Exact Mass: 255.10077180000002

CONFIDENCE standard compound; EAWAG_UCHEM_ID 707 CONFIDENCE standard compound; INTERNAL_ID 8395 CONFIDENCE standard compound; INTERNAL_ID 3390

2-Amino-6-[(1R,2S)-1,2,3-trihydroxypropyl]-7,8-dihydro-3H-pteridin-4-one

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

Ganciclovir

2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one

Ganciclovir is only found in individuals that have used or taken this drug. It is an acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. [PubChem]Ganciclovirs antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK). TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes. In vitro, ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, ganciclovir triphosphate competitively inhibits dATP leading to the formation of faulty DNA. This is where ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed. J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals D000890 - Anti-Infective Agents > D000998 - Antiviral Agents C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor C254 - Anti-Infective Agent > C281 - Antiviral Agent KEIO_ID G088; [MS2] KO008989 KEIO_ID G088 Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].

N-D-Glucosylarylamine

2-anilino-6-(hydroxymethyl)oxane-3,4,5-triol

Nicotinamide riboside

3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium

C11H15N2O5+ (255.098092)

Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside was originally identified as a nutrient in milk. It is a useful compound for the elevation of NAD+ levels in humans. Nicotinamide riboside has recently been discovered to be an NAD(+) precursor that is converted into nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2. It has been shown that exogenous nicotinamide riboside promotes Sir2-dependent repression of recombination, improves gene silencing, and extends the lifespan of certain animal models without calorie restriction (PMID: 17482543). Supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities (PMID: 22682224). Recent data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis (PMID: 18429699). Nicotinamide riboside kinase has an essential role in the phosphorylation of nicotinamide riboside and the cancer drug tiazofurin (PMID: 15137942). Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside has been identified as a nutrient in milk. It is a useful compound for elevation of NAD+ levels in humans. Recent data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis (PMID: 18429699). Nicotinamide riboside kinase has an essential role for phosphorylation of nicotinamide riboside and the cancer drug tiazofurin (PMID 15137942). [HMDB] COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map C26170 - Protective Agent > C275 - Antioxidant Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

7,8-dihydromonapterin

7,8-Dihydroneopterin

2-Amino-4-hydroxy-6-(D-erythro-1’,2’,3’-trihydroxypropyl)-7,8-dihydropteridine

7,8-Dihydroneopterin, also known as dihydroneopterin, belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are synthesized in several parts of the body, including the pineal gland. 7,8-Dihydroneopterin is a strong basic compound (based on its pKa). Within humans, 7,8-dihydroneopterin participates in a number of enzymatic reactions. In particular, 7,8-dihydroneopterin can be biosynthesized from sepiapterin; which is catalyzed by the enzyme sepiapterin reductase or carbonyl reductase [NADPH] 1. In humans, 7,8-dihydroneopterin is involved in the metabolic disorder called hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase (PTPS) deficiency. 7,8-Dihydroneopterin is produced by human monocyte-derived macrophages upon stimulation with interferon-gamma. Increased amounts of 7,8-dihydroneopterin in human body fluids are found in many disorders, including viral infections and autoimmune diseases (PMID: 12804528). 7,8-dihydroneopterin, also known as npr, belongs to biopterins and derivatives class of compounds. Those are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. 7,8-dihydroneopterin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 7,8-dihydroneopterin can be found in a number of food items such as prickly pear, star anise, cocoa bean, and black salsify, which makes 7,8-dihydroneopterin a potential biomarker for the consumption of these food products. 7,8-dihydroneopterin exists in all living organisms, ranging from bacteria to humans. In humans, 7,8-dihydroneopterin is involved in the pterine biosynthesis. 7,8-dihydroneopterin is also involved in several metabolic disorders, some of which include hyperphenylalaninemia due to dhpr-deficiency, sepiapterin reductase deficiency, dopa-responsive dystonia, and hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency. 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

Hydroxybupropion

1-(3-chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one

Hydroxybupropion is found in the bupropion degradation pathway. Bupropion reacts with NADPH and O2 to produce hydroxybupropion, with NADP+ and H2O as byproducts. [HMDB] Hydroxybupropion is found in the bupropion degradation pathway. Bupropion reacts with NADPH and O2 to produce hydroxybupropion, with NADP+ and H2O as byproducts.

