Exact Mass: 129.0425912
Exact Mass Matches: 129.0425912
Found 83 metabolites which its exact mass value is equals to given mass value 129.0425912,
within given mass tolerance error 1.28E-8 dalton. Try search metabolite list with more accurate mass tolerance error
2.56E-9 dalton.
Pyroglutamic acid
Pyroglutamic acid (5-oxoproline) is a cyclized derivative of L-glutamic acid. It is an uncommon amino acid derivative in which the free amino group of glutamic acid cyclizes to form a lactam. It is formed nonenzymatically from glutamate, glutamine, and gamma-glutamylated peptides, but it can also be produced by the action of gamma-glutamylcyclotransferase on an L-amino acid. Elevated blood levels may be associated with problems of glutamine or glutathione metabolism. This compound is found in substantial amounts in brain tissue and other tissues in bound form, especially skin. It is also present in plant tissues. It is sold, over the counter, as a "smart drug" for improving blood circulation in the brain. Pyroglutamate in the urine is a biomarker for the consumption of cheese. When present in sufficiently high levels, pyroglutamic acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of pyroglutamic acid are associated with at least five inborn errors of metabolism including 5-oxoprolinuria, 5-oxoprolinase deficiency, glutathione synthetase deficiency, hawkinsinuria, and propionic acidemia. Pyroglutamic acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of the untreated IEMs mentioned above. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. It has been shown that pyroglutamic acid releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments, pyroglutamic acid significantly shortens the plasma half-life of ethanol during acute intoxication. Found in vegetables, fruits and molasses. A cyclized derivative of L-glutamic acid. It is an uncommon amino acid derivative in which the free amino group of glutamic acid cyclizes to form a lactam. Pyroglutamate in the urine is a biomarker for the consumption of cheese C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
Pyrroline hydroxycarboxylic acid
Pyrroline hydroxycarboxylic acid is a metabolite identified in the urine of patients with type II hyperprolinemia. (OMIM 239510). The urinary excretion of Pyrroline hydroxycarboxylic acid increased in hyperprolinemic patients but not in healthy controls during oral loading of hydroxyproline and hydroxyproline-ornithine. (PMID: 533224). Hyperprolinemia type II (HP II) is a rare inherited metabolic disease due to the deficiency of pyroline-5-carboxylate dehydrogenase. It is generally believed to be a benign condition although some patients have neurological problems such as refractory convulsions. (PMID: 15214748). The oxidation of pyrroline-carboxylate generates glutamate and pyrroline-hydroxycarboxylate, a reaction catalyzed by hydroxyproline oxidase (PMID: 500817). Pyrroline hydroxycarboxylic acid is a metabolite identified in the urine of patients with type II hyperprolinemia. (OMIM 239510)
1-Pyrroline-4-hydroxy-2-carboxylate
Much or all of the pyrrole-2-carboxylate (PCA) in human urine may be formed in urine from a labile precursor, presumably delta(1)-pyrroline-4-hydroxy-2-carboxylate. Normal human values for endogenous urinary PCA in 16 individuals averaged 0.51 mumol/day, with a range of 0.20-1.3 mumol and a SD of 0.31 mumol. The probable source of human PCA is free hydroxy-L-proline, as inferred from the high value for PCA in the urine of a subject with hereditary hydroxyprolinemia, and from the threeto eightfold elevation in PCA excretion by two normal subjects after a large oral load of hydroxyl-L-proline. (PMID: 4430715). Much or all of the pyrrole-2-carboxylate (PCA) in human urine may be formed in urine from a labile precursor, presumably delta(1)-pyrroline-4-hydroxy-2-carboxylate.
D-Pyroglutamate
KEIO_ID P092 (R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.
