Donepezil Hydrochloride (BioDeep_00000645305)
代谢物信息卡片
Donepezil Hydrochloride
化学式: C24H30ClNO3 (415.19141)
中文名称: 盐酸多奈哌齐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:4696
- KEGGdrug: D00670
- PubChem: 5741
- ChEMBL: CHEMBL1678
- MeSH: Donepezil
- CAS: 120011-70-3
- CAS: 110119-84-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haifei Lu, Aihua Tan, Yini Zhang, Yumeng Chen, Simiao Ran, Ping Wang. Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl3-induced zebrafish (Danio rerio) model of Alzheimer's disease.
Journal of ethnopharmacology.
2024 Jun; 328(?):117993. doi:
10.1016/j.jep.2024.117993. [PMID: 38423408] - Eshani Mahajan, Anupam Raja, Amit Raj Sharma, Ashish Jain, Praisy K Prabha, Ajay Prakash, Bikash Medhi. To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration elicited by amyloid-β in rats.
Experimental neurology.
2024 May; 375(?):114720. doi:
10.1016/j.expneurol.2024.114720. [PMID: 38342181] - Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K Sreedhara Ranganath Pai. Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies.
Scientific reports.
2024 04; 14(1):9897. doi:
10.1038/s41598-024-57188-7. [PMID: 38688962] - Sun Linjuan, L I Chengfu, Liu Jiangang, L I Nannan, Han Fuhua, Qiao Dandan, Tao Zhuang, Zhan Min, Chen Wenjie, Zhang Xiaohui, Tong Chenguang, Chen Dong, Qi Jiangxia, Liu Yang, Liang Xiao, Zheng Xiaoying, Zhang Yunling. Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Apr; 44(2):289-302. doi:
10.19852/j.cnki.jtcm.20240203.007. [PMID: 38504535] - Rei Funahashi, Fumiaki Matsuura, Masayuki Ninomiya, Sayo Okabe, Shigeo Takashima, Kaori Tanaka, Atsuyoshi Nishina, Mamoru Koketsu. Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors.
Bioorganic chemistry.
2024 Apr; 145(?):107229. doi:
10.1016/j.bioorg.2024.107229. [PMID: 38401360] - Doha M Beltagy, Nagat F Nawar, Tarek M Mohamed, Ehab Tousson, Mai M El-Keey. The synergistic effect of nanocurcumin and donepezil on Alzheimer's via PI3K/AKT/GSK-3β pathway modulating.
Prostaglandins & other lipid mediators.
2024 Feb; 170(?):106791. doi:
10.1016/j.prostaglandins.2023.106791. [PMID: 37918555] - Mohan Gupta, Swati Pant, Preeti Rana, Avinash Kumar, Chakrawarti Prasun, Maya S Nair, Sarvesh Paliwal, Sumitra Nain. Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations.
Scientific reports.
2024 01; 14(1):1687. doi:
10.1038/s41598-024-51713-4. [PMID: 38242995] - Ismaheel Akinwale Adeniyi, Peace Oluwafolakemi Oregbesan, Adegboyega Adesanya, Mujeedat Adebukola Olubori, Gbenga Stanley Olayinka, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo. Olax subscorpioidea prevented scopolamine-induced memory impairment through the prevention of oxido-inflammatory damage and modulation of cholinergic transmission.
Journal of ethnopharmacology.
2024 Jan; 318(Pt B):116995. doi:
10.1016/j.jep.2023.116995. [PMID: 37541399] - Yi Zhou, Ying He, Xue Teng, Jing Mi, Jing Yang, Rongrui Wei, Wenmin Liu, Qinge Ma, Zhenghuai Tan, Zhipei Sang. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Journal of enzyme inhibition and medicinal chemistry.
2023 Dec; 38(1):2231661. doi:
10.1080/14756366.2023.2231661. [PMID: 37414563] - Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee. The Neuroprotective Effects of Dendropanax morbifera Water Extract on Scopolamine-Induced Memory Impairment in Mice.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216444. [PMID: 38003650] - Avinash R Tekade, Mayuri R Suryavanshi, Ashutosh B Shewale, Vilas S Patil. Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer's disease.
