1-Ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate (BioDeep_00000173755)
human metabolite blood metabolite
代谢物信息卡片
5-[(ethoxycarbonyl)azanidyl]-3-(morpholin-4-yl)-1,2,3λ⁵-oxadiazol-3-ylium
化学式: C9H14N4O4 (242.1015)
中文名称: 吗多明
谱图信息:
最多检出来源 Homo sapiens(blood) 27.93%
分子结构信息
SMILES: CCOC(=NC1=C[N+](=NO1)N2CCOCC2)[O-]
InChI: InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
68 个代谢物同义名
5-[(ethoxycarbonyl)azanidyl]-3-(morpholin-4-yl)-1,2,3λ⁵-oxadiazol-3-ylium; Ethyl N-[3-(morpholin-4-yl)-5H-1,2,3λ⁵-oxadiazol-5-ylidene]carbamic acid; 1-Ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate; CT-Arzneimittel brand OF molsidomine; CT Arzneimittel brand OF molsidomine; Molsidomine CT-arzneimittel brand; Stadapharm brand OF molsidomine; Merck dura brand OF molsidomine; Ratiopharm brand OF molsidomine; Betapharm brand OF molsidomine; Azupharma brand OF molsidomine; Alpharma brand OF molsidomine; Molsidomine ratiopharm brand; Schwarz brand OF molsidomine; Salutas brand OF molsidomine; Aventis brand OF molsidomine; Heumann brand OF molsidomine; Molsidomine stadapharm brand; Molsidomine betapharm brand; Normon brand OF molsidomine; Molsidomine azupharma brand; Molsidomine alpharma brand; Sanol brand OF molsidomine; Hexal brand OF molsidomine; Molsidomine aventis brand; Molsidomine schwarz brand; Molsidomine heumann brand; Molsidomine salutas brand; Molsidomine normon brand; MTW Brand OF molsidomine; 1a Brand OF molsidomine; Molsidomine hexal brand; Molsidomine sanol brand; Molsidomine MTW brand; Molsidomin-ratiopharm; Molsidomin ratiopharm; Molsidomine 1a brand; Molsidominratiopharm; Heumann, molsidomin; Von CT, molsidomin; Molsidomin heumann; Molsidomin von CT; Molsidomin stada; Molsi 1a pharma; MTW Molsidomin; MTW-Molsidomin; Molsi-puren; Morsydomine; molsidomine; Molsi puren; Molsihexal; Sydnopharm; Molsidomin; Molsi azu; Korvatone; Molsi-azu; Duracoron; Molsibeta; Molsidain; Corvaton; Molsicor; Molsiket; Fali cor; Fali-cor; SIN-10; Corpea; SIN 10; SIN10
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:92623
- PubChem: 5353788
- HMDB: HMDB0245703
- DrugBank: DB09282
- ChEMBL: CHEMBL4059924
- ChEMBL: CHEMBL1256353
- ChEMBL: CHEMBL1329455
- Wikipedia: Molsidomine
- MeSH: Molsidomine
- CAS: 25717-80-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Pranav Nayak B, Nathani Minaz, Khadar Pasha. Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats.
Animal models and experimental medicine.
2021 09; 4(3):243-248. doi:
10.1002/ame2.12162. [PMID: 34557650] - Marcelo Paes de Barros, Juliana Casares Araujo-Chaves, Adrianne Marlise Mendes Brito, Iseli Lourenço Nantes-Cardoso. Oxidative/Nitrative Mechanism of Molsidomine Mitotoxicity Assayed by the Cytochrome c Reaction with SIN-1 in Models of Biological Membranes.
Chemical research in toxicology.
2020 11; 33(11):2775-2784. doi:
10.1021/acs.chemrestox.0c00122. [PMID: 32706246] - Hideaki Ono, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Takaaki Aratake, Tomoya Hamada, Yoshiki Nagao, Shogo Shimizu, Youichirou Higashi, Motoaki Saito. Brain nitric oxide induces facilitation of the micturition reflex through brain glutamatergic receptors in rats.
Neurourology and urodynamics.
2020 08; 39(6):1687-1699. doi:
10.1002/nau.24440. [PMID: 32558992] - Emine Turkmen Samdanci, Mustafa Huz, Onural Ozhan, Kevser Tanbek, Esra Pamukcu, Ayse Nur Akatli, Hakan Parlakpinar. Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study.
Drug design, development and therapy.
