Clodronate (BioDeep_00000033258)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(Dichloro-phosphono-methyl)-phosphonic acid
化学式: CH4Cl2O6P2 (243.88602040000004)
中文名称: 氯屈瞵酸
谱图信息:
最多检出来源 Homo sapiens(blood) 8.33%
分子结构信息
SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
InChI: InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
描述信息
Clodronate is only found in individuals that have used or taken this drug. It is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. [PubChem]The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. The exact mechanism of action of clodronate is not known, however it is known that it does not inhibit protein isoprenylation but can be metabolized intracellularly to a β-γ-methylene (AppCp-type) analog of ATP (AppCCl2p), which is cytotoxic to macrophages in vitro. Inhibition of the ADP/ATP translocase by the metabolite AppCCl2p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption. Recently, the slime mold Dictyostelium discoideum was shown to take up bisphosphonates by pinocytosis. In these cells, clodronate, but not other pharmacologically active bisphosphonates, was incorporated into adenine nucleotides, which could potentially explain why this bisphosphonate sometimes seems to act differently than the other bisphosphonates. Clodronate, like all biphosphonates, also binds protein-tyrosine-phosphatase.
M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
36 个代谢物同义名
(Dichloro-phosphono-methyl)-phosphonic acid; [dichloro(phosphono)methyl]phosphonic acid; Dichloromethylene-1,1-bisphosphonic acid; (Dichloro-phosphono-methyl)-phosphonate; Dichloromethylene-1,1-diphosphonic acid; (Dichloromethylene)bisphosphonic acid; Dichloromethylidene diphosphonic acid; Dichloromethylene-1,1-bisphosphonate; (Dichloromethylene)diphosphonic acid; Dichloromethylene-1,1-diphosphonate; Acid, dichloromethanediphosphonic; (Dichloromethylene)bisphosphonate; Dichloromethylidene diphosphonate; (Dichloromethylene)diphosphonate; Diphosphonate, dichloromethylene; Dichloromethanediphosphonic acid; Biphosphonate, dichloromethylene; Dichloromethylenebisphosphonate; Dichloromethylene biphosphonate; Dichloromethylene diphosphonate; Diphosphonate, dichloromethane; Dichloromethane diphosphonate; Dichloromethanediphosphonate; Disodium, clodronate; Clodronate Disodium; Acidum clodronicum; Sodium, clodronate; Acide clodronique; Clodronate sodium; Acido clodronico; Acid, clodronic; Clodronic Acid; Clodronsaeure; Clodronate; Bonefos; CL2MDP
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:110423
- PubChem: 25419
- HMDB: HMDB0014858
- DrugBank: DB00720
- ChEMBL: CHEMBL12318
- Wikipedia: Clodronic acid
- MeSH: Clodronic Acid
- chemspider: 23731
- CAS: 10596-23-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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Nephron. Experimental nephrology.
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Electromagnetic biology and medicine.
2013 Sep; 32(3):342-54. doi:
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Cancer research.
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PloS one.
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Kidney international.
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International journal of cancer.
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Kidney international.
2012 Oct; 82(8):928-33. doi:
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Anesthesiology.
2012 Oct; 117(4):822-35. doi:
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Kidney international.
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Cellular immunology.
2012 Jul; 278(1-2):103-12. doi:
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The EMBO journal.
2012 May; 31(10):2378-90. doi:
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Gut and liver.
2012 Apr; 6(2):149-71. doi:
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Annals of laboratory medicine.
2012 Mar; 32(2):105-12. doi:
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Bone.
2012 Mar; 50(3):798-803. doi:
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International journal of nanomedicine.
2012; 7(?):123-31. doi:
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American journal of nephrology.
2012; 35(2):181-90. doi:
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PloS one.
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The Journal of pharmacology and experimental therapeutics.
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Hepatobiliary & pancreatic diseases international : HBPD INT.
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Journal of Korean medical science.
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BMC cancer.
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Diabetes.
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The American journal of pathology.
2011 Jul; 179(1):240-7. doi:
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PLoS pathogens.
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International journal of clinical pharmacology and therapeutics.
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The international journal of biochemistry & cell biology.
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Journal of drug delivery.
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PloS one.
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PloS one.
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Frontiers in immunology.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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Kidney international.
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Hepatology (Baltimore, Md.).
2010 Oct; 52(4):1420-30. doi:
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European journal of gastroenterology & hepatology.
2010 Sep; 22(9):1039-49. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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Journal of neurochemistry.
2010 Sep; 114(6):1687-700. doi:
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Journal of leukocyte biology.
2010 Sep; 88(3):597-603. doi:
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Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
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