Drug development and industrial pharmacy.
2023 Sep; 49(9):590-600. doi:
10.1080/03639045.2023.2262035. [PMID: 37733474] - Manfei Xu, Yuebing Yue, Jie Huang. Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment.
Journal of pharmaceutical and biomedical analysis.
2023 Jul; 235(?):115610. doi:
10.1016/j.jpba.2023.115610. [PMID: 37542831] - Shenwei Li, Dongyan Wang, Yiyin Zhang, Hong Huo, Yue Liu, Yiyan Wang, Dongxue Zhao, Xu Dong, Hongyan Zhang. The efficacy of acupuncture combined with other therapies in post stroke cognitive impairment: A network meta-analysis.
Medicine.
2023 Jul; 102(29):e34086. doi:
10.1097/md.0000000000034086. [PMID: 37478264] - Aliasgar F Shahiwala, Samar Salam Qawoogha, Nuruzzaman Faruqui. Designing Optimum Drug Delivery Systems Using Machine Learning Approaches: a Prototype Study of Niosomes.
AAPS PharmSciTech.
2023 Apr; 24(4):94. doi:
10.1208/s12249-023-02547-2. [PMID: 37012582] - Eman M Elbaz, Reham M Essam, Kawkab A Ahmed, Maheera H Safwat. Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity.
International immunopharmacology.
2023 Feb; 116(?):109841. doi:
10.1016/j.intimp.2023.109841. [PMID: 36764270] - Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect.
Drug development and industrial pharmacy.
2023 Feb; 49(2):240-247. doi:
10.1080/03639045.2023.2201625. [PMID: 37032647] - Yuqiu Yang, Yufeng Gao, Chelimoge Wang. [Mongolian medicine Heisuga-25 promotes the expression of neuroskeletal protein, increases the content of neurotransmitter and improves the symptoms of Alzheimer's disease in mice].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2023 Feb; 39(2):153-158. doi:
. [PMID: 36872434] - Mustafa K Shehata, Assem A Ismail, Maher A Kamel. Combined Donepezil with Astaxanthin via Nanostructured Lipid Carriers Effective Delivery to Brain for Alzheimer's Disease in Rat Model.
International journal of nanomedicine.
2023; 18(?):4193-4227. doi:
10.2147/ijn.s417928. [PMID: 37534058] - Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao. Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway.
Metabolic brain disease.
2022 12; 37(8):2751-2762. doi:
10.1007/s11011-022-00980-z. [PMID: 35921056] - De-Feng Liu, Ming Bai, Ning-Ning Du, Shuai Shen, Zhi-Yuan Li, Xin Zhang, Rui Guo, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang. Insight into Isolation and Characterization of Phenolic Compounds from Hawthorn (Crataegus pinnatifida Bge.) with Antioxidant, Anti-Acetylcholinesterase, and Neuroprotective Activities.
Plant foods for human nutrition (Dordrecht, Netherlands).
2022 Dec; 77(4):538-544. doi:
10.1007/s11130-022-01004-y. [PMID: 35986175] - Xin-Chen Wang, Chen-Liang Chu, Kuan Lu, Xi Chen, Xiao-Qian Jin, Shi-Jian Quan. The role of tonifying kidney decoction and acupuncture in the treatment of Alzheimer's disease: A network meta-analysis.
Medicine.
2022 Nov; 101(46):e31243. doi:
10.1097/md.0000000000031243. [PMID: 36401402] - Opeyemi B Ogunsuyi, Folorunsho B Omage, Omamuyovwi M Ijomone, Ganiyu Oboh, João B T Rocha. Effect of chlorogenic acid plus donepezil on critical neurocortical enzyme activities, inflammatory markers, and synaptophysin immunoreactivity in scopolamine-assaulted rats, supported by multiple ligand simultaneous docking.
