Exact Mass: 222.1038

Buthionine sulfoximine

C8H18N2O3S (222.1038)

Buthionine Sulfoximine is a synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04) D020011 - Protective Agents > D011837 - Radiation-Protective Agents D009676 - Noxae > D000963 - Antimetabolites D011838 - Radiation-Sensitizing Agents D000970 - Antineoplastic Agents D004791 - Enzyme Inhibitors Buthionine sulfoximine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=5072-26-4 (retrieved 2024-09-04) (CAS RN: 5072-26-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

(2R)-2-Amino-4-(amino-butyl-oxo-lambda6-sulfanylidene)butanoic acid

C8H18N2O3S (222.1038)

DL-Buthionine sulfoximine

C8H18N2O3S (222.1038)

Benzeneacetaldehyde, .alpha.-(2-phenylethylidene)-

C16H14O (222.1045)

4,4-diphenylbut-3-en-2-one

C16H14O (222.1045)

9-(2-Hydroxyethyl)anthracene

C16H14O (222.1045)

1-CYCLOPROPYLNAPHTHALENE

C16H14O (222.1045)

1-(TRIFLUOROMETHYL)VINYL BORONIC ACID HEXYLENE GLYCOL ESTER

C9H14BF3O2 (222.1039)

1,3-diphenyl-2-buten-1-one

C16H14O (222.1045)

1,4-DIPHENYL-BUT-3-YN-2-OL

C16H14O (222.1045)

l-Buthionine sulfoximine

C8H18N2O3S (222.1038)

C471 - Enzyme Inhibitor > C2130 - Gamma-Glutamylcysteine Synthetase Inhibitor

1H-Inden-1-one,2,3-dihydro-2-(phenylmethyl)-

C16H14O (222.1045)

2,4-DIPHENYL-3-BUTYN-2-OL

C16H14O (222.1045)

1-Naphthol,phosphate

C16H14O (222.1045)

1-(9-Anthracenyl)ethanol

C16H14O (222.1045)

2-METHYL-2-PHENYL-INDAN-1-ONE

C16H14O (222.1045)

1-[3-(Trimethoxysilyl)propyl]urea

C7H18N2O4Si (222.1036)

Melitracen hydrochloride

C16H14O (222.1045)

Methylethylfluoren-9-one(mixture of isomers)

C16H14O (222.1045)

1-(ANTHRACEN-2-YL)ETHANOL

C16H14O (222.1045)

2-Methyl-4-phenyl-2,3-dihydro-1H-inden-1-one

C16H14O (222.1045)

D-Buthionine-(S,R)-sulfoximine

C8H18N2O3S (222.1038)

1-(9,10-Dihydrophenanthren-2-yl)ethanone

C16H14O (222.1045)

2-amino-4-(S-Butylsulfonimidoyl)butanoate

C8H18N2O3S (222.1038)

BUTHIONINE SULFOXIMINE

C8H18N2O3S (222.1038)

D020011 - Protective Agents > D011837 - Radiation-Protective Agents D009676 - Noxae > D000963 - Antimetabolites D011838 - Radiation-Sensitizing Agents D000970 - Antineoplastic Agents D004791 - Enzyme Inhibitors

(2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid

C8H18N2O3S (222.1038)

S-butyl-DL-homocysteine (S,R)-sulfoximine

C8H18N2O3S (222.1038)

A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

(e)-2,4-diphenylcrotonaldehyde

C16H14O (222.1045)

2,4-diphenylbut-2-enal

C16H14O (222.1045)