1-Methylpyrrole-2,3,5-triol (BioDeep_00000181451)
human metabolite blood metabolite
代谢物信息卡片
化学式: C5H7NO3 (129.0426)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=CC(=C1O)O)O
InChI: InChI=1S/C5H7NO3/c1-6-4(8)2-3(7)5(6)9/h2,7-9H,1H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Birgit K Schindler, Stephan Koslitz, Swetlana Meier, Vladimir N Belov, Holger M Koch, Tobias Weiss, Thomas Brüning, Heiko U Käfferlein. Quantification of four major metabolites of embryotoxic N-methyl- and N-ethyl-2-pyrrolidone in human urine by cooled-injection gas chromatography and isotope dilution mass spectrometry.
Analytical chemistry.
2012 Apr; 84(8):3787-94. doi:
10.1021/ac300439w. [PMID: 22449166] - Yoshihiro Suzuki, Yoko Endo, Masanori Ogawa, Shinobu Yamamoto, Akito Takeuchi, Tomoo Nakagawa, Nobuhiko Onda. Direct determination of N-methyl-2-pyrrolidone metabolites in urine by HPLC-electrospray ionization-MS/MS using deuterium-labeled compounds as internal standard.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(29):3743-7. doi:
10.1016/j.jchromb.2009.08.036. [PMID: 19744900] - Michael Bader, Renate Wrbitzky, Meinolf Blaszkewicz, Michael Schäper, Christoph van Thriel. Human volunteer study on the inhalational and dermal absorption of N-methyl-2-pyrrolidone (NMP) from the vapour phase.
Archives of toxicology.
2008 Jan; 82(1):13-20. doi:
10.1007/s00204-007-0230-5. [PMID: 17721780] - Ryuichi Kubota, Yoko Endo, Akito Takeuchi, Yoshinori Inoue, Hiroko Ogata, Masanori Ogawa, Tomoo Nakagawa, Nobuhiko Onda, Ginji Endo. SPE-GC/FTD determination of N-methyl-2-pyrrolidone and its metabolites in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):204-10. doi:
10.1016/j.jchromb.2007.04.022. [PMID: 17485256] - Michael Bader, Renate Wrbitzky, Meinolf Blaszkewicz, Christoph van Thriel. Human experimental exposure study on the uptake and urinary elimination of N-methyl-2-pyrrolidone (NMP) during simulated workplace conditions.
Archives of toxicology.
2007 May; 81(5):335-46. doi:
10.1007/s00204-006-0161-6. [PMID: 17103143] - Stephen A Keener, Renate Wrbitzky, Michael Bader. Human volunteer study on the influence of exposure duration and dilution of dermally applied N-methyl-2-pyrrolidone (NMP) on the urinary elimination of NMP metabolites.
International archives of occupational and environmental health.
2007 Feb; 80(4):327-34. doi:
10.1007/s00420-006-0138-z. [PMID: 16897094] - Michael Bader, Wolfgang Rosenberger, Thomas Rebe, Stephen A Keener, Thomas H Brock, Hans-Jürgen Hemmerling, Renate Wrbitzky. Ambient monitoring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone in an industrial facility.
International archives of occupational and environmental health.
2006 May; 79(5):357-64. doi:
10.1007/s00420-005-0065-4. [PMID: 16362322] - Martin A Carnerup, Anne Marie Saillenfait, Bo A G Jönsson. Concentrations of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine following oral administration of NMP to rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2005 Sep; 43(9):1441-7. doi:
10.1016/j.fct.2005.04.007. [PMID: 15951091] - Bengt Akesson, Martin A Carnerup, Bo A G Jönsson. Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone.
Scandinavian journal of work, environment & health.
2004 Aug; 30(4):306-12. doi:
10.5271/sjweh.799. [PMID: 15458014] - B A G Jönsson, B Akesson. Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy- N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy- N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker.
International archives of occupational and environmental health.
2003 May; 76(4):267-74. doi:
10.1007/s00420-003-0438-5. [PMID: 12684812] - M A Carnerup, B Akesson, B A Jönsson. Determination of 5-hydroxy-N-methyl-2-pyrrolidone and 2-hydroxy-N-methylsuccinimide in human plasma and urine using liquid chromatography-electrospray tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Sep; 761(1):107-13. doi:
10.1016/s0378-4347(01)00312-7. [PMID: 11585124]