Journal of food biochemistry.
2022 11; 46(11):e14312. doi:
10.1111/jfbc.14312. [PMID: 35791518] - Yibin Hu, Lijuan Zhang, Xiuju Guan, Hanru Hou, Shuyue Bi, Changning Liu, Mingxiang Li, Kangfeng Wang. Gunao-Yizhi decoction combined with donepezil for vascular dementia: A systematic review and meta-analysis.
Medicine.
2022 Oct; 101(40):e30971. doi:
10.1097/md.0000000000030971. [PMID: 36221397] - Zhipei Sang, Ping Bai, Yujuan Ban, Keren Wang, Anguo Wu, Jing Mi, Jiaqi Hu, Rui Xu, Gaofeng Zhu, Jianta Wang, Jiquan Zhang, Changning Wang, Zhenghuai Tan, Lei Tang. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Bioorganic chemistry.
2022 10; 127(?):106007. doi:
10.1016/j.bioorg.2022.106007. [PMID: 35849893] - Yasir Hasan Siddique, Rahul, Gulshan Ara, Mohammad Afzal, Himanshi Varshney, Kajal Gaur, Iqra Subhan, I Mantasha, M Shahid. Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease.
Chemico-biological interactions.
2022 Oct; 366(?):110120. doi:
10.1016/j.cbi.2022.110120. [PMID: 36027948] - Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke. Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems.
Drug and chemical toxicology.
2022 Sep; ?(?):1-9. doi:
10.1080/01480545.2022.2119995. [PMID: 36069210] - Qin-Hui Fu, Jian Pei, Hou-Guang Zhou, Tao Wang, Yi-Jun Zhan, Lin Tao, Jia Xu, Qian Zhou, Liao-Yao Wang. Effect of acupuncture with donepezil based on syndrome differentiation on cognitive function in patients with mild-to-moderate Alzheimer's disease: a study protocol for a multicenter randomized controlled trial.
Trials.
2022 Aug; 23(1):695. doi:
10.1186/s13063-022-06532-1. [PMID: 35986297] - Qiang Yang, Jia Liu, Kai-Lin Huang, Guang-Yao Wang, Mi-Yuan Wang, Ai-Hua Tan, Si-Miao Ran. A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia.
Medicine.
2022 Aug; 101(31):e29307. doi:
10.1097/md.0000000000029307. [PMID: 35945739] - Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Masashi Inagaki, Keita Saku, Masaru Sugimachi. Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction.
The journal of physiological sciences : JPS.
2022 Jun; 72(1):12. doi:
10.1186/s12576-022-00836-2. [PMID: 35725377] - Hien Thu Nguyen, Xoan Thi Le, Tai Van Nguyen, Hoa Nhu Phung, Hang Thi Nguyet Pham, Khoi Minh Nguyen, Kinzo Matsumoto. Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice.
Journal of natural medicines.
2022 Jun; 76(3):621-633. doi:
10.1007/s11418-022-01609-2. [PMID: 35218459] - Ayokunle O Ademosun, Adeniyi A Adebayo, Temitope V Popoola, Ganiyu Oboh. Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats.
Drug and chemical toxicology.
2022 May; 45(3):1073-1080. doi:
10.1080/01480545.2020.1808668. [PMID: 32847424] - Yan-Wen Huang, Li Ding, YuanMing Chen, Weichen Lin, Fei Lin, Yunsheng Hsieh. 2-μm fused-core column ultra-high-performance liquid chromatography/tandem mass spectrometric determination of donepezil in human plasma: Application to a bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2022 Mar; 211(?):114596. doi:
10.1016/j.jpba.2022.114596. [PMID: 35104737] - Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
European journal of medicinal chemistry.
2022 Feb; 229(?):114045. doi:
10.1016/j.ejmech.2021.114045. [PMID: 34922191] - Mahdieh Anoush, Nasrin Tayebi, Soroush Bijani, Mina Ebrahimi, Ali Reza Yazdinezhad, Mir-Jamal Hosseini. Thymus daenensis extract prevents scopolamine‑induced memory impairment through declining oxidative stress in rats.
