Exact Mass: 415.2067
Exact Mass Matches: 415.2067
Found 500 metabolites which its exact mass value is equals to given mass value 415.2067
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Mavelertinib
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163952 - EGFR-targeting Agent C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Rupatadine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist Rupatadine is a second-generation tricyclic H1-antihistamine.
4,8-Methano-8aH-bisbenzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol,7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-, (4bS,8R,8aS,14bR)-
CID 9844747
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3].
Sabeluzole
C26170 - Protective Agent > C1509 - Neuroprotective Agent
(2S)-2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]-(2-benzamidoethyl)amino]-4-methylpentanoic acid
Protostemotinine
Protostemotinine is a natural product found in Stemona sessilifolia, Stemona kerrii, and Stemona japonica with data available. Protostemotinine is an alkaloid isolated from the roots and rhizomes of Stemona sessilifolia. Protostemotinine is an alkaloid isolated from the roots and rhizomes of Stemona sessilifolia.
3-benzhydryloxy-1-[2-(1,3-benzodioxol-5-yl)ethyl]piperidine
AM toxin-II|Am-II-Toxin|AM-toxin II|N-(L-2-hydroxy-3-methyl-butyryl)-5-phenyl-L-norvalyl->2,3-didehydro-alanyl->L-alanine lactone|toxin II (Alternaria mali)
(S)-2-((S)-3-(1H-Imidazol-4-yl)-2-((S)-pyrrolidine-2-carboxamido)Propanamido)-3-(4-hydroxyphenyl)Propanoic acid
zamifenacin
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8319; ORIGINAL_PRECURSOR_SCAN_NO 8318 CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8358; ORIGINAL_PRECURSOR_SCAN_NO 8357 CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8363; ORIGINAL_PRECURSOR_SCAN_NO 8361 CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8403; ORIGINAL_PRECURSOR_SCAN_NO 8402 CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8404; ORIGINAL_PRECURSOR_SCAN_NO 8402 CONFIDENCE standard compound; INTERNAL_ID 734; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8409; ORIGINAL_PRECURSOR_SCAN_NO 8407 Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome[1].
Ala Ile Asn Val
Ala Ile Val Asn
Ala Lys Pro Thr
Ala Lys Thr Pro
Ala Leu Asn Val
Ala Leu Val Asn
Ala Asn Ile Val
Ala Asn Leu Val
Ala Asn Val Ile
Ala Asn Val Leu
Ala Pro Lys Thr
Ala Pro Gln Thr
Ala Pro Thr Lys
Ala Pro Thr Gln
Ala Gln Pro Thr
Ala Gln Thr Pro
Ala Gln Val Val
Ala Thr Lys Pro
Ala Thr Pro Lys
Ala Thr Pro Gln
Ala Thr Gln Pro
Ala Val Ile Asn
Ala Val Leu Asn
Ala Val Asn Ile
Ala Val Asn Leu
Ala Val Gln Val
Ala Val Val Gln
Asp Gly Lys Pro
Asp Gly Pro Lys
Asp Lys Gly Pro
Asp Lys Pro Gly
Asp Pro Gly Lys
Asp Pro Lys Gly
Gly Asp Lys Pro
Gly Asp Pro Lys
Gly Gly Pro Trp
Gly Gly Trp Pro
Gly Ile Ile Asn
Gly Ile Leu Asn
Gly Ile Asn Ile
Gly Ile Asn Leu
Gly Ile Gln Val
Gly Ile Val Gln
Gly Lys Asp Pro
Gly Lys Pro Asp
Gly Leu Ile Asn
Gly Leu Leu Asn
Gly Leu Asn Ile
Gly Leu Asn Leu
Gly Leu Gln Val
Gly Leu Val Gln
Gly Asn Ile Ile
