Benzoxazinone (BioDeep_00000176572)
human metabolite blood metabolite
代谢物信息卡片
3,4-dihydro-2H-1,2-benzoxazin-3-one
化学式: C8H7NO2 (149.0477)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 5.33%
分子结构信息
SMILES: C1C2=CC=CC=C2ONC1=O
InChI: InChI=1S/C8H7NO2/c10-8-5-6-3-1-2-4-7(6)11-9-8/h1-4H,5H2,(H,9,10)
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 19937448
- HMDB: HMDB0249036
- Wikipedia: Oxazines
- MeSH: Benzoxazines
- chemspider: 10619736
- CAS: 37204-63-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Waseem Mushtaq, Marie-Laure Fauconnier, Caroline de Clerck. Assessment of induced allelopathy in crop-weed co-culture with rye-pigweed model.
Scientific reports.
2024 05; 14(1):10446. doi:
10.1038/s41598-024-60663-w. [PMID: 38714777] - Jawameer R Hama, Inge S Fomsgaard, Olivera Topalović, Mette Vestergård. Root uptake of cereal benzoxazinoids grants resistance to root-knot nematode invasion in white clover.
Plant physiology and biochemistry : PPB.
2024 May; 210(?):108636. doi:
10.1016/j.plaphy.2024.108636. [PMID: 38657547] - Zixuan Cen, Bijie Hu, Siyin Yang, Guanglei Ma, Yiran Zheng, Yan Dong. Mechanism of benzoxazinoids affecting the growth and development of Fusarium oxysporum f. sp. fabae.
Plant molecular biology.
2024 Apr; 114(3):42. doi:
10.1007/s11103-024-01439-8. [PMID: 38630198] - Le Wang, Zhaobin Lei, Guanjie Zhang, Yang Cheng, Mingwei Zhong, Guangyong Zhang, Sanyuan Hu. Olodaterol promotes thermogenesis in brown adipocytes via regulation of the β2-AR/cAMP/PKA signaling pathway.
Biochemical and biophysical research communications.
2024 Apr; 703(?):149689. doi:
10.1016/j.bbrc.2024.149689. [PMID: 38382361] - Chunmei Wang, Xiaoli Yu, Yingchun Ke, Yanhua Fu, Yanhe Luo, Ying Li, Yanmei Bi, Xingqiong Chen, Linghua Li, Xiuhong Zhao, Zhong Chen. Efficacy and effect on lipid profiles of switching to ainuovirine-based regimen versus continuing efavirenz-based regimen in people with HIV-1: 24-week results from a real-world, retrospective, multi-center cohort study.
Antimicrobial agents and chemotherapy.
2024 Apr; 68(4):e0166823. doi:
10.1128/aac.01668-23. [PMID: 38483175] - Guanglei Ma, Bijie Hu, Siyin Yang, Zixuan Cen, Yiran Zheng, Yan Dong. Benzoxazinoids secreted by wheat root weaken the pathogenicity of Fusarium oxysporum f. sp. fabae by inhibiting linoleic acid and nucleotide metabolisms.
Plant cell reports.
2024 Apr; 43(4):109. doi:
10.1007/s00299-024-03188-w. [PMID: 38564014] - Veronica Caggìa, Jan Wälchli, Gabriel Deslandes-Hérold, Pierre Mateo, Christelle A M Robert, Hang Guan, Moritz Bigalke, Sandra Spielvogel, Adrien Mestrot, Klaus Schlaeppi, Matthias Erb. Root-exuded specialized metabolites reduce arsenic toxicity in maize.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Mar; 121(13):e2314261121. doi:
10.1073/pnas.2314261121. [PMID: 38513094] - Ethan Bass. Getting to the root of divergent outcomes in the modulation of plant-soil feedbacks by benzoxazinoids.
The New phytologist.
2024 Mar; 241(6):2316-2319. doi:
10.1111/nph.19545. [PMID: 38263679] - Valentin Gfeller, Lisa Thoenen, Matthias Erb. Root-exuded benzoxazinoids can alleviate negative plant-soil feedbacks.
The New phytologist.
2024 Mar; 241(6):2575-2588. doi:
10.1111/nph.19401. [PMID: 38087806] - Raufa Batool, Gou Xuelian, Dong Hui, Long Xiuzhen, Muhammad Jawad Umer, Ivan Rwomushana, Abid Ali, Kotb A Attia, Guo Jingfei, Wang Zhenying. Endophytic Fungi-Mediated Defense Signaling in Maize: Unraveling the Role of WRKY36 in Regulating Immunity against Spodoptera frugiperda.
Physiologia plantarum.
2024 Mar; 176(2):e14243. doi:
10.1111/ppl.14243. [PMID: 38467539] - Sylvain Sutour, Van Cong Doan, Pierre Mateo, Tobias Züst, Ella Raymonde Hartmann, Gaétan Glauser, Christelle Aurélie Maud Robert. Isolation and Structure Determination of Drought-Induced Multihexose Benzoxazinoids from Maize (Zea mays).
Journal of agricultural and food chemistry.
2024 Feb; 72(7):3427-3435. doi:
10.1021/acs.jafc.3c09141. [PMID: 38336361] - Huabin Zhang, Dan Mu, Yushan Li, Xilin Li, Xue Yan, Ke Li, Yanyang Jiao, Jiayu Li, Hongmei Lin, Wenxiong Lin, Changxun Fang. Glutathione S-transferase activity facilitates rice tolerance to the barnyard grass root exudate DIMBOA.
BMC plant biology.
