Bindarit (BioDeep_00000176695)
Main id: BioDeep_00000017474
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
2-[(1-benzyl-1h-indazol-3-yl)methoxy]-2-methylpropanoic acid
化学式: C19H20N2O3 (324.147385)
中文名称: 宾达利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)O)OCC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3
InChI: InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
描述信息
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C29629 - Combination Medication > C29634 - Antirheumatic Preparation
D000893 - Anti-Inflammatory Agents
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 71354
- HMDB: HMDB0249216
- DrugBank: DB12739
- ChEMBL: CHEMBL2107549
- CAS: 130641-38-2
- medchemexpress: HY-B0498
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shi-Guo Yuan, Hong-Ling Hu, Xin-Jia Wang, Jin-Cheng Yang, Rong-Ping Zhou, Xiao-Chun Bai, Ping-Lin Lai. Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF-κB Signaling Pathway.
Orthopaedic surgery.
2022 Jun; 14(6):1203-1216. doi:
10.1111/os.13252. [PMID: 35470579] - Chunmei Xu, Luqi Yin, Zhipeng Teng, Xuemei Zhou, Wenjie Li, Qiong Lai, Cuiping Peng, Chengyuan Zhang, Jie Lou, Xing Zhou. Prevention of Obesity Related Diseases through Laminarin-induced targeted delivery of Bindarit.
Theranostics.
2020; 10(21):9544-9560. doi:
10.7150/thno.45788. [PMID: 32863944] - Sergio Oddi, Lucia Scipioni, Antonio Totaro, Clotilde Angelucci, Beatrice Dufrusine, Annalaura Sabatucci, Daniel Tortolani, Isabella Coletta, Maria Alessandra Alisi, Lorenzo Polenzani, Michael Assfalg, Carlo Caltagirone, Enrico Dainese, Mauro Maccarrone. The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells.
Scientific reports.
2019 10; 9(1):15155. doi:
10.1038/s41598-019-51691-y. [PMID: 31641194] - Yuya Futagi, Masaki Kobayashi, Katsuya Narumi, Ayako Furugen, Ken Iseki. Identification of a selective inhibitor of human monocarboxylate transporter 4.
Biochemical and biophysical research communications.
2018 01; 495(1):427-432. doi:
10.1016/j.bbrc.2017.10.025. [PMID: 28993194] - Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection.
Journal of virology.
2015 Jan; 89(1):581-93. doi:
10.1128/jvi.02034-14. [PMID: 25339772] - Carlamaria Zoja, Daniela Corna, Monica Locatelli, Daniela Rottoli, Anna Pezzotta, Marina Morigi, Cristina Zanchi, Simona Buelli, Angelo Guglielmotti, Norberto Perico, Andrea Remuzzi, Giuseppe Remuzzi. Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic kidney disease.
Nephron.
2015; 129(1):52-61. doi:
10.1159/000369149. [PMID: 25531096] - J L Steiner, J M Davis, J L McClellan, A Guglielmotti, E A Murphy. Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer.
Cytokine.
2014 Mar; 66(1):60-8. doi:
10.1016/j.cyto.2013.12.011. [PMID: 24548426] - Sara Paccosi, Claudia Musilli, Giorgina Mangano, Angelo Guglielmotti, Astrid Parenti. The monocyte chemotactic protein synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling.
Pharmacological research.
2012 Dec; 66(6):526-35. doi:
10.1016/j.phrs.2012.09.006. [PMID: 22982961] - Marcella Maddaluno, Gianluca Grassia, Maria Vittoria Di Lauro, Antonio Parisi, Francesco Maione, Carla Cicala, Daniele De Filippis, Teresa Iuvone, Angelo Guglielmotti, Pasquale Maffia, Nicola Mascolo, Armando Ialenti. Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching.
PloS one.