Acta neurobiologiae experimentalis.
2022; 82(3):380-388. doi:
10.55782/ane-2022-036. [PMID: 36214720] - Shatw Khalid Ali, Rojgar H Ali. Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
PloS one.
2022; 17(7):e0271138. doi:
10.1371/journal.pone.0271138. [PMID: 35802659] - Fangcheng Fan, Hua Liu, Xiaojie Shi, Yangwen Ai, Qingshan Liu, Yong Cheng. The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review.
Journal of Alzheimer's disease : JAD.
2022; 85(3):1195-1204. doi:
10.3233/jad-215423. [PMID: 34924395] - Ping-Song Chou, Ling-Chun Huang, Tzyh-Chyuan Hour, Chen-Wen Yen, Yuan-Han Yang. Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 Jan; 121(1 Pt 2):409-415. doi:
10.1016/j.jfma.2021.05.026. [PMID: 34120801] - Shuai-Nan Zheng, Long Pan, Ai-Mei Liao, Yin-Chen Hou, Guang-Hai Yu, Xiao-Xiao Li, Yong-Jian Yuan, Yu-Qi Dong, Zi-Shan Zhang, Cui-Zhu Tian, Zeng-Liang Liu, Wen-Jin Lin, Ming Hui, Jian Cao, Ji-Hong Huang. Wheat embryo globulin nutrients ameliorate d-galactose and aluminum chloride-induced cognitive impairment in rats.
Brain research.
2021 12; 1773(?):147672. doi:
10.1016/j.brainres.2021.147672. [PMID: 34606748] - Tajudeen O Obafemi, Olutumise V Owolabi, Benjamin O Omiyale, Blessing A Afolabi, Oluwafemi A Ojo, Amos Onasanya, Isaac A I Adu, Damilare Rotimi. Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats.
Metabolic brain disease.
2021 12; 36(8):2511-2519. doi:
10.1007/s11011-021-00749-w. [PMID: 33978901] - Shu-Quan Yang, De-Hui Fan, Zhi-Xian Yuan, Mei-Yi Su, Zhen-Ning Zhang, Ying Lin, Hu-Guang Lin. [Abdominal acupoint thread embedding therapy based on 'brain-intestinal connection' for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ1-42].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2021 Nov; 41(11):1231-5. doi:
10.13703/j.0255-2930.20201106-k0002. [PMID: 34762376] - Hsin-Miao Wang, Li-Min Liou, Chung-Yao Hsu, Hsiu-Fen Lin. Letter to the editor: Donepezil-induced parkinsonism in end-stage renal disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2021 Nov; 42(11):4809-4812. doi:
10.1007/s10072-021-05522-6. [PMID: 34346013] - Mingcui Zheng, Zhenhong Liu, Lulu Mana, Gaofeng Qin, Shuaiyang Huang, Zhuoyan Gong, Meijing Tian, Yannan He, Pengwen Wang. Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway.
Journal of ethnopharmacology.
2021 Oct; 278(?):114264. doi:
10.1016/j.jep.2021.114264. [PMID: 34082015] - Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Tsuyoshi Akiyama, Masaru Sugimachi. Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.
Cardiovascular drugs and therapy.
2021 10; 35(5):877-888. doi:
10.1007/s10557-020-07062-1. [PMID: 32860618] - Mamali Das, Devasahayam Jaya Balan, Pandima Devi Kasi. Mitigation of oxidative stress with dihydroactinidiolide, a natural product against scopolamine-induced amnesia in Swiss albino mice.
Neurotoxicology.
2021 09; 86(?):149-161. doi:
10.1016/j.neuro.2021.08.003. [PMID: 34371027] - Pankaj Bhatia, Nirmal Singh. Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia-induced experimental vascular cognitive impairment and dementia.
Fundamental & clinical pharmacology.