2024 Feb; 24(1):117. doi:
10.1186/s12870-024-04802-5. [PMID: 38365588] - Chloe Orkin, Jean-Michel Molina, Pedro Cahn, Johannes Lombaard, Khuanchai Supparatpinyo, Sushma Kumar, Havilland Campbell, Hong Wan, Valerie Teal, Zhi Jin Xu, Ernest Asante-Appiah, Peter Sklar, Hedy Teppler, Rima Lahoulou. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials.
The lancet. HIV.
2024 Feb; 11(2):e75-e85. doi:
10.1016/s2352-3018(23)00258-8. [PMID: 38141637] - Abigail L Brewer, Claire E Felter, Anna R Sternitzky, Sade M Spencer. Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212-2.
Pharmacology, biochemistry, and behavior.
2024 Jan; ?(?):173707. doi:
10.1016/j.pbb.2024.173707. [PMID: 38244864] - Chunmei Yuan, Jiao Tian, Qing Zhou, Hui Xin, Yi Liu, Tianyu Deng, Wei Zeng, Zhilin Sun, Wei Xue. Myricetin derivatives containing the benzoxazinone moiety discovered as potential anti-tobacco mosaic virus agents.
Fitoterapia.
2023 Dec; 173(?):105812. doi:
10.1016/j.fitote.2023.105812. [PMID: 38168568] - Lisa Thoenen, Caitlin Giroud, Marco Kreuzer, Jan Waelchli, Valentin Gfeller, Gabriel Deslandes-Hérold, Pierre Mateo, Christelle A M Robert, Christian H Ahrens, Ignacio Rubio-Somoza, Rémy Bruggmann, Matthias Erb, Klaus Schlaeppi. Bacterial tolerance to host-exuded specialized metabolites structures the maize root microbiome.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Oct; 120(44):e2310134120. doi:
10.1073/pnas.2310134120. [PMID: 37878725] - Jinye Huang, Jun Li, Hui Chen, Chensi Shen, Yuezhong Wen. Phytotoxicity alleviation of imazethapyr to non-target plant wheat: active regulation between auxin and DIMBOA.
Environmental science and pollution research international.
2023 Oct; ?(?):. doi:
10.1007/s11356-023-30608-3. [PMID: 37897577] - Thi-Phuong Doan, Mi Zhang, Eun-Jin Park, Jorge-Eduardo Ponce-Zea, Van-Hieu Mai, Hyo-Moon Cho, Ha-Thanh-Tung Pham, Won-Keun Oh. Oxindole and Benzoxazinone Alkaloids from the Seeds of Persea americana (Avocado) and Their SIRT1 Stimulatory Activity.
Journal of natural products.
2023 10; 86(10):2270-2282. doi:
10.1021/acs.jnatprod.3c00214. [PMID: 37792632] - Matilde Florean, Katrin Luck, Benke Hong, Yoko Nakamura, Sarah E O'Connor, Tobias G Köllner. Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.
Proceedings of the National Academy of Sciences of the United States of America.
2023 10; 120(42):e2307981120. doi:
10.1073/pnas.2307981120. [PMID: 37812727] - Jingfei Guo, Shen Liu, Dapeng Jing, Kanglai He, Yongjun Zhang, Mingshun Li, Jinfeng Qi, Zhenying Wang. Genotypic variation in field-grown maize eliminates trade-offs between resistance, tolerance and growth in response to high pressure from the Asian corn borer.
Plant, cell & environment.
2023 10; 46(10):3072-3089. doi:
10.1111/pce.14458. [PMID: 36207806] - Valentin Gfeller, Jan Waelchli, Stephanie Pfister, Gabriel Deslandes-Hérold, Fabio Mascher, Gaetan Glauser, Yvo Aeby, Adrien Mestrot, Christelle A M Robert, Klaus Schlaeppi, Matthias Erb. Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field.
eLife.
2023 08; 12(?):. doi:
10.7554/elife.84988. [PMID: 37526647] - Vieites-Álvarez Yedra, Paz Otero, Miguel Angel Prieto, Jesus Simal-Gandara, Manuel J Reigosa, Adela M Sánchez-Moreiras, M Iftikhar Hussain. Testing the role of allelochemicals in different wheat cultivars to sustainably manage weeds.
Pest management science.
2023 Jul; 79(7):2625-2638. doi:
10.1002/ps.7444. [PMID: 36890109] - Josef J Gross, Pierre Mateo, Dietmar Ramhold, Ewald Kramer, Matthias Erb, Christelle A M Robert. Turnover of Benzoxazinoids during the Aerobic Deterioration of Maize Silage (Zea mays).
Journal of agricultural and food chemistry.
2023 Feb; 71(5):2370-2376. doi:
10.1021/acs.jafc.2c06699. [PMID: 36692976] - Adem Simsek, Oguz Karabay, Ertugrul Guclu, Hande Toptan. Comparison of Metabolic Effects of Three Different Treatment Combinations with Retrospective Real-life Data in People Living with HIV.
Current HIV research.
2023; 21(5):314-322. doi:
10.2174/011570162x266922231107094649. [PMID: 37990894] - Mohammed Jemal, Tewodros Shibabaw Molla, Markeshaw Tiruneh G Medhin, Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie. Blood glucose level and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based cART; a comparative cross-sectional study.
Annals of medicine.
2023; 55(2):2295435. doi:
10.1080/07853890.2023.2295435. [PMID: 38118463] - Christelle Aurélie Maud Robert, Pierre Mateo. The Chemical Ecology of Benzoxazinoids.
Chimia.
