Exact Mass: 421.1121018
Exact Mass Matches: 421.1121018
Found 252 metabolites which its exact mass value is equals to given mass value 421.1121018,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
5-O-p-Coumaroylnigrumin
5-O-p-Coumaroylnigrumin is found in fruits. 5-O-p-Coumaroylnigrumin is a constituent of the seeds of Ribes nigrum (blackcurrant). Constituent of the seeds of Ribes nigrum (blackcurrant). 5-O-p-Coumaroylnigrumin is found in fruits.
3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
C25H19N5S (421.13610940000007)
Mosapride
C21H25ClFN3O3 (421.15683820000004)
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent D005765 - Gastrointestinal Agents
Hyzetimibe
C25H21F2NO3 (421.14894200000003)
Neurokinin-1 Receptor Antagonist
C21H16ClN5OS (421.07640360000005)
Mosapride
C21H25ClFN3O3 (421.15683820000004)
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent D005765 - Gastrointestinal Agents
(3S,4R)-4-(5,7-dihydroxy-2-methyl-4-oxo-4H-1-benzopyran-8-yl)piperidin-3-yl (2E)-3-phenylprop-2-enoate|chrotacumine F
(2S)-2-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-3-methylbut-3-enenitrile|proacacipetalin 6?-O-b-d-glucopyranoside
C17H27NO11 (421.15840319999995)
1D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-chiro-inositol 1-phosphate
C12H24NO13P (421.09852240000004)
3-(4-Methyl-thiazol-2-yl)-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one
Piragliatin
C19H20ClN3O4S (421.0862990000001)
CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3431; ORIGINAL_PRECURSOR_SCAN_NO 3429 C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3421; ORIGINAL_PRECURSOR_SCAN_NO 3418 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3414; ORIGINAL_PRECURSOR_SCAN_NO 3413 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3421; ORIGINAL_PRECURSOR_SCAN_NO 3419 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3430; ORIGINAL_PRECURSOR_SCAN_NO 3428 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7552; ORIGINAL_PRECURSOR_SCAN_NO 7548 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7558; ORIGINAL_PRECURSOR_SCAN_NO 7553 INTERNAL_ID 985; CONFIDENCE standard compound; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7580; ORIGINAL_PRECURSOR_SCAN_NO 7576 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7580; ORIGINAL_PRECURSOR_SCAN_NO 7576 CONFIDENCE standard compound; INTERNAL_ID 985; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7590; ORIGINAL_PRECURSOR_SCAN_NO 7586
Ala Cys Asp Asn
Ala Cys Asn Asp
Ala Asp Cys Asn
Ala Asp Asn Cys
Ala Asn Cys Asp
Ala Asn Asp Cys
Cys Ala Asp Asn
Cys Ala Asn Asp
Cys Asp Ala Asn
Cys Asp Gly Gln
Cys Asp Asn Ala
Cys Asp Gln Gly
Cys Glu Gly Asn
Cys Glu Asn Gly
Cys Gly Asp Gln
Cys Gly Glu Asn
Cys Gly Gly Trp
C18H23N5O5S (421.14198280000005)
Cys Gly Asn Glu
Cys Gly Gln Asp
Cys Gly Trp Gly
