morpholino (BioDeep_00000181098)
human metabolite blood metabolite
代谢物信息卡片
Oligomers, phosphorodiamidate morpholino
化学式: C4H8NO (86.06058580000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.57%
分子结构信息
SMILES: C1COCC[N]1
InChI: InChI=1S/C4H8NO/c1-3-6-4-2-5-1/h1-4H2
描述信息
同义名列表
19 个代谢物同义名
Oligomers, phosphorodiamidate morpholino; Morpholino oligomers, phosphorodiamidate; Oligomer, phosphorodiamidate morpholino; Morpholino oligomer, phosphorodiamidate; Phosphorodiamidate morpholino oligomers; Phosphorodiamidate morpholino oligomer; Oligonucleotides, morpholino; Morpholino oligonucleotides; Oligonucleotide, morpholino; Morpholino oligonucleotide; Oligos, morpholino; Morpholino oligos; Oligomers, morf; Oligomers, pmo; MORF oligomers; morpholin-4-yl; PMO oligomers; Morpholinos; morpholino
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 5476374
- HMDB: HMDB0254896
- Wikipedia: Morpholino
- MeSH: Morpholinos
- chemspider: 10620292
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinyan Ma, Ruixian Guo, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Jingpu Zhang, Ying Han. Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish.
Journal of thrombosis and haemostasis : JTH.
2024 Apr; 22(4):951-964. doi:
10.1016/j.jtha.2023.12.010. [PMID: 38104724] - Martin Egli, Muthiah Manoharan. Chemistry, structure and function of approved oligonucleotide therapeutics.
Nucleic acids research.
2023 04; 51(6):2529-2573. doi:
10.1093/nar/gkad067. [PMID: 36881759] - Sheng-Ge Li, Xu Hu, Qin Zhang, Yan-Hui Zan, Kai-Bo Wang, Chun-Yu Jiang, Jing-Jing Xue, Yong-Xiang Liu, Bin Lin, Yong-Kui Jing, Da-Hong Li, Hui-Ming Hua. (±)-Pheharmines A-B, two pairs of racemic alkaloids with a morpholino[4,3,2-hi]β-carboline core, from the roots of Peganum harmala.
Organic & biomolecular chemistry.
2022 Nov; 20(43):8528-8532. doi:
10.1039/d2ob01608g. [PMID: 36278495] - Abhishek Gupta, Shalini Gupta, Ujjal Das, Surajit Sinha. Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro.
Bioconjugate chemistry.
2022 05; 33(5):907-917. doi:
10.1021/acs.bioconjchem.2c00129. [PMID: 35486710] - Lan Yang, Xingyan Ye, Xiating Li, Zhihong Huang, Fengping Chen, Weijuan Yang, Zongwen Wang. Colorimetric aptasensor for sensitive detection of quinclorac based on exonuclease III-assisted cyclic release of phosphorodiamidate morpholino oligomer mimic enzyme strategy.
Analytica chimica acta.
2022 May; 1207(?):339815. doi:
10.1016/j.aca.2022.339815. [PMID: 35491044] - Biao Gu, Cuiyan Wu, Chunxiang Zhang, Shihui He, Siping Tang, Haitao Li, Youming Shen. A morpholino hydrazone-based lysosome-targeting fluorescent probe with fast response and high sensitivity for imaging peroxynitrite in living cells.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 262(?):120100. doi:
10.1016/j.saa.2021.120100. [PMID: 34186297] - Marie Claire Mukashyaka, Chia-Ling Wu, Kristin Ha, Jianbo Zhang, Jenna Wood, Samantha Foley, Bryan Mastis, Nino Jungels, Huadong Sun, Mohammad Shadid, Shawn Harriman, John R Hadcock. Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice.
Pharmaceutical research.
2021 Oct; 38(10):1731-1745. doi:
10.1007/s11095-021-03118-5. [PMID: 34671920] - M Tommy Gambles, Jiahui Li, Jiawei Wang, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček. Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells.
Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
10.3390/molecules26154658. [PMID: 34361811] - Chengxi Li, Alex J Callahan, Mark D Simon, Kyle A Totaro, Alexander J Mijalis, Kruttika-Suhas Phadke, Genwei Zhang, Nina Hartrampf, Carly K Schissel, Ming Zhou, Hong Zong, Gunnar J Hanson, Andrei Loas, Nicola L B Pohl, David E Verhoeven, Bradley L Pentelute. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers.
Nature communications.
2021 07; 12(1):4396. doi:
10.1038/s41467-021-24598-4. [PMID: 34285203] - Jiahao Li, Ding Wu, Yi Yu, Tingxian Li, Kun Li, Meng-Meng Xiao, Yirong Li, Zhi-Yong Zhang, Guo-Jun Zhang. Rapid and unamplified identification of COVID-19 with morpholino-modified graphene field-effect transistor nanosensor.
