Lometrexol (BioDeep_00000650570)
代谢物信息卡片
Lometrexol
化学式: C21H25N5O6 (443.180475)
中文名称: 洛美曲索
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2692 - Glycinamide Ribonucleotide Formyltransferase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J D Roberts, E A Poplin, M B Tombes, B Kyle, D V Spicer, S Grant, T Synold, R Moran. Weekly lometrexol with daily oral folic acid is appropriate for phase II evaluation.
Cancer chemotherapy and pharmacology.
2000; 45(2):103-10. doi:
10.1007/s002800050017. [PMID: 10663624] - D R Newell. Clinical pharmacokinetics of antitumor antifolates.
Seminars in oncology.
1999 Apr; 26(2 Suppl 6):74-81. doi:
. [PMID: 10598559] - T W Synold, E M Newman, M Carroll, F M Muggia, S Groshen, K Johnson, J H Doroshow. Cellular but not plasma pharmacokinetics of lometrexol correlate with the occurrence of cumulative hematological toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Oct; 4(10):2349-55. doi:
NULL. [PMID: 9796964] - L L Habeck, S H Chay, R C Pohland, J F Worzalla, C Shih, L G Mendelsohn. Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet.
Cancer chemotherapy and pharmacology.
1998; 41(3):201-9. doi:
10.1007/s002800050729. [PMID: 9443636] - C H Takimoto. Antifolates in clinical development.
Seminars in oncology.
1997 Oct; 24(5 Suppl 18):S18-40. doi:
". [PMID: 9420020] - S B Gates, J F Worzalla, C Shih, G B Grindey, L G Mendelsohn. Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts.
Biochemical pharmacology.
1996 Nov; 52(9):1477-9. doi:
10.1016/s0006-2952(96)00554-0. [PMID: 8937460] - T W Synold, B Xi, E M Newman, F M Muggia, J H Doroshow. Simple and sensitive method for the quantitative analysis of lometrexol in plasma using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical applications.
1996 Aug; 683(2):245-9. doi:
10.1016/0378-4347(96)00122-3. [PMID: 8891922] - S Laohavinij, S R Wedge, M J Lind, N Bailey, A Humphreys, M Proctor, F Chapman, D Simmons, A Oakley, L Robson, L Gumbrell, G A Taylor, H D Thomas, A V Boddy, D R Newell, A H Calvert. A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.
Investigational new drugs.
1996; 14(3):325-35. doi:
10.1007/bf00194536. [PMID: 8958188] - L G Mendelsohn, S B Gates, L L Habeck, K A Shackelford, J Worzalla, C Shih, G B Grindey. The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol.
Advances in enzyme regulation.
1996; 36(?):365-81. doi:
10.1016/0065-2571(96)00001-5. [PMID: 8869756] - S R Wedge, S Laohavinij, G A Taylor, A Boddy, A H Calvert, D R Newell. Clinical pharmacokinetics of the antipurine antifolate (6R)-5,10- dideaza-5,6,7,8-tetrahydrofolic acid (Lometrexol) administered with an oral folic acid supplement.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1995 Dec; 1(12):1479-86. doi:
. [PMID: 9815947] - G R Westerhof, S Rijnboutt, J H Schornagel, H M Pinedo, G J Peters, G Jansen. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Cancer research.
1995 Sep; 55(17):3795-802. doi:
. [PMID: 7641196] - S R Wedge, S Laohavinij, G A Taylor, D R Newell. Measurement of 5,10-dideaza-5,6,7,8-tetrahydrofolate (lometrexol) in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1995 Jan; 663(2):327-35. doi:
10.1016/0378-4347(94)00441-7. [PMID: 7735480] - R C Pohland, T Alati, R J Lantz, G B Grindey. Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets.
Journal of pharmaceutical sciences.
1994 Oct; 83(10):1396-9. doi:
10.1002/jps.2600831006. [PMID: 7884657] - J C Schmitz, G B Grindey, R M Schultz, D G Priest. Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity.
Biochemical pharmacology.
1994 Jul; 48(2):319-25. doi:
10.1016/0006-2952(94)90103-1. [PMID: 8053927] - E Erba, S Sen, C Sessa, F L Vikhanskaya, M D'Incalci. Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
British journal of cancer.
1994 Feb; 69(2):205-11. doi:
10.1038/bjc.1994.40. [PMID: 8297715] - J R Muindi, C W Young, C Shih. Specific and sensitive high-performance liquid chromatographic method with fluorescence detection for measurement of lometrexol and its polyglutamates in biologic samples.
Journal of chromatography.
1993 Nov; 621(1):55-64. doi:
10.1016/0378-4347(93)80076-g. [PMID: 7508451] - G Pizzorno, A R Cashmore, B A Moroson, A D Cross, A K Smith, M Marling-Cason, B A Kamen, G P Beardsley. 5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines.
The Journal of biological chemistry.
1993 Jan; 268(2):1017-23. doi:
10.1016/s0021-9258(18)54035-7. [PMID: 8419310] - G F Fleming, R L Schilsky. Antifolates: the next generation.
Seminars in oncology.
1992 Dec; 19(6):707-19. doi:
". [PMID: 1462168] - O van Tellingen, J H Sips, J H Beijnen, J H Schornagel, W J Nooyen. Bioanalysis of the investigational anti-tumour drug 5,10-dideaza-5,6,7,8-tetrahydrofolic acid by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography.
1992 Apr; 576(1):158-62. doi:
10.1016/0378-4347(92)80188-v. [PMID: 1500451] - L D Taber, P O'Brien, R R Bowsher, J R Sportsman. Competitive particle concentration fluorescence immunoassay for measuring 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) in serum.
Clinical chemistry.
1991 Feb; 37(2):254-60. doi:
10.1093/clinchem/37.2.254. [PMID: 1993335] - J Galivan, M S Rhee, T B Johnson, T C Chou, M G Nair, M Bunni, D Priest. The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.
Advances in enzyme regulation.
1989; 28(?):13-21. doi:
10.1016/0065-2571(89)90060-5. [PMID: 2624172]