C18H23N5O5S (421.14198280000005)
Cys Asn Ala Asp
Cys Asn Asp Ala
Cys Asn Glu Gly
Cys Asn Gly Glu
Cys Gln Asp Gly
Cys Gln Gly Asp
Cys Trp Gly Gly
C18H23N5O5S (421.14198280000005)
Asp Ala Cys Asn
Asp Ala Asn Cys
Asp Cys Ala Asn
Asp Cys Gly Gln
Asp Cys Asn Ala
Asp Cys Gln Gly
Asp Gly Cys Gln
Asp Gly Gln Cys
Asp Asn Ala Cys
Asp Asn Cys Ala
Asp Asn Ser Ser
Asp Gln Cys Gly
Asp Gln Gly Cys
Asp Ser Asn Ser
Asp Ser Ser Asn
Glu Cys Gly Asn
Glu Cys Asn Gly
Glu Gly Cys Asn
Glu Gly Asn Cys
Glu Asn Cys Gly
Glu Asn Gly Cys
Gly Cys Asp Gln
Gly Cys Glu Asn
Gly Cys Gly Trp
C18H23N5O5S (421.14198280000005)
Gly Cys Asn Glu
Gly Cys Gln Asp
Gly Cys Trp Gly
C18H23N5O5S (421.14198280000005)
Gly Asp Cys Gln
Gly Asp Gln Cys
Gly Glu Cys Asn
Gly Glu Asn Cys
Gly Gly Cys Trp
C18H23N5O5S (421.14198280000005)
Gly Gly Trp Cys
C18H23N5O5S (421.14198280000005)
Gly Asn Cys Glu
Gly Asn Glu Cys
Gly Gln Cys Asp
Gly Gln Asp Cys
Gly Trp Cys Gly
C18H23N5O5S (421.14198280000005)
Gly Trp Gly Cys
C18H23N5O5S (421.14198280000005)
Asn Ala Cys Asp
Asn Ala Asp Cys
Asn Cys Ala Asp
Asn Cys Asp Ala
Asn Cys Glu Gly
Asn Cys Gly Glu
Asn Asp Ala Cys
Asn Asp Cys Ala
Asn Asp Ser Ser
Asn Glu Cys Gly
Asn Glu Gly Cys
Asn Gly Cys Glu
Asn Gly Glu Cys
Asn Ser Asp Ser
Asn Ser Ser Asp
Gln Cys Asp Gly
Gln Cys Gly Asp
Gln Asp Cys Gly
Gln Asp Gly Cys
Gln Gly Cys Asp
Gln Gly Asp Cys
Ser Asp Asn Ser
Ser Asp Ser Asn
Ser Asn Asp Ser
Ser Asn Ser Asp
Ser Ser Asp Asn
Ser Ser Asn Asp
Trp Cys Gly Gly
C18H23N5O5S (421.14198280000005)
Trp Gly Cys Gly
C18H23N5O5S (421.14198280000005)
Trp Gly Gly Cys
C18H23N5O5S (421.14198280000005)
Asn-Phe4Cl-OH
C18H16ClN3O7 (421.06767360000003)
Phe4Cl-Asn-OH
C18H16ClN3O7 (421.06767360000003)
5-O-p-Coumaroylnigrumin
2-([4-(2-Chlorophenyl)-5-methoxycarbonyl-3-ethoxycarbonyl-6-methyl-2-pyridyl]methoxyacetic acid
C20H20ClNO7 (421.09282400000006)
4-(4-CHLORO-PHENYL)-3-METHYL-1-PHENYL-1H-INDENO[1,2-B]PYRAZOLO[4,3-E]PYRIDIN-5-ONE
Chlorotripyrrolidinophosphonium hexafluorophosphate
3-(4-CHLORO-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID
C24H20ClNO4 (421.1080790000001)
2-[[4-[ethyl(2-phenoxyethyl)amino]phenyl]azo]-5-nitro-3-Thiophenecarbonitrile
C21H19N5O3S (421.1208544000001)
4-Chloro-N-[1-[2-(4-nitrophenyl)ethyl]-2-piperidinylidene]benzenesulfonamide
C19H20ClN3O4S (421.0862990000001)
Fmoc-(R)-3-Amino-3-(2-chloro-phenyl)-propionic acid
C24H20ClNO4 (421.1080790000001)
fmoc-(r)-3-amino-3-(3-chloro-phenyl)-propionic acid
C24H20ClNO4 (421.1080790000001)
1-{3-Isopropoxy-5-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3- yl]phenyl}methanamine
fmoc-(s)-3-amino-3-(2-chloro-phenyl)-propionic acid
C24H20ClNO4 (421.1080790000001)
fmoc-(s)-3-amino-3-(3-chloro-phenyl)-propionic acid
C24H20ClNO4 (421.1080790000001)
Methylbenactyzium Bromide
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor.