Biosensors & bioelectronics.
2021 Jul; 183(?):113206. doi:
10.1016/j.bios.2021.113206. [PMID: 33823464] - Rui Vilar, Samuel W Lukowski, Marco Garieri, Corinne Di Sanza, Marguerite Neerman-Arbez, Richard J Fish. Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.
Thrombosis and haemostasis.
2021 Apr; 121(4):433-448. doi:
10.1055/s-0040-1718414. [PMID: 33302304] - Kevin A Lidberg, Andrew J Annalora, Marija Jozic, Daniel J Elson, Lu Wang, Theo K Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B Marcus, Patrick L Iversen, Edward J Kelly. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.
Scientific reports.
2021 02; 11(1):4722. doi:
10.1038/s41598-021-84194-w. [PMID: 33633318] - Franciele Lanzarini, Fernanda Alves Pereira, Janine de Camargo, Andressa Minozzo Oliveira, Katia Roberta Anacleto Belaz, Jose Javier Melendez-Perez, Marcos Nogueira Eberlin, Mário Celso Sperotto Brum, Fernando Silveira Mesquita, Mateus José Sudano. ELOVL5 Participates in Embryonic Lipid Determination of Cellular Membranes and Cytoplasmic Droplets.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031311. [PMID: 33525659] - Rui Guo, Kangkang Ge, Yuying Wang, Minxia Lu, Fei Li, Lili Tian, Lin Gan, Donglai Sheng. LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish.
Scientific reports.
2021 01; 11(1):1977. doi:
10.1038/s41598-021-81211-w. [PMID: 33479361] - Kyle Rosenke, Shanna Leventhal, Hong M Moulton, Susan Hatlevig, David Hawman, Heinz Feldmann, David A Stein. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers.
The Journal of antimicrobial chemotherapy.
2021 01; 76(2):413-417. doi:
10.1093/jac/dkaa460. [PMID: 33164048] - Dervla M Connaughton, Rufeng Dai, Danielle J Owen, Jonathan Marquez, Nina Mann, Adda L Graham-Paquin, Makiko Nakayama, Etienne Coyaud, Estelle M N Laurent, Jonathan R St-Germain, Lot Snijders Blok, Arianna Vino, Verena Klämbt, Konstantin Deutsch, Chen-Han Wilfred Wu, Caroline M Kolvenbach, Franziska Kause, Isabel Ottlewski, Ronen Schneider, Thomas M Kitzler, Amar J Majmundar, Florian Buerger, Ana C Onuchic-Whitford, Mao Youying, Amy Kolb, Daanya Salmanullah, Evan Chen, Amelie T van der Ven, Jia Rao, Hadas Ityel, Steve Seltzsam, Johanna M Rieke, Jing Chen, Asaf Vivante, Daw-Yang Hwang, Stefan Kohl, Gabriel C Dworschak, Tobias Hermle, Mariëlle Alders, Tobias Bartolomaeus, Stuart B Bauer, Michelle A Baum, Eva H Brilstra, Thomas D Challman, Jacob Zyskind, Carrie E Costin, Katrina M Dipple, Floor A Duijkers, Marcia Ferguson, David R Fitzpatrick, Roger Fick, Ian A Glass, Peter J Hulick, Antonie D Kline, Ilona Krey, Selvin Kumar, Weining Lu, Elysa J Marco, Ingrid M Wentzensen, Heather C Mefford, Konrad Platzer, Inna S Povolotskaya, Juliann M Savatt, Natalia V Shcherbakova, Prabha Senguttuvan, Audrey E Squire, Deborah R Stein, Isabelle Thiffault, Victoria Y Voinova, Michael J G Somers, Michael A Ferguson, Avram Z Traum, Ghaleb H Daouk, Ankana Daga, Nancy M Rodig, Paulien A Terhal, Ellen van Binsbergen, Loai A Eid, Velibor Tasic, Hila Milo Rasouly, Tze Y Lim, Dina F Ahram, Ali G Gharavi, Heiko M Reutter, Heidi L Rehm, Daniel G MacArthur, Monkol Lek, Kristen M Laricchia, Richard P Lifton, Hong Xu, Shrikant M Mane, Simone Sanna-Cherchi, Andrew D Sharrocks, Brian Raught, Simon E Fisher, Maxime Bouchard, Mustafa K Khokha, Shirlee Shril, Friedhelm Hildebrandt. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.
American journal of human genetics.
2020 10; 107(4):727-742. doi:
10.1016/j.ajhg.2020.08.013. [PMID: 32891193] - Andrés F Sandoval-Mojica, Sidney Altman, Wayne B Hunter, Kirsten S Pelz-Stelinski. Peptide conjugated morpholinos for management of the huanglongbing pathosystem.
Pest management science.