Gly Asn Ile Leu
Gly Asn Leu Ile
Gly Asn Leu Leu
Gly Pro Asp Lys
Gly Pro Gly Trp
Gly Pro Lys Asp
Gly Pro Arg Ser
Gly Pro Ser Arg
Gly Pro Trp Gly
Gly Gln Ile Val
Gly Gln Leu Val
Gly Gln Val Ile
Gly Gln Val Leu
Gly Arg Pro Ser
Gly Arg Ser Pro
Gly Ser Pro Arg
Gly Ser Arg Pro
Gly Val Ile Gln
Gly Val Leu Gln
Gly Val Gln Ile
Gly Val Gln Leu
Gly Trp Gly Pro
Gly Trp Pro Gly
Lys Asp Gly Pro
Lys Asp Pro Gly
Lys Gly Asp Pro
Lys Gly Pro Asp
Lys Pro Asp Gly
Lys Pro Gly Asp
Asn Pro Ser Val
Asn Pro Val Ser
Asn Ser Pro Val
Asn Ser Val Pro
Asn Val Pro Ser
Asn Val Ser Pro
Pro Ala Gln Thr
Pro Ala Thr Gln
Pro Asp Gly Lys
Pro Asp Lys Gly
Pro Gly Asp Lys
Pro Gly Gly Trp
Pro Gly Lys Asp
Pro Gly Arg Ser
Pro Gly Ser Arg
Pro Gly Trp Gly
Pro Lys Asp Gly
Pro Lys Gly Asp
Pro Asn Ser Val
Pro Asn Val Ser
Pro Gln Ala Thr
Pro Gln Thr Ala
Pro Arg Gly Ser
Pro Arg Ser Gly
Pro Ser Gly Arg
Pro Ser Asn Val
Pro Ser Arg Gly
Pro Ser Val Asn
Pro Thr Ala Gln
Pro Thr Gln Ala
Pro Val Asn Ser
Pro Val Ser Asn
Pro Trp Gly Gly
Gln Ala Pro Thr
Gln Ala Thr Pro
Gln Pro Ala Thr
Gln Pro Thr Ala
Gln Thr Ala Pro
Gln Thr Pro Ala
Arg Gly Pro Ser
Arg Gly Ser Pro
Arg Pro Gly Ser
Arg Pro Ser Gly
Arg Ser Gly Pro
Arg Ser Pro Gly
Ser Gly Pro Arg
Ser Gly Arg Pro
Ser Asn Pro Val
Ser Asn Val Pro
Ser Pro Gly Arg
Ser Pro Asn Val
Ser Pro Arg Gly
Ser Pro Val Asn
Ser Arg Gly Pro
Ser Arg Pro Gly
Ser Val Asn Pro
Ser Val Pro Asn
Thr Ala Pro Gln
Thr Ala Gln Pro
Thr Pro Ala Gln
Thr Pro Gln Ala
Thr Gln Ala Pro
Thr Gln Pro Ala
Val Asn Pro Ser
Val Asn Ser Pro
Val Pro Asn Ser
Val Pro Ser Asn
Val Ser Asn Pro
Val Ser Pro Asn
Trp Gly Gly Pro
Trp Gly Pro Gly
Trp Pro Gly Gly
5,6-dimethoxy-2-methyl-3-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-indole hydrochloride
Donepezil Hydrochloride
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018697 - Nootropic Agents C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D004791 - Enzyme Inhibitors
Benzeneethanol, 4-[1-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1-methylethyl]-, 4-methylbenzenesulfonate (ester)
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-[4-(DIETHOXY-PHOSPHORYLMETHYL)-PHENYL]-PROPIONIC ACID
3-phenylacrylic acid (2r,3s)-3-dibenzylamino-2-hydroxybutyl ester
(S)-3-(4-ACETYLPHENYL)-4-ISOPROPYLOXAZOLIDIN-2-ONE
Celiprolol HCl
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Coelenterazine cp
(S)-2-(3-BENZOYLPHENYL)-N-(4-HYDROXYPHENETHYL)-N-ISOPROPYLPROPANAMIDE
1,11-bis(trimethoxysilyl)-4-oxa-8-azaundecan-6-ol,50 in methanol
Thiourea, N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-N-phenyl-N-(3-pyridinylmethyl)- (9CI)
(2R)-2-[4-[(4-chlorophenyl)methyl]-5-methyl-1,2,4-triazol-3-yl]-N-cycloheptylpyrrolidine-1-carboxamide
methyl 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-1,3,3-trimethylindoline-5-carboxylate
(S)-2-[2-[Bis(2-tolyl)phosphino]phenyl]-4-tert-butyl-4,5-dihydro-oxazole
3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
N-(3,4-Diethyloxy)phenylethyl-3,4-diethyloxyphenyl acetamide
N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2].
