Exact Mass: 337.2913094

N-linoleoyl glycine, also known as 15-methylpalmitate or C17ISO belongs to the class of compounds known as N-acylamides. These are molecules characterized by a fatty acyl group linked to a primary amine by an amide bond. More specifically, it is a Linoleic acid amide of Glycine. It is believed that there are more than 800 types of N-acylamides in the human body. N-acylamides fall into several categories: amino acid conjugates (e.g., those acyl amides conjugated with amino acids), neurotransmitter conjugates (e.g., those acylamides conjugated with neurotransmitters), ethanolamine conjugates (e.g., those acylamides conjugated to ethanolamine), and taurine conjugates (e.g., those acyamides conjugated to taurine). N-Linoleoyl Glycine is an amino acid conjugate. N-acylamides can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain N-acylamides; 2) medium-chain N-acylamides; 3) long-chain N-acylamides; and 4) very long-chain N-acylamides; 5) hydroxy N-acylamides; 6) branched chain N-acylamides; 7) unsaturated N-acylamides; 8) dicarboxylic N-acylamides and 9) miscellaneous N-acylamides. N-Linoleoyl Glycine is therefore classified as a long chain N-acylamide. N-acyl amides have a variety of signaling functions in physiology, including in cardiovascular activity, metabolic homeostasis, memory, cognition, pain, motor control and others (PMID: 15655504). N-acyl amides have also been shown to play a role in cell migration, inflammation and certain pathological conditions such as diabetes, cancer, neurodegenerative disease, and obesity (PMID: 23144998; PMID: 25136293; PMID: 28854168).N-acyl amides can be synthesized both endogenously and by gut microbiota (PMID: 28854168). N-acylamides can be biosynthesized via different routes, depending on the parent amine group. N-acyl ethanolamines (NAEs) are formed via the hydrolysis of an unusual phospholipid precursor, N-acyl-phosphatidylethanolamine (NAPE), by a specific phospholipase D. N-acyl amino acids are synthesized via a circulating peptidase M20 domain containing 1 (PM20D1), which can catalyze the bidirectional the condensation and hydrolysis of a variety of N-acyl amino acids. The degradation of N-acylamides is largely mediated by an enzyme called fatty acid amide hydrolase (FAAH), which catalyzes the hydrolysis of N-acylamides into fatty acids and the biogenic amines. Many N-acylamides are involved in lipid signaling system through interactions with transient receptor potential channels (TRP). TRP channel proteins interact with N-acyl amides such as N-arachidonoyl ethanolamide (Anandamide), N-arachidonoyl dopamine and others in an opportunistic fashion (PMID: 23178153). This signaling system has been shown to play a role in the physiological processes involved in inflammation (PMID: 25136293). Other N-acyl amides, including N-oleoyl-glutamine, have also been characterized as TRP channel antagonists (PMID: 29967167). N-acylamides have also been shown to have G-protein-coupled receptors (GPCRs) binding activity (PMID: 28854168). The study of N-acylamides is an active area of research and it is likely that many novel N-acylamides will be discovered in the coming years. It is also likely that many novel roles in health and disease will be uncovered for these molecules.

suloctidil

2-(Octylamino)-1-[4-(propan-2-ylsulphanyl)phenyl]propan-1-ol

13-Docosenamide

Docos-13-enimidate

A natural product found in Rubia yunnanensis.

(7Z)-2-acetamido-3-acetoxyhexadeca-7,15-diene|diacetyl obscuraminol B

laingolide A

19-isothiocyanato-18-nonadecenal

N-Pentadecylcyclohexanecarboxamide

suloctidil

(1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

linoleoyl glycine

N-9Z,12Z-1-oxo-octadecadien-1-yl-glycine

13Z-docosenamide

cis-13-Docosenoamide

A primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia. It is commonly used as a slip additive in the plastic manufacturing industry. [Raw Data] CBA63_Erucamide_pos_50eV.txt [Raw Data] CBA63_Erucamide_pos_40eV.txt [Raw Data] CBA63_Erucamide_pos_30eV.txt [Raw Data] CBA63_Erucamide_pos_20eV.txt [Raw Data] CBA63_Erucamide_pos_10eV.txt