2020 Sep; 76(9):3217-3224. doi:
10.1002/ps.5877. [PMID: 32358830] - Qi Xu, Ziyu Chen, Borong Zhu, Gaorui Wang, Qi Jia, Yiming Li, Xiaojun Wu. A-Type Cinnamon Procyanidin Oligomers Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity in Mice Through Inhibiting the P38 Mitogen-Activated Protein Kinase/P53/BCL-2 Associated X Protein Signaling Pathway.
The Journal of nutrition.
2020 07; 150(7):1731-1737. doi:
10.1093/jn/nxaa128. [PMID: 32386222] - Yaqi Qiu, Shuna Sun, Xianxian Yu, Jiefei Zhou, Wei Cai, Linxi Qian. Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 06; 1865(6):158663. doi:
10.1016/j.bbalip.2020.158663. [PMID: 32061751] - Lindsey Kennedy, Vik Meadows, Konstantina Kyritsi, Linh Pham, Debjyoti Kundu, Rewa Kulkarni, Karla Cerritos, Jennifer Demieville, Laura Hargrove, Shannon Glaser, Tianhao Zhou, Victoria Jaeger, Gianfranco Alpini, Heather Francis. Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment.
The American journal of pathology.
2020 05; 190(5):1018-1029. doi:
10.1016/j.ajpath.2020.01.013. [PMID: 32142732] - Tejal Aslesh, Toshifumi Yokota. Development of Antisense Oligonucleotide Gapmers for the Treatment of Dyslipidemia and Lipodystrophy.
Methods in molecular biology (Clifton, N.J.).
2020; 2176(?):69-85. doi:
10.1007/978-1-0716-0771-8_5. [PMID: 32865783] - Vik Meadows, Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Fanyin Meng, Shohaib Virani, Evan Reinhart, Konstantina Kyritsi, Pietro Invernizzi, Zhihong Yang, Nan Wu, Suthat Liangpunsakul, Gianfranco Alpini, Heather Francis. Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage/senescence and liver fibrosis in Mdr2-/- mice.
Biochimica et biophysica acta. Molecular basis of disease.
2019 12; 1865(12):165557. doi:
10.1016/j.bbadis.2019.165557. [PMID: 31521820] - Jianqing She, Yue Wu, Bowen Lou, Elisabeth Lodd, Alina Klems, Felix Schmoehl, Zuyi Yuan, Ferdinand Le Noble, Jens Kroll. Genetic compensation by epob in pronephros development in epoa mutant zebrafish.
Cell cycle (Georgetown, Tex.).
2019 Oct; 18(20):2683-2696. doi:
10.1080/15384101.2019.1656019. [PMID: 31451030] - Jianli Chen, Ting Yu, Xian He, Yao Fu, Lu Dai, Bin Wang, Yan Wu, Jianbo He, Yang Li, Fang Zhang, Jinghong Zhao, Chi Liu. Dual roles of hydrogen peroxide in promoting zebrafish renal repair and regeneration.
Biochemical and biophysical research communications.
2019 08; 516(3):680-685. doi:
10.1016/j.bbrc.2019.06.052. [PMID: 31248596] - J Müller-Deile, H Schenk, P Schroder, K Schulze, P Bolaños-Palmieri, F Siegerist, N Endlich, H Haller, M Schiffer. Circulating factors cause proteinuria in parabiotic zebrafish.
Kidney international.
2019 08; 96(2):342-349. doi:
10.1016/j.kint.2019.02.013. [PMID: 31076096] - Eugenel B Espiritu, Huajun Jiang, Sophie Moreau-Marquis, Mara Sullivan, Kunimasa Yan, Donna Beer Stolz, Matthew G Sampson, Neil A Hukriede, Agnieszka Swiatecka-Urban. The human nephrin Y1139RSL motif is essential for podocyte foot process organization and slit diaphragm formation during glomerular development.
The Journal of biological chemistry.
2019 07; 294(28):10773-10788. doi:
10.1074/jbc.ra119.008235. [PMID: 31152064] - Yirong Zhang, Yawen Chen, Jianqun Zheng, Juan Wang, Shichao Duan, Wei Zhang, Xiumin Yan, Xueliang Zhu. Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Journal of molecular cell biology.
2019 05; 11(5):383-394. doi:
10.1093/jmcb/mjy043. [PMID: 30060180] - Shanshan Xie, Juan Jin, Zhangqi Xu, Yuliang Huang, Wen Zhang, Lu Zhao, Li Jan Lo, Jinrong Peng, Wei Liu, Fudi Wang, Qiang Shu, Tianhua Zhou. Centrosomal protein FOR20 is essential for cilia-dependent development in zebrafish embryos.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 03; 33(3):3613-3622. doi:
10.1096/fj.201801235rr. [PMID: 30475641] - Josephine A Bonventre, Chelsea Holman, Aayushi Manchanda, Sara J Codding, Trisha Chau, Jacob Huegel, Carrie Barton, Robert Tanguay, Colin P Johnson. Fer1l6 is essential for the development of vertebrate muscle tissue in zebrafish.