2022 Nov; 76(11):928-938. doi:
10.2533/chimia.2022.928. [PMID: 38069788] - Jawameer R Hama, Kourosh Hooshmand, Bente B Laursen, Mette Vestergård, Inge S Fomsgaard. Clover Root Uptake of Cereal Benzoxazinoids (BXs) Caused Accumulation of BXs and BX Transformation Products Concurrently with Substantial Increments in Clover Flavonoids and Abscisic Acid.
Journal of agricultural and food chemistry.
2022 Nov; 70(46):14633-14640. doi:
10.1021/acs.jafc.2c04715. [PMID: 36350751] - Canrong Ma, Ruoyue Li, Yan Sun, Mou Zhang, Sen Li, Yuxing Xu, Juan Song, Jing Li, Jinfeng Qi, Lei Wang, Jianqiang Wu. ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate.
Journal of integrative plant biology.
2022 Nov; ?(?):. doi:
10.1111/jipb.13404. [PMID: 36349965] - Liqin Sun, Yun He, Liumei Xu, Fang Zhao, Yang Zhou, Lukun Zhang, Qiaoli Peng, Haitao Zhang, Qiuyue Zhang, Tingzhi Cao, Ying Song, Siyuan Wang, Man Rao, Xinyun Jia, Xiaoning Liu, Jing Zhou, Bin Ju, Hui Wang, Jiaye Liu. Higher Risk of Dyslipidemia With Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide than Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate Among Antiretroviral-Naive People Living With HIV in China.
Journal of acquired immune deficiency syndromes (1999).
2022 10; 91(S1):S8-S15. doi:
10.1097/qai.0000000000003040. [PMID: 36094509] - Xixi Piao, Hanxiang Guo, Yizhong Cao, Zhe Wang, Chunde Jin. Exploration of multifunctional wood coating based on an interpenetrating network system of rosin-CO2-based polyurethane and mussel bionic rosin-based benzoxazine.
Journal of materials chemistry. B.
2022 09; 10(36):6939-6945. doi:
10.1039/d2tb01535h. [PMID: 36040715] - Elia Stahl. New insights into the transcriptional regulation of benzoxazinoid biosynthesis in wheat.
Journal of experimental botany.
2022 09; 73(16):5358-5360. doi:
10.1093/jxb/erac244. [PMID: 36095661] - Zhaniya S Batyrshina, Reut Shavit, Beery Yaakov, Samuel Bocobza, Vered Tzin. The transcription factor TaMYB31 regulates the benzoxazinoid biosynthetic pathway in wheat.
Journal of experimental botany.
2022 09; 73(16):5634-5649. doi:
10.1093/jxb/erac204. [PMID: 35554544] - Eva Knoch, Judit Kovács, Sebastian Deiber, Keisuke Tomita, Reshi Shanmuganathan, Núria Serra Serra, Kazunori Okada, Claude Becker, Niklas Schandry. Transcriptional response of a target plant to benzoxazinoid and diterpene allelochemicals highlights commonalities in detoxification.
BMC plant biology.
2022 Aug; 22(1):402. doi:
10.1186/s12870-022-03780-w. [PMID: 35974304] - Peng Wang, Lucas Dantas Lopes, Martha G Lopez-Guerrero, Karin van Dijk, Sophie Alvarez, Jean-Jack Riethoven, Daniel P Schachtman. Natural variation in root exudation of GABA and DIMBOA impacts the maize root endosphere and rhizosphere microbiomes.
Journal of experimental botany.
2022 08; 73(14):5052-5066. doi:
10.1093/jxb/erac202. [PMID: 35552399] - Meiyuan Ji, Huyen Bui, Ricardo A Ramirez, Richard M Clark. Concerted cis and trans effects underpin heightened defense gene expression in multi-herbivore-resistant maize lines.
The Plant journal : for cell and molecular biology.
2022 07; 111(2):508-528. doi:
10.1111/tpj.15812. [PMID: 35575017] - Haixu Liu, Tai An, Yifan Zhao, Xiuming Du, Xiangqi Bi, Zhuoqun Zhang, Yufei Chen, Jingzhi Wen. Benzoxazines in the Root Exudates Responsible for Nonhost Disease Resistance of Maize to Phytophthora sojae.
Phytopathology.
2022 Jul; 112(7):1537-1544. doi:
10.1094/phyto-12-21-0508-r. [PMID: 35113672] - Rohini Kharwade, Sachin More, Elizabeth Suresh, Amol Warokar, Nilesh Mahajan, Ujwala Mahajan. Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers.
AAPS PharmSciTech.
2022 Jun; 23(6):177. doi:
10.1208/s12249-022-02315-8. [PMID: 35750994] - Bhawana Israni, Katrin Luck, Samantha C W Römhild, Bettina Raguschke, Natalie Wielsch, Yvonne Hupfer, Michael Reichelt, Aleš Svatoš, Jonathan Gershenzon, Daniel Giddings Vassão. Alternative transcript splicing regulates UDP-glucosyltransferase-catalyzed detoxification of DIMBOA in the fall armyworm (Spodoptera frugiperda).
Scientific reports.
2022 06; 12(1):10343. doi:
10.1038/s41598-022-14551-w. [PMID: 35725775] - Zelalem Petros, Abiy Habtewold, Eyasu Makonnen, Eleni Aklillu. Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.
Scientific reports.
2022 06; 12(1):9698. doi:
10.1038/s41598-022-14032-0. [PMID: 35690682] - Cecilia M Shikuma, Thuy Le, Thao Vu Phuong, Glen M Chew, Van Vinh Chau Nguyen, Trieu Ly Vo, Chathura Siriwardhana, Dominic Chow, Hayk Ghukasyan, Nath Limpruttidham, Thomas Premeaux, Louie Mar Gangcuangco, Robert Paul, Lishomwa C Ndhlovu. Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam.
