N-(4-{2-[(6s)-2-Amino-4-Oxo-1,4,5,6,7,8-Hexahydropyrido[2,3-D]pyrimidin-6-Yl]ethyl}benzoyl)-L-Glutamic Acid (BioDeep_00000839553)

代谢物信息卡片

N-(4-{2-[(6s)-2-Amino-4-Oxo-1,4,5,6,7,8-Hexahydropyrido[2,3-D]pyrimidin-6-Yl]ethyl}benzoyl)-L-Glutamic Acid

化学式: C21H25N5O6 (443.1805)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

N-(4-{2-[(6s)-2-Amino-4-Oxo-1,4,5,6,7,8-Hexahydropyrido[2,3-D]pyrimidin-6-Yl]ethyl}benzoyl)-L-Glutamic Acid

数据库引用编号

3 个数据库交叉引用编号

PubChem: 135409836
DrugBank: DB04322
CAS: 106400-18-4

分类词条

代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

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PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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亚细胞结构定位		关联基因列表

文献列表

J D Roberts, E A Poplin, M B Tombes, B Kyle, D V Spicer, S Grant, T Synold, R Moran. Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation. Cancer chemotherapy and pharmacology. 2000; 45(2):103-10. doi: 10.1007/s002800050017. [PMID: 10663624]
D R Newell. Clinical pharmacokinetics of antitumor antifolates. Seminars in oncology. 1999 Apr; 26(2 Suppl 6):74-81. doi: . [PMID: 10598559]
T W Synold, E M Newman, M Carroll, F M Muggia, S Groshen, K Johnson, J H Doroshow. Cellular but not plasma pharmacokinetics of lometrexol correlate with the occurrence of cumulative hematological toxicity. Clinical cancer research : an official journal of the American Association for Cancer Research. 1998 Oct; 4(10):2349-55. doi: NULL. [PMID: 9796964]
L L Habeck, S H Chay, R C Pohland, J F Worzalla, C Shih, L G Mendelsohn. Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet. Cancer chemotherapy and pharmacology. 1998; 41(3):201-9. doi: 10.1007/s002800050729. [PMID: 9443636]
S B Gates, J F Worzalla, C Shih, G B Grindey, L G Mendelsohn. Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts. Biochemical pharmacology. 1996 Nov; 52(9):1477-9. doi: 10.1016/s0006-2952(96)00554-0. [PMID: 8937460]
T W Synold, B Xi, E M Newman, F M Muggia, J H Doroshow. Simple and sensitive method for the quantitative analysis of lometrexol in plasma using high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications. 1996 Aug; 683(2):245-9. doi: 10.1016/0378-4347(96)00122-3. [PMID: 8891922]
S Laohavinij, S R Wedge, M J Lind, N Bailey, A Humphreys, M Proctor, F Chapman, D Simmons, A Oakley, L Robson, L Gumbrell, G A Taylor, H D Thomas, A V Boddy, D R Newell, A H Calvert. A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid. Investigational new drugs. 1996; 14(3):325-35. doi: 10.1007/bf00194536. [PMID: 8958188]
L G Mendelsohn, S B Gates, L L Habeck, K A Shackelford, J Worzalla, C Shih, G B Grindey. The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol. Advances in enzyme regulation. 1996; 36(?):365-81. doi: 10.1016/0065-2571(96)00001-5. [PMID: 8869756]
S R Wedge, S Laohavinij, G A Taylor, A Boddy, A H Calvert, D R Newell. Clinical pharmacokinetics of the antipurine antifolate (6R)-5,10- dideaza-5,6,7,8-tetrahydrofolic acid (Lometrexol) administered with an oral folic acid supplement. Clinical cancer research : an official journal of the American Association for Cancer Research. 1995 Dec; 1(12):1479-86. doi: . [PMID: 9815947]
G R Westerhof, S Rijnboutt, J H Schornagel, H M Pinedo, G J Peters, G Jansen. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein. Cancer research. 1995 Sep; 55(17):3795-802. doi: . [PMID: 7641196]
S R Wedge, S Laohavinij, G A Taylor, D R Newell. Measurement of 5,10-dideaza-5,6,7,8-tetrahydrofolate (lometrexol) in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Jan; 663(2):327-35. doi: 10.1016/0378-4347(94)00441-7. [PMID: 7735480]
R C Pohland, T Alati, R J Lantz, G B Grindey. Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets. Journal of pharmaceutical sciences. 1994 Oct; 83(10):1396-9. doi: 10.1002/jps.2600831006. [PMID: 7884657]
J C Schmitz, G B Grindey, R M Schultz, D G Priest. Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity. Biochemical pharmacology. 1994 Jul; 48(2):319-25. doi: 10.1016/0006-2952(94)90103-1. [PMID: 8053927]
E Erba, S Sen, C Sessa, F L Vikhanskaya, M D'Incalci. Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid. British journal of cancer. 1994 Feb; 69(2):205-11. doi: 10.1038/bjc.1994.40. [PMID: 8297715]
J R Muindi, C W Young, C Shih. Specific and sensitive high-performance liquid chromatographic method with fluorescence detection for measurement of lometrexol and its polyglutamates in biologic samples. Journal of chromatography. 1993 Nov; 621(1):55-64. doi: 10.1016/0378-4347(93)80076-g. [PMID: 7508451]
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L D Taber, P O'Brien, R R Bowsher, J R Sportsman. Competitive particle concentration fluorescence immunoassay for measuring 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) in serum. Clinical chemistry. 1991 Feb; 37(2):254-60. doi: 10.1093/clinchem/37.2.254. [PMID: 1993335]