Molecular biology of the cell.
2019 02; 30(3):293-301. doi:
10.1091/mbc.e18-06-0401. [PMID: 30516436] - Heiko Schenk, Anna Masseli, Patricia Schroder, Patricia Bolaños-Palmieri, Michaela Beese, Jan Hegermann, Jan Hinrich Bräsen, Hermann Haller. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
BioMed research international.
2019; 2019(?):4508048. doi:
10.1155/2019/4508048. [PMID: 31428635] - David Merrick, Kavita Mistry, Jingshing Wu, Nikolay Gresko, Julie E Baggs, John B Hogenesch, Zhaoxia Sun, Michael J Caplan. Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ.
Human molecular genetics.
2019 01; 28(1):16-30. doi:
10.1093/hmg/ddy322. [PMID: 30215740] - Atsushi Fujita, Hiroyasu Tsukaguchi, Eriko Koshimizu, Hitoshi Nakazato, Kyoko Itoh, Shohei Kuraoka, Yoshihiro Komohara, Masaaki Shiina, Shohei Nakamura, Mika Kitajima, Yoshinori Tsurusaki, Satoko Miyatake, Kazuhiro Ogata, Kazumoto Iijima, Naomichi Matsumoto, Noriko Miyake. Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome.
Annals of neurology.
2018 12; 84(6):814-828. doi:
10.1002/ana.25370. [PMID: 30427554] - Joseph M Chambers, Shahram Jevin Poureetezadi, Amanda Addiego, Manuela Lahne, Rebecca A Wingert. ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny.
eLife.
2018 11; 7(?):. doi:
10.7554/elife.40266. [PMID: 30475208] - Adam M Belanger, Malgorzata Przybylska, Estelle Gefteas, Matthew Furgerson, Sarah Geller, Alla Kloss, Seng H Cheng, Yunxiang Zhu, Nelson S Yew. Inhibiting neutral amino acid transport for the treatment of phenylketonuria.
JCI insight.
2018 07; 3(14):. doi:
10.1172/jci.insight.121762. [PMID: 30046012] - Junchi Mei, Yu-Tao Li, Hong Zhang, Meng-Meng Xiao, Yong Ning, Zhi-Yong Zhang, Guo-Jun Zhang. Molybdenum disulfide field-effect transistor biosensor for ultrasensitive detection of DNA by employing morpholino as probe.
Biosensors & bioelectronics.
2018 Jul; 110(?):71-77. doi:
10.1016/j.bios.2018.03.043. [PMID: 29602033] - Xuejin Zhang, Chi Yong Kim, Tori Worthen, William H Witola. Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity.
International journal for parasitology.
2018 07; 48(8):649-656. doi:
10.1016/j.ijpara.2018.01.005. [PMID: 29530646] - Amber M Cheatham, Shamara E Davis, Atanu K Khatua, Waldemar Popik. Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch.
Scientific reports.
2018 06; 8(1):8739. doi:
10.1038/s41598-018-27104-x. [PMID: 29880816] - Nadine Artelt, Tim A Ludwig, Henrik Rogge, Panagiotis Kavvadas, Florian Siegerist, Antje Blumenthal, Jens van den Brandt, Carol A Otey, Marie-Louise Bang, Kerstin Amann, Christos E Chadjichristos, Christos Chatziantoniou, Karlhans Endlich, Nicole Endlich. The Role of Palladin in Podocytes.
Journal of the American Society of Nephrology : JASN.
2018 06; 29(6):1662-1678. doi:
10.1681/asn.2017091039. [PMID: 29720549] - Ludger Johannes, Marco Lucchino. Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs.
Nucleic acid therapeutics.
2018 06; 28(3):178-193. doi:
10.1089/nat.2017.0716. [PMID: 29883296] - Eugene J Wyatt, Alexis R Demonbreun, Ellis Y Kim, Megan J Puckelwartz, Andy H Vo, Lisa M Dellefave-Castillo, Quan Q Gao, Mariz Vainzof, Rita C M Pavanello, Mayana Zatz, Elizabeth M McNally. Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers.
JCI insight.
2018 05; 3(9):. doi:
10.1172/jci.insight.99357. [PMID: 29720576] - Hirofumi Komaki, Tetsuya Nagata, Takashi Saito, Satoru Masuda, Eri Takeshita, Masayuki Sasaki, Hisateru Tachimori, Harumasa Nakamura, Yoshitsugu Aoki, Shin'ichi Takeda. Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy.
Science translational medicine.
2018 04; 10(437):. doi:
10.1126/scitranslmed.aan0713. [PMID: 29669851] - Yosuke Takahashi, Yuki Araie, Daiki Nomura, Yuki Takahashi, Kohei Sano, Hideo Saji, Yoshinobu Takakura, Makiya Nishikawa. Construction of nanostructured DNA harbouring phosphorodiamidate morpholino oligonucleotide for controlled tissue distribution in mice.