2021 Aug; 35(4):650-666. doi:
10.1111/fcp.12610. [PMID: 33020931] - Guiliang Zhang, Jiahui Wu, Chunhui Huang, Jiehong Cheng, Zhiyang Su, Zeyu Zhu, Xifei Yang, Baojian Guo, Liangmiao Wu, Zaijun Zhang, Gaoxiao Zhang, Haiyun Chen, Yewei Sun, Yuqiang Wang. The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
Journal of molecular neuroscience : MN.
2021 Jul; 71(7):1456-1466. doi:
10.1007/s12031-020-01762-x. [PMID: 33403592] - Yoshiyuki Kagawa, Yoshiaki Yamamoto, Ayami Ueno, Toshio Maeda, Tomokazu Obi. Impact of CYP2D6, CYP3A5, and ABCB1 Polymorphisms on Plasma Concentrations of Donepezil and Its Metabolite in Patients With Alzheimer Disease.
Therapeutic drug monitoring.
2021 06; 43(3):429-435. doi:
10.1097/ftd.0000000000000823. [PMID: 33065613] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova. The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082160. [PMID: 33918638] - Jiajia Zhao, Kun Li, Yingying Wang, Dan Li, Qianwen Wang, Shengsheng Xie, Jianxin Wang, Zhong Zuo. Enhanced anti-amnestic effect of donepezil by Ginkgo biloba extract (EGb 761) via further improvement in pro-cholinergic and antioxidative activities.
Journal of ethnopharmacology.
2021 Apr; 269(?):113711. doi:
10.1016/j.jep.2020.113711. [PMID: 33352242] - Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Koki Chiba, Takeshi Wada, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 04; 394(4):581-589. doi:
10.1007/s00210-020-01997-w. [PMID: 33064166] - Waqas Aslam, Carla R Lamb, Nadia Ali. Torsades de pointes in SARS-CoV-2 (COVID-19) pneumonia: medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications.
BMJ case reports.
2021 Mar; 14(3):. doi:
10.1136/bcr-2020-239963. [PMID: 33762277] - Zhipeng Zhang, Jie Guo, Maojun Cheng, Weixin Zhou, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Jing Liu, Sai-Sai Xie. Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2021 Mar; 213(?):113154. doi:
10.1016/j.ejmech.2021.113154. [PMID: 33476932] - Jill K Morris, Colin S McCoin, Kelly N Fuller, Casey S John, Heather M Wilkins, Zachary D Green, Xiaowan Wang, Palash Sharma, Jeffrey M Burns, Eric D Vidoni, Jonathan D Mahnken, Kartik Shankar, Russell H Swerdlow, John P Thyfault. Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.
Function (Oxford, England).
2021; 2(6):zqab045. doi:
10.1093/function/zqab045. [PMID: 34661111] - Akiko Kiriyama. [Pharmacokinetics/Pharmacodynamic Analysis to Link Pharmacokinetics to Efficacy and Drug Interaction of Alzheimer's Disease Drugs].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2021; 141(6):831-833. doi:
10.1248/yakushi.20-00251-3. [PMID: 34078790] - Yuki Takada-Takatori. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2021; 141(6):851-856. doi:
10.1248/yakushi.20-00251-6. [PMID: 34078793] - Serseg Talia, Khedidja Benarous, Meriem Lamrani, Mohamed Yousfi. Lepidine B from Lepidium sativum Seeds as Multi-Functional Anti- Alzheimer's Disease Agent: In Vitro and In Silico Studies.
Current computer-aided drug design.
2021; 17(3):360-377. doi:
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Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
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The international journal of neuropsychopharmacology.
2020 12; 23(9):581-586. doi:
10.1093/ijnp/pyaa046. [PMID: 32640027] - Chang Yell Shin, Hae-Sun Kim, Kwang -Ho Cha, Hyun Jung Kim, Won Seok Choi, Sun Woo Jang, Uy Dong Sohn. Pharmacological evaluation and safety of a donepezil patch.