AIDS research and human retroviruses.
2022 06; 38(6):441-450. doi:
10.1089/aid.2021.0076. [PMID: 34861767] - M A Ortíz-Rodríguez, J Oaxaca-Navarro, S I Patiño-Camacho, S García-Jiménez, M Déciga-Campos, M F Martínez-Salazar. Plasma levels of efavirenz and frequency of the CYP2B6 516G>T polymorphism in people living with HIV-1 in Mexico.
Die Pharmazie.
2022 Jun; 77(6):191-195. doi:
10.1691/ph.2022.2382. [PMID: 35751161] - Lauren Jennings, Tracy Kellermann, Matthew Spinelli, Zukiswa Nkantsu, Dolphina Cogill, Marije van Schalkwyk, Eric Decloedt, Gert van Zyl, Catherine Orrell, Monica Gandhi. Drug Resistance, Rather than Low Tenofovir Levels in Blood or Urine, Is Associated with Tenofovir, Emtricitabine, and Efavirenz Failure in Resource-Limited Settings.
AIDS research and human retroviruses.
2022 06; 38(6):455-462. doi:
10.1089/aid.2021.0135. [PMID: 34779228] - Jinye Huang, Manxin Bao, Jun Li, Hui Chen, Dongmei Xu, Zunwei Chen, Yuezhong Wen. Enantioselective Response of Wheat Seedlings to Imazethapyr: From the Perspective of Fe and the Secondary Metabolite DIMBOA.
Journal of agricultural and food chemistry.
2022 May; 70(18):5516-5525. doi:
10.1021/acs.jafc.1c07727. [PMID: 35476430] - Dongya Wu, Bowen Jiang, Chu-Yu Ye, Michael P Timko, Longjiang Fan. Horizontal transfer and evolution of the biosynthetic gene cluster for benzoxazinoids in plants.
Plant communications.
2022 05; 3(3):100320. doi:
10.1016/j.xplc.2022.100320. [PMID: 35576160] - Xuesong Zhang, Tingzhi Huang, Qianchao Wang, Yirui Guo, Ping Zhang, Heng Xie, Junna Liu, Li Li, Chuanli Zhang, Peng Qin. Mechanisms of Resistance to Spot Blotch in Yunnan Iron Shell Wheat Based on Metabolome and Transcriptomics.
International journal of molecular sciences.
2022 May; 23(9):. doi:
10.3390/ijms23095184. [PMID: 35563578] - Monkgomotsi J Maseng, Leabaneng Tawe, Prisca K Thami, Sikhulile Moyo, Ishmael Kasvosve, Vladimir Novitsky, Max Essex, Gianluca Russo, Simani Gaseitsiwe, Giacomo M Paganotti. The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana.
Medicine.
2022 Apr; 101(17):e29066. doi:
10.1097/md.0000000000029066. [PMID: 35512066] - Jing Xiao, Jiang Xiao, Ying Liu, Bei Li, Leidan Zhang, Junyan Han, Hongxin Zhao. Efficacy and safety of Efavirenz 400 mg-based regimens switching from 600 mg-based regimens in people living with HIV with virological suppression in China: a randomized, open-label, non-inferiority study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Apr; 117(?):48-55. doi:
10.1016/j.ijid.2022.01.051. [PMID: 35108610] - Alba Angelina, Rodrigo Jiménez-Saiz, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares. Cannabinoid WIN55212-2 impairs peanut-allergic sensitization and promotes the generation of allergen-specific regulatory T cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2022 04; 52(4):540-549. doi:
10.1111/cea.14092. [PMID: 34995385] - Elise Nordin, Stine K Steffensen, Bente B Laursen, Sven-Olof Andersson, Jan-Erik Johansson, Per Åman, Göran Hallmans, Michael Borre, Dan Stærk, Kati Hanhineva, Inge S Fomsgaard, Rikard Landberg. An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method.
Scientific reports.
2022 03; 12(1):5260. doi:
10.1038/s41598-022-08856-z. [PMID: 35347164] - Reut Shavit, Zhaniya S Batyrshina, Beery Yaakov, Matilde Florean, Tobias G Köllner, Vered Tzin. The wheat dioxygenase BX6 is involved in the formation of benzoxazinoids in planta and contributes to plant defense against insect herbivores.
Plant science : an international journal of experimental plant biology.
2022 Mar; 316(?):111171. doi:
10.1016/j.plantsci.2021.111171. [PMID: 35151455] - Christiane Förster, Jonathan Gershenzon, Tobias G Köllner. Evolution of DIMBOA-Glc O-Methyltransferases from Flavonoid O-Methyltransferases in the Grasses.
Molecules (Basel, Switzerland).
2022 Feb; 27(3):. doi:
10.3390/molecules27031007. [PMID: 35164272] - Paniz Heydari, Wenlong Li, Alfred H Schinkel, Jos H Beijnen, Rolf W Sparidans. Development and validation of an LC-MS/MS assay for the quantification of cintirorgon (LYC-55716) in mouse plasma and tissue homogenates.
Journal of pharmaceutical and biomedical analysis.
2022 Jan; 207(?):114421. doi:
10.1016/j.jpba.2021.114421. [PMID: 34710729] - Wondmagegn Tamiru Tadesse, Birhanemeskel T Adankie, Workineh Shibeshi, Wondwossen Amogne, Eleni Aklillu, Ephrem Engidawork. Prevalence and predictors of glucose metabolism disorders among People Living with HIV on combination antiretroviral therapy.