Journal of drug targeting.
2018 04; 26(4):373-381. doi:
10.1080/1061186x.2017.1387789. [PMID: 28972806] - Patta Phumesin, Mutita Junking, Aussara Panya, Petlada Yongpitakwattana, Sansanee Noisakran, Thawornchai Limjindaporn, Pa-Thai Yenchitsomanus. Vivo-morpholino oligomers strongly inhibit dengue virus replication and production.
Archives of virology.
2018 Apr; 163(4):867-876. doi:
10.1007/s00705-017-3666-9. [PMID: 29260328] - Xiaoping Song, Xingxing Gao, Jiali Lu, Hongfang Liang, Peng Su, Qingwei Li, Yue Pang. High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation.
Development, growth & differentiation.
2018 Apr; 60(3):146-157. doi:
10.1111/dgd.12426. [PMID: 29520767] - Michiel van Veen, Laurie A Mans, Elisa Matas-Rico, Jason van Pelt, Anastassis Perrakis, Wouter H Moolenaar, Anna-Pavlina G Haramis. Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.
The international journal of biochemistry & cell biology.
2018 01; 94(?):71-78. doi:
10.1016/j.biocel.2017.11.015. [PMID: 29203233] - Seth M Daly, Carolyn R Sturge, Christina F Felder-Scott, Bruce L Geller, David E Greenberg. MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli.
mBio.
2017 11; 8(6):. doi:
10.1128/mbio.01315-17. [PMID: 29114023] - Behnoosh Tajik-Ahmadabad, Anastasios Polyzos, Frances Separovic, Fazel Shabanpoor. Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts.
International journal of pharmaceutics.
2017 Oct; 532(1):21-28. doi:
10.1016/j.ijpharm.2017.08.116. [PMID: 28864392] - Janina Müller-Deile, Jan Dannenberg, Patricia Schroder, Meei-Hua Lin, Jeffrey H Miner, Rongjun Chen, Jan-Hinrich Bräsen, Thomas Thum, Jenny Nyström, Lynne Beverly Staggs, Hermann Haller, Jan Fiedler, Johan M Lorenzen, Mario Schiffer. Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases.
Kidney international.
2017 10; 92(4):836-849. doi:
10.1016/j.kint.2017.03.005. [PMID: 28476557] - Daisuke Kobayashi, Anshin Asano-Hoshino, Takashi Nakakura, Toshiyuki Nishimaki, Satoshi Ansai, Masato Kinoshita, Motoyuki Ogawa, Haruo Hagiwara, Takahiko Yokoyama. Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Developmental biology.
2017 10; 430(1):69-79. doi:
10.1016/j.ydbio.2017.08.016. [PMID: 28823919] - Marine Joris, Marie Schloesser, Denis Baurain, Marc Hanikenne, Marc Muller, Patrick Motte. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors.
Nucleic acids research.
2017 Sep; 45(16):9547-9557. doi:
10.1093/nar/gkx638. [PMID: 28934490] - Tami Murphy, Heather Melville, Eliza Fradkin, Giana Bistany, Gregory Branigan, Kelly Olsen, Catharine R Comstock, Hayley Hanby, Ellie Garbade, Angela J DiBenedetto. Knockdown of epigenetic transcriptional co-regulator Brd2a disrupts apoptosis and proper formation of hindbrain and midbrain-hindbrain boundary (MHB) region in zebrafish.
Mechanisms of development.
2017 08; 146(?):10-30. doi:
10.1016/j.mod.2017.05.003. [PMID: 28549975] - Paul T Kroeger, Bridgette E Drummond, Rachel Miceli, Michael McKernan, Gary F Gerlach, Amanda N Marra, Annemarie Fox, Kristen K McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth BreMiller, Ryan Thummel, Alan J Davidson, John Postlethwait, Wolfram Goessling, Rebecca A Wingert. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.
Developmental biology.
2017 08; 428(1):148-163. doi:
10.1016/j.ydbio.2017.05.025. [PMID: 28579318] - Fazel Shabanpoor, Suzan M Hammond, Frank Abendroth, Gareth Hazell, Matthew J A Wood, Michael J Gait. Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy.
Nucleic acid therapeutics.
2017 Jun; 27(3):130-143. doi:
10.1089/nat.2016.0652. [PMID: 28118087] - Tangbin Liao, Xiaorui Li, Qian Tong, Kai Zou, Hang Zhang, Lina Tang, Zhongyue Sun, Guo-Jun Zhang. Ultrasensitive Detection of MicroRNAs with Morpholino-Functionalized Nanochannel Biosensor.
Analytical chemistry.