(2R)-2-(Tert-butylamino)-1-(3-chlorophenyl)-3-hydroxypropan-1-one

6-(4-Methoxyphenyl)-2-methyl-7H-imidazo[1,2-a]pyrazin-3-one

2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents

1-(3-Chloro-4-hydroxyphenyl)-2-((1,1-dimethylethyl)amino)-1-propanone

Alaproclate

L-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AB - Selective serotonin reuptake inhibitors D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent D049990 - Membrane Transport Modulators

Isoquinoline, 1-(1-naphthalenyl)-

2-Amino-7-[(2R)-2,3-dihydroxypropanoyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one

Radafaxine

2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol

7,8-dihydromonapterin

(1S,2S)-1-(4-hydroxy-2-imino-1,2,7,8-tetrahydropteridin-6-yl)propane-1,2,3-triol

7,8-dihydromonapterin, also known as dhm or h2-mpt, belongs to biopterins and derivatives class of compounds. Those are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. 7,8-dihydromonapterin is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). 7,8-dihydromonapterin can be found in a number of food items such as mugwort, pineapple, eggplant, and japanese pumpkin, which makes 7,8-dihydromonapterin a potential biomarker for the consumption of these food products.

Radicamine A

Rubrobramide

Hydroxy Bupropion

2-Hydroxy-2-(3-chlorophenyl)-3,5,5-trimethylmorpholine

Phospholine

2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium

C9H22NO3PS (255.1057952)

Alaproclate

ALAPROCLATE HCL

hydroxybupropion

2-Hydroxy-2-(3-chlorophenyl)-3,5,5-trimethylmorpholine

4-ACETYL-N,N-DIETHYL-BENZENESULFONAMIDE

Cloforex

ethyl N-[1-(4-chlorophenyl)-2-methylpropan-2-yl]carbamate

C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

N-[[2-chloro-5-(2-methoxyethoxy)phenyl]methyl]cyclopropanamine

4-AMINOPHENYL-β-L-FUCOPYRANOSIDE

ethyl 4-methyl-2-piperazin-1-yl-1,3-thiazole-5-carboxylate

2-[(5-cyclohexyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetic acid

Benzoic acid, 2-(4-piperidinyl)-, methyl ester

Methyl 1-benzylpyrrolidine-3-carboxylate hydrochloride

Hydrazinecarbothioamide,N-[2-(3,4-dimethoxyphenyl)ethyl]-

3-AMINO-3-(2,4,6-TRIMETHOXY-PHENYL)-PROPIONIC ACID

4-hydroxy-3-(morpholin-4-ylmethyl)benzoic acid,hydrate

1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

2,4,6-Trimethyl-2,4,6-trivinylcyclotrisilazane

C9H21N3Si3 (255.1043226)

{3-[(4-Methylphenyl)carbamoyl]phenyl}boronic acid

6,7-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinoline hydrochloride

1-Benzylpiperidine-3-carboxylic acid hydrochloride

ETHYL 3-(3-CHLORO-PHENYL)-2-METHYLAMINOMETHYL-PROPIONATE

N-(tert-Butoxycarbonyl)-3-(2-furyl)-L-alanine

(S)-ALPHA-(2-BROMOBENZYL)-PROLINE-HCL

4-[(4-Methylpiperazine-1-)sulfonyl]aniline

2-(4-methylpiperazin-1-yl)sulfonylaniline

3-(1-piperidinylmethyl)benzoic acid

[3-(Benzylcarbamoyl)phenyl]boronic acid

4-Methoxy-1-(triisopropylsilyl)-1H-pyrrolo[2,3-c]pyridine

C10H16F3NO3 (255.1082222)

[4-(Benzylcarbamoyl)phenyl]boronic acid

4-(5-AMINO-1H-BENZOIMIDAZOL-2-YL)-2-METHOXY-PHENOL

4-(4-(Methylsulfonyl)piperazin-1-yl)aniline

2-(Benzenesulfonyl)-N,N-diethylacetamide

1-[(4-methoxyphenyl)methyl]-2H-pyrazolo[3,4-b]pyridin-4-one

5-CYANO-1-P-TOLYL-1H-PYRAZOLE-4-CARBOXYLICACIDETHYLESTER

9-Phenylacridine

C11H15BFNO4 (255.10781120000001)