PloS one.
2022; 17(1):e0262604. doi:
10.1371/journal.pone.0262604. [PMID: 35045105] - Meng-Jer Hsieh, Ning-Hung Chen, Shih-Lung Cheng, Chi-Wei Tao, Yu-Feng Wei, Yao-Kuang Wu, Ming-Cheng Chan, Shih-Feng Liu, Wu-Huei Hsu, Tsung-Ming Yang, Ming-Shian Lin, Ching-Lung Liu, Ping-Hung Kuo, Ying-Huang Tsai. Comparing Clinical Outcomes of Tiotropium/Olodaterol, Umeclidinium/Vilanterol, and Indacaterol/Glycopyrronium Fixed-Dose Combination Therapy in Patients with Chronic Obstructive Pulmonary Disease in Taiwan: A Multicenter Cohort Study.
International journal of chronic obstructive pulmonary disease.
2022; 17(?):967-976. doi:
10.2147/copd.s353799. [PMID: 35510163] - Zeynep Gizem Todurga Seven, Fatma Kubra Tombulturk, Selim Gokdemir, Sibel Ozyazgan. The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch.
International archives of allergy and immunology.
2022; 183(4):443-452. doi:
10.1159/000520509. [PMID: 34864727] - David W Haas, Rosie Mngqibisa, Jose Francis, Helen McIlleron, Jennifer A Robinson, Michelle A Kendall, Paxton Baker, Sajeeda Mawlana, Sharlaa Badal-Faesen, Francis Angira, Ayotunde Omoz-Oarhe, Wadzanai P Samaneka, Paolo Denti, Susan E Cohn. Pharmacogenetics of interaction between depot medroxyprogesterone acetate and efavirenz, rifampicin, and isoniazid during treatment of HIV and tuberculosis.
Pharmacogenetics and genomics.
2022 01; 32(1):24-30. doi:
10.1097/fpc.0000000000000448. [PMID: 34369424] - Chunran Zhou, Dong Li, Xinlei Shi, Jingbang Zhang, Quanshun An, Yangliu Wu, Lu Kang, Jia-Qi Li, Canping Pan. Nanoselenium Enhanced Wheat Resistance to Aphids by Regulating Biosynthesis of DIMBOA and Volatile Components.
Journal of agricultural and food chemistry.
2021 Dec; 69(47):14103-14114. doi:
10.1021/acs.jafc.1c05617. [PMID: 34784717] - Xian-Min Meng, Zi-Ran Li, Xin-Yin Zheng, Yi-Xi Liu, Wan-Jie Niu, Xiao-Yan Qiu, Hong-Zhou Lu. Effect of albumin and CYP2B6 polymorphisms on exposure of efavirenz: A population pharmacokinetic analysis in Chinese HIV-infected adults.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Dec; 167(?):105986. doi:
10.1016/j.ejps.2021.105986. [PMID: 34474119] - Aleksej Abramov, Thomas Hoffmann, Timo D Stark, Linlin Zheng, Stefan Lenk, Richard Hammerl, Tobias Lanzl, Corinna Dawid, Chris-Carolin Schön, Wilfried Schwab, Alfons Gierl, Monika Frey. Engineering of benzoxazinoid biosynthesis in Arabidopsis thaliana: Metabolic and physiological challenges.
Phytochemistry.
2021 Dec; 192(?):112947. doi:
10.1016/j.phytochem.2021.112947. [PMID: 34534712] - Selwyn J Hurwitz, Sijia Tao, Christina Gavegnano, Yong Jiang, Randall L Tressler, Athe Tsibris, Carlos Del Rio, Edgar T Overton, Michael M Lederman, Amy Kantor, Carlee Moser, James J Kohler, Jeffrey Lennox, Vincent C Marconi, Charles W Flexner, Raymond F Schinazi. Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study.
Journal of clinical pharmacology.
2021 12; 61(12):1555-1566. doi:
10.1002/jcph.1930. [PMID: 34169526] - Selma Cadot, Valentin Gfeller, Lingfei Hu, Nikhil Singh, Andrea Sánchez-Vallet, Gaétan Glauser, Daniel Croll, Matthias Erb, Marcel G A van der Heijden, Klaus Schlaeppi. Soil composition and plant genotype determine benzoxazinoid-mediated plant-soil feedbacks in cereals.
Plant, cell & environment.
2021 12; 44(12):3502-3514. doi:
10.1111/pce.14184. [PMID: 34505297] - Lisa M Frenkel, R Leavitt Morrison, Trevon L Fuller, Maria Isabel Gouvêa, Maria de Lourdes Benamor Teixeira, Robert W Coombs, David E Shapiro, Mark Mirochnick, Roslyn Hennessey, Kyle Whitson, Nahida Chakhtoura, Esaú C João. Brief Report: Vaginal Viral Shedding With Undetectable Plasma HIV Viral Load in Pregnant Women Receiving 2 Different Antiretroviral Regimens: A Randomized Clinical Trial.
Journal of acquired immune deficiency syndromes (1999).
2021 12; 88(4):361-365. doi:
10.1097/qai.0000000000002771. [PMID: 34369908] - Musa Otieno Ngayo, Margaret Oluka, Wallace Dimbuson Bulimo, Faith Apolot Okalebo. Association between social psychological status and efavirenz and nevirapine plasma concentration among HIV patients in Kenya.
Scientific reports.
2021 11; 11(1):22071. doi:
10.1038/s41598-021-01345-9. [PMID: 34764325] - Natália Bordin Andriguetti, Helena Katherina Van Schalkwyk, Daniel Thomas Barratt, Joseph Tucci, Paul Pumuye, Andrew Alexander Somogyi. Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele.
