Exact Mass: 276.1355
Exact Mass Matches: 276.1355
Found 224 metabolites which its exact mass value is equals to given mass value 276.1355
,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Saccharopine
Saccharopine is an intermediate in the degradation of lysine, formed by the condensation of lysine and alpha-ketoglutarate. The saccharopine pathway is the main route for lysine degradation in mammals, and its first two reactions are catalyzed by enzymatic activities known as lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which reside on a single bifunctional polypeptide (LOR/SDH) (EC 1.5.1.8). The reactions involved with saccharopine dehydrogenases have very strict substrate specificity for L-lysine, 2-oxoglutarate, and NADPH. LOR/SDH has been detected in a number of mammalian tissues, mainly in the liver and kidney, contributing not only to the general nitrogen balance in the organism but also to the controlled conversion of lysine into ketone bodies. A tetrameric form has also been observed in human liver and placenta. LOR activity has also been detected in brain mitochondria during embryonic development, and this opens up the question of whether or not lysine degradation has any functional significance during brain development. As a result, there is now a new focus on the nutritional requirements for lysine in gestation and infancy. Finally, LOR and/or SDH deficiencies seem to be involved in a human autosomal genetic disorder known as familial hyperlysinemia, which is characterized by serious defects in the functioning of the nervous system and characterized by a deficiency in lysine-ketoglutarate reductase, saccharopine dehydrogenase, and saccharopine oxidoreductase activities. Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation (PMID: 463877, 10567240, 10772957, 4809305). If present in sufficiently high levels, saccharopine can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Saccharopine is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). Many affected children with organic acidemias experience intellectual disability or delayed development. Amino acid from Saccharomyces cerevisiae and Neurospora crassaand is also found in mushrooms and seeds
Acetylpterosin C
Acetylpterosin C is found in green vegetables. Acetylpterosin C is from Pteridium aquilinum (bracken fern
1-[(2,5-Dimethylphenyl)azo]-2-naphthalenol
1-[(2,5-Dimethylphenyl)azo]-2-naphthalenol is a food dye; delisted for foods by FDA. Food dye; delisted for foods by FDA
9-Methoxyellipticine
D000970 - Antineoplastic Agents > D000972 - Antineoplastic Agents, Phytogenic > D004611 - Ellipticines
1-(5,7-dihydroxy-2,2,6-trimethyl-2 h -1-benzopyran-8-yl)-2-methyl-1-propanone
(4S,4aR,6R)-1-acetyl-6-(acetyloxy)-4,4a,5,6-tetrahydro-4,7-dimethylnaphthalen-2(3H)-one|eupatorone
Ac-1beta-1-Hydroxy-13-nor-6,9-eremophiladiene-8,11-dione
3-(3-Methyl-2-butenyl)-4-isobutyryloxybenzoic acid
(2E,2E)-4-Me ether,Me ester-3-[4-Hydroxy-3-(4-hydroxy-3-methyl-2-buteny)phenyl]-2-propenoic acid|methyl 3-(4-hydroxyprenyl)-coumarate 4-O-methyl ether
8,12-epoxy-1alpha-methoxy-4alphaH,5alphaH-eudesma-7,11-dien-6,9-dione
6,8-Dimethoxy-3-isobutyl-2-methyl-4H-1-benzopyran-4-one
2,3-Dihydro-5,7-dihydroxy-2,6-dimethyl-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
(S)-Aspertetronin A|2-[(1E,3E)-hexa-1,3-dien-1-yl]-5-methoxy-2-methyl-4-[(2E)-1-oxobut-2-en-1-yl]furan-3-(2H)-one|aspertetronin A
9-Methoxyellipticine
D000970 - Antineoplastic Agents > D000972 - Antineoplastic Agents, Phytogenic > D004611 - Ellipticines
2-Methyl-2-isobutyryl-6,7-dimethoxy-2H-1-benzopyran
methyl (4R,5S,6R,7R,11S)-2,9-dioxo-1(10)-aromadendren-12-oate
2,3-Dihydro-5,7-dihydroxy-2,8-dimethyl-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
Chlorajapolide F
3beta-acetoxy-6,9-dien-8-oxoeremophil-12-nor-11-one
2,2-dimethyl-6-hydroxy-8-(3-hydroxy-3-methyl-1E-butenyl)-chromanone
4-hydroxy-2-(3-hydroxy-2-methoxy-3-methyl-butylidene)-3,4-dihydro-2h-naphthalen-1-one
norpinguisone acetate
A natural product found in Porella chilensis and Porella recurva.
(3aR,4S,5aR,10aR,10bR)-3,3a,4,5,5a,9,10,10b-octahydro-3a,4,10b-trimethyl-2H,7H-naphtho[4a,4-b:1,8-b?c?]difuran-2,7-dione|ciliatolide A
3-crotonoyl-5-<(1E,3E)-hexa-1,3-dienyl>-4-methoxy-5-methylfuran-2(5H)-one|iso-aspertetronin A
2-methyl-6-hydroxycyclohexenyl-3-methyl-1-acetophenone ether
3-oxo-8alpha-methoxy-10aH-eremophila-1,7(11)-dien-12,8beta-olide|3-oxo-8alpha-methoxy-10alphaH-eremophila-1,7(11)-dien-12,8beta-olide|8beta-hydroxy-8alpha-methoxy-3-oxo-eremophil-1,7(11)-dien-12-oic acid lactone
13,14,15,16-tetranorlabd-7-en-(19,6beta),(12,17)-diolide|13,14,15,16-tetranorlabd-7-en-16,6beta:12,17-diolide|13,14,15,16-tetranorlabd-7-ene-19,6b:12,17-diolide
2-isopropyl-9S-methoxy-7R-methyl-6,7-dihydro-2H-furo[3,2-h]isochromen-3(9H)-one|ustusorane D
2,3-Dihydro-6,7-dimethoxy-2-methyl-2-(2-methyl-1-propenyl)-4H-1-benzopyran-4-one
1,6-dichloro-1,6-dimethyl-4-(propan-2-yl)decahydronaphthalene
2-hexyl-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one|5-hydroxy-2-hexyl-7-methoxy-4-chromone
2,2-Dimethyl-5-methoxy-2H-1-benzopyran-6-propionic acid methyl ester
methyl-3-<3,3-dimethyl-3-hydroxyallyl>-p-coumarate-O-methyl ether
3-(2-TriMethylsilanyl-ethoxyMethyl)-6-vinyl-3H-[1,2,3]triazolo[4,5-b]pyridine
Urea, N-(3-fluorophenyl)-N-[3-(2-furanyl)-1-methylpropyl]- (9CI)
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-1H-pyrazole
4-(1-ADAMANTYL)-6-(METHYLTHIO)-1,3,5-TRAZIN-2-AMINE
3-(2,5-dimethylphenyl)-1-phenylpyrazole-4-carbaldehyde
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-
2-([1,1-BIPHENYL]-4-CARBONYL)-3-(DIMETHYLAMINO)ACRYLONITRILE
Ethambutol hydrochloride
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Target: Antibacterial Ethambutol dihydrochloride (Emb dihydrochloride) directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50\% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60\% changes in the embB gene in M. tuberculosis resistant mutants [1]. Ethambutol dihydrochloride (Emb dihydrochloride) is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol dihydrochloride (Emb dihydrochloride) is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro [2]. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) [3].