2017 05; 89(10):5511-5518. doi:
10.1021/acs.analchem.7b00487. [PMID: 28429595] - Richard W Naylor, Hwa In Han, Neil A Hukriede, Alan J Davidson. Wnt8a expands the pool of embryonic kidney progenitors in zebrafish.
Developmental biology.
2017 05; 425(2):130-141. doi:
10.1016/j.ydbio.2017.03.027. [PMID: 28359809] - Min Meng, Jianbo Zhang, Aihua Liu, Scott Reuschel, Pete Sazani, Michael Wong. Quantitative determination of AVI-7100 (Radavirsen), a phosphorodiamidate morpholino oligomer (PMOplus® ), in human plasma using LC-MS/MS.
Bioanalysis.
2017 May; 9(10):827-839. doi:
10.4155/bio-2016-0289. [PMID: 28520455] - Vahid Pazhakh, Sharon Clark, M Cristina Keightley, Graham J Lieschke. A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia.
Scientific reports.
2017 03; 7(?):44455. doi:
10.1038/srep44455. [PMID: 28281657] - Wai Ming Li, Ching-Man Chan, Andrew L Miller, Chow H Lee. Dual Functional Roles of Molecular Beacon as a MicroRNA Detector and Inhibitor.
The Journal of biological chemistry.
2017 03; 292(9):3568-3580. doi:
10.1074/jbc.m116.765776. [PMID: 28100783] - Kenji Rowel Q Lim, Rika Maruyama, Toshifumi Yokota. Eteplirsen in the treatment of Duchenne muscular dystrophy.
Drug design, development and therapy.
2017; 11(?):533-545. doi:
10.2147/dddt.s97635. [PMID: 28280301] - Umar Burki, Volker Straub. Ultrasensitive Hybridization-Based ELISA Method for the Determination of Phosphorodiamidate Morpholino Oligonucleotides in Biological samples.
Methods in molecular biology (Clifton, N.J.).
2017; 1565(?):265-277. doi:
10.1007/978-1-4939-6817-6_22. [PMID: 28364250] - Jordan Boutilier, Hong M Moulton. Surface Plasmon Resonance-Based Concentration Determination Assay: Label-Free and Antibody-Free Quantification of Morpholinos.
Methods in molecular biology (Clifton, N.J.).
2017; 1565(?):251-263. doi:
10.1007/978-1-4939-6817-6_21. [PMID: 28364249] - Jana Krtková, Alexander R Paredez. Use of Translation Blocking Morpholinos for Gene Knockdown in Giardia lamblia.
Methods in molecular biology (Clifton, N.J.).
2017; 1565(?):123-140. doi:
10.1007/978-1-4939-6817-6_11. [PMID: 28364239] - Raymond W M Kwong, Yusuke Kumai, Velislava Tzaneva, Estelle Azzi, Nina Hochhold, Cayleih Robertson, Bernd Pelster, Steve F Perry. Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia-inducible factor.
The Journal of experimental biology.
2016 12; 219(Pt 24):3988-3995. doi:
10.1242/jeb.148700. [PMID: 27802147] - Sibasish Paul, Marvin H Caruthers. Synthesis of Phosphorodiamidate Morpholino Oligonucleotides and Their Chimeras Using Phosphoramidite Chemistry.
Journal of the American Chemical Society.
2016 12; 138(48):15663-15672. doi:
10.1021/jacs.6b08854. [PMID: 27934012] - Michael P Carver, Jay S Charleston, Courtney Shanks, Jianbo Zhang, Mark Mense, Alok K Sharma, Harjeet Kaur, Peter Sazani. Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates.
Journal of neuromuscular diseases.
2016 08; 3(3):381-393. doi:
10.3233/jnd-160157. [PMID: 27854228] - Emily S Mathews, Bruce Appel. Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2016 07; 36(29):7628-39. doi:
10.1523/jneurosci.0726-16.2016. [PMID: 27445141] - Birgit Perner, Danny Schnerwitzki, Michael Graf, Christoph Englert. Analysis of Zebrafish Kidney Development with Time-lapse Imaging Using a Dissecting Microscope Equipped for Optical Sectioning.
Journal of visualized experiments : JoVE.
2016 Apr; ?(110):e53921. doi:
10.3791/53921. [PMID: 27078207] - Elisabeth Ott, Björn Wendik, Monika Srivastava, Frederic Pacho, Sonja Töchterle, Willi Salvenmoser, Dirk Meyer. Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm.
Developmental biology.
2016 Mar; 411(1):101-14. doi:
10.1016/j.ydbio.2015.10.014. [PMID: 26472045] - Barbara Verstraeten, Jolanda van Hengel, Ann Huysseune. Beta-Catenin and Plakoglobin Expression during Zebrafish Tooth Development and Replacement.
PloS one.
