Exact Mass: 203.113
Exact Mass Matches: 203.113
Found 221 metabolites which its exact mass value is equals to given mass value 203.113,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
N-(3-Methylbut-2-EN-1-YL)-9H-purin-6-amine
N6-prenyladenine, also known as isopentenyladenine or ip, is a member of the class of compounds known as 6-alkylaminopurines. 6-alkylaminopurines are compounds that contain an alkylamine group attached at the 6-position of a purine. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. N6-prenyladenine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). N6-prenyladenine can be found in a number of food items such as lime, lemon thyme, nectarine, and napa cabbage, which makes n6-prenyladenine a potential biomarker for the consumption of these food products. D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins Acquisition and generation of the data is financially supported in part by CREST/JST. CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 74 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
Tryptophanamide
Tryptophanamide is a substrate for tryptophan aminopeptidase (EC: 3.5.1.57)and is converted to L-Tryptophan via enzymatic hydrolysis. [HMDB] Tryptophanamide is a substrate for tryptophan aminopeptidase (EC: 3.5.1.57)and is converted to L-Tryptophan via enzymatic hydrolysis. KEIO_ID T054; [MS3] KO009291 KEIO_ID T054; [MS2] KO009290 KEIO_ID T054
Acetyl-L-carnitine
L-Acetylcarnitine (Acetylcarnitine or ALC or LAC) is an acetic acid ester of carnitine that facilitates the movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids. Acetylcarnitine is an endogenous compound widely distributed in many tissues, including brain. Chemically, acetylcarnitine is the acetylated derivative of the amino acid L-carnitine whose function is generally correlated with regulation of energy metabolism within mitochondria. The synthesis of acetylcarnitine is catalyzed by the enzyme carnitine acetyltransferase (CAT), which is located on the inner mitochondrial membrane as well as in endoplasmic reticulum and peroxisome. CAT promotes the transfer of an acetyl group from acetyl-Coenzyme A (acetyl-CoA) to carnitine, thereby producing acetylcarnitine and free CoA (PMID: 29267192). After being synthetized, acetylcarnitine is transported outside mitochondria into the cytosol by the enzyme carnitine/acetylcarnitine translocase (CACT). This is a crucial metabolic reaction for beta-oxidation of fatty acids whereby acetylcarnitine facilitates the transport of acetyl-CoA across mitochondrial membranes (PMID: 29267192). In addition to his metabolic role, L-acetylcarnitine possesses unique neuroprotective, neuromodulatory, and neurotrophic properties. acetylcarnitine is mobile throughout the plasma membranes and can rapidly cross blood-brain barrier. Indeed, acetylcarnitine can be transported by the high-affinity sodium-dependent organic cation/transporter (OCTN2), which is functionally expressed in cells forming the blood-brain barrier (PMID: 29267192). A wide range of mechanisms have been proposed to explain the multiplicity of acetylcarnitine activities within nervous tissues. In particular, it has been demonstrated that acetylcarnitine modulates the activity of nerve growth factor (NGF) and enhances the expression of NGF receptors in striatum/hippocampus during development (PMID: 29267192). Moreover, acetylcarnitine modulates different neurotransmitter systems, including the GABAergic, dopaminergic, and cholinergic system by increasing acetyl-CoA content and choline acetyltransferase (ChAT) activity. This may play an important role in counteracting various neurodegenerative disease processes (PMID: 15363640).
N-Lactoylleucine
N-Lactoylleucine is a lactoyl derivative of phenylalanine. N-Lactoyl-amino acids are ubiquitous pseudodipeptides of lactic acid and amino acids that are rapidly formed by reverse proteolysis. A protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation. The plasma levels of these metabolites strongly correlate with plasma levels of lactate and amino acid (PMID: 25964343).
OR-1855
OR-1855 is a metabolite of levosimendan. Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax. (Wikipedia)
1-Carboxyethylleucine
1-Carboxyethylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from a reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 1-Carboxyethylleucine was identified as one of forty plasma metabolites that could be used to predict gut microbiome Shannon diversity (PMID: 31477923). Shannon diversity is a metric that summarizes both species abundance and evenness, and it has been suggested as a marker for microbiome health.
Acetyl-D-carnitine
Acetyl-D-carnitine is an acylcarnitine. More specifically, it is an acetic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. Acetyl-D-carnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine Acetyl-D-carnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. In particular Acetyl-D-carnitine is elevated in the blood or plasma of individuals with very long chain acyl-CoA dehydrogenase deficiency (PMID: 9034211), colorectal cancer (PMID: 25105552), short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (PMID: 11489939), paclitaxel induced neuropathy (PMID: 29946863), type 2 diabetes Mellitus (PMID: 28726959; PMID: 25964024, PMID: 28726959, PMID: 19369366, PMID: 24358186), chronic heart failure (PMID: 22622056), ornithine transcarbamylase (PMID: 3346778), pre-diabetes (PMID: 23010998, PMID: 24358186), type 1 diabetes mellitus (PMID: 16789638), methylmalonic acidemia (PMID: 8214594), myeloma (PMID: 30096165), and diastolic heart failure (PMID: 26010610). It is also decreased in the blood or plasma of individuals with 3-methyl-crotonyl-glycinuria (PMID: 25732994), antiviral drug induced neuropathy (PMID: 9030365, PMID: 11364244), Alzheimer Disease (PMID: 27196316), major depressive disorder (PMID: 30061399), carnitine palmitoyltransferase 2 deficiency (PMID: 20543534), Familial Mediterranean Fever (PMID: 29900937), chronic fatigue syndrome (PMID: 9854142), methylmalonic acidemia (PMID: 15164354), hepatocellular carcinoma (PMID: 26976432, PMID: 31662827), and coronary artery disease (PMID: 20173117). Acetyl-D-carnitine is elevated in the urine of individuals with colorectal cancer (25105552), uterine fibroids (32590215), heart failure (8070147), diabetes mellitus (10221661), and hepatocellular carcinoma (24923488). It is also decreased in the urine of individuals with carnitine palmitoyltransferase 2 deficiency (20543534). Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, incre...
DL-Acetylcarnitine
DL-Acetylcarnitine is an acylcarnitine. More specifically, it is an acetic acid ester of carnitine. Acylcarnitines were first discovered more than 70 year ago (PMID: 13825279). It is believed that there are more than 1000 types of acylcarnitines in the human body. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation. According to a recent review [Dambrova et al. 2021, Physiological Reviews], acylcarnitines (ACs) can be classified into 9 different categories depending on the type and size of their acyl-group: 1) short-chain ACs; 2) medium-chain ACs; 3) long-chain ACs; 4) very long-chain ACs; 5) hydroxy ACs; 6) branched chain ACs; 7) unsaturated ACs; 8) dicarboxylic ACs and 9) miscellaneous ACs. Short-chain ACs have acyl-groups with two to five carbons (C2-C5), medium-chain ACs have acyl-groups with six to thirteen carbons (C6-C13), long-chain ACs have acyl-groups with fourteen to twenty once carbons (C14-C21) and very long-chain ACs have acyl groups with more than 22 carbons. DL-Acetylcarnitine is therefore classified as a long chain AC. As a long-chain acylcarnitine DL-Acetylcarnitine is generally formed through esterification with long-chain fatty acids obtained from the diet. The main function of most long-chain acylcarnitines is to ensure long chain fatty acid transport into the mitochondria (PMID: 22804748). Altered levels of long-chain acylcarnitines can serve as useful markers for inherited disorders of long-chain fatty acid metabolism. In particular DL-Acetylcarnitine is elevated in the blood or plasma of individuals with very long chain acyl-CoA dehydrogenase deficiency (PMID: 9034211), colorectal cancer (PMID: 25105552), short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (PMID: 11489939), paclitaxel induced neuropathy (PMID: 29946863), type 2 diabetes Mellitus (PMID: 28726959; PMID: 25964024, PMID: 28726959, PMID: 19369366, PMID: 24358186), chronic heart failure (PMID: 22622056), ornithine transcarbamylase (PMID: 3346778), pre-diabetes (PMID: 23010998, PMID: 24358186), type 1 diabetes mellitus (PMID: 16789638), methylmalonic acidemia (PMID: 8214594), myeloma (PMID: 30096165), and diastolic heart failure (PMID: 26010610). It is also decreased in the blood or plasma of individuals with 3-methyl-crotonyl-glycinuria (PMID: 25732994), antiviral drug induced neuropathy (PMID: 9030365, PMID: 11364244), Alzheimer Disease (PMID: 27196316), major depressive disorder (PMID: 30061399), carnitine palmitoyltransferase 2 deficiency (PMID: 20543534), Familial Mediterranean Fever (PMID: 29900937), chronic fatigue syndrome (PMID: 9854142), methylmalonic acidemia (PMID: 15164354), hepatocellular carcinoma (PMID: 26976432, PMID: 31662827), and coronary artery disease (PMID: 20173117). DL-Acetylcarnitine is elevated in the urine of individuals with colorectal cancer (25105552), uterine fibroids (32590215), heart failure (8070147), diabetes mellitus (10221661), and hepatocellular carcinoma (24923488). It is also decreased in the urine of individuals with carnitine palmitoyltransferase 2 deficiency (20543534). Carnitine palmitoyltransferase I (CPT I, EC:2.3.1.21) is involved in the synthesis of long-chain acylcarnitines (more than C12) on the mitochondrial outer membrane. Elevated serum/plasma levels of long-chain acylcarnitines are not only markers for incomplete FA oxidation but also are indicators of altered carbohydrate and lipid metabolism. High serum concentrations of long-chain acylcarnitines in the postprandial or fed state are markers of insulin resistance and arise from insulins inability to inhibit CPT-1-dependent fatty acid metabolism in muscles and the heart (PMID: 19073774). Increased intracellular content of long-chain acylcarnitines is thought to serve as a feedback inhibition mechanism of insulin action (PMID: 23258903). In healthy subjects, incre... An acetic acid ester of carnitine that facilitates movement of acetyl CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids. In addition to his metabolic role, acetyl-L-carnitine (ALC) posses unique neuroprotective, neuromodulatory, and neurotrophic properties this may play an important role in counteracting various disease processes. (PubMed ID 15363640) [HMDB] N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics D002491 - Central Nervous System Agents > D018697 - Nootropic Agents D018977 - Micronutrients > D014815 - Vitamins
4-Aminoantipyrine
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents
5-Carboxamidotryptamine
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
4-Aminoantipyrine
A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 80 CONFIDENCE standard compound; INTERNAL_ID 8660 CONFIDENCE standard compound; EAWAG_UCHEM_ID 845
1-{1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}pyrrolidine
1,2-Dihydroxy-3,5-bis(hydroxymethyl)hexahydro-1H-pyrrolizine
Isopentenyl-Adenine
Acquisition and generation of the data is financially supported by the Max-Planck-Society
isopentenyl-Adenine-[d6]
Acquisition and generation of the data is financially supported by the Max-Planck-Society
4-Aminoantipyrin
Annotation level-1 D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents D002491 - Central Nervous System Agents > D000700 - Analgesics CONFIDENCE standard compound; INTERNAL_ID 4083 D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents
O-Acetyl-L-carnitine
An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.
N6-(delta2-Isopentenyl)-adenine
6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
6-(γ,γ-Dimethylallylamino)purine
6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
methyl 2-(2-hydroxypropanoylamino)-3-methylbutanoate
Acetylcarnitine
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics D002491 - Central Nervous System Agents > D018697 - Nootropic Agents D018977 - Micronutrients > D014815 - Vitamins MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; RDHQFKQIGNGIED_STSL_0139_Acetylcarnitine_0031fmol_180430_S2_LC02_MS02_47; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I. MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
CAR 2:0
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics D002491 - Central Nervous System Agents > D018697 - Nootropic Agents D018977 - Micronutrients > D014815 - Vitamins COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
1H-Pyrazolo[4,3-d]pyrimidin-7-amine,N-cyclobutyl-3-methyl-(9CI)
2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]ethanamine
4-(2-Ethyl-1-methyl-1H-imidazol-5-yl)-2-pyrimidinamine
1-(4,6-DIMETHYLPYRIMIDIN-2-YL)-3-METHYL-1H-PYRAZOL-5-AMINE
N-Methyl-1-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]methanamine
(S)-2-(1-Chloro-2-Methyl-2-propanyl)-4-isopropyl-4,5-dihydrooxazole
2-Methyl-L-aspartic acid 4-(1,1-dimethylethyl) ester
N-METHYL-N-[3-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZYL]AMINE
N-METHYL-[4-(3-METHYL-1,2,4-OXADIAZOL-5-YL)PHENYL]METHYLAMINE
4-Amino-2-(1-piperidinyl)pyrimidine-5-carbonitrile
(2S,4E)-5-Chloro-N,N-dimethyl-2-(1-methylethyl)-4-pentenamide
n-methyl[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]methylamine
1H-1,2,3-Triazole,5-ethoxy-4-methyl-1-phenyl-(7CI)
SPIRO[PIPERIDINE-4,3-PYRROLO[2,3-B]PYRIDIN]-2(1H)-ONE
3-tert-Butoxycarbonylamino-2-methyl-propionic acid
(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)METHANAMINEHYDROCHLORIDE
([3-(4-methoxyphenyl)-1h-pyrazol-4-yl]methyl)amine
N-methyl-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]methanamine
OR-1855
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents
Benzenamine, 3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)- (9CI)
N-METHYL-N-[4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZYL]AMINE
3,4-dihydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
(3R,4S)-tert-Butyl 3,4-dihydroxypyrrolidine-1-carboxylate
(S)-N-tert-butoxycarbonyl-N-methyl-2-amino-propionic acid
trans-tert-butyl 4-hydroxytetrahydrofuran-3-ylcarbaMate
6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
Sumanirole
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
(3S,4S)-tert-Butyl 3,4-dihydroxypyrrolidine-1-carboxylate
3-methoxy-2-methyl-5-(1-methylpyrazol-4-yl)pyridine
Diethyl 2-aminopentanedioate
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
3-(Methoxycarbonylamino)-2,2,3-trimethylbutanoic acid
2-(Acetyl-hydroxy-amino)-4-methyl-pentanoic acid methyl ester
N6-dimethylallyladenine
N-(3-methylbut-2-en-1-yl)-9h-purin-6-amine, also known as isopentenyladenine or ip, is a member of the class of compounds known as 6-alkylaminopurines. 6-alkylaminopurines are compounds that contain an alkylamine group attached at the 6-position of a purine. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. N-(3-methylbut-2-en-1-yl)-9h-purin-6-amine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). N-(3-methylbut-2-en-1-yl)-9h-purin-6-amine can be found in a number of food items such as sorghum, green zucchini, enokitake, and star fruit, which makes N-(3-methylbut-2-en-1-yl)-9h-purin-6-amine a potential biomarker for the consumption of these food products. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
(2S,3R,4S,5R,6R)-6-methyl-4-(prop-1-en-2-ylamino)oxane-2,3,5-triol
3-Methyl-6-(1-pyrrolidinyl)-[1,2,4]triazolo[4,3-b]pyridazine
Methyl 2-(2-hydroxypropanoylamino)-3-methylbutanoate
2-[(2R,5S,6S)-5-amino-6-(hydroxymethyl)-2-oxanyl]acetic acid methyl ester
2-[(2R,5R,6S)-5-amino-6-(hydroxymethyl)-2-oxanyl]acetic acid methyl ester
2-[(2R,5R,6R)-5-amino-6-(hydroxymethyl)-2-oxanyl]acetic acid methyl ester
(3R)-3-[(2,2,2-2H3)acetyloxy]-4-(trimethylazaniumyl)butanoate
N(6)-dimethylallyladenine
A 6-isopentenylaminopurine in which has the isopentenyl double bond is located between the 2 and 3 positions of the isopentenyl group. D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.
Acetyl-L-carnitine
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials D002491 - Central Nervous System Agents > D018697 - Nootropic Agents D018977 - Micronutrients > D014815 - Vitamins Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
5-carboxamidotryptamine
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
O-acetyl-D-carnitine
An O-acyl-D-carnitine in which the acyl group specified is acetyl.
Valiloxibic acid
Valiloxibic acid is a proagent of γ-Hydroxybutyric acid (GHB).GHB is a naturally occurring neurotransmitter and a psychoactive agent, it acts on the GHB receptor and is a weak agonist at the GABAB receptor[1].