2019; 13(?):13-21. doi:
10.2147/dddt.s181550. [PMID: 30587924] - Tzu-Hsuan Chung, Yung-Peng Wu, Chee Ying Chew, Chak Hin Lam, Kui-Thong Tan. Imaging and Quantification of Secreted Peroxynitrite at the Cell Surface by a Streptavidin-Biotin-Controlled Binding Probe.
Chembiochem : a European journal of chemical biology.
2018 12; 19(24):2584-2590. doi:
10.1002/cbic.201800542. [PMID: 30352141] - Anaïs Aulas, Shawn M Lyons, Marta M Fay, Paul Anderson, Pavel Ivanov. Nitric oxide triggers the assembly of 'type II' stress granules linked to decreased cell viability.
Cell death & disease.
2018 11; 9(11):1129. doi:
10.1038/s41419-018-1173-x. [PMID: 30425239] - Ying He, Ying Zhang, Dan Zhang, Meng Zhang, Mengying Wang, Zhuocheng Jiang, Miguel Otero, Jinghong Chen. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):1696-1704. doi:
10.1016/j.biopha.2018.07.128. [PMID: 30119244] - Nathani Minaz, Rema Razdan, Lokesh Pathak. Repositioning of molsidomine for its efficacy in diabetes induced erectile dysfunction in rats: In silico, in vitro and in vivo approach.
Pharmacological reports : PR.
2018 Apr; 70(2):309-315. doi:
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Acta physiologica (Oxford, England).
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Current eye research.
2017 05; 42(5):803-809. doi:
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Redox biology.
2017 04; 11(?):438-455. doi:
10.1016/j.redox.2016.12.028. [PMID: 28086193] - Olga Lenčová-Popelová, Hana Jansová, Eduard Jirkovský, Jan Bureš, Anna Jirkovská-Vávrová, Yvona Mazurová, Petra Reimerová, Lucie Vostatková, Michaela Adamcová, Miloš Hroch, Zuzana Pokorná, Petra Kovaříková, Tomáš Šimůnek, Martin Štěrba. Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?.
Toxicology.
2016 Nov; 372(?):52-63. doi:
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Enfermedades infecciosas y microbiologia clinica.
2016 Oct; 34(8):490-8. doi:
10.1016/j.eimc.2015.11.005. [PMID: 26832645] - Nathani Minaz, Rema Razdan. Therapeutic insight into molsidomine, a nitric oxide donor in streptozotocin-induced diabetic nephropathy in rats.
Indian journal of pharmacology.
2016 Sep; 48(5):544-549. doi:
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Clinical and investigative medicine. Medecine clinique et experimentale.
2016 Feb; 39(1):E7-14. doi:
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Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2015 Jul; 24(4):585-93. doi:
10.17219/acem/47742. [PMID: 26469102] - Recep Bentli, Hakan Parlakpinar, Alaadin Polat, Emine Samdanci, Mehmet Ediz Sarihan, Mustafa Sagir. Molsidomine prevents cisplatin-induced hepatotoxicity.
Archives of medical research.
2013 Oct; 44(7):521-8. doi:
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Molecular medicine reports.
2013 May; 7(5):1607-12. doi:
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Laboratory investigation; a journal of technical methods and pathology.
2013 Mar; 93(3):334-43. doi:
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Physiologia plantarum.
2013 Feb; 147(2):194-206. doi:
10.1111/j.1399-3054.2012.01654.x. [PMID: 22607494] - Kandikattu Hemanth Kumar, Anand Tamatam, Ajay Pal, Farhath Khanum. Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.
Neurotoxicology.
2013 Jan; 34(?):150-9. doi:
10.1016/j.neuro.2012.11.002. [PMID: 23174672] - Moumita Bose, Rina Saha, Sumit Sen Santara, Supratim Mukherjee, Jayasree Roy, Subrata Adak. Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
Free radical biology & medicine.
2012 Nov; 53(10):1819-28. doi:
10.1016/j.freeradbiomed.2012.08.583. [PMID: 22985938] - Stefanie Ruhs, Nicole Strätz, Kathleen Schlör, Sandra Meinel, Sigrid Mildenberger, Sindy Rabe, Michael Gekle, Claudia Grossmann. Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress.
Free radical biology & medicine.
2012 Sep; 53(5):1088-100. doi:
10.1016/j.freeradbiomed.2012.06.028. [PMID: 22749806] - Daniel L Graham, Michel Carail, Catherine Caris-Veyrat, Gordon M Lowe. (13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1.
Free radical research.
2012 Jul; 46(7):891-902. doi:
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European journal of pharmacology.