Clinical and translational science.
2021 11; 14(6):2521-2531. doi:
10.1111/cts.13120. [PMID: 34415664] - Lingfei Hu, Zhenwei Wu, Christelle A M Robert, Xiao Ouyang, Tobias Züst, Adrien Mestrot, Jianming Xu, Matthias Erb. Soil chemistry determines whether defensive plant secondary metabolites promote or suppress herbivore growth.
Proceedings of the National Academy of Sciences of the United States of America.
2021 10; 118(43):. doi:
10.1073/pnas.2109602118. [PMID: 34675080] - Huan Xia, Xiao-Jie Huang, Yue Hu, Li-Ying Gao, Yue Wu, Hao Wu, Zhong-Fang Yan, Ping Ma. Switching from efavirenz to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide reduces central nervous system symptoms in people living with HIV.
Chinese medical journal.
2021 Oct; 134(23):2850-2856. doi:
10.1097/cm9.0000000000001824. [PMID: 34653085] - Jessica Cusato, Massimo Tempestilli, Andrea Calcagno, Alessandra Vergori, Pierluca Piselli, Miriam Antonucci, Valeria Avataneo, Alice Palermiti, Stefania Notari, Andrea Antinori, Giovanni Di Perri, Chiara Agrati, Antonio D'Avolio. Vitamin D as Modulator of Drug Concentrations: A Study on Two Italian Cohorts of People Living with HIV Administered with Efavirenz.
Nutrients.
2021 Oct; 13(10):. doi:
10.3390/nu13103571. [PMID: 34684572] - Jesper Sundell, Emile Bienvenu, Angela Äbelö, Michael Ashton. Effect of efavirenz-based ART on the pharmacokinetics of rifampicin and its primary metabolite in patients coinfected with TB and HIV.
The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2950-2957. doi:
10.1093/jac/dkab258. [PMID: 34337654] - Gavin Bart, Le Minh Giang, Hoang Yen, James S Hodges, Richard C Brundage. Effect of HIV, antiretrovirals, and genetics on methadone pharmacokinetics: Results from the methadone antiretroviral pharmacokinetics study.
Drug and alcohol dependence.
2021 10; 227(?):109025. doi:
10.1016/j.drugalcdep.2021.109025. [PMID: 34482033] - Wangu Masenga, Giacomo Maria Paganotti, Kaelo Seatla, Simani Gaseitsiwe, Kwenga Sichilongo. A fast-screening dispersive liquid-liquid microextraction-gas chromatography-mass spectrometry method applied to the determination of efavirenz in human plasma samples.
Analytical and bioanalytical chemistry.
2021 Oct; 413(25):6401-6412. doi:
10.1007/s00216-021-03604-0. [PMID: 34557941] - Natália Bordin Andriguetti, Daniel T Barratt, Joseph Tucci, Paul Pumuye, Andrew A Somogyi. Instability of Efavirenz Metabolites Identified During Method Development and Validation.
Journal of pharmaceutical sciences.
2021 10; 110(10):3362-3366. doi:
10.1016/j.xphs.2021.06.028. [PMID: 34175301] - Wei-Chieh Huang, Chun-Kai Huang, Sung-Hsi Huang, Shu-Wen Lin, Shyh-Tyan Ou, Yi-Ting Chen, Ya-Wen Chen, Shu-Yuan Chang, Wen-Chun Liu, Hsin-Yun Sun, Chien-Ching Hung. Therapeutic drug monitoring study on the switch from coformulated 600-mg efavirenz, tenofovir disoproxil fumarate, and emtricitabine to coformulated 400-mg efavirenz, tenofovir disoproxil fumarate, and lamivudine among HIV-positive patients with viral suppression.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2021 Oct; 54(5):944-951. doi:
10.1016/j.jmii.2020.06.010. [PMID: 32675042] - Ngah Kuan Chow, Sabariah Noor Harun, E-Jinq Wong, Lee Lee Low, Siti Maisharah Sheikh Ghadzi, Amer Hayat Khan. The association between cigarette smoking and efavirenz plasma concentration using the population pharmacokinetic approach.
British journal of clinical pharmacology.
2021 10; 87(10):3756-3765. doi:
10.1111/bcp.14783. [PMID: 33608883] - Birgit E Watson, Kieran Atkinson, Kathleen Auyeung, Katherine A Baynes, Katherine J Lepik, Junine Toy, Paul Sereda, Rolando Barrios, Chanson J Brumme. Untimed Efavirenz Drug Levels After Switching From Brand to Generic Formulations: A Short Communication.
Therapeutic drug monitoring.
2021 10; 43(5):701-705. doi:
10.1097/ftd.0000000000000876. [PMID: 33560098] - Jacinta N Nwogu, Monica Gandhi, Andrew Owen, Saye H Khoo, Babafemi Taiwo, Adeniyi Olagunju, Baiba Berzins, Hideaki Okochi, Regina Tallerico, Kevin Robertson, Chinedum P Babalola. Associations between efavirenz concentrations, pharmacogenetics and neurocognitive performance in people living with HIV in Nigeria.
AIDS (London, England).
2021 10; 35(12):1919-1927. doi:
10.1097/qad.0000000000002984. [PMID: 34115651] - Jose Francis, Rosie Mngqibisa, Helen McIlleron, Michelle A Kendall, Xingye Wu, Kelly E Dooley, Cynthia Firnhaber, Catherine Godfrey, Susan E Cohn, Paolo Denti. A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment.
