Diminazene (BioDeep_00000012254)
Secondary id: BioDeep_00001868551
human metabolite blood metabolite
代谢物信息卡片
4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide
化学式: C14H15N7 (281.138887)
中文名称: 三氮脒
谱图信息:
最多检出来源 Homo sapiens(blood) 96.55%
分子结构信息
SMILES: C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N
InChI: InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:81724
- KEGG: C18388
- PubChem: 2354
- HMDB: HMDB0251412
- Metlin: METLIN72197
- DrugBank: DB03608
- ChEMBL: CHEMBL35241
- Wikipedia: Diminazen
- MeSH: Diminazene
- chemspider: 2264
- CAS: 1443105-71-2
- CAS: 536-71-0
- PMhub: MS000026553
- PubChem: 124489062
- PDB-CCD: BRN
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Betelhem Sirak, Gizachew Kassahun Bizuneh, Peter Imming, Kaleab Asres. In vitro and in vivo antitrypanosomal activity of the fresh leaves of Ranunculus Multifidus Forsk and its major compound anemonin against Trypanosoma congolense field isolate.
BMC veterinary research.
2024 Jan; 20(1):32. doi:
10.1186/s12917-023-03856-1. [PMID: 38279149] - Thomas Boehm, Marion Alix, Karin Petroczi, Serhii Vakal, Elisabeth Gludovacz, Nicole Borth, Tiina A Salminen, Bernd Jilma. Nafamostat is a Potent Human Diamine Oxidase Inhibitor Possibly Augmenting Hypersensitivity Reactions during Nafamostat Administration.
The Journal of pharmacology and experimental therapeutics.
2022 08; 382(2):113-122. doi:
10.1124/jpet.122.001248. [PMID: 35688477] - Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du, Guoxing Wang. Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model.
BMC pharmacology & toxicology.
2022 07; 23(1):44. doi:
10.1186/s40360-022-00584-4. [PMID: 35787308] - Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukla. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease.
ACS chemical neuroscience.
2022 05; 13(10):1491-1504. doi:
10.1021/acschemneuro.1c00797. [PMID: 35533351] - Shengwei Ji, Mingming Liu, Eloiza May Galon, Mohamed Abdo Rizk, Jixu Li, Yongchang Li, Iqra Zafar, Ikuo Igarashi, Xuenan Xuan. In vitro screening of novel anti-Babesia gibsoni drugs from natural products.
Parasitology international.
2021 Dec; 85(?):102437. doi:
10.1016/j.parint.2021.102437. [PMID: 34389492] - Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Magdalena Białas, Magdalena Łomnicka, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Giżycka, Jacek Jawień, Rafał Olszanecki. Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115861. [PMID: 34070749] - Hanzhao Zhu, Liyun Zhang, Yubo Ma, Mengen Zhai, Lin Xia, Jincheng Liu, Shiqiang Yu, Weixun Duan. The role of SARS-CoV-2 target ACE2 in cardiovascular diseases.
Journal of cellular and molecular medicine.
2021 02; 25(3):1342-1349. doi:
10.1111/jcmm.16239. [PMID: 33443816] - Tatiane Cristine Silva de Almeida, Katharina Lanza, Roberta da Silva Filha, Leda Maria de Castro C Campos, Esdras G Fonseca, Mariana W Chagas, Natalia Pessoa Rocha, Marcos Augusto de Sá, Maria Aparecida Ribeiro Vieira, Marcelo Vidigal Caliari, Lucas M Kangussu, Anderson José Ferreira, Ana Cristina Simões E Silva. ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats.
Clinical science (London, England : 1979).
2020 12; 134(23):3093-3106. doi:
10.1042/cs20201022. [PMID: 33206153] - Nisha Sharma, Anil Bhanudas Gaikwad. Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103501. doi:
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Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.01372-20. [PMID: 32816737] - Tawar Qaradakhi, Laura Gadanec, John Matsoukas, Vasso Apostolopoulos, Anthony Zulli. Could DIZE be the answer to COVID-19?.