N-Acryloylglycine
N-Acryloylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. N-Acryloylglycine is an acylglycines found in normal human biofluids (PMID 7364920; 912020; 7438429). N-Acryloylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
dimethadione
dimethadione is a metabolite of trimethadione. Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments. (Wikipedia) C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylic Acid
(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylic Acid is also known as 3-Hydroxy-L-1-pyrroline-5-carboxylate. (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylic Acid is considered to be soluble (in water) and acidic
pyrrolidone carboxylic acid
2-Pyrrolidone-5-carboxylic acid (PCA) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments, PCA significantly shortens the plasma half-life of ethanol during acute intoxication. [HMDB] (R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.
(2S)-6-Oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acid
L-5-Oxoproline
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
2-methyl-fumaramic acid|2-Methyl-fumaramidsaeure|Mesaconsaeure-alpha-amid
(2S,3R)-2-Amino-3-hydroxy-4-pentynoic acid|2(S).3(R)-2-amino-3-hydroxypent-4-ynsaeure
L-Pyroglutamicacid
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D-Pyroglutamic acid
The D-enantiomer of 5-oxoproline. (R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.
L-Pyroglutamic acid
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; ODHCTXKNWHHXJC-VKHMYHEASA-N_STSL_0190_2-Pyrrolidone-5-carboxylic acid_2000fmol_180831_S2_L02M02_41; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I. MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
Pyroglutamic acid (not validated, isomer of 89)
Annotation level-3
Pyroglutamic acid (not validated, isomer of 88)
Annotation level-2
DL-Pyroglutamic acid
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2]. DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].
2-Furancarboxylicacid,4-amino-4,5-dihydro-,(R)-(9ci)
(S)-4-hydroxy-1-pyrroline-2-carboxylic acid
A 4-hydroxy-1-pyrroline-2-carboxylic acid in which the 4-hydroxy group has S-configuration.
dimethadione
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Psidiolic acid
Pyroglutamic acid, also known as pyroglutamate or (-)-2-pyrrolidone-5-carboxylic acid, belongs to alpha amino acids and derivatives class of compounds. Those are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Pyroglutamic acid is soluble (in water) and a weakly acidic compound (based on its pKa). Pyroglutamic acid can be found in a number of food items such as sesame, mexican groundcherry, sorghum, and breakfast cereal, which makes pyroglutamic acid a potential biomarker for the consumption of these food products. Pyroglutamic acid can be found primarily in most biofluids, including blood, feces, urine, and saliva, as well as in human brain, prostate and skin tissues. Pyroglutamic acid exists in all eukaryotes, ranging from yeast to humans. In humans, pyroglutamic acid is involved in the glutathione metabolism. Pyroglutamic acid is also involved in several metabolic disorders, some of which include 5-Oxoprolinuria, gamma-glutamyltransferase deficiency, gamma-glutamyl-transpeptidase deficiency, and glutathione synthetase deficiency. Moreover, pyroglutamic acid is found to be associated with schizophrenia, glutathione synthetase deficiency, and 5-oxoprolinase deficiency. Pyroglutamic acid is a non-carcinogenic (not listed by IARC) potentially toxic compound.
L-beta-ethynylserine zwitterion
An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy group to the amino group of L-beta-ethynylserine. The major species at pH 7.3.
(2R,4S)-4-hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid
4-hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid
5-Oxoproline
An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.
4-oxoproline zwitterion
An amino acid zwitterion obtained from 4-oxoproline by transfer of a proton from the alpha-carboxy group to the amino group; major species at pH 7.3.
4-oxo-L-proline zwitterion
An amino acid zwitterion resulting from a transfer of a proton from the carboxy to the amino group of 4-oxo-L-proline; major species at pH 7.3.
L-beta-ethynylserine
A non-proteinogenic L-alpha-amino acid that is L-propargylglycine which is carrying a hydroxy group at the 3R position.
4-Hydroxy-1-pyrroline-2-carboxylic acid
A 1-pyrrolinecarboxylic acid having a hydroxy substituent at the 4-position.
1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrroidine-2-carboxylic acid L-pyroglutamic acid
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