Clinical pharmacology and therapeutics.
2021 10; 110(4):1057-1065. doi:
10.1002/cpt.2324. [PMID: 34151439] - Fei Zhang, Jinfeng Wu, Nir Sade, Si Wu, Aiman Egbaria, Alisdair R Fernie, Jianbing Yan, Feng Qin, Wei Chen, Yariv Brotman, Mingqiu Dai. Genomic basis underlying the metabolome-mediated drought adaptation of maize.
Genome biology.
2021 09; 22(1):260. doi:
10.1186/s13059-021-02481-1. [PMID: 34488839] - Ken Ogasawara, Jeanelle Kam, Mark Thomas, Liangang Liu, Mary Liu, Yongjun Xue, Sekhar Surapaneni, Leonidas N Carayannopoulos, Simon Zhou, Maria Palmisano, Gopal Krishna. Effects of strong and moderate CYP3A4 inducers on the pharmacokinetics of fedratinib in healthy adult participants.
Cancer chemotherapy and pharmacology.
2021 09; 88(3):369-377. doi:
10.1007/s00280-021-04292-4. [PMID: 34019108] - Eleni Aklillu, Alimuddin Zumla, Abiy Habtewold, Wondwossen Amogne, Eyasu Makonnen, Getnet Yimer, Jürgen Burhenne, Ulf Diczfalusy. Early or deferred initiation of efavirenz during rifampicin-based TB therapy has no significant effect on CYP3A induction in TB-HIV infected patients.
British journal of pharmacology.
2021 08; 178(16):3294-3308. doi:
10.1111/bph.15309. [PMID: 33155675] - Thalita Martins da Silva, Thiago da Silva Honorio, Marcelo Henrique da Cunha Chaves, Marcelo Dutra Duque, Lucio Mendes Cabral, Beatriz Ferreira de Carvalho Patricio, Helvécio Vinícius Antunes Rocha. In silico bioavailability for BCS class II efavirenz tablets using biorelevant dissolution media for IVIVR and simulation of formulation changes.
Drug development and industrial pharmacy.
2021 Aug; 47(8):1342-1352. doi:
10.1080/03639045.2021.1991368. [PMID: 34622730] - Laura L Erwin, Mark R Nilges, Ian B Denys, Jane C Sutphen, Ashton J Friend, Daniel R Kapusta, Peter J Winsauer. Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Pharmacology, biochemistry, and behavior.
2021 08; 207(?):173218. doi:
10.1016/j.pbb.2021.173218. [PMID: 34118232] - Lucio Litti, Stefano Trivini, Davide Ferraro, Javier Reguera. 3D Printed Microfluidic Device for Magnetic Trapping and SERS Quantitative Evaluation of Environmental and Biomedical Analytes.
ACS applied materials & interfaces.
2021 Jul; 13(29):34752-34761. doi:
10.1021/acsami.1c09771. [PMID: 34256559] - Lirong Liu, Feng Liu, Yingjie Guan, Jianan Zou, Chunyun Zhang, Chongxiang Xiong, Ting C Zhao, George Bayliss, Xiaogang Li, Shougang Zhuang. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 07; 35(7):e21715. doi:
10.1096/fj.202000554rrr. [PMID: 34143514] - Ketan Mahajan, Satish Rojekar, Dipen Desai, Smita Kulkarni, Gandhali Bapat, Smita Zinjarde, Pradeep Vavia. Layer-by-Layer Assembled Nanostructured Lipid Carriers for CD-44 Receptor-Based Targeting in HIV-Infected Macrophages for Efficient HIV-1 Inhibition.
AAPS PharmSciTech.
2021 Jun; 22(5):171. doi:
10.1208/s12249-021-01981-4. [PMID: 34100170] - Wissam Bessa, Djalal Trache, Mehdi Derradji, Benaouda Bentoumia, Ahmed Fouzi Tarchoun, Larbi Hemmouche. Effect of silane modified microcrystalline cellulose on the curing kinetics, thermo-mechanical properties and thermal degradation of benzoxazine resin.
International journal of biological macromolecules.
2021 Jun; 180(?):194-202. doi:
10.1016/j.ijbiomac.2021.03.080. [PMID: 33737176] - Sung-Hsi Huang, Wei-Chieh Huang, Shu-Wen Lin, Yu-Chung Chuang, Hsin-Yun Sun, Sui-Yuan Chang, Po-Hsien Kuo, Pei-Ying Wu, Wen-Chun Liu, Chieh Chiang, Chien-Ching Hung, Shan-Chwen Chang. Impact of Efavirenz Mid-dose Plasma Concentration on Long-Term Weight Change Among Virologically Suppressed People Living With HIV.
Journal of acquired immune deficiency syndromes (1999).
2021 06; 87(2):834-841. doi:
10.1097/qai.0000000000002650. [PMID: 33587507] - Nathalie De Castro, Olivier Marcy, Corine Chazallon, Eugène Messou, Serge Eholié, Jean-Baptiste N'takpe, Nilesh Bhatt, Celso Khosa, Isabel Timana Massango, Didier Laureillard, Giang Do Chau, Anaïs Domergue, Valdilea Veloso, Rodrigo Escada, Sandra Wagner Cardoso, Constance Delaugerre, Xavier Anglaret, Jean-Michel Molina, Beatriz Grinsztejn. Standard dose raltegravir or efavirenz-based antiretroviral treatment for patients co-infected with HIV and tuberculosis (ANRS 12 300 Reflate TB 2): an open-label, non-inferiority, randomised, phase 3 trial.
The Lancet. Infectious diseases.
