5S (443.1766)

8-oxo-Guo

C21H25N5O6 (443.1805)

ST 22:6;O5;Gly

C24H29NO7 (443.1944)

ALOX15-IN-2

C23H29N3O4S (443.1879)

ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].

JNJ-61432059

C25H22FN5O2 (443.1757)

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

5-{2,5-dihydroxy-7-oxabicyclo[4.1.0]heptan-2-yl}-3-(2,6-dimethyl-1,2,4a,5,8,8a-hexahydronaphthalene-1-carbonyl)-1,4-dihydroxypyridin-2-one

C24H29NO7 (443.1944)

(12s,13r,16r)-12-hydroxy-5-methyl-4,6-dioxo-15-[(1e,3e)-penta-1,3-dien-1-yl]-14-oxa-9-azatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-1(15),2-dien-5-yl 3-hydroxybutanoate

C24H29NO7 (443.1944)

methyl 3'-ethyl-1-hydroxy-6',7'-dimethoxy-2'-methyl-3,4'-dioxo-1,4,5,6-tetrahydro-3'h-spiro[indene-2,1'-isoquinoline]-3a-carboxylate

C24H29NO7 (443.1944)

3-[(1r,2r,4as,6r,8ar)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-1,4-dihydroxy-5-[(1s,2r,6r)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]heptan-2-yl]pyridin-2-one

C24H29NO7 (443.1944)

3-[(1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene)amino]-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

C16H25N7O8 (443.1765)

(2s,3s,4s,5r,6r)-3-{[(2r)-1,3-dihydroxy-2-{[1-hydroxy-2-(methylamino)ethylidene]amino}propylidene]amino}-4,5-dihydroxy-6-(2-hydroxy-4-iminopyrimidin-1-yl)oxane-2-carboximidic acid

C16H25N7O8 (443.1765)

(2s)-2-{[(2s)-1-hydroxy-2-({hydroxy[(2s)-5-hydroxy-3,4-dihydro-2h-pyrrol-2-yl]methylidene}amino)-4-(c-hydroxycarbonimidoyl)butylidene]amino}-3-(1h-indol-3-yl)propanoic acid

C21H25N5O6 (443.1805)

2,4-dihydroxy-3-({1-hydroxy-3-[(1s,5s,6r,8s,9r)-9-hydroxy-5,9-dimethyl-4-oxotricyclo[6.2.2.0¹,⁶]dodec-2-en-5-yl]propylidene}amino)benzoic acid

C24H29NO7 (443.1944)

2,4-dihydroxy-3-[(1-hydroxy-3-{9-hydroxy-5,9-dimethyl-4-oxotricyclo[6.2.2.0¹,⁶]dodec-2-en-5-yl}propylidene)amino]benzoic acid

C24H29NO7 (443.1944)

3-(2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl)-1,4-dihydroxy-5-{2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]heptan-2-yl}pyridin-2-one

C24H29NO7 (443.1944)

2-[(1-hydroxy-2-{[hydroxy(5-hydroxy-3,4-dihydro-2h-pyrrol-2-yl)methylidene]amino}-4-(c-hydroxycarbonimidoyl)butylidene)amino]-3-(1h-indol-3-yl)propanoic acid

C21H25N5O6 (443.1805)

3-[(1s,2s,4ar,8as)-2,6-dimethyl-1,2,4a,5,8,8a-hexahydronaphthalene-1-carbonyl]-5-[(1s,2r,5s,6s)-2,5-dihydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-1,4-dihydroxypyridin-2-one

C24H29NO7 (443.1944)