suloctidil (BioDeep_00000390804)

   


代谢物信息卡片


(1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol

化学式: C20H35NOS (337.2439)
中文名称: 舒美地尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O
InChI: InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3

描述信息

C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

2 个代谢物同义名

suloctidil; (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qianyi Chen, Shilin Xia, Hua Sui, Xueying Shi, Bingqian Huang, Tingxin Wang. Identification of hub genes associated with COVID-19 and idiopathic pulmonary fibrosis by integrated bioinformatics analysis. PloS one. 2022; 17(1):e0262737. doi: 10.1371/journal.pone.0262737. [PMID: 35045126]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • A Kotyk, G Lapathitis, S Krenková. Glucose- and K(+)-induced acidification in different yeast species. Folia microbiologica. 1999; 44(3):295-8. doi: 10.1007/bf02818550. [PMID: 10664885]
  • G Lapathitis, A Kotyk. Different sources of acidity in glucose-elicited extracellular acidification in the yeast Saccharomyces cerevisiae. Biochemistry and molecular biology international. 1998 Dec; 46(5):973-8. doi: 10.1080/15216549800204522. [PMID: 9861451]
  • A Kotyk, M Dvoráková. Are proton symports in yeast directly linked to H(+)-ATPase acidification?. Biochimica et biophysica acta. 1992 Mar; 1104(2):293-8. doi: 10.1016/0005-2736(92)90043-l. [PMID: 1347702]
  • M W Chung, R A Komorowski, R R Varma. Suloctidil-induced hepatotoxicity. Gastroenterology. 1988 Aug; 95(2):490-1. doi: 10.1016/0016-5085(88)90510-0. [PMID: 2839389]
  • C Valenzuela Miranda, M A Aller Reyero, J Arias Pérez, A Alsasua del Valle, J L Arias Pérez, J C Rodríguez Sánchez, H Durán Sacristán. [Suloctidil decreases the serotonin concentration in the brain stem of rats with a portacaval shunt]. Revista espanola de las enfermedades del aparato digestivo. 1988 May; 73(5 Pt 2):547-52. doi: NULL. [PMID: 2845525]
  • F Bucchi, C Cerletti, G de Gaetano. Inhibition of platelet thromboxane generation by suloctidil in man. Haemostasis. 1986; 16(5):362-8. doi: 10.1159/000215309. [PMID: 3023210]
  • R Merchan, I E Zurita, J F Martinez. Suloctidil: long-term trial in the aged. Study of microcirculation, viscosity, red cell deformability, fibrinolysis and lipid fractions. Arzneimittel-Forschung. 1985; 35(5):855-7. doi: NULL. [PMID: 2992530]
  • A G Turpie, M Gent, A C deBoer, M Giroux, D Kinch, R Butt, J Gunstensen, E Saerens, E Genton. Effect of suloctidil on platelet function in patients with shortened platelet survival time. Thrombosis research. 1984 Aug; 35(4):397-406. doi: 10.1016/0049-3848(84)90231-7. [PMID: 6091290]
  • R Brasseur, J M Ruysschaert, P Chatelain. Conformational analysis of suloctidil and derivatives inserted in lipid layers. Biochemical pharmacology. 1984 Apr; 33(7):1015-21. doi: 10.1016/0006-2952(84)90508-2. [PMID: 6324809]
  • C Chieffo, A Postiglione, C Tritto, M Mancini. Hypocholesterolaemic activity of suloctidil: double-blind, crossover short-term and long-term treatment trial. Current medical research and opinion. 1984; 9(3):147-52. doi: 10.1185/03007998409109573. [PMID: 6094103]
  • K Takahashi, Y Arai. [Antigenicity of suloctidil]. The Journal of toxicological sciences. 1983 Aug; 8(3):231-42. doi: 10.2131/jts.8.231. [PMID: 6319726]
  • G W Borst-Pauwels, A P Theuvenet, A L Stols. All-or-none interactions of inhibitors of the plasma membrane ATPase with Saccharomyces cerevisiae. Biochimica et biophysica acta. 1983 Jul; 732(1):186-92. doi: 10.1016/0005-2736(83)90202-x. [PMID: 6307362]
  • O Montefusco, C Missale, S Govoni, R Rozzini, M Trabucchi. Effect of suloctidil on dopaminergic transmission in various rat brain areas: possible uses as drug for the elderly. Pharmacological research communications. 1983 Mar; 15(3):317-27. doi: 10.1016/s0031-6989(83)80016-2. [PMID: 6304786]
  • G Baele, J L Bary, F van Stalle. Activation of platelets and of fibrinolysis by venous occlusion in healthy volunteers and influence of suloctidil in comparison with placebo. Arzneimittel-Forschung. 1983; 33(8):1203-5. doi: NULL. [PMID: 6315025]
  • G Pilla, A Ciaponi, A Migliavacca, C Bonora. [Chronic senile cerebrovascular insufficiency. Effects of suloctidil and pentoxifylline on erythrocyte deformability]. La Ricerca in clinica e in laboratorio. 1983; 13 Suppl 3(?):459-64. doi: NULL. [PMID: 6324325]
  • J A Schouten, R F Westerman. Elevated liver enzymes in serum during suloctidil treatment. European journal of clinical pharmacology. 1982; 22(6):559-60. doi: 10.1007/bf00609631. [PMID: 6290229]
  • M Amico-Roxas, F Drago, P L Canonico, A Russo, R Terranova, A Spitaleri, A Bianchi. Plasma viscosity: relation to age, atherogenic diet and suloctidil. Pharmacological research communications. 1981 Sep; 13(8):765-7. doi: 10.1016/s0031-6989(81)80094-x. [PMID: 6270707]
  • C Col-de Beys, A Ferrant, M Moriau. Effects of suloctidil on platelet survival time following cardiac valve replacement. Thrombosis and haemostasis. 1981 Aug; 46(2):550-3. doi: 10.1055/s-0038-1653408. [PMID: 6272442]
  • P Chatelain, J M Ruysschaert. Suloctidil-phospholipid interaction in bilayer membranes: effects on lipid dynamics. Biochemical pharmacology. 1981 Feb; 30(4):313-7. doi: 10.1016/0006-2952(81)90060-5. [PMID: 6260117]
  • F Drago, M Amico-Roxas, A Russo, A Bianchi, G Mazzoleni. [Effect of suloctidil on plasma viscosity in rats on an atherogenic diet]. Il Farmaco; edizione pratica. 1980 Aug; 35(8):423-6. doi: NULL. [PMID: 6256204]
  • J P Dufour, M Boutry, A Goffeau. Inhibition kinetics of the plasma membrane ATPase activity of the yeast Schizosaccharomyces pombe [proceedings]. Archives internationales de physiologie et de biochimie. 1979 Oct; 87(4):810-2. doi: NULL. [PMID: 93918]
  • R Roncucci, R De Hertogh, J A Dormandy, J Doumont, V Gurewich, G Lambelin, J Lansen, R Rottiers, E Souridis, F Van Stalle, L Versee. Effects of long-term treatment with suloctidil on blood viscosity, erythrocyte deformability and total fibrinogen plasma levels in diabetic patients. Arzneimittel-Forschung. 1979; 29(4):682-4. doi: NULL. [PMID: 582768]