Exact Mass: 294.9624746
Exact Mass Matches: 294.9624746
Found 88 metabolites which its exact mass value is equals to given mass value 294.9624746,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Chlorothiazide
Chlorothiazide is only found in individuals that have used or taken this drug. It is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents CONFIDENCE standard compound; EAWAG_UCHEM_ID 3256 D049990 - Membrane Transport Modulators
3-(2-Chlorophenyl)-2-(1,3-dithian-2-yliden)-3-oxopropanenitrile
3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID
3-[5-(4-bromophenyl)-1,2-oxazol-3-yl]propanoic acid
ethyl 6-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate
ethyl 1-(5-bromopyridin-2-yl)pyrazole-4-carboxylate
3-[5-(4-bromophenyl)-1,3-oxazol-2-yl]propanoic acid
2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
methyl 5-chloro-7-(trifluoromethyl)thieno[3,2-b]pyridine-3-carboxylate
C10H5ClF3NO2S (294.96816160000003)
3-(2-BROMO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
5-(4-Bromophenyl)-2-chloropyridine-3-carboxaldehyde
C12H7BrClNO (294.93995020000006)
N-[2-(3-BROMO-PHENYL)-ETHYL]-2,2,2-TRIFLUORO-ACETAMIDE
Methyl 5-bromo-8-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate
4-Diazo-3,4-dihydro-7-nitro-3-oxo-1-naphthalenesulfonic acid
2-BROMO-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)-1-ETHANONE
C12H10BrNOS (294.96664300000003)
4-((2,4-Dichlorophenyl)sulfonyl)morpholine
C10H11Cl2NO3S (294.98366760000005)
6-Chloro-4-hydroxy-3-methoxycarbonyl-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide
N1-(4-IODOPHENYL)-2-CHLOROACETAMIDE
C8H7ClINO (294.92609120000003)
3-Quinolinecarboxylic acid, 7-bromo-3,4-dihydro-4-oxo-, ethyl ester
(2-bromophenyl)-(6-chloropyridin-3-yl)methanone
C12H7BrClNO (294.93995020000006)
4-(N-Acetylacetamido)benzenesulfonate potassium salt
C10H10KNO5S (294.99167500000004)
ETHYL5-BROMO-1-(PYRIDIN-2-YL)-1H-PYRAZOLE-4-CARBOXYLATE
Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)
n-(2-chloro-4-iodophenyl)acetamide
C8H7ClINO (294.92609120000003)
4-(4,6-DICHLORO-5-(2-CHLOROETHYL)PYRIMIDIN-2-YL)MORPHOLINE
4-ALLYL-5-(4-BROMOPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
C11H10BrN3S (294.97787600000004)
1-(4-bromo-2-fluorophenyl)-2,5-dimethylpyrrole-3-carbaldehyde
2-Chloro-N-(2-iodophenyl)acetamide
C8H7ClINO (294.92609120000003)
7-iodo-1,2,3,4-tetrahydro-isoquinoline hydrochloride
(S)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide
Manganese,bis(dimethylcarbamodithioato-kS,kS)-, (T-4)- (9CI)
ETHYL 6-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol
Methyl 4-chloro-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate
C10H5ClF3NO2S (294.96816160000003)
5-(5,6-dichloro-1H-indol-2-yl)furan-2-carboxylic acid
2-(BROMOMETHYL)-5-(TRIFLUOROMETHYL) BENZOTHIAZOLE
C9H5BrF3NS (294.92781460000003)
ETHYL 7-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
1-(4-BROMOBENZYL)-5-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
8-nitronaphth[1,2-d][1,2,3]oxadiazole-5-sulphonic acid
N-(2-Formylphenyl)-4-chloro-benzenesulfonamide
C13H10ClNO3S (295.00699000000003)
5-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridin-5-ium,chloride
C14H11Cl2NS (294.99892260000007)
5-(3-BROMO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
ETHYL 7-BROMO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
2-(2,4-Dichlorophenyl)-1,2-benzothiazol-3-one
C13H7Cl2NOS (294.96253920000004)
3-[1-(3,5-Dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole
N-[(2-bromophenyl)methyl]-2-thiophenecarboxamide
C12H10BrNOS (294.96664300000003)
chlorothiazide
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators