CAR 2:0 (BioDeep_00000630461)
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
D018977 - Micronutrients > D014815 - Vitamins
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
13 个代谢物同义名
3-(acetyloxy)-4-(trimethylazaniumyl)butanoate; Acetyl-DL-carnitine; DL-Acetylcarnitine; Acetyllcarnitine; Acetylcarnitine; CAR 2:0; (3R)-3-acetyloxy-4-(trimethylazaniumyl)butanoate; O-Acetyl-L-carnitine; Acetyl-L-carnitine; L-Acetylcarnitine; (3S)-3-acetoxy-4-(trimethylammonio)butyrate; Acetyl-D-carnitine; Acetyl-L-carnitine
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:73024
- ChEBI: CHEBI:57589
- ChEBI: CHEBI:86045
- PubChem: 1
- PubChem: 7045767
- PubChem: 18230
- DrugBank: DB08842
- ChEMBL: CHEMBL1697733
- LipidMAPS: LMFA07070060
- LipidMAPS: LMFA07070050
- LipidMAPS: LMFA07070049
- MeSH: Acetylcarnitine
- CAS: 14992-62-2
- CAS: 870-77-9
- CAS: 3040-38-8
- CAS: 4398-79-2
- RefMet: CAR 2:0
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-821
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
2-Methyl-3-acetoacetyl-CoA + Coenzyme A ⟶ Acetyl-CoA + Propanoyl-CoA
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 183589 - Pseudo-nitzschia multistriata: 10.3390/MD18060313
- 4896 - Schizosaccharomyces pombe: 10.1039/C4MB00346B
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jennifer K Frediani, Asim A Lal, Esther Kim, Sharon L Leslie, David W Boorman, Vinita Singh. The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: A systematic review.
Pain practice : the official journal of World Institute of Pain.
2023 Aug; ?(?):. doi:
10.1111/papr.13291. [PMID: 37654090] - Hyo-Suk Ahn, Eun Young Cho, Keun-Sang Yum. Efficacy of γ-linolenic acid, Vitis vinifera extract, and acetyl-L-carnitine combination therapy for improving arterial stiffness in Korean adults: Real-world evidence.
Journal of clinical hypertension (Greenwich, Conn.).
2023 Aug; ?(?):. doi:
10.1111/jch.14708. [PMID: 37608640] - Xu-Dong Jiang, Yu Liu, Jian-Fei Wu, San-Ni Gong, Yao Ma, Xiang-Dong Zi. Regulation of proliferation, apoptosis, hormone secretion and gene expression by acetyl-L-carnitine in yak (Bos grunniens) granulosa cells.
Theriogenology.
2023 Jun; 203(?):61-68. doi:
10.1016/j.theriogenology.2023.03.016. [PMID: 36972666] - Yongan Tan, Liubin Xiao, Jing Zhao, Jieyu Zhang, Sheraz Ahmad, Dejin Xu, Guangchun Xu, Linquan Ge. Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis in Apolygus lucorum.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108587. [PMID: 37239932] - Luke T Izzo, Sophie Trefely, Christina Demetriadou, Jack M Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T Farria, Phuong T T Nguyen, Nivitha Murali, Lauren Reich, Daniel S Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C Capell, Nathaniel W Snyder, Kathryn E Wellen. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Science advances.
2023 May; 9(18):eadf0115. doi:
10.1126/sciadv.adf0115. [PMID: 37134161] - Haoya Yao, Yaoqing Wang, Xiao Zhang, Ping Li, Lin Shang, Xiaocui Chen, Jia Zeng. Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
The Journal of biological chemistry.
2023 02; 299(2):102845. doi:
10.1016/j.jbc.2022.102845. [PMID: 36586435] - Jake Hsu, Nina Fatuzzo, Nielson Weng, Wojciech Michno, Wentao Dong, Maryline Kienle, Yuqin Dai, Anca Pasca, Monther Abu-Remaileh, Natalie Rasgon, Benedetta Bigio, Carla Nasca, Chaitan Khosla. Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells.
The Journal of biological chemistry.
2023 02; 299(2):102848. doi:
10.1016/j.jbc.2022.102848. [PMID: 36587768] - Yvo J M Op den Kamp, Anne Gemmink, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Johanna A Jorgensen, Gert Schaart, Russell Esterline, Diego A Pava, Joris Hoeks, Vera B Schrauwen-Hinderling, Sander Kersten, Bas Havekes, Timothy R Koves, Deborah M Muoio, Matthijs K C Hesselink, Jan Oscarsson, Esther Phielix, Patrick Schrauwen. Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism.
Molecular metabolism.
2022 12; 66(?):101620. doi:
10.1016/j.molmet.2022.101620. [PMID: 36280113] - Jonathan D Reiss, Alan L Chang, Jonathan A Mayo, Katherine Bianco, Henry C Lee, David K Stevenson, Gary M Shaw, Nima Aghaeepour, Karl G Sylvester. Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.
Pediatric research.
2022 08; 92(2):490-497. doi:
10.1038/s41390-021-01753-7. [PMID: 34671094] - Ceren Kencebay Manas, Narin Derin, Ramazan Yavuz Arican, Gamze Tanriover, Sayra Dilmac, Haluk Ozcanli. Comparison of the therapeutic effects of erythropoietin and acetyl-l-carnitine on sciatic nerve injury in rats.
Neurological research.
2022 Jul; 44(7):659-666. doi:
10.1080/01616412.2022.2029293. [PMID: 35129095] - Awot Teklu Mebratu, Yohannes Tekle Asfaw, Geert Paul Jules Janssens. Exploring the functional and metabolic effects of adding garra fish meal to a plant-based broiler chicken diet.
Tropical animal health and production.
2022 Jun; 54(3):196. doi:
10.1007/s11250-022-03200-z. [PMID: 35654900] - Muhammad Zubair Israr, Hong Zhan, Andrea Salzano, Adriaan A Voors, John G Cleland, Stefan D Anker, Marco Metra, Dirk J van Veldhuisen, Chim C Lang, Faiez Zannad, Nilesh J Samani, Leong L Ng, Toru Suzuki. Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium.
American heart journal.
2022 06; 248(?):108-119. doi:
10.1016/j.ahj.2022.03.002. [PMID: 35278373] - Z Naureen, A Dautaj, S Nodari, F Fioretti, K Dhuli, K Anpilogov, L Lorusso, S Paolacci, S Michelini, T Guda, M Kallazi, M Bertelli. Proposal of a food supplement for the management of post-COVID syndrome.
European review for medical and pharmacological sciences.
2021 12; 25(1 Suppl):67-73. doi:
10.26355/eurrev_202112_27335. [PMID: 34890036] - Quentin L Sciascia, Cornelia Prehn, Jerzy Adamski, Gürbüz Daş, Iris S Lang, Winfried Otten, Solvig Görs, Cornelia C Metges. The Effect of Dietary Protein Imbalance during Pregnancy on the Growth, Metabolism and Circulatory Metabolome of Neonatal and Weaned Juvenile Porcine Offspring.
Nutrients.
2021 Sep; 13(9):. doi:
10.3390/nu13093286. [PMID: 34579160] - Saman Tauqir, Momina Israr, Bushra Rauf, Muhammad Omar Malik, Syed Hamid Habib, Fawad Ali Shah, Muhammad Usman, Muhammad Asif Raza, Inayat Shah, Haroon Badshah, Ehtesham Ehtesham, Mohsin Shah. Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Advances in therapy.
2021 07; 38(7):3842-3856. doi:
10.1007/s12325-021-01789-5. [PMID: 34047916] - Hui Li, Yan Wang, Shizhao Ma, Chaoqun Zhang, Hua Liu, Dianxing Sun. Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury.
Scientific reports.
2021 06; 11(1):11642. doi:
10.1038/s41598-021-91164-9. [PMID: 34079030] - Suo Decheng, Fan Xia, Wei Shulin, Li Yang. Analysis of Choline, Carnitine, Acetylcarnitine and Acetylcholine in Animal Feeds, Blood and Urine Using Ion Chromatography Coupled with Tandem Mass Spectrometry.
Journal of chromatographic science.
2021 Apr; 59(5):405-411. doi:
10.1093/chromsci/bmab011. [PMID: 33618354] - Muhammad Zubair Israr, Dennis Bernieh, Andrea Salzano, Shabana Cassambai, Yoshiyuki Yazaki, Liam M Heaney, Donald J L Jones, Leong L Ng, Toru Suzuki. Association of gut-related metabolites with outcome in acute heart failure.
American heart journal.
2021 04; 234(?):71-80. doi:
10.1016/j.ahj.2021.01.006. [PMID: 33454370] - Guangzhu Wei, Zhongbao Zhou, Yuanshan Cui, Yongjin Huang, Zijin Wan, Xuanyan Che, Yumeng Chai, Yong Zhang. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia.
American journal of men's health.
2021 Mar; 15(2):15579883211011371. doi:
10.1177/15579883211011371. [PMID: 33906513] - Li-Juan Nie, Jun Liang, Feng Shan, Ya-Yun Xu, Chun-Yu Yan, Xuan Zhou, Zhuo-Yu Cheng, Qing-Rong Xia. A UPLC-MS/MS method for determination of endogenous l-carnitine and acetyl-l-carnitine in serum of patients with depression.
Biomedical chromatography : BMC.
2021 Mar; 35(3):e4991. doi:
10.1002/bmc.4991. [PMID: 33119931] - Sakshi Dhir, Zaira Khalid, Jisselly Salcedo, Alaa Shanbour. Acetyl-l-Carnitine and New-Onset Psychosis During the COVID-19 Pandemic.
The primary care companion for CNS disorders.
2020 12; 22(6):. doi:
10.4088/pcc.20l02804. [PMID: 33271642] - Arash Abdolmaleki, Mohammad-Bagher Ghayour, Morteza Behnam-Rassouli. Protective effects of acetyl-L-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells.
Cell and tissue banking.
2020 Dec; 21(4):655-666. doi:
10.1007/s10561-020-09844-1. [PMID: 32564258] - Elizabeth K Neumann, Lukasz G Migas, Jamie L Allen, Richard M Caprioli, Raf Van de Plas, Jeffrey M Spraggins. Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry.
Analytical chemistry.
2020 10; 92(19):13084-13091. doi:
10.1021/acs.analchem.0c02051. [PMID: 32668145] - Piotr Tomasz Protas, Alina Kępka, Agnieszka Rybi-Szuminska, Justyna Storonowicz, Mark Klukowski, Anna Wasilewska. Are low birth weight children predisposed to renal loss of carnitine?.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2020 Aug; 33(15):2612-2617. doi:
10.1080/14767058.2018.1555813. [PMID: 30513037] - Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.
The American journal of clinical nutrition.
2020 08; 112(2):413-426. doi:
10.1093/ajcn/nqaa072. [PMID: 32320006] - Radka Klepochová, Michael Leutner, Magdalena Bastian, Michael Krebs, Michael Weber, Siegfried Trattnig, Alexandra Kautzky-Willer, Martin Krššák. Muscle-Specific Relation of Acetylcarnitine and Intramyocellular Lipids to Chronic Hyperglycemia: A Pilot 3-T 1H MRS Study.
Obesity (Silver Spring, Md.).
2020 08; 28(8):1405-1411. doi:
10.1002/oby.22846. [PMID: 32820618] - Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients.
Nature communications.
2020 06; 11(1):3169. doi:
10.1038/s41467-020-16810-8. [PMID: 32576825] - Malkanthi Evans, Abdul M Sulley, David C Crowley, Jamie Langston, Najla Guthrie. Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Nutrients.
2020 Jun; 12(6):. doi:
10.3390/nu12061831. [PMID: 32575480] - Ahlam Alhusaini, Iman H Hasan, Bashayer Alrumayyan, Marwa Alesikri, Khansa Alanazi, Rawan Almasoud, Sarah Almarshad. Neuroprotective efficacy of nano-CoQ against propionic acid toxicity in rats: Role of BDNF and CREB protein expressions.
Journal of biochemical and molecular toxicology.
2020 Apr; 34(4):e22449. doi:
10.1002/jbt.22449. [PMID: 31967697] - Shixun Wang, Jingtao Xu, Jiahui Zheng, Xincai Zhang, Jingbo Shao, Luyan Zhao, Junqiang Hao. Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2020 Jan; 26(?):e920250. doi:
10.12659/msm.920250. [PMID: 31945029] - Antoine Cherix, Thomas Larrieu, Jocelyn Grosse, João Rodrigues, Bruce McEwen, Carla Nasca, Rolf Gruetter, Carmen Sandi. Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine.
eLife.
2020 01; 9(?):. doi:
10.7554/elife.50631. [PMID: 31922486] - Satoshi Odo, Koji Tanabe, Masafumi Yohda, Masamitsu Yamauchi. Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under Fat-Mobilizing Conditions: Pilot Human Clinical Trial.
Journal of nutritional science and vitaminology.
2020; 66(2):136-149. doi:
10.3177/jnsv.66.136. [PMID: 32350175] - Denisa Baci, Antonino Bruno, Caterina Cascini, Matteo Gallazzi, Lorenzo Mortara, Fausto Sessa, Giuseppe Pelosi, Adriana Albini, Douglas M Noonan. Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies.
Journal of experimental & clinical cancer research : CR.
2019 Nov; 38(1):464. doi:
10.1186/s13046-019-1461-z. [PMID: 31718684] - Zhen Liu, Peng Zhang, Lars Kästner, Dietrich A Volmer. A simple MALDI target plate with channel design to improve detection sensitivity and reproducibility for quantitative analysis of biomolecules.
Journal of mass spectrometry : JMS.
2019 Nov; 54(11):878-884. doi:
10.1002/jms.4447. [PMID: 31652368] - Andrew G Wang, Michele Diamond, Jaylyn Waddell, Mary C McKenna. Effect of Acetyl-L-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats.
Neurochemical research.
2019 Oct; 44(10):2405-2412. doi:
10.1007/s11064-019-02807-3. [PMID: 31041669] - Juan Shen, Xue-Feng Zhang, Qin Hao, Lin Zhao, Yan-Ling Yang. [Effects of acetyl-L-carnitine on the recovery of hindlimb movement afterspinal cord injury in rats and its mechamism].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2019 Sep; 35(5):438-442. doi:
10.12047/j.cjap.5801.2019.095. [PMID: 31894677] - L-L Liu, Y Lin, J-C Zhuang, J Ren, X-Y Jiang, M-H Chen, W Chen, X Luo, J-H Yan, J-J Niu, T-C Yang. Analysis of serum metabolite profiles in syphilis patients by untargeted metabolomics.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2019 Jul; 33(7):1378-1385. doi:
10.1111/jdv.15530. [PMID: 30803039] - Susan Burks, James Raymick, Bonnie Robinson, Joseph Hanig, Sumit Sarkar. Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects.
Neuroscience letters.
2019 06; 703(?):86-95. doi:
10.1016/j.neulet.2019.03.015. [PMID: 30890473] - Matheus Marcon, Ricieri Mocelin, Diogo L de Oliveira, Alex Sander da Rosa Araujo, Ana P Herrmann, Angelo Piato. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model.
Neuropharmacology.
2019 05; 150(?):145-152. doi:
10.1016/j.neuropharm.2019.03.024. [PMID: 30917915] - Evan L Pannkuk, Evagelia C Laiakis, Kirandeep Gill, Shreyans K Jain, Khyati Y Mehta, Denise Nishita, Kim Bujold, James Bakke, Janet Gahagen, Simon Authier, Polly Chang, Albert J Fornace. Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels.
Journal of proteome research.
2019 05; 18(5):2260-2269. doi:
10.1021/acs.jproteome.9b00101. [PMID: 30843397] - Edyta Adamska-Patruno, Joanna Godzien, Michal Ciborowski, Paulina Samczuk, Witold Bauer, Katarzyna Siewko, Maria Gorska, Coral Barbas, Adam Kretowski. The Type 2 Diabetes Susceptibility PROX1 Gene Variants Are Associated with Postprandial Plasma Metabolites Profile in Non-Diabetic Men.
Nutrients.
2019 Apr; 11(4):. doi:
10.3390/nu11040882. [PMID: 31010169] - Dan-Qian Chen, Gang Cao, Hua Chen, Christos P Argyopoulos, Hui Yu, Wei Su, Lin Chen, David C Samuels, Shougang Zhuang, George P Bayliss, Shilin Zhao, Xiao-Yong Yu, Nosratola D Vaziri, Ming Wang, Dan Liu, Jia-Rong Mao, Shi-Xing Ma, Jin Zhao, Yuan Zhang, You-Quan Shang, Huining Kang, Fei Ye, Xiao-Hong Cheng, Xiang-Ri Li, Li Zhang, Mei-Xia Meng, Yan Guo, Ying-Yong Zhao. Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
Nature communications.
2019 04; 10(1):1476. doi:
10.1038/s41467-019-09329-0. [PMID: 30931940] - Soyoung Shin, Hyeon Myeong Jeong, Seung Eun Chung, Tae Hwan Kim, Subindra Kazi Thapa, Da Young Lee, Chang Ho Song, Jun Young Lim, Sang-Min Cho, Kyu-Yeol Nam, Won-Ho Kang, Youn-Woong Choi, Beom Soo Shin. Simultaneous analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as potential plasma biomarkers to evaluate NSAIDs-induced gastric injury by liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 165(?):101-111. doi:
10.1016/j.jpba.2018.11.051. [PMID: 30522064] - Wei Perng, Lu Tang, Peter X K Song, Martha Maria Tellez-Rojo, Alejandra Cantoral, Karen E Peterson. Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project.
Pediatric research.
2019 02; 85(3):262-268. doi:
10.1038/s41390-018-0195-5. [PMID: 30297880] - Kuei-Pin Chung, Guan-Yuan Chen, Tzu-Yi Chuang, Yen-Tsung Huang, Hou-Tai Chang, Yen-Fu Chen, Wei-Lun Liu, Yi-Jung Chen, Chia-Lin Hsu, Miao-Tzu Huang, Ching-Hua Kuo, Chong-Jen Yu. Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
Critical care medicine.
2019 02; 47(2):210-218. doi:
10.1097/ccm.0000000000003517. [PMID: 30379669] - Nadezda V Khodorova, Douglas N Rutledge, Marion Oberli, David Mathiron, Paulo Marcelo, Robert Benamouzig, Daniel Tomé, Claire Gaudichon, Serge Pilard. Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans.
Molecular nutrition & food research.
2019 01; 63(1):e1700834. doi:
10.1002/mnfr.201700834. [PMID: 29468821] - Hui-Yan Xu, Shuang-Shuang Geng, Ting-Ting Li, Qiang Fu, Sheng-Sheng Lu, Xing-Wei Liang, Yang-Qing Lu, Ming Zhang, Xiao-Gan Yang, Ke-Huan Lu. Maturation of buffalo oocytes in vitro with acetyl-L-carnitine improves cryotolerance due to changes in mitochondrial function and the membrane lipid profile.
Reproduction, fertility, and development.
2019 Jan; 31(2):386-394. doi:
10.1071/rd18102. [PMID: 30309436] - Xiao-Jun Cai, Lei Wang, Chun-Mei Hu. Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Journal of cellular biochemistry.
2018 11; 119(10):8336-8345. doi:
10.1002/jcb.26886. [PMID: 29932239] - Denisa Baci, Antonino Bruno, Barbara Bassani, Matilde Tramacere, Lorenzo Mortara, Adriana Albini, Douglas M Noonan. Acetyl-l-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways.
Cancer letters.
2018 08; 429(?):100-116. doi:
10.1016/j.canlet.2018.04.018. [PMID: 29678548] - Emily Evans, Laura Piccio, Anne H Cross. Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
JAMA neurology.
2018 08; 75(8):1013-1021. doi:
10.1001/jamaneurol.2018.0611. [PMID: 29710293] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Nicholas B Vera, Zhidan Chen, Evan Pannkuk, Evagelia C Laiakis, Albert J Fornace, Derek M Erion, Stephen L Coy, Jeffrey A Pfefferkorn, Paul Vouros. Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non-human primates (NHPs) exposed to radiation.
Journal of mass spectrometry : JMS.
2018 Jul; 53(7):548-559. doi:
10.1002/jms.4085. [PMID: 29596720] - Yeji Sung, Konstantina Spagou, Marina Kafeza, Michael Kyriakides, Brahman Dharmarajah, Joseph Shalhoub, Jose A Diaz, Thomas W Wakefield, Elaine Holmes, Alun H Davies. Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.
2018 05; 55(5):703-713. doi:
10.1016/j.ejvs.2018.01.027. [PMID: 29526653] - Sahir Kalim, Ron Wald, Andrew T Yan, Marc B Goldstein, Mercedeh Kiaii, Dihua Xu, Anders H Berg, Clary Clish, Ravi Thadhani, Eugene P Rhee, Jeffrey Perl. Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles.
Clinical journal of the American Society of Nephrology : CJASN.
2018 03; 13(3):436-444. doi:
10.2215/cjn.08790817. [PMID: 29444900] - Joy Leng, Chris Proudman, Alistair Darby, Frances Blow, Neil Townsend, Andrew Miller, Jonathan Swann. Exploration of the Fecal Microbiota and Biomarker Discovery in Equine Grass Sickness.
Journal of proteome research.
2018 03; 17(3):1120-1128. doi:
10.1021/acs.jproteome.7b00784. [PMID: 29364680] - Vida Bodaghi-Namileh, Mohammad Reza Sepand, Ameneh Omidi, Mehdi Aghsami, Seyed Afshin Seyednejad, Sara Kasirzadeh, Omid Sabzevari. Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats.
Environmental toxicology and pharmacology.
2018 Mar; 58(?):11-20. doi:
10.1016/j.etap.2017.12.005. [PMID: 29278859] - Ashok Agarwal, Pallav Sengupta, Damayanthi Durairajanayagam. Role of L-carnitine in female infertility.
Reproductive biology and endocrinology : RB&E.
2018 Jan; 16(1):5. doi:
10.1186/s12958-018-0323-4. [PMID: 29373970] - Denis Anywar Arony, Suzanne Gazda, David Lagoro Kitara. Could nodding syndrome in Northern Uganda be a form of autism spectrum disorder? an observational study design.
The Pan African medical journal.
2018; 30(?):115. doi:
10.11604/pamj.2018.30.115.13634. [PMID: 30364427] - Yuiko Kamei, Daigo Kamei, Ken Tsuchiya, Michio Mineshima, Kosaku Nitta. Association between 4-year all-cause mortality and carnitine profile in maintenance hemodialysis patients.
PloS one.
2018; 13(8):e0201591. doi:
10.1371/journal.pone.0201591. [PMID: 30133480] - Alessandro D Genazzani, Giulia Despini, Adam Czyzyk, Agnieszka Podfigurna, Tommaso Simoncini, Blazej Meczekalski. Modulatory effects of l-carnitine plus l-acetyl-carnitine on neuroendocrine control of hypothalamic functions in functional hypothalamic amenorrhea (FHA).
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2017 Dec; 33(12):963-967. doi:
10.1080/09513590.2017.1332587. [PMID: 28573875] - Radka Klepochová, Ladislav Valkovič, Martin Gajdošík, Thomas Hochwartner, Harald Tschan, Michael Krebs, Siegfried Trattnig, Martin Krššák. Detection and Alterations of Acetylcarnitine in Human Skeletal Muscles by 1H MRS at 7 T.
Investigative radiology.
2017 07; 52(7):412-418. doi:
10.1097/rli.0000000000000355. [PMID: 28195849] - Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Deusdedit Tusubira, Asbjørn Svardal, Gro Vatne Røsland, Karl Johan Tronstad, Seth Hallström, Rolf Kristian Berge. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats.
Journal of lipid research.
2017 07; 58(7):1362-1373. doi:
10.1194/jlr.m074849. [PMID: 28473603] - Rongli Sun, Juan Zhang, Haiyan Wei, Xing Meng, Qin Ding, Fengxia Sun, Meng Cao, Lihong Yin, Yuepu Pu. Acetyl-l-carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in C3H/He mice.
Environmental toxicology and pharmacology.
2017 Apr; 51(?):108-113. doi:
10.1016/j.etap.2017.02.013. [PMID: 28233701] - Meng Yu, Hong-Mei Jia, Feng-Xia Cui, Yong Yang, Yang Zhao, Mao-Hua Yang, Zhong-Mei Zou. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations.
International journal of molecular sciences.
2017 Mar; 18(3):. doi:
10.3390/ijms18030602. [PMID: 28287417] - Lucas Lindeboom, Yvonne M H Bruls, Petronella A van Ewijk, Matthijs K C Hesselink, Joachim E Wildberger, Patrick Schrauwen, Vera B Schrauwen-Hinderling. Longitudinal relaxation time editing for acetylcarnitine detection with 1 H-MRS.
Magnetic resonance in medicine.
2017 02; 77(2):505-510. doi:
10.1002/mrm.26149. [PMID: 26887359] - Hui Li, Su-Fang Fan, Yan Wang, Shi-Gang Shen, Dian-Xing Sun. Rapid Detection of Small Molecule Metabolites in Serum of Hepatocellular Carcinoma Patients Using Ultrafast Liquid Chromatography-Ion Trap-Time of Flight Tandem Mass Spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2017; 33(5):573-578. doi:
10.2116/analsci.33.573. [PMID: 28496060] - Mohammad Mohammadi, Azita Hajhossein Talasaz, Mohammad Alidoosti. Preventive effect of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation.
Clinical nutrition ESPEN.
2016 Oct; 15(?):1-10. doi:
10.1016/j.clnesp.2016.06.009. [PMID: 28531771] - Sonu Singh, Akanksha Mishra, Shubha Shukla. ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats.
Molecular neurobiology.
2016 09; 53(7):4286-301. doi:
10.1007/s12035-015-9361-5. [PMID: 26223802] - Yonghai Lu, Ning Li, Liang Gao, Yong-Jiang Xu, Chong Huang, Kangkang Yu, Qingxia Ling, Qi Cheng, Shengsen Chen, Mengqi Zhu, Jinling Fang, Mingquan Chen, Choon Nam Ong. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma.
Cancer research.
2016 05; 76(10):2912-20. doi:
10.1158/0008-5472.can-15-3199. [PMID: 26976432] - Mohammad Reza Sepand, Kamal Razavi-Azarkhiavi, Ameneh Omidi, Mohammad Reza Zirak, Samin Sabzevari, Ali Reza Kazemi, Omid Sabzevari. Effect of Acetyl-L-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat.
Biological trace element research.
2016 May; 171(1):107-15. doi:
10.1007/s12011-015-0436-y. [PMID: 26349760] - Matthew W T Curran, Jaret Olson, Michael Morhart, Dory Sample, K Ming Chan. Acetyl-L-carnitine (ALCAR) to enhance nerve regeneration in carpal tunnel syndrome: study protocol for a randomized, placebo-controlled trial.
Trials.
2016 Apr; 17(?):200. doi:
10.1186/s13063-016-1324-2. [PMID: 27079660] - Amir Baghaei, Reza Solgi, Abbas Jafari, Amir Hossein Abdolghaffari, Alireza Golaghaei, Mohammad Hossein Asghari, Maryam Baeeri, Seyed Nasser Ostad, Mohammad Sharifzadeh, Mohammad Abdollahi. Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-L-carnitine.
Environmental toxicology and pharmacology.
2016 Mar; 42(?):30-7. doi:
10.1016/j.etap.2015.12.019. [PMID: 26773361] - Bonnie L Robinson, Melanie Dumas, Elvis Cuevas, Qiang Gu, Merle G Paule, Syed F Ali, Jyotshna Kanungo. Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish.
Neurotoxicology and teratology.
2016 Mar; 54(?):52-60. doi:
10.1016/j.ntt.2016.02.004. [PMID: 26898327] - Cecilia Maldonado, Natalia Guevara, Cecilia Queijo, Raquel González, Pietro Fagiolino, Marta Vázquez. Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
BioMed research international.
2016; 2016(?):2920108. doi:
10.1155/2016/2920108. [PMID: 26998483] - E F Diekman, G Visser, J P J Schmitz, R A J Nievelstein, M de Sain-van der Velden, M Wardrop, W L Van der Pol, S M Houten, N A W van Riel, T Takken, J A L Jeneson. Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
PloS one.
2016; 11(2):e0147818. doi:
10.1371/journal.pone.0147818. [PMID: 26881790] - Arpit Mehrotra, Abhilasha Sood, Rajat Sandhir. Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
Molecular and cellular biochemistry.
2015 Dec; 410(1-2):281-92. doi:
10.1007/s11010-015-2561-5. [PMID: 26374445] - Sang-Min Baek, Renhua Zheng, Eun-Jung Seo, Dae-Yeon Hwang, Bo-Hyung Kim. Pharmacokinetic comparisons of two acetyl-L-carnitine formulations in healthy Korean volunteers.
International journal of clinical pharmacology and therapeutics.
2015 Nov; 53(11):980-6. doi:
10.5414/cp202381. [PMID: 26396135] - Bonnie L Robinson, Melanie Dumas, Merle G Paule, Syed F Ali, Jyotshna Kanungo. Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish.
Neuroscience letters.
2015 Oct; 607(?):17-22. doi:
10.1016/j.neulet.2015.09.006. [PMID: 26365406] - S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Binienda. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine.
Neuroscience letters.
2015 Oct; 606(?):53-9. doi:
10.1016/j.neulet.2015.08.044. [PMID: 26321151] - Bo Ma, Huanhuan Qi, Jing Li, Hong Xu, Bo Chi, Jianwei Zhu, Lisha Yu, Guohua An, Qi Zhang. Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study.
Toxicology.
2015 Oct; 336(?):84-95. doi:
10.1016/j.tox.2015.07.008. [PMID: 26219505] - Lianshu Han, Shengnan Wu, Jun Ye, Wenjuan Qiu, Huiwen Zhang, Xiaolan Gao, Yu Wang, Zhuwen Gong, Jing Jin, Xuefan Gu. Biochemical, molecular and outcome analysis of eight chinese asymptomatic individuals with methyl malonic acidemia detected through newborn screening.
American journal of medical genetics. Part A.
2015 Oct; 167A(10):2300-5. doi:
10.1002/ajmg.a.37147. [PMID: 25982642] - Ricardo J Samms, Michelle Murphy, Maxine J Fowler, Scott Cooper, Paul Emmerson, Tamer Coskun, Andrew C Adams, Alexei Kharitonenkov, Francis J P Ebling, Kostas Tsintzas. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.
The Journal of endocrinology.
2015 Oct; 227(1):37-47. doi:
10.1530/joe-15-0334. [PMID: 26294388] - Brian R Holder, Colleen A McNaney, David Luchetti, Eric Schaeffer, Dieter M Drexler. Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.
Biomedical chromatography : BMC.
2015 Sep; 29(9):1375-9. doi:
10.1002/bmc.3433. [PMID: 25712252] - Marieke G Schooneman, Gabriella A M Ten Have, Naomi van Vlies, Sander M Houten, Nicolaas E P Deutz, Maarten R Soeters. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism.
American journal of physiology. Endocrinology and metabolism.
2015 Aug; 309(3):E256-64. doi:
10.1152/ajpendo.00503.2014. [PMID: 26037250] - Federica Ferrari, Antonella Gorini, Roberto Federico Villa. Functional proteomics of synaptic plasma membrane ATP-ases of rat hippocampus: effect of l-acetylcarnitine and relationships with Dementia and Depression pathophysiology.
European journal of pharmacology.
2015 Jun; 756(?):67-74. doi:
10.1016/j.ejphar.2015.03.011. [PMID: 25797282] - Karen L Reader, Neil R Cox, Jo-Ann L Stanton, Jennifer L Juengel. Effects of acetyl-L-carnitine on lamb oocyte blastocyst rate, ultrastructure, and mitochondrial DNA copy number.
Theriogenology.
2015 Jun; 83(9):1484-92. doi:
10.1016/j.theriogenology.2015.01.028. [PMID: 25748246] - Taha Haffar, Félix-Antoine Bérubé-Simard, Nicolas Bousette. Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.
Biochemical and biophysical research communications.
2015 Mar; 459(1):54-9. doi:
10.1016/j.bbrc.2015.02.062. [PMID: 25712520] - Marina Morigi, Luca Perico, Cinzia Rota, Lorena Longaretti, Sara Conti, Daniela Rottoli, Rubina Novelli, Giuseppe Remuzzi, Ariela Benigni. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury.
The Journal of clinical investigation.
2015 Feb; 125(2):715-26. doi:
10.1172/jci77632. [PMID: 25607838] - Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, Yingmei Zhang. ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain.
Neurotoxicology.
2015 Jan; 46(?):19-24. doi:
10.1016/j.neuro.2014.11.007. [PMID: 25464205] - Karen L Lindsay, Christian Hellmuth, Olaf Uhl, Claudia Buss, Pathik D Wadhwa, Berthold Koletzko, Sonja Entringer. Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy.
PloS one.
2015; 10(12):e0145794. doi:
10.1371/journal.pone.0145794. [PMID: 26716698] - R Jia, Y H Bao, Y Zhang, C Ji, L H Zhao, J Y Zhang, C Q Gao, Q G Ma. Effects of dietary α-lipoic acid, acetyl-l-carnitine, and sex on antioxidative ability, energy, and lipid metabolism in broilers.
Poultry science.
2014 Nov; 93(11):2809-17. doi:
10.3382/ps.2014-03921. [PMID: 25239530] - Nimzing G Ladep, Anthony C Dona, Matthew R Lewis, Mary M E Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F Njai, Haddy K S Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A Khan, Deborah A Garside, Anisha Wijeyesekera, Andrew V Thillainayagam, Edmund Banwat, Mark R Thursz, Jeremy K Nicholson, Ramou Njie, Elaine Holmes, Simon D Taylor-Robinson. Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.
Hepatology (Baltimore, Md.).
2014 Oct; 60(4):1291-301. doi:
10.1002/hep.27264. [PMID: 24923488] - Réjane Morand, Jamal Bouitbir, Andrea Felser, Jürgen Hench, Christoph Handschin, Stephan Frank, Stephan Krähenbühl. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice.
European journal of nutrition.
2014 Sep; 53(6):1313-25. doi:
10.1007/s00394-013-0631-6. [PMID: 24337254] - Huawei Zhang, Peng Fu, Beilei Ke, Shuping Wang, Min Li, Lin Han, Chengcheng Peng, Weidong Zhang, Runhui Liu. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang.
Journal of ethnopharmacology.
2014 May; 154(1):55-64. doi:
10.1016/j.jep.2014.03.007. [PMID: 24709313] - Lamiaa M Farghaly, Waleed A Ghobashy, Youssef Shoukry, Mona F El-Azab. Ameliorative effect of acetyl-L-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats.
European journal of pharmacology.
2014 Apr; 729(?):1-9. doi:
10.1016/j.ejphar.2014.02.005. [PMID: 24530554] - Arpit Mehrotra, Rajat Sandhir. Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
Behavioural brain research.
2014 Mar; 261(?):345-55. doi:
10.1016/j.bbr.2013.12.035. [PMID: 24393741] - Anita Dayaldasani, Juan Ruiz-Escalera, Manuel Rodríguez-Espinosa, Inmaculada Rueda, Vidal Pérez-Valero, Raquel Yahyaoui. Serum vitamin B12 levels during the first trimester of pregnancy correlate with newborn screening markers of vitamin B12 deficiency.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2014; 84(1-2):92-7. doi:
10.1024/0300-9831/a000196. [PMID: 25835239] - Jenna Pekkinen, Kaisa Olli, Anne Huotari, Kirsti Tiihonen, Pekka Keski-Rahkonen, Marko Lehtonen, Seppo Auriola, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen, Kati Hanhineva. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach.
Molecular nutrition & food research.
2013 Nov; 57(11):1959-68. doi:
10.1002/mnfr.201300142. [PMID: 23868375] - Elango Kathirvel, Kengathevy Morgan, Samuel W French, Timothy R Morgan. Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Nutrition research (New York, N.Y.).
2013 Nov; 33(11):932-41. doi:
10.1016/j.nutres.2013.08.001. [PMID: 24176233]