2012 Mar; 679(1-3):40-50. doi:
10.1016/j.ejphar.2012.01.005. [PMID: 22293370] - Koji Aoyama, Fan Wang, Nobuko Matsumura, Hiroshi Kiyonari, Go Shioi, Karo Tanaka, Chisato Kinoshita, Kazue Kikuchi-Utsumi, Masahiko Watabe, Toshio Nakaki. Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.
Neurobiology of disease.
2012 Mar; 45(3):973-82. doi:
10.1016/j.nbd.2011.12.016. [PMID: 22210510] - Monica G Ferrini, Joanne Moon, Steve Rivera, Jacob Rajfer, Nestor F Gonzalez-Cadavid. Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-β1 therapies in inducible nitric oxide synthase-deficient mice.
BJU international.
2012 Feb; 109(4):586-93. doi:
10.1111/j.1464-410x.2011.10397.x. [PMID: 21851542] - Laurine Mattart, Damien Calay, Dorothy Simon, Laura Roebroek, Laura Roebroeck, Ludmilla Caesens-Koenig, Martine Van Steenbrugge, Virginie Tevel, Carine Michiels, Thierry Arnould, Karim Zouaoui Boudjeltia, Martine Raes. The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells.
Cellular signalling.
2012 Jan; 24(1):199-213. doi:
10.1016/j.cellsig.2011.09.002. [PMID: 21945407] - Yuling Zhao, Naihao Lu, Yan Zhang, Zhonghong Gao. High glucose induced rat aorta vascular smooth muscle cell oxidative injury: involvement of protein tyrosine nitration.
Journal of physiology and biochemistry.
2011 Dec; 67(4):539-49. doi:
10.1007/s13105-011-0099-x. [PMID: 21626204] - Raffaella Priora, Antonios Margaritis, Simona Frosali, Lucia Coppo, Domenico Summa, Danila Di Giuseppe, Carlo Aldinucci, Gianpaolo Pessina, Anna Di Stefano, Paolo Di Simplicio. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.
Pharmacological research.
2011 Sep; 64(3):289-97. doi:
10.1016/j.phrs.2011.03.014. [PMID: 21539916] - Frank Gaupels, Elodie Spiazzi-Vandelle, Dan Yang, Massimo Delledonne. Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response.
Nitric oxide : biology and chemistry.
2011 Aug; 25(2):222-8. doi:
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Journal of neuroinflammation.
2011 Jul; 8(?):78. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
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Neuroscience.
2011 Feb; 174(?):91-103. doi:
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American journal of physiology. Heart and circulatory physiology.
2010 Dec; 299(6):H2037-45. doi:
10.1152/ajpheart.00400.2010. [PMID: 20852057] - Joseph H Holthoff, Kellie A Woodling, Daniel R Doerge, Samuel T Burns, Jack A Hinson, Philip R Mayeux. Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.
Biochemical pharmacology.
2010 Oct; 80(8):1260-5. doi:
10.1016/j.bcp.2010.06.027. [PMID: 20599800] - D L Graham, M Carail, C Caris-Veyrat, G M Lowe. Cigarette smoke and human plasma lycopene depletion.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Aug; 48(8-9):2413-20. doi:
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American journal of hypertension.
2010 Jul; 23(7):802-8. doi:
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American journal of physiology. Endocrinology and metabolism.
2010 Apr; 298(4):E846-53. doi:
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Journal of neurochemistry.
2010 Mar; 112(6):1574-83. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
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Platelets.
2009 Dec; 20(8):555-65. doi:
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Molecular nutrition & food research.
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Nitric oxide : biology and chemistry.
2009 Jun; 20(4):270-8. doi:
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Free radical research.
2009 Jun; 43(6):604-12. doi:
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Planta.
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Oxidative medicine and cellular longevity.
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Toxicology and applied pharmacology.
2009 Jan; 234(2):236-46. doi:
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Nutrients.
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Chemical & pharmaceutical bulletin.
2008 Dec; 56(12):1738-43. doi:
10.1248/cpb.56.1738. [PMID: 19043251] - Yo Omata, Yoshiro Saito, Katsuhide Fujita, Yoko Ogawa, Keiko Nishio, Yasukazu Yoshida, Etsuo Niki. Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation.
Free radical biology & medicine.
2008 Nov; 45(10):1437-45. doi:
10.1016/j.freeradbiomed.2008.08.018. [PMID: 18793714] - Ryan T Hamilton, Liana Asatryan, Jon T Nilsen, Jose M Isas, Timothy K Gallaher, Tatsuya Sawamura, Tzung K Hsiai. LDL protein nitration: implication for LDL protein unfolding.