2012; 7(10):e47464. doi:
10.1371/journal.pone.0047464. [PMID: 23077623] - Armando Ialenti, Gianluca Grassia, Peter Gordon, Marcella Maddaluno, Maria Vittoria Di Lauro, Andrew H Baker, Angelo Guglielmotti, Antonio Colombo, Giuseppe Biondi, Simon Kennedy, Pasquale Maffia. Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Nov; 31(11):2448-54. doi:
10.1161/atvbaha.111.230078. [PMID: 21852559] - Alessandro Ble, Marta Mosca, Giorgio Di Loreto, Angelo Guglielmotti, Giuseppe Biondi, Stefano Bombardieri, Giuseppe Remuzzi, Piero Ruggenenti. Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis.
American journal of nephrology.
2011; 34(4):367-72. doi:
10.1159/000330685. [PMID: 21876349] - Guo-Xiong Zhou, Xue-Juan Zhu, Xiao-Ling Ding, Hong Zhang, Jian-Ping Chen, Hui Qiang, Hai-Feng Zhang, Qun Wei. Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2010 Apr; 9(2):201-7. doi:
NULL. [PMID: 20382594] - Xiang-Yang Zhu, Alejandro R Chade, James D Krier, Elena Daghini, Ronit Lavi, Angelo Guglielmotti, Amir Lerman, Lilach O Lerman. The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension.
Journal of hypertension.
2009 Oct; 27(10):2063-73. doi:
10.1097/hjh.0b013e3283300192. [PMID: 19730125] - A Guglielmotti, E D'Onofrio, I Coletta, L Aquilini, C Milanese, M Pinza. Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-alpha production.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2002 May; 51(5):252-8. doi:
10.1007/pl00000301. [PMID: 12056513] - M Sironi, A Guglielmotti, N Polentarutti, F Fioretti, C Milanese, M Romano, C Vigini, I Coletta, S Sozzani, S Bernasconi, A Vecchi, M Pinza, A Mantovani. A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1.
European cytokine network.
1999 Sep; 10(3):437-42. doi:
NULL. [PMID: 10477401] - L Saso, G Valentini, M L Casini, E Mattei, L Braghiroli, G Mazzanti, C Panzironi, E Grippa, B Silvestrini. Inhibition of protein denaturation by fatty acids, bile salts and other natural substances: a new hypothesis for the mechanism of action of fish oil in rheumatic diseases.
Japanese journal of pharmacology.
1999 Jan; 79(1):89-99. doi:
10.1254/jjp.79.89. [PMID: 10082322] - C Zoja, D Corna, G Benedetti, M Morigi, R Donadelli, A Guglielmotti, M Pinza, T Bertani, G Remuzzi. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease.
Kidney international.
1998 Mar; 53(3):726-34. doi:
10.1046/j.1523-1755.1998.00804.x. [PMID: 9507220] - A Guglielmotti, L Aquilini, E D'Onofrio, M T Rosignoli, C Milanese, M Pinza. Bindarit prolongs survival and reduces renal damage in NZB/W lupus mice.
Clinical and experimental rheumatology.
1998 Mar; 16(2):149-54. doi:
NULL. [PMID: 9536390] - A Guglielmotti, B Silvestrini, L Saso, I Zwain, C Y Cheng. Chronic inflammatory response in the rat can be blocked by bindarit.
Biochemistry and molecular biology international.
1993 Mar; 29(4):747-56. doi:
NULL. [PMID: 7683947] - L Saso, B Silvestrini, I Zwain, A Guglielmotti, M R Luparini, V Cioli, C Y Cheng. Abnormal glycosylation of hemopexin in arthritic rats can be blocked by bindarit.
The Journal of rheumatology.
1992 Dec; 19(12):1859-67. doi:
NULL. [PMID: 1284132] - V Cioli, M G Ciarniello, A Guglielmotti, M R Luparini, L Durando, B Martinelli, B Catanese, L Fava, B Silvestrini. A new protein antidenaturant agent, bindarit, reduces secondary phase of adjuvant arthritis in rats.
The Journal of rheumatology.
1992 Nov; 19(11):1735-42. doi:
NULL. [PMID: 1491393]