Clodronate (BioDeep_00000614975)
代谢物信息卡片
[dichloro(phosphono)methyl]phosphonic acid
化学式: CH4Cl2O6P2 (243.88602040000004)
中文名称: 氯屈瞵酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
InChI: InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
描述信息
M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:110423
- PubChem: 25419
- Metlin: METLIN85418
- DrugBank: DB00720
- ChEMBL: CHEMBL12318
- MeSH: Clodronic Acid
- CAS: 10596-23-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dhaval Oza, Fernando Ivich, Joshua Pace, Mikyung Yu, Mark Niedre, Mansoor Amiji. Lipid nanoparticle encapsulated large peritoneal macrophages migrate to the lungs via the systemic circulation in a model of clodronate-mediated lung-resident macrophage depletion.
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Veterinary pathology.
2022 07; 59(4):627-638. doi:
10.1177/03009858221095270. [PMID: 35499307] - Daiki Goto, Soichiro Nagata, Yoshitaka Naito, Shinsuke Isobe, Takamasa Iwakura, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Ken Sugimoto, Hideo Yasuda. Nicotinic acetylcholine receptor agonist reduces acute lung injury after renal ischemia-reperfusion injury by acting on splenic macrophages in mice.
American journal of physiology. Renal physiology.
2022 05; 322(5):F540-F552. doi:
10.1152/ajprenal.00334.2021. [PMID: 35311383] - Alexander Jacob, Michael Phelps, Shane Fraher, Marcos Lopez, Anthony Chang, Richard J Quigg, Jessy J Alexander. Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis.
Journal of immunology research.
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10.1155/2022/1737419. [PMID: 35097132] - Patrice Garcia, Isabelle Perot, Benoit Loup, Frederic Balssa, Murielle Jaubert, Vivian Delcourt, Chris Dujardin, Marie-Agnes Popot, Ludovic Bailly-Chouriberry. Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2021 Aug; 13(8):1527-1534. doi:
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Clinical rheumatology.
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International journal of cancer.
2012 Nov; 131(10):2402-10. doi:
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Kidney international.
2012 Oct; 82(8):928-33. doi:
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Anesthesiology.
2012 Oct; 117(4):822-35. doi:
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Kidney international.
2012 Oct; 82(8):835-7. doi:
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Cellular immunology.
2012 Jul; 278(1-2):103-12. doi:
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The EMBO journal.
2012 May; 31(10):2378-90. doi:
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Gut and liver.
2012 Apr; 6(2):149-71. doi:
10.5009/gnl.2012.6.2.149. [PMID: 22570745] - Jehoon Lee, Samuel Vasikaran. Current recommendations for laboratory testing and use of bone turnover markers in management of osteoporosis.
Annals of laboratory medicine.
2012 Mar; 32(2):105-12. doi:
10.3343/alm.2012.32.2.105. [PMID: 22389876] - Eetu Heervä, Sirkku Peltonen, Erkki Svedström, Hannu T Aro, Kalervo Väänänen, Juha Peltonen. Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro.
Bone.
2012 Mar; 50(3):798-803. doi:
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International journal of nanomedicine.
2012; 7(?):123-31. doi:
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American journal of nephrology.
2012; 35(2):181-90. doi:
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PloS one.
2012; 7(10):e47417. doi:
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Bioinformation.
2012; 8(1):48-57. doi:
10.6026/97320630008048. [PMID: 22359435] - Ji-Ho Lim, Sung-Kyun You, Jong-Suep Baek, Chan-Ju Hwang, Young-Guk Na, Sang-Chul Shin, Cheong-Weon Cho. Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine.
International journal of nanomedicine.
2012; 7(?):2307-14. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):93-8. doi:
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Hepatobiliary & pancreatic diseases international : HBPD INT.
2011 Oct; 10(5):544-51. doi:
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Journal of the American Society of Nephrology : JASN.
2011 Oct; 22(10):1809-14. doi:
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Journal of Korean medical science.
2011 Oct; 26(10):1310-5. doi:
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BMC cancer.
2011 Sep; 11(?):403. doi:
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Diabetes.
2011 Aug; 60(8):2134-43. doi:
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The American journal of pathology.
2011 Jul; 179(1):240-7. doi:
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PLoS pathogens.
2011 Jun; 7(6):e1002078. doi:
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Talanta.
2011 Apr; 84(2):437-42. doi:
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International journal of clinical pharmacology and therapeutics.
2011 Feb; 49(2):128-36. doi:
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The international journal of biochemistry & cell biology.
2011 Jan; 43(1):154-62. doi:
10.1016/j.biocel.2010.10.013. [PMID: 21044893] - Ciara Kelly, Caroline Jefferies, Sally-Ann Cryan. Targeted liposomal drug delivery to monocytes and macrophages.
Journal of drug delivery.
2011; 2011(?):727241. doi:
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PloS one.
2011; 6(12):e28917. doi:
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PloS one.
2011; 6(11):e26644. doi:
10.1371/journal.pone.0026644. [PMID: 22073179] - Joan Clària, Ana González-Périz, Cristina López-Vicario, Bibiana Rius, Esther Titos. New insights into the role of macrophages in adipose tissue inflammation and Fatty liver disease: modulation by endogenous omega-3 Fatty Acid-derived lipid mediators.
Frontiers in immunology.
2011; 2(?):49. doi:
10.3389/fimmu.2011.00049. [PMID: 22566839] - Laëtitia Michou, Jacques P Brown. Emerging strategies and therapies for treatment of Paget's disease of bone.
Drug design, development and therapy.
2011; 5(?):225-39. doi:
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Journal of drug delivery.
2011; 2011(?):863734. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Dec; 25(12):3874-84. doi:
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Toxins.
2010 11; 2(11):2490-518. doi:
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Kidney international.
2010 Nov; 78(10):981-92. doi:
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Hepatology (Baltimore, Md.).
2010 Oct; 52(4):1420-30. doi:
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European journal of gastroenterology & hepatology.
2010 Sep; 22(9):1039-49. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Sep; 25(9):2908-21. doi:
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Journal of neurochemistry.
2010 Sep; 114(6):1687-700. doi:
10.1111/j.1471-4159.2010.06879.x. [PMID: 20584104] - Andrew J Mitchell, Lydie C Pradel, Lionel Chasson, Nico Van Rooijen, Georges E Grau, Nicholas H Hunt, Giovanna Chimini. Technical advance: autofluorescence as a tool for myeloid cell analysis.
Journal of leukocyte biology.
2010 Sep; 88(3):597-603. doi:
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Journal of immunology (Baltimore, Md. : 1950).
2010 Aug; 185(3):1976-83. doi:
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Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2010 Aug; 28(8):1084-91. doi:
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