Archives of biochemistry and biophysics.
2008 Nov; 479(1):1-14. doi:
10.1016/j.abb.2008.07.026. [PMID: 18713619] - S S Kwiecien, M W Pawlik, T Brzozowski, P C Konturek, Z Sliwowski, W W Pawlik, S J Konturek. Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Aug; 59 Suppl 2(?):103-15. doi:
". [PMID: 18812632] - Sofia Axelrod, Hartmut Oschkinat, Jana Enders, Brigitte Schlegel, Volker Brinkmann, Stefan H E Kaufmann, Albert Haas, Ulrich E Schaible. Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.
Cellular microbiology.
2008 Jul; 10(7):1530-45. doi:
10.1111/j.1462-5822.2008.01147.x. [PMID: 18363878] - Maarten P Koeners, Branko Braam, Dionne M van der Giezen, Roel Goldschmeding, Jaap A Joles. A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1847-55. doi:
10.1152/ajpregu.00073.2008. [PMID: 18417652] - Xiang-Lan Piao, Eun Jung Cho, Moon Hee Jang. Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 May; 46(5):1576-81. doi:
10.1016/j.fct.2007.12.023. [PMID: 18299170] - Xiang-Lan Piao, Moon Hee Jang, Jian Cui, Xiangshu Piao. Lignans from the fruits of Forsythia suspensa.
Bioorganic & medicinal chemistry letters.
2008 Mar; 18(6):1980-4. doi:
10.1016/j.bmcl.2008.01.115. [PMID: 18295482] - Metta Pinthong, Stefanie A G Black, Fabiola M Ribeiro, Chumpol Pholpramool, Stephen S G Ferguson, R Jane Rylett. Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Molecular pharmacology.
2008 Mar; 73(3):801-12. doi:
10.1124/mol.107.040881. [PMID: 17971421] - Amit Gupta, Sameer Sharma, Kanwaljit Chopra. Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Feb; 46(2):537-43. doi:
10.1016/j.fct.2007.08.041. [PMID: 17935848] - Estíbaliz Larrainzar, Estíbaliz Urarte, Iñigo Auzmendi, Idoia Ariz, Cesar Arrese-Igor, Esther M González, Jose F Moran. Use of recombinant iron-superoxide dismutase as a marker of nitrative stress.
Methods in enzymology.
2008; 437(?):605-18. doi:
10.1016/s0076-6879(07)37031-6. [PMID: 18433650] - Dong Young Rhyu, Ki Sung Kang, Michiko Sekiya, Takashi Tanaka, Jong Cheol Park, Takako Yokozawa. Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK(1) cell damage.
The American journal of Chinese medicine.
2008; 36(4):761-70. doi:
10.1142/s0192415x08006211. [PMID: 18711772] - Kavita Gulati, Ayanabha Chakraborti, Arunabha Ray. Modulation of stress-induced neurobehavioral changes and brain oxidative injury by nitric oxide (NO) mimetics in rats.
Behavioural brain research.
2007 Nov; 183(2):226-30. doi:
10.1016/j.bbr.2007.06.018. [PMID: 17675257] - Lana Kupershmidt, Tamar Amit, Orit Bar-Am, Moussa B H Youdim, Zeev Blumenfeld. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Journal of neurochemistry.
2007 Nov; 103(3):962-71. doi:
10.1111/j.1471-4159.2007.04785.x. [PMID: 17680997] - Kristy Welshhans, Vincent Rehder. Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.
The European journal of neuroscience.
2007 Sep; 26(6):1537-47. doi:
10.1111/j.1460-9568.2007.05768.x. [PMID: 17714493] - Wagner Luis Reis, Alexandre Giusti-Paiva, Renato Rizo Ventura, Lisandra Oliveira Margatho, Dayane Aparecida Gomes, Lucila Leico Kagohara Elias, José Antunes-Rodrigues. Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats.
Experimental physiology.
2007 Sep; 92(5):903-11. doi:
10.1113/expphysiol.2007.037911. [PMID: 17513344] - Julio C Sartori-Valinotti, Radu Iliescu, Lourdes A Fortepiani, Licy L Yanes, Jane F Reckelhoff. Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease.
Clinical and experimental pharmacology & physiology.
2007 Sep; 34(9):938-45. doi:
10.1111/j.1440-1681.2007.04643.x. [PMID: 17645644] - Indrapal N Singh, Patrick G Sullivan, Edward D Hall. Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.