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine Maleate
5-[[4-(2-Amino-2-oxoethoxy)-3-methoxyphenyl]methylamino]-2-(4-morpholinyl)benzoic acid
4-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-[[3-(trifluoromethyl)phenyl]methyl]piperidine
1-(phenylmethyl)-N-(2,4,6-trimethylphenyl)sulfonyl-4-piperidinecarbohydrazide
[1-acetyl-4-tert-butyl-3,6-bis(tert-butylsulfanyl)-3,6-dihydro-2H-pyridin-2-yl] acetate
(2S)-1-[4-({6-[(2,6-Difluorophenyl)amino]pyrimidin-4-YL}amino)phenoxy]-3-(dimethylamino)propan-2-OL
(2R)-1-[4-({6-[(2,6-Difluorophenyl)amino]pyrimidin-4-YL}amino)phenoxy]-3-(dimethylamino)propan-2-OL
1-{[(1E)-(3-Hydroxy-2-methyl-5-{[(trihydroxy-lambda^5^-phosphanyl)oxy]methyl}pyridin-4-YL)methylidene]amino}undecan-2-one
Rupatadine
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
N-[4-(4-methylphenoxy)phenyl]-2-[2-(2-oxopyrrolidin-1-yl)anilino]acetamide
N-[[4-(2-propan-2-yl-5-pyridin-4-ylpyrimidin-4-yl)cyclohexyl]methyl]pyridine-3-carboxamide
4,8-Methano-8aH-bisbenzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol,7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-, (4bS,8R,8aS,14bR)-
17-O-deacetylvindolinium
A vinca alkaloid cation that is the conjugate acid of 17-O-deacetylvindoline.
(10S,12S)-3-acetyl-10-(2-methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.02,10.04,9.015,20]henicosa-4,6,8,15,17,19-hexaene-13,21-dione
(2S)-2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]-(2-benzamidoethyl)amino]-4-methylpentanoic acid
smenospongines C
A sesquiterpenoid isolated from the marine sponge Dactylospongia elegans.
3,6-Bis(dimethylamino)-9-(2-(ethoxycarbonyl)-phenyl)xanthylium
6-phenyl-N-[(3-phenylphenyl)methyl]-3-(2-pyridinyl)-1,2,4-triazin-5-amine
(3S,3aR,8aS,8bS)-5-ethyl-2-(phenylmethyl)spiro[1H-indole-3,4-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]-1,2,3-trione
1-acetyl-N-[3-(N-ethyl-3-methylanilino)propyl]-2,3-dihydroindole-5-sulfonamide
1-(4-tert-butylphenyl)sulfonyl-N-(2-pyridinylmethyl)-2-piperidinecarboxamide
5-(Pentoxymethyl)-3-[(2E)-2-[(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]propyl]oxolan-2-one
(12R,15S,16R,8R)-15-methoxy-7,8,10-trimethyl-6,9-dioxo-13,14,15,16-tetrahydro-12H-4-oxa-7,10-diaza-1(2,6)-pyrana-5(1,2)-benzenacycloundecaphane-56-carbonitrile
[2-(2,5-dimethylanilino)-2-oxoethyl] (E)-3-(2-methoxyphenyl)-2-phenylprop-2-enoate
(1R,4R,5R,5S,8S)-1-methyl-5-(2-methylpropyl)-4-[(2S)-3-oxobutan-2-yl]spiro[2-oxatricyclo[6.4.1.04,13]tridec-4(13)-ene-5,3-pyrrolidine]-2,3,6-trione
1-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]ethanone
(1S,12R,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
4-[(3aR,4R,9bR)-1-[cyclohexyl(oxo)methyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-8-yl]benzonitrile
4-[(3aS,4R,9bS)-1-[cyclohexyl(oxo)methyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-8-yl]benzonitrile
4-[(3aR,4S,9bR)-1-[cyclohexyl(oxo)methyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-8-yl]benzonitrile
2-[(2R,5R,6S)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2S,5S,6S)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-fluoro-N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
(1S,13S,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1S,13R,17R,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1S,13R,17S,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13R,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13R,17S,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1S,13R,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13R,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13S,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13R,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1R,13S,17R,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13R,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1R,12S,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12S,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12S,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12S,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12S,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12R,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12S,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12R,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12R,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12R,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
[(1R,2aR,8bR)-1-(hydroxymethyl)-2-[(2-methoxyphenyl)methyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-4-yl]-(3-pyridinyl)methanone
[(1S,2aR,8bR)-1-(hydroxymethyl)-2-[(2-methoxyphenyl)methyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-4-yl]-(3-pyridinyl)methanone
1-[(2R,3R)-6-[(2,5-difluorophenyl)methyl]-2-(hydroxymethyl)-3-phenyl-1,6-diazaspiro[3.3]heptan-1-yl]-2-(dimethylamino)ethanone