Maturitas.
2020 10; 140(?):83-84. doi:
10.1016/j.maturitas.2020.07.002. [PMID: 32636103] - Thaiany G Souza-Silva, Diego F Vilas-Boas, Elda Gonçalves-Santos, Ana Lia Mazzeti, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Life sciences.
2020 Sep; 257(?):118067. doi:
10.1016/j.lfs.2020.118067. [PMID: 32652140] - Nisha Sharma, Anil Bhanudas Gaikwad. Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2.
European journal of pharmacology.
2020 Sep; 882(?):173241. doi:
10.1016/j.ejphar.2020.173241. [PMID: 32565336] - George Mihai Nitulescu, Horia Paunescu, Sterghios A Moschos, Dimitrios Petrakis, Georgiana Nitulescu, George Nicolae Daniel Ion, Demetrios A Spandidos, Taxiarchis Konstantinos Nikolouzakis, Nikolaos Drakoulis, Aristidis Tsatsakis. Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review).
International journal of molecular medicine.
2020 Aug; 46(2):467-488. doi:
10.3892/ijmm.2020.4608. [PMID: 32468014] - Hesham Farouk Hasan, Eman M Elgazzar, Dalia M Mostafa. Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Life sciences.
2020 Jul; 253(?):117749. doi:
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Tropical animal health and production.
2020 Jul; 52(4):1699-1705. doi:
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PloS one.
2020; 15(2):e0228996. doi:
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International journal of medical sciences.
2020; 17(16):2594-2602. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2019 12; 42(12):1883-1893. doi:
10.1038/s41440-019-0321-8. [PMID: 31506648] - Vajir Malek, Nisha Sharma, Anil Bhanudas Gaikwad. Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy.
Pharmacological reports : PR.
2019 Oct; 71(5):958-967. doi:
10.1016/j.pharep.2019.05.008. [PMID: 31470292] - Vajir Malek, Nisha Sharma, Himanshu Sankrityayan, Anil Bhanudas Gaikwad. Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.
Life sciences.
2019 Mar; 221(?):159-167. doi:
10.1016/j.lfs.2019.02.027. [PMID: 30769114] - Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Naoaki Yokoyama, Ikuo Igarashi. Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.
Parasites & vectors.
2019 Jan; 12(1):37. doi:
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Protein and peptide letters.
2019; 26(7):523-531. doi:
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Neuropharmacology.
2018 05; 133(?):85-93. doi:
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European journal of medicinal chemistry.
2018 Apr; 150(?):385-402. doi:
10.1016/j.ejmech.2018.02.075. [PMID: 29544150] - Azirwan Guswanto, Arifin Budiman Nugraha, Bumduuren Tuvshintulga, Dickson Stuart Tayebwa, Mohamed Abdo Rizk, Gaber El-Saber Batiha, Sambuu Gantuya, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi. 17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.
International journal for parasitology. Drugs and drug resistance.
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Parasitology.
2018 03; 145(3):371-377. doi:
10.1017/s0031182017001585. [PMID: 28942737] - Pu Ge, Xin Yao, Jing Li, Rong Jiang, Jie Dai, Li Zhang. Diminazene aceturate alleviated lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Feb; 98(?):142-148. doi:
10.1016/j.biopha.2017.12.034. [PMID: 29253761] - Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Anuradha Pandey, Nisha Sharma, Anil Bhanudas Gaikwad. Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes.
British journal of pharmacology.
2017 Sep; 174(18):3118-3130. doi:
10.1111/bph.13946. [PMID: 28688122] - Maxwell W Waema, Naomi W Maina, Maina Ngotho, Simon M Karanja, Beatrice M Gachie, Dawn N Maranga, John M Kagira. IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis.
Acta tropica.