4-N-Boc-amino-3-fluorophenylboronic acid

METHYL 4-(PIPERIDIN-4-YL)BENZOATE HYDROCHLORIDE

3-AMINO-3-(2,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID

tert-butyl N-[[4-(chloromethyl)phenyl]methyl]carbamate

3-AMINO-4-CYANO-1-PHENYL-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER

4-[3-(4-Chlorophenoxy)propyl]morpholine

(R)-4-CYANO-THIAZOLIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER

2-Amino-6,7-dihydro-5H-thiazolo[5,4-b]pyridine-4-carboxylic acid tert-butyl ester

C12H12F3N3 (255.09832679999997)

4-[3-(trifluoromethyl)phenyl]piperazine-1-carbonitrile

4-(4-Methoxybenzoyl)piperidine hydrochloride

Phenanthridine,6-phenyl-

ethyl 2-[(4-chlorophenyl)methyl]-3-(methylamino)propanoate

1-Propanone,3-(4-morpholinyl)-1-phenyl-, hydrochloride (1:1)

2-[2-Hydroxy-5-(2-hydroxyethyl)phenyl]-2H-benzotriazole

(S)-2-(2-METHYLBENZYL)PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

1-methyl-4-phenylpiperidine-4-carboxylic acid,hydrochloride

1,1-DIOXO-4-PHENETHYLAMINO-TETRAHYDRO-1LAMBDA6-THIOPHEN-3-OL

3-Deoxy-D-manno-2-octulosonic acid ammonium salt

C8H17NO8 (255.0954122)

1-Benzoyl-4-phenylsemicarbazide

5-CYANO-1-P-TOLYL-1H-PYRAZOLE-3-CARBOXYLICACIDETHYLESTER

tert-butyl 3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carboxylate

C10H16F3NO3 (255.1082222)

diethyl-n-benzylideneaminomethylphosphonate

C12H18NO3P (255.1024248)

3-(3-METHOXYCARBONYLPHENYL) PIPERIDINE HCL

2-Ethyl-6-methylpyridin-3-ol succinate

3-(4-Methyl-piperazine-1-sulfonyl)-phenylamine

(S)-1-[4-(Trifluoromethyl)phenyl]ethylamine

3-AMINO-3-(3,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID

2-(Benzylcarbamoyl)benzeneboronic acid

N-(4-Chloro-2-ethoxyphenyl)-2,2-dimethylpropanamide

C16H14FNO (255.10593659999998)

5-(Benzyloxy)-4-fluoro-2-methyl-1H-indole

(S)-2-(3-METHYLBENZYL)PYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE

p-Aminobenzoyl Benzamide

C12H12F3N3 (255.09832679999997)

[2-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenyl]methanamine

tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

3-PIPERIDIN-4-YL-BENZOIC ACID METHYL ESTER HCL

alpha-Phenyl-2-piperidineacetic acid hydrochloride

Radafaxine

C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist

a 7,8-Dihydroneopterin

2-Chloro-N-(2,6-diethylphenyl)-N-(hydroxymethyl)acetamide

Isoquinoline, 1-(1-naphthalenyl)-

4-(3-Aminoimidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol

N-[[(6-methyl-2-pyridinyl)amino]-oxomethyl]benzamide

4-aminophenyl alpha-L-fucoside

4-Amino-2-(butylthio)-5-pyrimidinecarboxylic acid ethyl ester

dihydro-(6H)-monapterin

6,7-Dihydroneopterin

2-Amino-7-[(2R)-2,3-dihydroxypropanoyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one

2-[(2E)-2-(1-Pyridin-4-ylethylidene)hydrazinyl]benzoic acid

N-tert-butyl-2-(4-chloro-3-methylphenoxy)acetamide

5-(methoxymethyl)-2-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one

N-(D-Glucopyranosyl)aniline

3-[1-(dimethylamino)-1H-pyrrol-2-yl]-2-(2-furylcarbonyl)acrylonitrile

ganciclovir

An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections. J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals D000890 - Anti-Infective Agents > D000998 - Antiviral Agents C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor C254 - Anti-Infective Agent > C281 - Antiviral Agent Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].

Nicotinamide riboside

C11H15N2O5+ (255.098092)

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map C26170 - Protective Agent > C275 - Antioxidant Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

7,8-Dihydroneopterin

A neopterin where positions C-7 and C-8 have been hydrogenated. 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

N-Ribosylnicotinamide

C11H15N2O5 (255.098092)

A pyridine nucleoside consisting of nicotinamide with a beta-D-ribofuranosyl moiety at the 1-position.

Dihydro-neopterin

(S)-UFR2709 (hydrochloride)