2016; 11(3):e0148114. doi:
10.1371/journal.pone.0148114. [PMID: 26938059] - Janina Müller-Deile, Finn Gellrich, Heiko Schenk, Patricia Schroder, Jenny Nyström, Johan Lorenzen, Hermann Haller, Mario Schiffer. Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 40(5):819-830. doi:
10.1159/000453142. [PMID: 27941332] - Patricia Q Rodriguez, Asmundur Oddsson, Lwaki Ebarasi, Bing He, Kjell Hultenby, Annika Wernerson, Christer Betsholtz, Karl Tryggvason, Jaakko Patrakka. Knockdown of Tmem234 in zebrafish results in proteinuria.
American journal of physiology. Renal physiology.
2015 Dec; 309(11):F955-66. doi:
10.1152/ajprenal.00525.2014. [PMID: 26377798] - Wei Deng, Melissa M J Farnham, Ewa M Goldys, Suja Mohammed, Paul M Pilowsky. Gene Interference with Morpholinos in a Gold Nanoparticle-Based Delivery Platform in Rat PC12 Cells.
Journal of biomedical nanotechnology.
2015 Dec; 11(12):2111-23. doi:
10.1166/jbn.2015.2171. [PMID: 26510306] - Yau-Hung Chen, Chiung-Fang Chang, Yen-Yu Lai, Chiao-Yin Sun, Yu-Ju Ding, Jen-Ning Tsai. von Hippel-Lindau gene plays a role during zebrafish pronephros development.
In vitro cellular & developmental biology. Animal.
2015 Nov; 51(10):1023-32. doi:
10.1007/s11626-015-9938-3. [PMID: 26194803] - Jingjing Zhang, Chen Ni, Zhenguo Yang, Anna Piontek, Huapu Chen, Sijie Wang, Yiming Fan, Zhihai Qin, Joerg Piontek. Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier.
Experimental dermatology.
2015 Aug; 24(8):605-10. doi:
10.1111/exd.12728. [PMID: 25869230] - Blair R Anderson, David N Howell, Karen Soldano, Melanie E Garrett, Nicholas Katsanis, Marilyn J Telen, Erica E Davis, Allison E Ashley-Koch. In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.
PLoS genetics.
2015 Jul; 11(7):e1005349. doi:
10.1371/journal.pgen.1005349. [PMID: 26147622] - Andrea Zecca, Sylvia Dyballa, Adria Voltes, Roger Bradley, Cristina Pujades. The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 May; 35(19):7475-86. doi:
10.1523/jneurosci.3743-14.2015. [PMID: 25972174] - Peter Järver, Eman M Zaghloul, Andrey A Arzumanov, Amer F Saleh, Graham McClorey, Suzan M Hammond, Mattias Hällbrink, Ülo Langel, C I Edvard Smith, Matthew J A Wood, Michael J Gait, Samir El Andaloussi. Peptide nanoparticle delivery of charge-neutral splice-switching morpholino oligonucleotides.
Nucleic acid therapeutics.
2015 Apr; 25(2):65-77. doi:
10.1089/nat.2014.0511. [PMID: 25594433] - Xinjun Zhang, Seong-Moon Cheong, Nathalia G Amado, Alice H Reis, Bryan T MacDonald, Matthias Zebisch, E Yvonne Jones, Jose Garcia Abreu, Xi He. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.
Developmental cell.
2015 Mar; 32(6):719-30. doi:
10.1016/j.devcel.2015.02.014. [PMID: 25771893] - Chong Pyo Choe, J Gage Crump. Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics.
Development (Cambridge, England).
2015 Mar; 142(6):1089-94. doi:
10.1242/dev.115774. [PMID: 25725065] - Yi Tao, Hangze Ruan, Xia Guo, Lixin Li, Wanhua Shen. HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.
PloS one.
2015; 10(3):e0120118. doi:
10.1371/journal.pone.0120118. [PMID: 25789466] - Peter Novodvorsky, Oliver Watson, Caroline Gray, Robert N Wilkinson, Scott Reeve, Carl Smythe, Richard Beniston, Karen Plant, Richard Maguire, Alexander M K Rothman, Stone Elworthy, Fredericus J M van Eeden, Timothy J A Chico. klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.
PloS one.
2015; 10(10):e0141611. doi:
10.1371/journal.pone.0141611. [PMID: 26506092] - Alison E Heald, Patrick L Iversen, Jay B Saoud, Peter Sazani, Jay S Charleston, Tim Axtelle, Michael Wong, William B Smith, Apinya Vutikullird, Edward Kaye. Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.
Antimicrobial agents and chemotherapy.
2014 Nov; 58(11):6639-47. doi:
10.1128/aac.03442-14. [PMID: 25155593] - Ting Zhang, Chaoran Yin, Liangjun Qiao, Lulu Jing, Hongda Li, Chun Xiao, Ning Luo, Song Lei, Wentong Meng, Hongyan Zhu, Jin Liu, Hong Xu, Xianming Mo. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Development (Cambridge, England).