2017 Apr; 168(?):45-49. doi:
10.1016/j.actatropica.2017.01.012. [PMID: 28099874] - Luan Kelves M Souza, Lucas A D Nicolau, Nayara A Sousa, Thiago S L Araújo, Francisca Beatriz M Sousa, Douglas S Costa, Fabiana M Souza, Dvison M Pacífico, Conceição S Martins, Renan O Silva, Marcellus H L P Souza, Gilberto S Cerqueira, Jand Venes R Medeiros. Diminazene aceturate, an angiotensin-converting enzyme II activator, prevents gastric mucosal damage in mice: Role of the angiotensin-(1-7)/Mas receptor axis.
Biochemical pharmacology.
2016 07; 112(?):50-9. doi:
10.1016/j.bcp.2016.05.010. [PMID: 27241079] - Matheus D Baldissera, Ricardo A Gonçalves, Michele R Sagrillo, Thirssa H Grando, Camila S Ritter, Fabielly S Grotto, Gerson F Brum, Sônia C A da Luz, Sergio O Silveira, Viviane P Fausto, Aline A Boligon, Rodrigo A Vaucher, Lenita M Stefani, Aleksandro S da Silva, Carine F Souza, Silvia G Monteiro. Effects of treatment with the anti-parasitic drug diminazene aceturate on antioxidant enzymes in rat liver and kidney.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Apr; 389(4):429-38. doi:
10.1007/s00210-016-1212-z. [PMID: 26809354] - Zuzana Husková, Libor Kopkan, Lenka Červenková, Šárka Doleželová, Zdeňka Vaňourková, Petra Škaroupková, Akira Nishiyama, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Herbert J Kramer, Luděk Červenka. Intrarenal alterations of the angiotensin-converting enzyme type 2/angiotensin 1-7 complex of the renin-angiotensin system do not alter the course of malignant hypertension in Cyp1a1-Ren-2 transgenic rats.
Clinical and experimental pharmacology & physiology.
2016 Apr; 43(4):438-49. doi:
10.1111/1440-1681.12553. [PMID: 26833491] - Elena Velkoska, Sheila K Patel, Karen Griggs, Louise M Burrell. Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease.
PloS one.
2016; 11(8):e0161760. doi:
10.1371/journal.pone.0161760. [PMID: 27571511] - Rodrigo A Fraga-Silva, Fabiana P Costa-Fraga, Fabrizio Montecucco, Mikael Sturny, Younoss Faye, François Mach, Graziano Pelli, Vinayak Shenoy, Rafaela F da Silva, Mohan K Raizada, Robson A S Santos, Nikolaos Stergiopulos. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.
The journal of sexual medicine.
2015 Feb; 12(2):289-302. doi:
10.1111/jsm.12757. [PMID: 25411084] - Guilherme M Do Carmo, Matheus D Baldissera, Rodrigo A Vaucher, Virginia Cielo Rech, Camila B Oliveira, Michele Rorato Sagrillo, Aline A Boligon, Margareth L Athayde, Marta P Alves, Raqueli T França, Sonia T A Lopes, Claiton I Schwertz, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silva. Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi.
Experimental parasitology.
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Protein and peptide letters.
2015; 22(4):332-40. doi:
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PloS one.
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Die Pharmazie.
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Arteriosclerosis, thrombosis, and vascular biology.
2014 Dec; 34(12):2617-23. doi:
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Pathology, research and practice.
2014 Dec; 210(12):840-6. doi:
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Hypertension (Dallas, Tex. : 1979).
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BMC complementary and alternative medicine.
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Research in veterinary science.
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Tropical animal health and production.
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Anti-cancer agents in medicinal chemistry.
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Veterinary parasitology.
2013 Sep; 196(3-4):283-8. doi:
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Journal of agricultural and food chemistry.
2013 Aug; 61(34):8034-8. doi:
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Experimental parasitology.
2013 Jul; 134(3):356-61. doi:
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Veterinary parasitology.
2012 Dec; 190(3-4):368-74. doi:
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Journal of veterinary internal medicine.
2012 Nov; 26(6):1490-3. doi:
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Neotropical entomology.
2012 Oct; 41(5):420-5. doi:
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