Die Pharmazie.
2020 12; 75(12):656-661. doi:
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Immunopharmacology and immunotoxicology.
2020 Dec; 42(6):625-631. doi:
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Pharmaceutical biology.
2020 Dec; 58(1):35-43. doi:
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Pharmaceutical biology.
2020 Dec; 58(1):1098-1104. doi:
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Biosensors & bioelectronics.
2020 Oct; 165(?):112411. doi:
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Acta pharmaceutica (Zagreb, Croatia).
2020 Sep; 70(3):411-422. doi:
10.2478/acph-2020-0032. [PMID: 32074067] - Jie Pang, Jiawei Hou, Zhangjiuzhi Zhou, Mengqiao Ren, Yuyan Mo, Guang Yang, Zuwei Qu, Yanli Hu. Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.
Neuromolecular medicine.
2020 09; 22(3):341-358. doi:
10.1007/s12017-020-08591-6. [PMID: 32048142] - Yu Qi, Huiting Jing, Xinhui Cheng, Tingxu Yan, Feng Xiao, Bo Wu, Kaishun Bi, Ying Jia. Alpinia oxyphylla-Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway.
Neuromolecular medicine.
2020 09; 22(3):370-383. doi:
10.1007/s12017-020-08595-2. [PMID: 32140977] - Julio Rodríguez-Lavado, Carlos Gallardo-Garrido, Michael Mallea, Victor Bustos, Rodrigo Osorio, Martín Hödar-Salazar, Hery Chung, Ramiro Araya-Maturana, Marcos Lorca, C David Pessoa-Mahana, Jaime Mella-Raipán, Claudio Saitz, Pablo Jaque, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez, Hernán Pessoa-Mahana. Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease.
European journal of medicinal chemistry.
2020 Jul; 198(?):112368. doi:
10.1016/j.ejmech.2020.112368. [PMID: 32388114] - Zhi-Xue Yang, Cheng-Lin Tang, Xiao-Hong Li, Zheng-Wei Zhu, Li Qiu, Hui-Yu An, Meng-Jia Wu, Yun-Hao Yang. [Effect of electroacupuncture combined with Donepezil on learning-memory ability and expression of hippocampal β-amyloid clearance-related genes in SAMP8 mice].
Zhen ci yan jiu = Acupuncture research.
2020 Apr; 45(4):281-6. doi:
10.13702/j.1000-0607.190081. [PMID: 32333532] - Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Xinfeng Cheng, Gaofeng Zhu, Yiling Wang, Yiyang Zhao, Zhanpin Qiao, Anguo Wu, Zhenghuai Tan. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2020 Apr; 192(?):112180. doi:
10.1016/j.ejmech.2020.112180. [PMID: 32131034] - Kun-Peng Xia, Jing Pang, Shu-Lin Li, Miao Zhang, Hong-Lin Li, Yu-Jue Wang. [Effect of electroacupuncture at governor vessel on learning-memory ability and serum level of APP, Aβ1-42 in patients with Alzheimer's disease].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2020 Apr; 40(4):375-8. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2020 Apr; 50(4):389-400. doi:
10.1080/00498254.2019.1643514. [PMID: 31298070] - Tatyana Dmitrievna Fedorova, Karoline Knudsen, Bolette Hartmann, Jens J Holst, Frank Viborg Mortensen, Klaus Krogh, Per Borghammer. In vivo positron emission tomography imaging of decreased parasympathetic innervation in the gut of vagotomized patients.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2020 03; 32(3):e13759. doi:
10.1111/nmo.13759. [PMID: 31715652] - Hui-Chan Wang, Nan-Yang Liu, Shuai Zhang, Yang Yang, Zhi-Yong Wang, Yun Wei, Jian-Gang Liu, Hui Pei, Hao Li. Clinical Experience in Treatment of Alzheimer's Disease with Jiannao Yizhi Formula () and Routine Western Medicine.
Chinese journal of integrative medicine.
