6-(4-Methoxyphenyl)-2-methyl-7H-imidazo[1,2-a]pyrazin-3-one (BioDeep_00000172668)

   

human metabolite blood metabolite


代谢物信息卡片


2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one

化学式: C14H13N3O2 (255.1008)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 96.05%

分子结构信息

SMILES: CC1=C(N2C=C(N=CC2=N1)C3=CC=C(C=C3)OC)O
InChI: InChI=1S/C14H13N3O2/c1-9-14(18)17-8-12(15-7-13(17)16-9)10-3-5-11(19-2)6-4-10/h3-8,18H,1-2H3

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents

同义名列表

5 个代谢物同义名

2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo(1,2-alpha)pyrazin-3-one; 6-(4-Methoxyphenyl)-2-methyl-7H-imidazo[1,2-a]pyrazin-3-one; 6-(4-methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3-ol; 6-(4-Methoxyphenyl)imidazo(1,2-a)pyrazin-3(7H)-one; MCLA



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Debin Zhu, Da Xing, Yadong Wei, Xian Li, Bo Gao. Evaluation of the degree of medical radiation damage with a highly sensitive chemiluminescence method. Luminescence : the journal of biological and chemical luminescence. 2004 Sep; 19(5):278-82. doi: 10.1002/bio.782. [PMID: 15386798]
  • Tadashi Hasegawa, Kazushi Sakurai, Yasuhiro Kambayashi, Abby R Saniabadi, Hisashi Nagamoto, Katsuhiko Tsukada, Atsushi Takahashi, Hiroyuki Kuwano, Minoru Nakano. Effects of OPC-6535 on lipopolysaccharide-induced acute liver injury in the rat: involvement of superoxide and tumor necrosis factor-alpha from hepatic macrophages. Surgery. 2003 Nov; 134(5):818-26. doi: 10.1016/s0039-6060(03)00297-6. [PMID: 14639361]
  • F Saez, C Motta, D Boucher, G Grizard. Prostasomes inhibit the NADPH oxidase activity of human neutrophils. Molecular human reproduction. 2000 Oct; 6(10):883-91. doi: 10.1093/molehr/6.10.883. [PMID: 11006316]
  • K Nara, D Konno, J Uchida, Y Kiuchi, K Oguchi. Protective effect of nitric oxide against iron-induced neuronal damage. Journal of neural transmission (Vienna, Austria : 1996). 1999; 106(9-10):835-48. doi: 10.1007/s007020050204. [PMID: 10599866]
  • Y Yamamoto, Y Kambayashi, T Ito, K Watanabe, M Nakano. 1,2-Diacylglycerol hydroperoxide induces the generation and release of superoxide anion from human polymorphonuclear leukocytes. Advances in experimental medicine and biology. 1999; 469(?):431-6. doi: 10.1007/978-1-4615-4793-8_63. [PMID: 10667364]
  • Y Tampo, M Tsukamoto, M Yonaha. The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alpha]pyra z in-3-one (MCLA), a chemiluminescence probe to detect superoxide anions. FEBS letters. 1998 Jul; 430(3):348-52. doi: 10.1016/s0014-5793(98)00689-9. [PMID: 9688569]
  • Y Yamamoto, Y Kambayashi, T Ito, K Watanabe, M Nakano. 1,2-Diacylglycerol hydroperoxides induce the generation and release of superoxide anion from human polymorphonuclear leukocytes. FEBS letters. 1997 Aug; 412(3):461-4. doi: 10.1016/s0014-5793(97)00823-5. [PMID: 9276447]
  • K Wada, Y Kamisaki, K Nakamoto, T Itoh. Effect of cystathionine as a scavenger of superoxide generated from human leukocytes or derived from xanthine oxidase in vitro. European journal of pharmacology. 1996 Feb; 296(3):335-40. doi: 10.1016/0014-2999(95)00717-2. [PMID: 8904086]
  • E de Lamirande, C Gagnon. Capacitation-associated production of superoxide anion by human spermatozoa. Free radical biology & medicine. 1995 Mar; 18(3):487-95. doi: 10.1016/0891-5849(94)00169-k. [PMID: 9101239]
  • A R Saniabadi, M Nakano. Improved preparation of leukocytes for chemiluminescent study of human phagocytic leukocyte-generated reactive oxygen species. Journal of bioluminescence and chemiluminescence. 1993 Jul; 8(4):207-13. doi: 10.1002/bio.1170080404. [PMID: 8396845]
  • M Nakano. A possible mechanism of iron neurotoxicity. European neurology. 1993; 33 Suppl 1(?):44-51. doi: 10.1159/000118537. [PMID: 8375432]
  • S Koga, M Nakano. A high involvement of O2- possibly generated in inner membranes for iron-induced microsomal lipid peroxidation. Biochemical and biophysical research communications. 1992 Jul; 186(2):1087-93. doi: 10.1016/0006-291x(92)90858-i. [PMID: 1323282]
  • S Koga, M Nakano, K Uehara. Mechanism for the generation of superoxide anion and singlet oxygen during heme compound-catalyzed linoleic acid hydroperoxide decomposition. Archives of biochemistry and biophysics. 1991 Sep; 289(2):223-9. doi: 10.1016/0003-9861(91)90465-u. [PMID: 1654851]