4-[4-[(2S,3R)-1-acetyl-6-[cyclopropyl(oxo)methyl]-2-(hydroxymethyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile
4-[4-[(2R,3R)-1-acetyl-6-[cyclopropyl(oxo)methyl]-2-(hydroxymethyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile
2-[(2R,5S,6R)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2S,5R,6S)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2S,5S,6R)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2R,5R,6R)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2R,5S,6S)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-[(2S,5R,6R)-5-[[(2-fluoroanilino)-oxomethyl]amino]-6-(hydroxymethyl)-2-oxanyl]-N-(phenylmethyl)acetamide
2-fluoro-N-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
2-fluoro-N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-[[1-oxo-2-(2-pyridinyl)ethyl]amino]ethyl]-3-oxanyl]benzamide
(1S,13S,17R,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13S,17R,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13S,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13R,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1S,13S,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1S,13S,17S,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13S,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5,7,9-triene-6-carbonitrile
(1R,13R,17S,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13S,17S,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13S,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1R,13R,17S,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1S,13S,17R,18S)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1R,13S,17R,18R)-18-methoxy-12,13,15-trimethyl-11,14-dioxo-4,21-dioxa-12,15-diazatricyclo[15.3.1.05,10]henicosa-5(10),6,8-triene-8-carbonitrile
(1R,12S,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12R,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12R,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12S,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12R,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12S,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12R,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12R,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1S,12R,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12R,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4(9),5,7-triene-7-carbonitrile
(1R,12R,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12R,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12S,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12S,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12S,17S,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12S,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12S,17S,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1R,12S,17R,20S)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
(1S,12R,17R,20R)-20-methoxy-11,12,14-trimethyl-10,13-dioxo-3,21-dioxa-11,14-diazatricyclo[15.3.1.04,9]henicosa-4,6,8-triene-5-carbonitrile
[(1R,2aS,8bS)-1-(hydroxymethyl)-2-[(2-methoxyphenyl)methyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-4-yl]-(3-pyridinyl)methanone
[(1S,2aS,8bS)-1-(hydroxymethyl)-2-[(2-methoxyphenyl)methyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-4-yl]-(3-pyridinyl)methanone
[(1S,2aS,8bS)-1-(hydroxymethyl)-2-[(3-methoxyphenyl)methyl]-1,2a,3,8b-tetrahydroazeto[2,3-c]quinolin-4-yl]-pyridin-4-ylmethanone
4-[(3aS,4S,9bS)-1-[cyclohexyl(oxo)methyl]-4-(hydroxymethyl)-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-8-yl]benzonitrile
1-[(2S,3R)-6-[(2,5-difluorophenyl)methyl]-2-(hydroxymethyl)-3-phenyl-1,6-diazaspiro[3.3]heptan-1-yl]-2-(dimethylamino)ethanone
4-[4-[(2S,3S)-1-acetyl-6-[cyclopropyl(oxo)methyl]-2-(hydroxymethyl)-1,6-diazaspiro[3.3]heptan-3-yl]phenyl]benzonitrile
(2R,3R)-6-[(3,5-difluorophenyl)methyl]-2-(hydroxymethyl)-3-phenyl-N-propan-2-yl-1,6-diazaspiro[3.3]heptane-1-carboxamide
ALM301
ALM301 is an orally active highly specific AKT inhibitor with IC50 values of 0.13 μM, 0.09 μM and 2.75 μM for AKT1, AKT2 and AKT3, respectively. ALM301 inhibits AKT phosphorylation and modulates downstream signalling in vitro. ALM301 can inhibit cancer cell proliferation and tumor growth[1].
BC1618
BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1].
GSK163090
GSK163090 is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7, respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK163090 has antidepressant and anxiolytic activities[1].
Ninerafaxstat
Ninerafaxstat (IMB-1018972) is a novel mitotropic agent. Ninerafaxstat increases myocardial metabolic efficiency by shifting substrate utilization towards glucose through reducing fatty acid oxidation (inhibiting 3-ketoacyl CoA thiolase). Ninerafaxstat can be used for the research of cardiovascular diseases[1].