Sarafloxacin hydrochloride (BioDeep_00000852617)
代谢物信息卡片
Sarafloxacin hydrochloride
化学式: C20H18ClF2N3O3 (421.1004692)
中文名称: 盐酸沙拉沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl
InChI: 1H
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Song Hu, Bolong Fang, Zhen Huang, Yuan Chen, Daofeng Liu, Keyu Xing, Juan Peng, Weihua Lai. Using molecular descriptors for assisted screening of heterologous competitive antigens to improve the sensitivity of ELISA for detection of enrofloxacin in raw milk.
Journal of dairy science.
2019 Jul; 102(7):6037-6046. doi:
10.3168/jds.2018-16048. [PMID: 31056338] - Yang Yu, Yu Feng Zhou, Jian Sun, Wei Shi, Xiao Ping Liao, Ya Hong Liu. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks.
BMC veterinary research.
2017 Feb; 13(1):47. doi:
10.1186/s12917-017-0964-0. [PMID: 28183350] - Xingxing Fang, Jianguo Zhou, Xiuhong Liu. Pharmacokinetics of sarafloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio.
Fish physiology and biochemistry.
2016 Feb; 42(1):335-41. doi:
10.1007/s10695-015-0141-y. [PMID: 26563280] - Ingrid Rosendahl, Jan Siemens, Reimo Kindler, Joost Groeneweg, Judith Zimmermann, Sonja Czerwinski, Marc Lamshöft, Volker Laabs, Berndt-Michael Wilke, Harry Vereecken, Wulf Amelung. Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.
Journal of environmental quality.
2012 Jul; 41(4):1275-83. doi:
10.2134/jeq2011.0459. [PMID: 22751072] - Arturo Anadón, Frank H Suárez, María A Martínez, Víctor Castellano, Marta Martínez, Irma Ares, Eva Ramos, Felipe Gamboa, María R Martínez-Larrañaga. Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Feb; 49(2):441-9. doi:
10.1016/j.fct.2010.11.021. [PMID: 21108984] - Simon N Muchohi, Nahashon Thuo, Japhet Karisa, Alex Muturi, Gilbert O Kokwaro, Kathryn Maitland. Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jan; 879(2):146-52. doi:
10.1016/j.jchromb.2010.11.032. [PMID: 21185790] - Eric Verdon, Pierrick Couedor, Brigitte Roudaut, Pascal Sandérs. Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.
Journal of AOAC International.
2005 Jul; 88(4):1179-92. doi:
. [PMID: 16156083] - Linlin Dong, Yanhua Liu, Xia Wang, Feng Zhong, Li Peng, Xiuying Yue, Lan Gao. [Simultaneous determination of four fluoroquinolone residues in edible chicken tissues by reversed-phase high performance liquid chromatography].
Se pu = Chinese journal of chromatography.
2005 May; 23(3):285-8. doi:
NULL. [PMID: 16124577] - H Z Ding, Z L Zeng, K F Fung, Z L Chen, G L Qiao. Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications.
Journal of veterinary pharmacology and therapeutics.
2001 Oct; 24(5):303-8. doi:
10.1046/j.1365-2885.2001.00348.x. [PMID: 11696079] - C K Holtzapple, S A Buckley, L H Stanker. Determination of fluoroquinolones in serum using an on-line clean-up column coupled to high-performance immunoaffinity-reversed-phase liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(1):1-9. doi:
10.1016/s0378-4347(00)00575-2. [PMID: 11318402] - C K Holtzapple, E J Pishko, L H Stanker. Separation and quantification of two fluoroquinolones in serum by on-line high-performance immunoaffinity chromatography.
Analytical chemistry.
2000 Sep; 72(17):4148-53. doi:
10.1021/ac000065k. [PMID: 10994977] - A Posyniak, J Zmudzki, S Semeniuk, J Niedzielska, R Ellis. Determination of fluoroquinolone residues in animal tissues by liquid chromatography.
Biomedical chromatography : BMC.
1999 Jun; 13(4):279-85. doi:
10.1002/(sici)1099-0801(199906)13:4<279::aid-bmc844>3.0.co;2-a. [PMID: 10416061] - S P Ho, C F Cheng, W S Wang. Pharmacokinetic and depletion studies of sarafloxacin after oral administration to eel (Anguilla anguilla).
The Journal of veterinary medical science.
1999 May; 61(5):459-63. doi:
10.1292/jvms.61.459. [PMID: 10379934] - W M Medders, R E Wooley, P S Gibbs, E B Shotts, J Brown. Mutation rate of avian intestinal coliform bacteria when pressured with fluoroquinolones.
Avian diseases.
1998 Jan; 42(1):146-53. doi:
10.2307/1592587. [PMID: 9533092] - B Martinsen, T E Horsberg. Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C.
Antimicrobial agents and chemotherapy.
1995 May; 39(5):1059-64. doi:
10.1128/aac.39.5.1059. [PMID: 7625789] - J S Giles, H Hariharan, S B Heaney. A microbiological assay for determining sarafloxacin and oxolinic acid concentrations in Atlantic salmon plasma.
The new microbiologica.
1994 Apr; 17(2):155-8. doi:
. [PMID: 8065273] - M B Bansal, H Thadepalli. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.
Antimicrobial agents and chemotherapy.
1987 Apr; 31(4):619-21. doi:
10.1128/aac.31.4.619. [PMID: 3606066] - J T Mader, L T Morrison, K R Adams. Comparative evaluation of A-56619, A-56620, and nafcillin in the treatment of experimental Staphylococcus aureus osteomyelitis.
Antimicrobial agents and chemotherapy.
1987 Feb; 31(2):259-63. doi:
10.1128/aac.31.2.259. [PMID: 3566251] - H Thadepalli, S V Gollapudi, S K Chuah. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.
Antimicrobial agents and chemotherapy.
1986 Oct; 30(4):574-6. doi:
10.1128/aac.30.4.574. [PMID: 3539011] - L Hirschhorn, H C Neu. Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.
Antimicrobial agents and chemotherapy.
1986 Jul; 30(1):143-6. doi:
10.1128/aac.30.1.143. [PMID: 3752975] - P B Fernandes, D T Chu, R R Bower, K P Jarvis, N R Ramer, N Shipkowitz. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
Antimicrobial agents and chemotherapy.
1986 Feb; 29(2):201-8. doi:
10.1128/aac.29.2.201. [PMID: 3521473] - J M Stamm, C W Hanson, D T Chu, R Bailer, C Vojtko, P B Fernandes. In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
Antimicrobial agents and chemotherapy.
1986 Feb; 29(2):193-200. doi:
10.1128/aac.29.2.193. [PMID: 3087274]