Etifoxine (BioDeep_00000178922)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H17ClN2O (300.1029)
中文名称: 艾替伏辛
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CCN=C1NC2=C(C=C(C=C2)Cl)C(O1)(C)C3=CC=CC=C3
InChI: InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics
Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135272
- PubChem: 135413553
- PubChem: 30768
- HMDB: HMDB0252098
- DrugBank: DB08986
- ChEMBL: CHEMBL2106227
- Wikipedia: Etifoxine
- CAS: 21715-46-8
- medchemexpress: HY-16579A
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Khalid S Ibrahim, John A Craft, Lincoln Biswas, Janice Spencer, Xinhua Shu. Etifoxine reverses weight gain and alters the colonic bacterial community in a mouse model of obesity.
Biochemical pharmacology.
2020 10; 180(?):114151. doi:
10.1016/j.bcp.2020.114151. [PMID: 32679124] - Yu-Min Lin, Hung-Yu Sun, Wen-Tai Chiu, Hui-Chen Su, Yu-Chieh Chien, Heng-Ai Chang, Lee-Won Chong, Hung-Chuen Chang, Kung-Chia Young, Chyi-Huey Bai, Chiung-Wen Tsao. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.
BioMed research international.
2019; 2019(?):3102414. doi:
10.1155/2019/3102414. [PMID: 30984779] - Lincoln Biswas, Xinzhi Zhou, Baljean Dhillon, Annette Graham, Xinhua Shu. Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration.
Human molecular genetics.
2017 11; 26(22):4327-4339. doi:
10.1093/hmg/ddx319. [PMID: 28973423] - Philippe Liere, Antoine Pianos, Jean-Paul Oudinet, Michael Schumacher, Yvette Akwa. Differential effects of the 18-kDa translocator protein (TSPO) ligand etifoxine on steroidogenesis in rat brain, plasma and steroidogenic glands: Pharmacodynamic studies.
Psychoneuroendocrinology.
2017 Sep; 83(?):122-134. doi:
10.1016/j.psyneuen.2017.05.022. [PMID: 28609670] - Barbara Costa, Chiara Cavallini, Eleonora Da Pozzo, Sabrina Taliani, Federico Da Settimo, Claudia Martini. The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.
ACS chemical neuroscience.
2017 07; 8(7):1448-1454. doi:
10.1021/acschemneuro.7b00027. [PMID: 28362078] - Judith Cottin, Aurore Gouraud, Marie-Josèphe Jean-Pastor, Anne Disson- Dautriche, Charlène Boulay, Hélène Geniaux, Marine Auffret, Nathalie Bernard, Jacques Descotes, Thierry Vial. Safety profile of etifoxine: A French pharmacovigilance survey.
Fundamental & clinical pharmacology.
2016 Apr; 30(2):147-52. doi:
10.1111/fcp.12169. [PMID: 26588183] - Susanna J Fenwick, James P Scarth. In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control.
Drug testing and analysis.
2011 Oct; 3(10):705-16. doi:
10.1002/dta.300. [PMID: 21916022] - Marc Verleye, Sylvie Dumas, Isabelle Heulard, Nicolas Krafft, Jean-Marie Gillardin. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2011 Jun; 21(6):457-70. doi:
10.1016/j.euroneuro.2010.09.008. [PMID: 20943351] - Zheng Lin Zhao, Guang Wen Zhao, Hou Zhong Li, Xu Dong Yang, Yi Yan Wu, Feng Lin, Li Xin Guan, Feng Guo Zhai, Jia Qi Liu, Chae Ha Yang, Sang Chan Kim, Kee Won Kim, Rong Jie Zhao. Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):429843. doi:
10.1093/ecam/neq045. [PMID: 21869897] - François-Ludovic Sauvage, Nicolas Picard, Franck Saint-Marcoux, Jean-Michel Gaulier, Gérard Lachâtre, Pierre Marquet. General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints.
Journal of separation science.
2009 Sep; 32(18):3074-83. doi:
10.1002/jssc.200900092. [PMID: 19697309] - Marc Verleye, Yvette Akwa, Philippe Liere, Nathalie Ladurelle, Antoine Pianos, Bernard Eychenne, Michael Schumacher, Jean-Marie Gillardin. The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
Pharmacology, biochemistry, and behavior.
2005 Dec; 82(4):712-20. doi:
10.1016/j.pbb.2005.11.013. [PMID: 16388839]