Rucaparib phosphate
C19H21FN3O5P (421.12027980000005)
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C62554 - Poly (ADP-Ribose) Polymerase Inhibitor D000970 - Antineoplastic Agents > D000067856 - Poly(ADP-ribose) Polymerase Inhibitors D004791 - Enzyme Inhibitors C471 - Enzyme Inhibitor
FMOC-3-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID
C24H20ClNO4 (421.1080790000001)
tert-Butyl 6-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
C19H25BBrNO4 (421.1059900000001)
tert-Butyl 4-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
C19H25BBrNO4 (421.1059900000001)
3-benzhydrylsulfanyl-2-phenylmethoxycarbonylamino-propanoic acid
C24H23NO4S (421.13477180000007)
BENZYL ((1R,2S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-1-HYDROXYPROPAN-2-YL)CARBAMATE
Sonedenoson
C18H20ClN5O5 (421.1152900000001)
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
4-[3-(4-Chlorophenoxy)benzyl]-N-phenyl-1-piperazinecarboxamide
3-acetamido-6-acetyl-2-nitrophenyl 4-(dimethylamino)-3,5-difluorobenzoate
C19H17F2N3O6 (421.10853660000004)
Fmoc-(R)-3-Amino-3-(4-chlorophenyl)propionic acid
C24H20ClNO4 (421.1080790000001)
2-({(5R)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
C22H19N3O6 (421.12737940000005)
TRANS-CYPERMETHRIN D6 (DIMETHYL D6)
C22H13Cl2D6NO3 (421.11185546800004)
2-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione
C22H19N3O6 (421.12737940000005)
Fmoc-(S)-3-Amino-3-(4-chlorophenyl)propionic acid
C24H20ClNO4 (421.1080790000001)
Dezapelisib
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2152 - Phosphatidylinositide 3-Kinase Inhibitor C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
N-[2-methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)-1-benzo[h][1,6]naphthyridinyl]phenyl]-2-propenamide
2-[(4-Chlorophenyl)methyl]-3-(4-methoxyphenyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxylic acid
C24H20ClNO4 (421.1080790000001)
Ethyl 4-(benzenesulfonyl)-1-[(4-chlorophenyl)methyl]piperidine-4-carboxylate
C21H24ClNO4S (421.1114494000001)
1-[2-[(4-Methyl-2-oxo-1-benzopyran-7-yl)oxy]-1-oxoethyl]-4-phenyl-4-piperidinecarboxylic acid
Sarafloxacin hydrochloride
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
(2r)-4-[(8r)-8-Methyl-2-(Trifluoromethyl)-5,6-Dihydro[1,2,4]triazolo[1,5-A]pyrazin-7(8h)-Yl]-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-Amine
alpha-L-galactopyranose-6-sulfate-(1,3)-beta-D-galactose
C12H21O14S- (421.06519860000003)
(2S)-2-[4-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]anilino]butanedioic acid
1-(4-fluorophenyl)-3-[(Z)-3-(4-fluorophenyl)-4-hydroxybut-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one
C25H21F2NO3 (421.14894200000003)
1-(4-chlorophenyl)-5-methyl-N-(phenylmethyl)-N-(thiophen-2-ylmethyl)-4-pyrazolecarboxamide
C23H20ClN3OS (421.1015540000001)
1-(4-Fluorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyrrolidine-2,5-dione
[4-(Butan-2-ylamino)-6-chloro-1,3,5-triazin-2-yl]-[(1,1,3-trioxo-1,2-benzothiazol-2-yl)methyl]cyanamide
C16H16ClN7O3S (421.07238159999997)
2-(2-furanylmethyl)-3-[[2-(3-pyridinyl)-3H-benzimidazol-5-yl]amino]-3H-isoindol-1-one
3-hydroxy-N-[[2-oxo-1-(phenylmethyl)-3-indolylidene]amino]-2-naphthalenecarboxamide
2-Furanyl-[4-[3-(4-methoxyphenyl)-7-isothiazolo[4,5-d]pyrimidinyl]-1-piperazinyl]methanone
C21H19N5O3S (421.1208544000001)
[4-[2-(3-Chlorophenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanone
C22H20ClN5O2 (421.13054500000004)
N-[4-[[2-(4-acetamidoanilino)-5-nitro-4-pyrimidinyl]amino]phenyl]acetamide