2020 Mar; 26(3):212-218. doi:
10.1007/s11655-019-2718-2. [PMID: 32180150] - Anas Shamsi, Moyad Al Shahwan, Shahzaib Ahamad, Md Imtaiyaz Hassan, Faizan Ahmad, Asimul Islam. Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer's drug donepezil with human transferrin: implications of Alzheimer's drug.
Journal of biomolecular structure & dynamics.
2020 03; 38(4):1094-1102. doi:
10.1080/07391102.2019.1595728. [PMID: 30898045] - Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Masaru Sugimachi. Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats.
The journal of physiological sciences : JPS.
2020 Feb; 70(1):11. doi:
10.1186/s12576-020-00739-0. [PMID: 32066375] - Chae Bin Lee, Jee Sun Min, Soon Uk Chae, Hye Min Kim, Jun Hee Jang, In Ho Jung, Yu Fen Zheng, Jong Hoon Ryu, Soo Kyung Bae. Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 178(?):112919. doi:
10.1016/j.jpba.2019.112919. [PMID: 31654856] - Roma Ghai, Kandasamy Nagarajan, Meenakshi Arora, Parul Grover, Nazakat Ali, Garima Kapoor. Current Strategies and Novel Drug Approaches for Alzheimer Disease.
CNS & neurological disorders drug targets.
2020; 19(9):676-690. doi:
10.2174/1871527319666200717091513. [PMID: 32679025] - Seok Kyu Yoon, Kyun-Seop Bae, Dong Hyun Hong, Seong Su Kim, Young Kweon Choi, Hyeong-Seok Lim. Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers.
Drug design, development and therapy.
2020; 14(?):1729-1737. doi:
10.2147/dddt.s244957. [PMID: 32440098] - Marion Ortner, Marion Stange, Heike Schneider, Charlotte Schröder, Katharina Buerger, Claudia Müller, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Timo Grimmer, Werner Steimer. Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil.
Drug design, development and therapy.
2020; 14(?):3251-3262. doi:
10.2147/dddt.s247259. [PMID: 32848364] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Yang Yang, Jian-Ping Liu, Jun-Yan Fang, Hui-Chan Wang, Yun Wei, Yu Cao, Jian-Gang Liu, Long-Tao Liu, Hao Li. Effect and Safety of Huannao Yicong Formula () in Patients with Mild-to-Moderate Alzheimer's Disease: A Randomized, Double-Blinded, Donepezil-Controlled Trial.
Chinese journal of integrative medicine.
2019 Aug; 25(8):574-581. doi:
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Annales pharmaceutiques francaises.
2019 Jul; 77(4):286-294. doi:
10.1016/j.pharma.2019.02.003. [PMID: 31027753] - Hongtao Du, Xinlian Liu, Jusen Xie, Fang Ma. Novel Deoxyvasicinone-Donepezil Hybrids as Potential Multitarget Drug Candidates for Alzheimer's Disease.
ACS chemical neuroscience.
2019 05; 10(5):2397-2407. doi:
10.1021/acschemneuro.8b00699. [PMID: 30720268] - I T Mendes, A L M Ruela, F C Carvalho, J T J Freitas, R Bonfilio, G R Pereira. Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil.
Colloids and surfaces. B, Biointerfaces.
2019 May; 177(?):274-281. doi:
10.1016/j.colsurfb.2019.02.007. [PMID: 30763792] - Pearl J C van Lonkhuizen, Kete M Klaver, Jeffrey S Wefel, Margriet M Sitskoorn, Sanne B Schagen, Karin Gehring. Interventions for cognitive problems in adults with brain cancer: A narrative review.
European journal of cancer care.
2019 May; 28(3):e13088. doi:
10.1111/ecc.13088. [PMID: 31090162] - Xinhua Zhou, Wei Xiao, Zhiyang Su, Jiehong Cheng, Chengyou Zheng, Zaijun Zhang, Yuqiang Wang, Liang Wang, Benhong Xu, Shupen Li, Xifei Yang, Maggie Pui Man Hoi. Hippocampal Proteomic Alteration in Triple Transgenic Mouse Model of Alzheimer's Disease and Implication of PINK 1 Regulation in Donepezil Treatment.