2021 06; 21(6):813-822. doi:
10.1016/s1473-3099(20)30869-0. [PMID: 33667406] - Selma Cadot, Hang Guan, Moritz Bigalke, Jean-Claude Walser, Georg Jander, Matthias Erb, Marcel G A van der Heijden, Klaus Schlaeppi. Specific and conserved patterns of microbiota-structuring by maize benzoxazinoids in the field.
Microbiome.
2021 05; 9(1):103. doi:
10.1186/s40168-021-01049-2. [PMID: 33962687] - Ulrike Mathesius, Sofia R Costa. Plant signals differentially affect rhizosphere nematode populations.
Journal of experimental botany.
2021 05; 72(10):3496-3499. doi:
10.1093/jxb/erab149. [PMID: 33948654] - Md Maniruzzaman Sikder, Mette Vestergård, Tina Kyndt, Inge S Fomsgaard, Enoch Narh Kudjordjie, Mogens Nicolaisen. Benzoxazinoids selectively affect maize root-associated nematode taxa.
Journal of experimental botany.
2021 05; 72(10):3835-3845. doi:
10.1093/jxb/erab104. [PMID: 33712814] - Danilo César Galindo Bedor, Noely Camila Tavares Cavalcanti Bedor, João Gomes Pontes Neto, Lucas José de Alencar Danda, Flávio Martins de Oliveira, Guilherme Henrique Onório de Oliveira, José Lamartine Soares Sobrinho, Eric Beyssac, Whocely Victor de Castro, Davi Pereira de Santana. Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials.
Drug development and industrial pharmacy.
2021 May; 47(5):725-734. doi:
10.1080/03639045.2021.1934860. [PMID: 34038291] - Bina Bhattarai, Stine K Steffensen, Per L Gregersen, Hanne L Kristensen, Inge S Fomsgaard. Stepwise mass spectrometry-based approach for confirming the presence of benzoxazinoids in herbs and vegetables.
Phytochemical analysis : PCA.
2021 May; 32(3):283-297. doi:
10.1002/pca.2973. [PMID: 32688439] - Chenai Sheilla Mutiti, Nyasha Nicole Kapungu, Comfort Ropafadzo Kanji, Nadina Stadler, Julia Stingl, Charles Nhachi, James Hakim, Collen Masimirembwa, Roslyn Stella Thelingwani. Clinically relevant enantiomer specific R- and S-praziquantel pharmacokinetic drug-drug interactions with efavirenz and ritonavir.
Pharmacology research & perspectives.
2021 05; 9(3):e00769. doi:
10.1002/prp2.769. [PMID: 33929078] - Monika Rakoczy-Trojanowska, Bartosz M Szabała, Elżbieta Różańska, Mariusz Kowalczyk, Wojciech Burza, Beata Bakera, Magdalena Święcicka. The Roots of Rye (Secale cereale L.) Are Capable of Synthesizing Benzoxazinoids.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094656. [PMID: 33925031] - Kamunkhwala Gausi, Lubbe Wiesner, Jennifer Norman, Carole L Wallis, Carolyne Onyango-Makumbi, Tsungai Chipato, David W Haas, Renee Browning, Nahida Chakhtoura, Grace Montepiedra, Lisa Aaron, Katie McCarthy, Sarah Bradford, Tichaona Vhembo, Lynda Stranix-Chibanda, Gaerolwe R Masheto, Avy Violari, Blandina T Mmbaga, Linda Aurpibul, Ramesh Bhosale, Neetal Nevrekhar, Vanessa Rouzier, Enid Kabugho, Mercy Mutambanengwe, Vongai Chanaiwa, Mandisa Nyati, Tsungai Mhembere, Fuanglada Tongprasert, Anneke Hesseling, Katherine Shin, Bonnie Zimmer, Diane Costello, Patrick Jean-Philippe, Timothy R Sterling, Gerhard Theron, Adriana Weinberg, Amita Gupta, Paolo Denti. Pharmacokinetics and Drug-Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping.
Clinical pharmacology and therapeutics.
2021 04; 109(4):1034-1044. doi:
10.1002/cpt.2044. [PMID: 32909316] - Annett Richter, Adrian F Powell, Mahdieh Mirzaei, Lucy J Wang, Navid Movahed, Julia K Miller, Miguel A Piñeros, Georg Jander. Indole-3-glycerolphosphate synthase, a branchpoint for the biosynthesis of tryptophan, indole, and benzoxazinoids in maize.
The Plant journal : for cell and molecular biology.
2021 04; 106(1):245-257. doi:
10.1111/tpj.15163. [PMID: 33458870] - Angela Shogbon Nwaesei, Pamela M Moye-Dickerson, Robin Henry Dretler. Efavirenz-Induced Vanishing Bile Duct Syndrome: A Case Report.
Journal of pharmacy practice.
2021 Apr; 34(2):319-324. doi:
10.1177/0897190019868358. [PMID: 31451051] - Mark Nelson, Alan Winston, Andrew Hill, Rosie Mngqibisa, Ayesha Bassa, Chloe Orkin, Mohammed Rassool, Anthony Rodgers, Valerie Teal, Sushma Kumar, Hedy Teppler. Efficacy, safety and central nervous system effects after switch from efavirenz/tenofovir/emtricitabine to doravirine/tenofovir/lamivudine.
AIDS (London, England).
2021 04; 35(5):759-767. doi:
10.1097/qad.0000000000002804. [PMID: 33587439] - Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M Schaetzl, Sabine Gilch. Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Acta neuropathologica communications.
2021 04; 9(1):58. doi:
10.1186/s40478-021-01162-1. [PMID: 33795005]
