Classification Term: 3338

Phenylhydrazines (ontology term: CHEMONTID:0000113)

Compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group." []

found 21 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Benzene and substituted derivatives

Child Taxonomies: There is no child term of current ontology term.

N-NITROSODIPHENYLAMINE

N-Nitrosodiphenylamine, 14C-labeled

C12H10N2O (198.0793)


CONFIDENCE standard compound; EAWAG_UCHEM_ID 3355 D009676 - Noxae > D002273 - Carcinogens

   

1,5-Diphenylcarbazide

1,5-Diphenylcarbohydrazide

C13H14N4O (242.1168)


D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents KEIO_ID D166; [MS2] KO009100 KEIO_ID D166

   

Phenylhydrazine

Phenylhydrazine monohydrochloride

C6H8N2 (108.0687)


Phenylhydrazine, also known as hydrazinobenzene or phenyldiazane, is a member of the class of compounds known as phenylhydrazines. Phenylhydrazines are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group. Phenylhydrazine is soluble (in water) and a very strong basic compound (based on its pKa). Phenylhydrazine can be found in sweet bay, which makes phenylhydrazine a potential biomarker for the consumption of this food product. Phenylhydrazine is the chemical compound with the formula C6H5NHNH2. It is often abbreviated as PhNHNH2 . D009676 - Noxae > D016877 - Oxidants

   

(3-Chlorophenyl)hydrazonomalononitrile

N-(3-chlorophenyl)-1-cyanomethanecarbohydrazonoyl cyanide

C9H5ClN4 (204.0203)


CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4918; ORIGINAL_PRECURSOR_SCAN_NO 4915 CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4931; ORIGINAL_PRECURSOR_SCAN_NO 4927 CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4927; ORIGINAL_PRECURSOR_SCAN_NO 4924 CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4922; ORIGINAL_PRECURSOR_SCAN_NO 4921 CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4919; ORIGINAL_PRECURSOR_SCAN_NO 4914 CONFIDENCE standard compound; INTERNAL_ID 675; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4898; ORIGINAL_PRECURSOR_SCAN_NO 4893 CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

   

Diminazene

4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide

C14H15N7 (281.1389)


D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

   

Levosimendan

1-cyano-N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}methanecarbohydrazonoyl cyanide

C14H12N6O (280.1073)


Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. It also has a vasodilatory effect, by opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle to cause smooth muscle relaxation. D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents

   

(3-Chlorophenyl)hydrazine

(3-chlorophenyl)hydrazine

C6H7ClN2 (142.0298)


   

1-Acetyl-2-phenylhydrazine

Acetic acid n-phenyl-hydrazide

C8H10N2O (150.0793)


   

2,4,6-Trichlorophenylhydrazine

2,4,6-Trichlorophenylhydrazine sulfate (1:1) salt

C6H5Cl3N2 (209.9518)


   

3-Chlorophenylhydrazone

(3-chlorophenyl)-lambda4-diazyne

C6H5ClN2 (140.0141)


   

3,4-Dephostatin, Ethyl-

4-[ethyl(nitroso)amino]benzene-1,2-diol

C8H10N2O3 (182.0691)


   

Ambazone

[(4-{[(diaminomethylidene)amino]amino}phenyl)imino]thiourea

C8H11N7S (237.0797)


   
   

Dithizone

N-(phenylamino)-N-(phenylimino)carbamimidothioate

C13H12N4S (256.0783)


   

Carbonyl cyanide p-trifluoromethoxyphenylhydrazone

1-cyano-N-[4-(trifluoromethoxy)phenyl]methanecarbohydrazonoyl cyanide

C10H5F3N4O (254.0415)


D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents D007476 - Ionophores > D061209 - Proton Ionophores D049990 - Membrane Transport Modulators FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

   

N-Nitroaniline

benzenamine, N-nitro-

C6H6N2O2 (138.0429)


   

Pentafluorophenylhydrazine

(2,3,4,5,6-pentafluorophenyl)hydrazine

C6H3F5N2 (198.0216)


   

N',N'-Diphenylhydrazinecarbohydrazide

N-amino-N-(diphenylamino)carbamimidate

C13H14N4O (242.1168)


   

N-Nitramido-N-phenylnitramide

1,2-dinitro-1-phenylhydrazine

C6H6N4O4 (198.0389)


   

Simendan

1-cyano-N-[4-(6-hydroxy-4-methyl-4,5-dihydropyridazin-3-yl)phenyl]methanecarbohydrazonoyl cyanide

C14H12N6O (280.1073)


D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D020011 - Protective Agents > D002316 - Cardiotonic Agents

   

Salicyaldehyde

(6E)-6-[(2-phenylhydrazin-1-yl)methylidene]cyclohexa-2,4-dien-1-one

C13H12N2O (212.095)


Salicyaldehyde, also known as salicylaldehyde phenylhydrazone, is a member of the class of compounds known as phenylhydrazines. Phenylhydrazines are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group. Salicyaldehyde is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Salicyaldehyde can be found in chinese cinnamon, which makes salicyaldehyde a potential biomarker for the consumption of this food product.