Classification Term: 658

Benzoxazines (ontology term: CHEMONTID:0001396)

Organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom)." []

found 16 associated metabolites at class metabolite taxonomy ontology rank level.

Ancestor: Organoheterocyclic compounds

Child Taxonomies: Benzoxazinones, Phenoxazines

Efavirenz

6-Chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[D][1,3]oxazin-2-one

C14H9ClF3NO2 (315.027388)


Efavirenz (brand names Sustiva and Stocrin) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AG - Non-nucleoside reverse transcriptase inhibitors C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065689 - Cytochrome P-450 CYP2C19 Inhibitors D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065688 - Cytochrome P-450 CYP2C9 Inhibitors D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors D065693 - Cytochrome P-450 Enzyme Inducers > D065695 - Cytochrome P-450 CYP2B6 Inducers D065693 - Cytochrome P-450 Enzyme Inducers > D065701 - Cytochrome P-450 CYP3A Inducers D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors C254 - Anti-Infective Agent > C281 - Antiviral Agent CONFIDENCE standard compound; EAWAG_UCHEM_ID 3292 CONFIDENCE standard compound; INTERNAL_ID 8518

   

Avenalumin III

2-[(1Z,3E)-4-(4-hydroxyphenyl)buta-1,3-dien-1-yl]-4H-3,1-benzoxazin-4-one

C18H13NO3 (291.0895388)


Phytoalexin isolated from oat (Avena sativa) infected with rust fungus (Puccinia coronata). Avenalumin III is found in oat and cereals and cereal products. Avenalumin III is found in cereals and cereal products. Phytoalexin isolated from oat (Avena sativa) infected with rust fungus (Puccinia coronata).

   

Avenalumin II

2-[2-(3-Methoxyphenyl)ethenyl]-4H-3,1-benzoxazin-4-one, 9ci

C17H13NO3 (279.0895388)


Phytoalexin from oat (Avena sativa) infected with rust fungus Puccinia coronata. Avenalumin II is found in oat and cereals and cereal products. Avenalumin II is found in cereals and cereal products. Phytoalexin from oat (Avena sativa) infected with rust fungus Puccinia coronata.

   

(6-Amino-3,4-dihydro-2H-1,4-benzoxazin-3-yl)methanol

(6-Amino-3,4-dihydro-2H-1,4-benzoxazin-3-yl)methanol

C9H12N2O2 (180.0898732)


   

4h-Benzoxazine

4H-1,2-benzoxazine

C8H7NO (133.0527612)


   

8-Hydroxyefavirenz

6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-4H-3,1-benzoxazine-2,8-diol

C14H9ClF3NO3 (331.02230299999997)


   

8,14-Dihydroxyefavirenz

6-chloro-4-[2-(1-hydroxycyclopropyl)ethynyl]-4-(trifluoromethyl)-4H-3,1-benzoxazine-2,8-diol

C14H9ClF3NO4 (347.017218)


   

6-Amino-2-methyl-2H-1,3-benzoxazin-4(3H)-one

6-amino-2-methyl-3,4-dihydro-2H-1,3-benzoxazin-4-one

C9H10N2O2 (178.07422400000002)


   

Benzoxazine

2H-1,2-benzoxazine

C8H7NO (133.0527612)


   

Benzoxazine-6-carboxylic acid

2H-1,2-benzoxazine-6-carboxylic acid

C9H7NO3 (177.0425912)


   

Benzoxazinone

3,4-dihydro-2H-1,2-benzoxazin-3-one

C8H7NO2 (149.0476762)


   

2-Methyl-2H-1,3-benzoxazin-4(3H)-one

2-methyl-3,4-dihydro-2H-1,3-benzoxazin-4-one

C9H9NO2 (163.06332540000002)


   

Cetilistat

2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one

C25H39NO3 (401.29297840000004)


C471 - Enzyme Inhibitor > C29715 - Gastrointestinal Lipase Inhibitor D057847 - Lipid Regulating Agents D019440 - Anti-Obesity Agents D004791 - Enzyme Inhibitors

   

Etifoxine

6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine

C17H17ClN2O (300.1029342)


D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].

   

sinitrodil

2-(4-oxo-3,4-Dihydro-2H-1,3-benzoxazin-3-yl)ethyl nitric acid

C10H10N2O5 (238.058969)


   

7-Hydroxyefavirenz

6-chloro-4-(2-cyclopropylethynyl)-7-hydroxy-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one

C14H9ClF3NO3 (331.02230299999997)