C20H19N7O4 (421.14984540000006)
2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)thio]-N-(4-phenyl-2-thiazolyl)acetamide
2-[[[5-(3-chlorophenyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1H-benzimidazole
C21H16ClN5OS (421.07640360000005)
2-[[2-[[5-(4-Tert-butylphenyl)-2-methoxycarbonyl-3-thiophenyl]amino]-2-oxoethyl]thio]acetic acid
N-(2,5-dimethoxyphenyl)-4-[(7H-purin-6-ylthio)methyl]benzamide
C21H19N5O3S (421.1208544000001)
2-[[4-(2-Methoxyphenyl)sulfonyl-1-piperazinyl]sulfonyl]benzonitrile
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(2,4-dichlorophenoxy)acetamide
C20H21Cl2N3O3 (421.09598960000005)
N-{[5-(5,7-dimethyl-1,3-benzoxazol-2-yl)-2-methylphenyl]carbamothioyl}thiophene-2-carboxamide
3-(1H-indol-3-yl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]propanamide
C21H19N5O3S (421.1208544000001)
N-(4-acetamidophenyl)-2-[5-(1-piperidinylsulfonyl)-2-thiophenyl]acetamide
C19H23N3O4S2 (421.11299180000003)
[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] 2-(2-fluoroanilino)pyridine-3-carboxylate
C19H20FN3O5S (421.11076420000006)
2-(1,3-Dimethylbenzimidazol-2-ylidene)-4-(6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-3-oxobutanenitrile
2-({(E)-[5-(4-fluoro-2-nitrophenyl)furan-2-yl]methylidene}amino)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
3-(Tert-butylsulfamoyl)-4-phenyl-5-(trifluoromethyl)-2-thiophenecarboxylic acid methyl ester
3,4-dihydro-1H-isoquinolin-2-yl-[1-(8-quinolinylsulfonyl)-2-pyrrolidinyl]methanone
2-[[5-(4-chlorophenyl)-1-(2-methoxyethyl)-2-imidazolyl]thio]-N-(thiophen-2-ylmethyl)acetamide
C19H20ClN3O2S2 (421.06854100000004)
2-[[5-[(1S)-1-amino-2-(1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-yl]thio]-N-(2,3-dimethylphenyl)acetamide
2-[[5-[(1S)-1-amino-2-(1H-indol-3-yl)ethyl]-1,3,4-oxadiazol-2-yl]thio]-N-(2,4-dimethylphenyl)acetamide
6-(4-Bromophenyl)-2-(4-methoxyphenyl)-1-aza-4-azoniatricyclo[5.4.1.04,12]dodeca-2,4(12),6-triene
[(1R,2aS,8bS)-4-(benzenesulfonyl)-2-(2-pyridinylmethyl)-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-1-yl]methanol
(1S,5R)-3-(2-methoxyphenyl)sulfonyl-7-[4-(3-pyridinyl)phenyl]-3,6-diazabicyclo[3.1.1]heptane
(1R,5S)-6-(2-methoxyphenyl)sulfonyl-7-(4-pyridin-4-ylphenyl)-3,6-diazabicyclo[3.1.1]heptane
(1R,5S)-6-(4-methoxyphenyl)sulfonyl-7-(4-pyridin-4-ylphenyl)-3,6-diazabicyclo[3.1.1]heptane
5-{[4-({Hydroxy[(4-nitrophenyl)amino]phosphoryl}methyl)phenyl]amino}-5-oxopentanoic acid
C18H20N3O7P (421.10388200000006)
N-[(E)-(5-chloro-2-hydroxyphenyl)methylideneamino]-4-piperidin-1-ylsulfonylbenzamide
C19H20ClN3O4S (421.0862990000001)
[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-[(1-hydroxy-2-oxoethyl)amino]-6-oxo-1H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate
3-(4-Methyl-thiazol-2-yl)-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one
2,8-Ditrimethylsilyloxy-4-quinolinecarboxylic acid trimethylsilyl ester
C19H31NO4Si3 (421.15608060000005)
2,6-Ditrimethylsilyloxy-4-quinolinecarboxylic acid trimethylsilyl ester
C19H31NO4Si3 (421.15608060000005)
BAY-4931
C22H16ClN3O4 (421.08292860000006)
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1].
MF-438
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].
p53-MDM2-IN-1
C23H20ClN3O3 (421.11931200000004)
p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an Ki value of 23.35 μM. p53-MDM2-IN-1 can be used for anti-tumor research[1].
UNC9995
C20H21Cl2N3OS (421.07823160000004)
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1].