Journal of neuroscience research.
2007 Aug; 85(10):2216-23. doi:
10.1002/jnr.21360. [PMID: 17510982] - Enrique Torres-Rasgado, Gilles Fouret, Marie-Annette Carbonneau, Claude-Louis Leger. Peroxynitrite mild nitration of albumin and LDL-albumin complex naturally present in plasma and tyrosine nitration rate-albumin impairs LDL nitration.
Free radical research.
2007 Mar; 41(3):367-75. doi:
10.1080/10715760601064706. [PMID: 17364966] - C Fotiadis, S Adamis, E P Misiakos, M Genetzakis, P T Antonakis, D K Tsekouras, V G Gorgoulis, G C Zografos, A Papalois, M Fotinou, D Perrea. The prophylactic effect of L-arginine in acute ischaemic colitis in a rat model of ischaemia/reperfusion injury.
Acta chirurgica Belgica.
2007 Mar; 107(2):192-200. doi:
10.1080/00015458.2007.11680039. [PMID: 17515270] - Herick C Ferreira, Carla P Serra, Virginia S Lemos, Fernão C Braga, Steyner F Cortes. Nitric oxide-dependent vasodilatation by ethanolic extract of Hancornia speciosa via phosphatidyl-inositol 3-kinase.
Journal of ethnopharmacology.
2007 Jan; 109(1):161-4. doi:
10.1016/j.jep.2006.06.009. [PMID: 16890389] - Manuchair Ebadi, Sushil Sharma. Metallothioneins 1 and 2 attenuate peroxynitrite-induced oxidative stress in Parkinson disease.
Experimental biology and medicine (Maywood, N.J.).
2006 Oct; 231(9):1576-83. doi:
10.1177/153537020623100919. [PMID: 17018883] - Francisco S Lozano, Carlos Cascajo, Enrique García-Sánchez, Marcello B Barros, Francisco J García-Criado, Felipe Parreño, José Elias García-Sánchez, Alberto Gómez-Alonso. Bacterial translocation as a source of Dacron-graft contamination in experimental aortic operation: the importance of controlling SIRS.
Surgery.
2006 Jul; 140(1):83-92. doi:
10.1016/j.surg.2006.01.011. [PMID: 16857446] - Syuhei Saito, Ayako Yamamoto-Katou, Hirofumi Yoshioka, Noriyuki Doke, Kazuhito Kawakita. Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Plant & cell physiology.
2006 Jun; 47(6):689-97. doi:
10.1093/pcp/pcj038. [PMID: 16556649] - Ruba S Deeb, Gang Hao, Steven S Gross, Muriel Lainé, Ju Hua Qiu, Brad Resnick, Elisar J Barbar, David P Hajjar, Rita K Upmacis. Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite.
Journal of lipid research.
2006 May; 47(5):898-911. doi:
10.1194/jlr.m500384-jlr200. [PMID: 16470026] - C Yang, W Hader, X Zhang. Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.
Brain research.
2006 Mar; 1076(1):238-42. doi:
10.1016/j.brainres.2005.12.101. [PMID: 16473327] - David R Wallace, Stephanie Dodson, Avindra Nath, Rosemarie M Booze. Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter function.
Synapse (New York, N.Y.).
2006 Jan; 59(1):51-60. doi:
10.1002/syn.20214. [PMID: 16237680] - Kwan-Hoon Moon, Bong-Jo Kim, Byoung J Song. Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.
FEBS letters.
2005 Nov; 579(27):6115-20. doi:
10.1016/j.febslet.2005.09.082. [PMID: 16242127] - Tong-Chun Wen, Marta R Rogido, James E Moore, Tom Genetta, Hui Peng, Augusto Sola. Cardiotrophin-1 protects cortical neuronal cells against free radical-induced injuries in vitro.
Neuroscience letters.
2005 Oct; 387(1):38-42. doi:
10.1016/j.neulet.2005.07.018. [PMID: 16084018] - Danxia Liu, Feng Bao, Donald S Prough, Douglas S Dewitt. Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin.
Journal of neurotrauma.
2005 Oct; 22(10):1123-33. doi:
10.1089/neu.2005.22.1123. [PMID: 16238488] - Vikas Chander, Kanwaljit Chopra. Renal protective effect of molsidomine and L-arginine in ischemia-reperfusion induced injury in rats.
The Journal of surgical research.