Melophlin D/H/I/J

Erucamide; AIF; CE0; CorrDec

Erucamide; AIF; CE10; CorrDec

Erucamide; AIF; CE30; CorrDec

Erucamide; AIF; CE0; MS2Dec

Erucamide; AIF; CE10; MS2Dec

Erucamide; AIF; CE30; MS2Dec

(1S,Z)-3-((2R)-6-hydroxy-2,5-dimethylnonylidene)-1-methyloctahydro-2H-quinolizin-1-ol

C21H39NO2 (337.2980634)

(7R,E)-8-((1S,Z)-1-hydroxy-1-methylhexahydro-2H-quinolizin-3(4H)-ylidene)-4,7-dimethyloct-4-ene-2,3-diol

N-Cyclohexanecarbonylpentadecylamine

C16:1-9-(L)-HSL

N-[(2S,9Z)-tetrahydro-2-oxo-3-furanyl]-9-hexadecenamide

Palmyrolide A

13E-Docosenamide

Leukotriene A4-d5 methyl ester

C21H27D5O3 (337.26651809)

C16:1-HSL

N-(9Z-hexadecenoyl)-homoserine lactone

2-methyl-N-octadecylprop-2-enamide

C17H39NO3S (337.26505040000006)

TETRABUTYLAMMONIUM METHANESULFONATE

4-(4-Pentyl-bicyclohexyl-4-yl)-benzonitrile

C24H35N (337.27693500000004)

methyltris(cyclohexylamino)silane

C19H39N3Si (337.2913094)

8-Boc-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-8-aza-bicyclo[3.2.1]octane

C18H32BNO4 (337.24242620000007)

Safingol hydrochloride

C18H40ClNO2 (337.27474100000006)

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor D004791 - Enzyme Inhibitors

13-Docosenamide

Pyrrolidine, 1-stearoyl-

Cerebro

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

Erucylamide

13-Docosenamide, (13Z)-

Erucate

A unsaturated fatty acid anion that is the conjugate base of erucic acid, formed by deprotonation of the carboxylic acid group.

2,4-Dimethyl-icos-14-enoate

2,4-Dimethyl-icos-11-enoate

N-linoleoylglycine

(+)-Palmyrolide A

Cetoleate

A straight-chain, monounsaturated fatty acid anion that is the conjugate base of cetoleic acid.

2-[[(9E,12E)-Octadeca-9,12-dienoyl]amino]acetic acid

N-[(4E,8E,12E)-1,3-dihydroxytetradeca-4,8,12-trien-2-yl]hexanamide

N-[(4E,8E,12E)-1,3-dihydroxyhexadeca-4,8,12-trien-2-yl]butanamide

N-[(4E,8E,12E)-1,3-dihydroxyoctadeca-4,8,12-trien-2-yl]acetamide

N-[(4E,8E,12E)-1,3-dihydroxyheptadeca-4,8,12-trien-2-yl]propanamide

N-[(4E,8E,12E)-1,3-dihydroxypentadeca-4,8,12-trien-2-yl]pentanamide

(9Z,12Z)-N-(2-hydroxyethyl)nonadeca-9,12-dienamide

C21H39NO2 (337.2980634)

trans-13-docosenamide

A 13-docosenamide in which the double bond adopts an (E)-configuration.

Docosenoate

C22H41O2 (337.3106386)

A monounsaturated fatty acid anion that is the conjugate base of docosenoic acid, formed by deprotonation of the carboxylic acid group. Major species at pH 7.3.

NA-Ala 17:2(9Z,12Z)

NA-Amylamine 17:1(9Z)

NA-Gly 18:2

NA-Gly 18:2(9E,12E)

NA-Gly 18:2(9Z,12Z)

Docosenamide

n-[3-(acetyloxy)hexadeca-11,15-dien-2-yl]ethanimidic acid

(13z)-docos-13-enimidic acid