Classification Term: 175

Morpholines (ontology term: CHEMONTID:0000392)

Organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively." []

found 21 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Oxazinanes

Child Taxonomies: Phenylmorpholines, Benzomorpholines, Morpholine carboxylic acids and derivatives, 2,5-disubstituted morpholines

Tridemorph

2,6-Dimethyl-N-tridecyl-morpholine

C19H39NO (297.3031484)


Systemic eradicant cereal fungicide Tridemorph is a fungicide. It was developed in the 1960s by the German multinational BASF who sell tridemorph under the trade name Calixin. It is used to control the fungus Erysiphe graminis in cereals, Mycosphaerella species in bananas, and Caticum solmonicolor in tea. Tridemorph is applied onto many crops across the world, but very little data on usage and production is in the public domain. In high doses it has been shown to have teratogenic effects. These effect are manifested in edemas, hemorrhages, hematomas, abnormal development of the brain (hydrocephalia), visceral cranium (micrognathia, cleft palate) and genitourinary system (hydronephrosis), in decreased size of pelvic bones, shoulder girdle, front and hind limbs, etc. (PMID 7324433

   

N-NITROSOMORPHOLINE

alpha-Acetoxy-N-nitrosomorpholine

C4H8N2O2 (116.0585748)


CONFIDENCE standard compound; EAWAG_UCHEM_ID 3454 CONFIDENCE standard compound; INTERNAL_ID 4127 CONFIDENCE standard compound; INTERNAL_ID 8689 D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D009153 - Mutagens

   

Morpholine

Morpholine, 4-soya alkyl derivs.

C4H9NO (87.0684104)


Morpholine is a permitted (FDA) in edible coatings for fruit and vegetables. Morpholine is a food contaminant arising from its use as a boiler water additive Morpholine is a common additive, in ppm concentrations, for pH adjustment in both fossil fuel and nuclear power plant steam systems. Morpholine is used because its volatility is about the same as water, so once it is added to the water, its concentration becomes distributed rather evenly in both the water and steam phases. Its pH adjusting qualities then become distributed throughout the steam plant to provide corrosion protection. Morpholine is often used in conjunction with low concentrations of hydrazine or ammonia to provide a comprehensive all-volatile treatment chemistry for corrosion protection for the steam systems of such plants. Morpholine decomposes reasonably slowly in the absence of oxygen even at the high temperatures and pressures in these steam systems. Morpholine is an organic chemical compound having the chemical formula O(CH2CH2)2NH. This heterocycle, pictured at right, features both amine and ether functional groups. Because of the amine, morpholine is a base; its conjugate acid is called morpholinium. For example, when morpholine is neutralized by hydrochloric acid, one obtains the salt morpholinium chloride. Morpholine is widely used in organic synthesis. For example, it is a building block in the preparation of the antibiotic linezolid and the anticancer agent gefitinib (Iressa) Permitted (FDA) in edible coatings for fruit and vegetables. Food contaminant arising from its use as a boiler water additive CONFIDENCE standard compound; INTERNAL_ID 8365

   

Tiotropium

(1R,2S,4R,5S)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-ium

C19H22NO4S2+ (392.09901920000004)


Tiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.

   

N-(2-Hydroxyethyl)-morpholine

N-(2-Hydroxyethyl)-morpholine

C6H13NO2 (131.0946238)


N-(2-Hydroxyethyl)-morpholine is a metabolite of mycophenolate mofetil. Mycophenolate mofetil (MMF) (brand names CellCept, Myfortic) is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis which is necessary for the growth of T cells and B cells. Other cells are able to recover purines via a separate, scavenger, pathway and are, thus, able to escape the effect. MMF is a less toxic alternative to azathioprine. (Wikipedia)

   

N-(2-Hydroxyethyl)-morpholine N-oxide

N-(2-Hydroxyethyl)-morpholine N-oxide

C6H13NO3 (147.0895388)


N-(2-Hydroxyethyl)-morpholine N-oxide is a metabolite of mycophenolate mofetil. Mycophenolate mofetil (MMF) (brand names CellCept, Myfortic) is an immunosuppressant and prodrug of mycophenolic acid, used extensively in transplant medicine. It is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis which is necessary for the growth of T cells and B cells. Other cells are able to recover purines via a separate, scavenger, pathway and are, thus, able to escape the effect. MMF is a less toxic alternative to azathioprine. (Wikipedia)

   

1-Deoxy-1-morpholino-D-fructose

3,4,5,6-tetrahydroxy-1-(morpholin-4-yl)hexan-2-one

C10H19NO6 (249.1212314)


   

(3S,4R,5R)-1,3,4,5,6-Pentahydroxy-1-morpholin-4-ylhexan-2-one

(3S,4R,5R)-1,3,4,5,6-Pentahydroxy-1-morpholin-4-ylhexan-2-one

C10H19NO7 (265.1161464)


   

2-(4-Morpholinyl)ethyl

2-(morpholin-4-yl)ethyl

C6H12NO (114.0918842)


   

1-Ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate

5-[(ethoxycarbonyl)azanidyl]-3-(morpholin-4-yl)-1,2,3λ⁵-oxadiazol-3-ylium

C9H14N4O4 (242.1015004)


C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

   

2-(N-Morpholino)-ethanesulfonic acid

2-(N-Morpholino)ethanesulfonic acid, sodium salt

C6H13NO4S (195.0565258)


COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

4-(3-Hydroxypropyl)morpholine

3-(morpholin-4-yl)propan-1-ol

C7H15NO2 (145.110273)


   

Delmopinol

2-[3-(4-propylheptyl)morpholin-4-yl]ethan-1-ol

C16H33NO2 (271.2511158)


D003358 - Cosmetics > D009067 - Mouthwashes D001697 - Biomedical and Dental Materials D013501 - Surface-Active Agents

   

Linsidomine

5-azanidyl-3-(morpholin-4-yl)-1,2,3lambda5-oxadiazol-3-ylium

C6H10N4O2 (170.080372)


C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D004791 - Enzyme Inhibitors

   

3[N-Morpholino]propane sulfonic acid

3-(morpholin-4-yl)propane-1-sulfonic acid

C7H15NO4S (209.072175)


COVID info from PDB, Protein Data Bank Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

2-Hydroxy-3-morpholinopropanesulfonic Acid

2-hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid

C7H15NO5S (225.06708999999998)


   

Morph

2,5-dihydroxy-5-methyl-3-[(morpholin-4-yl)amino]cyclopent-2-en-1-one

C10H16N2O4 (228.11100159999998)


   

morpholino

Oligomers, phosphorodiamidate morpholino

C4H8NO (86.06058580000001)


   

2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate

2-(Morpholin-4-yl)ethyl 1-phenylcyclohexane-1-carboxylic acid

C19H27NO3 (317.1990832)


   

Scopine

9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]nonan-7-ol

C8H13NO2 (155.0946238)


   

(2Z)-2-Morpholin-4-yliminoacetonitrile

N-(morpholin-4-yl)carbonimidoyl cyanide

C6H9N3O (139.0745584)