2005 Sep; 128(1):132-9. doi:
10.1016/j.jss.2005.04.023. [PMID: 15936772] - Lourdes A Fortepiani, Jane F Reckelhoff. Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
American journal of physiology. Regulatory, integrative and comparative physiology.
2005 Sep; 289(3):R763-70. doi:
10.1152/ajpregu.00526.2004. [PMID: 15905221] - Sandeep Khurana, Masahisa Yamada, Jürgen Wess, Richard H Kennedy, Jean-Pierre Raufman. Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent.
European journal of pharmacology.
2005 Jul; 517(1-2):103-10. doi:
10.1016/j.ejphar.2005.05.037. [PMID: 15964566] - Francisco S Lozano, José M López-Novoa, José M Rodriguez, Marcello B Barros, Francisco J García-Criado, Juan L Nicolás, Alvaro Parreño, José Revilla, Alberto Gómez-Alonso. Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery.
Journal of vascular surgery.
2005 Jul; 42(1):129-39. doi:
10.1016/j.jvs.2005.03.030. [PMID: 16012462] - Vikas Chander, Kanwaljit Chopra. Molsidomine, a nitric oxide donor and L-arginine protects against rhabdomyolysis-induced myoglobinuric acute renal failure.
Biochimica et biophysica acta.
2005 May; 1723(1-3):208-14. doi:
10.1016/j.bbagen.2005.01.016. [PMID: 15777642] - Maria Kopff, Edward Kowalczyk, Anna Kopff. [Nitric oxide and cardiologic drugs].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2005 May; 18(107):521-3. doi:
NULL. [PMID: 16161946] - Takako Yokozawa, Akiko Satoh, Eun Ju Cho, Yoshiki Kashiwada, Yasumasa Ikeshiro. Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.
The Journal of pharmacy and pharmacology.
2005 Mar; 57(3):367-74. doi:
10.1211/0022357055470. [PMID: 15807993] - Vikas Chander, Kanwaljit Chopra. Effect of molsidomine and L-arginine in cyclosporine nephrotoxicity: role of nitric oxide.
Toxicology.
2005 Feb; 207(3):463-74. doi:
10.1016/j.tox.2004.10.018. [PMID: 15664273] - Yolanda Gutiérrez-Martín, Francisco Javier Martín-Romero, Fernando Henao, Carlos Gutiérrez-Merino. Alteration of cytosolic free calcium homeostasis by SIN-1: high sensitivity of L-type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells.
Journal of neurochemistry.
2005 Feb; 92(4):973-89. doi:
10.1111/j.1471-4159.2004.02964.x. [PMID: 15686499] - Ana Rodriguez-Peña, Francisco J Garcia-Criado, Nelida Eleno, Miguel Arevalo, Jose M Lopez-Novoa. Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2004 Oct; 4(10):1605-13. doi:
10.1111/j.1600-6143.2004.00560.x. [PMID: 15367215] - Hüiseyin Büyükbayram, Hayrettin Oztürk, Ismail H Kara, Adem Arslan. Does the analysis based on a histological and immunohistochemical grading system in the model of BDL kidney allow the quantification of the degree of injury?.
Renal failure.
2004 Sep; 26(5):487-95. doi:
10.1081/jdi-200031727. [PMID: 15526906] - Vance G Nielsen, John P Crow, Ashish Mogal, Fen Zhou, Dale A Parks. Peroxynitrite decreases hemostasis in human plasma in vitro.
Anesthesia and analgesia.
2004 Jul; 99(1):21-26. doi:
10.1213/01.ane.0000116962.93953.70. [PMID: 15281495] - Kiyotoshi Maruyama, Takashi Ohuchi, Kenji Yoshida, Yasushi Shibata, Fumio Sugawara, Takao Arai. Protective properties of neoechinulin A against SIN-1-induced neuronal cell death.
Journal of biochemistry.
2004 Jul; 136(1):81-7. doi:
10.1093/jb/mvh103. [PMID: 15269243] - Peter M Burch, Ziqiang Yuan, Anne Loonen, Nicholas H Heintz. An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry.
Molecular and cellular biology.
2004 Jun; 24(11):4696-709. doi:
10.1128/mcb.24.11.4696-4709.2004. [PMID: 15143165] - Vance G Nielsen, John P Crow, Fen Zhou, Dale A Parks. Peroxynitrite inactivates tissue plasminogen activator.
Anesthesia and analgesia.
2004 May; 98(5):1312-7, table of contents. doi:
10.1213/01.ane.0000111105.38836.f6. [PMID: 15105207]
