Exact Mass: 243.8857334

Exact Mass Matches: 243.8857334

Found 20 metabolites which its exact mass value is equals to given mass value 243.8857334, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

Clodronate

(Dichloro-phosphono-methyl)-phosphonic acid

CH4Cl2O6P2 (243.88602040000004)

Clodronate is only found in individuals that have used or taken this drug. It is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. [PubChem]The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. The exact mechanism of action of clodronate is not known, however it is known that it does not inhibit protein isoprenylation but can be metabolized intracellularly to a β-γ-methylene (AppCp-type) analog of ATP (AppCCl2p), which is cytotoxic to macrophages in vitro. Inhibition of the ADP/ATP translocase by the metabolite AppCCl2p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption. Recently, the slime mold Dictyostelium discoideum was shown to take up bisphosphonates by pinocytosis. In these cells, clodronate, but not other pharmacologically active bisphosphonates, was incorporated into adenine nucleotides, which could potentially explain why this bisphosphonate sometimes seems to act differently than the other bisphosphonates. Clodronate, like all biphosphonates, also binds protein-tyrosine-phosphatase. M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates

Clodronate

[dichloro(phosphono)methyl]phosphonic acid

CH4Cl2O6P2 (243.88602040000004)

M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates

Exact Mass: 243.8857334

Exact Mass Matches: 243.8857334

Clodronate

Clodronate

trimethyltin bromide

2,4-Dichlorobenzenesulfonyl chloride

3,5-Dichlorobenzenesulfonyl chloride

sodium molybdate dihydrate

2,6-DICHLOROBENZENESULFONYL CHLORIDE

divinyltin dichloride

1-chloro-2-iodo-1,1,2-trifluoroethane

2,5-DICHLOROBENZENESULFONYL CHLORIDE

2,4,6-trichloropyrimidine-5-carbonyl chloride

1-Bromo-2-chloro-3,4,5-trifluorobenzene

2,3-Dichlorobenzenesulfonyl chloride

3,4-Dichlorobenzenesulfonyl chloride

p-chlorophenyltrichlorosilane

sodium silicate

Hafnium sulfide

1-BroMo-3-chloro-2,4,5-trifluorobenzene[3-chloro-2,4,5-trifluorobroMobenzene]

Clodronic Acid

Metasilicate