Journal of proteome research.
2019 04; 18(4):1542-1552. doi:
10.1021/acs.jproteome.8b00818. [PMID: 30484658] - G H Ragab, E A Bahgat. Development of bioanalytical HPLC method for simultaneous determination of the antialzhiemer, donepezil hydrochloride and the antidepressant, citalopram hydrobromide in raw materials, spiked human plasma and tablets dosage form.
Annales pharmaceutiques francaises.
2019 Mar; 77(2):112-120. doi:
10.1016/j.pharma.2018.09.004. [PMID: 30528254] - Keshireddy AnjiReddy, Subramanian Karpagam. Hyperbranched cellulose polyester of oral thin film and nanofiber for rapid release of donepezil; preparation and in vivo evaluation.
International journal of biological macromolecules.
2019 Mar; 124(?):871-887. doi:
10.1016/j.ijbiomac.2018.11.224. [PMID: 30496855] - Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Lee. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease.
International journal of molecular sciences.
2019 Feb; 20(4):. doi:
10.3390/ijms20041000. [PMID: 30823604] - Jing Zhang, Jun Wang, Gui-Sheng Zhou, Ya-Jie Tan, Hui-Juan Tao, Jia-Qian Chen, Zong-Jin Pu, Jia-Yan Ma, Wen She, An Kang, Yue Zhu, Pei Liu, Zhen-Hua Zhu, Xu-Qin Shi, Yu-Ping Tang, Jin-Ao Duan. Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice.
Oxidative medicine and cellular longevity.
2019; 2019(?):8636835. doi:
10.1155/2019/8636835. [PMID: 30911351] - Fizza Naqvi, Saida Haider, Faizan Naqvi, Sadia Saleem, Tahira Perveen, Zehra Batool. A comparative study showing greater effects of curcumin compared to donepezil on memory function in rats.
Pakistan journal of pharmaceutical sciences.
2019 Jan; 32(1):53-60. doi:
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Neuroscience letters.
2018 11; 687(?):268-275. doi:
10.1016/j.neulet.2018.09.058. [PMID: 30290248] - Alana C Costa, Helena P G Joaquim, Valéria S Nunes, Daniel S Kerr, Guilherme S Ferreira, Orestes V Forlenza, Wagner F Gattaz, Leda Leme Talib. Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer's disease patients.
European archives of psychiatry and clinical neuroscience.
2018 Aug; 268(5):501-507. doi:
10.1007/s00406-017-0838-2. [PMID: 28861608] - Naresh Mittapelly, Gitu Pandey, Sachin Laxman Tulsankar, Sadaf Arfi, Rabi Sankar Bhatta, Prabhat Ranjan Mishra. In Depth Analysis of Pressure-Sensitive Adhesive Patch-Assisted Delivery of Memantine and Donepezil Using Physiologically Based Pharmacokinetic Modeling and in Vitro/in Vivo Correlations.
Molecular pharmaceutics.
2018 07; 15(7):2646-2655. doi:
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Journal of pharmaceutical and biomedical analysis.
2018 Jun; 155(?):177-184. doi:
10.1016/j.jpba.2018.03.060. [PMID: 29635172] - Jai Malik, Jagpreet Kaur, Sunayna Choudhary. Standardized extract of Lactuca sativa Linn. and its fractions abrogates scopolamine-induced amnesia in mice: A possible cholinergic and antioxidant mechanism.
Nutritional neuroscience.
2018 Jun; 21(5):361-372. doi:
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Psychopharmacology.
2018 05; 235(5):1571-1580. doi:
10.1007/s00213-018-4867-y. [PMID: 29502274] - Ehsan Mirparizi, Maryam Rajabi, Alireza Asghari. Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Journal of separation science.
2018 May; 41(10):2214-2220. doi:
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