2014 Nov; 141(22):4332-42. doi:
10.1242/dev.104885. [PMID: 25371367] - Elizabeth A O'Hare, Xiaochun Wang, May E Montasser, Yen-Pei C Chang, Braxton D Mitchell, Norann A Zaghloul. Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia.
Journal of lipid research.
2014 Nov; 55(11):2242-53. doi:
10.1194/jlr.m046540. [PMID: 25201834] - Débora M Cerqueira, Uyen Tran, Daniel Romaker, José G Abreu, Oliver Wessely. Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts.
Developmental biology.
2014 Oct; 394(1):54-64. doi:
10.1016/j.ydbio.2014.07.025. [PMID: 25127994] - Trent A Waugh, Eric Horstick, Junguk Hur, Samuel W Jackson, Ann E Davidson, Xingli Li, James J Dowling. Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy.
Human molecular genetics.
2014 Sep; 23(17):4651-62. doi:
10.1093/hmg/ddu185. [PMID: 24760771] - Danny Schnerwitzki, Birgit Perner, Beate Hoppe, Stefan Pietsch, Rebecca Mehringer, Frank Hänel, Christoph Englert. Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 results in protein isoforms with different functions.
Developmental biology.
2014 Sep; 393(1):24-32. doi:
10.1016/j.ydbio.2014.06.026. [PMID: 25014653] - Ju Chang-Chien, Yung-Chang Yen, Kuo-Hsuan Chien, Shaun-Yow Li, Tsai-Ching Hsu, Jiann-Jou Yang. The connexin 30.3 of zebrafish homologue of human connexin 26 may play similar role in the inner ear.
Hearing research.
2014 Jul; 313(?):55-66. doi:
10.1016/j.heares.2014.04.010. [PMID: 24811980] - Shannon Glaser, Fanyin Meng, Yuyan Han, Paolo Onori, Billy K Chow, Heather Francis, Julie Venter, Kelly McDaniel, Marco Marzioni, Pietro Invernizzi, Yoshiyuki Ueno, Jia-ming Lai, Li Huang, Holly Standeford, Domenico Alvaro, Eugenio Gaudio, Antonio Franchitto, Gianfranco Alpini. Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.
Gastroenterology.
2014 Jun; 146(7):1795-808.e12. doi:
10.1053/j.gastro.2014.02.030. [PMID: 24583060] - Adam M Tuttle, Trevor L Hoffman, Thomas F Schilling. Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration.
PLoS biology.
2014 May; 12(5):e1001852. doi:
10.1371/journal.pbio.1001852. [PMID: 24802872] - Ying-Jey Guh, Yung-Che Tseng, Chao-Yew Yang, Pung-Pung Hwang. Endothelin-1 regulates H⁺-ATPase-dependent transepithelial H⁺ secretion in zebrafish.
Endocrinology.
2014 May; 155(5):1728-37. doi:
10.1210/en.2013-1775. [PMID: 24424055] - Joseph Burgon, Anne L Robertson, Pranvera Sadiku, Xingang Wang, Edward Hooper-Greenhill, Lynne R Prince, Paul Walker, Emily E Hoggett, Jonathan R Ward, Stuart N Farrow, William J Zuercher, Philip Jeffrey, Caroline O Savage, Philip W Ingham, Adam F Hurlstone, Moira K B Whyte, Stephen A Renshaw. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.
Journal of immunology (Baltimore, Md. : 1950).
2014 Feb; 192(4):1796-805. doi:
10.4049/jimmunol.1300087. [PMID: 24431232] - Giuseppina Gariano, Michela Guarienti, Roberto Bresciani, Giuseppe Borsani, Giulia Carola, Eugenio Monti, Roberta Giuliani, Rita Rezzani, Francesca Bonomini, Augusto Preti, Peter Schu, Daniela Zizioli. Analysis of three μ1-AP1 subunits during zebrafish development.
Developmental dynamics : an official publication of the American Association of Anatomists.
2014 Feb; 243(2):299-314. doi:
10.1002/dvdy.24071. [PMID: 24123392] - Gauri Khandekar, Pudur Jagadeeswaran. Role of hepsin in factor VII activation in zebrafish.
Blood cells, molecules & diseases.
2014 Jan; 52(1):76-81. doi:
10.1016/j.bcmd.2013.07.014. [PMID: 23954211] - Ehtesham Arif, Babita Kumari, Mark C Wagner, Weibin Zhou, Lawrence B Holzman, Deepak Nihalani. Myo1c is an unconventional myosin required for zebrafish glomerular development.
Kidney international.
2013 Dec; 84(6):1154-65. doi:
10.1038/ki.2013.201. [PMID: 23715127] - Yao-Qiu Liu, Gui-Xian Song, Hai-Lang Liu, Xue-Jie Wang, Ya-Hui Shen, Li-Juan Zhou, Jin Jin, Ming Liu, Chun-Mei Shi, Ling-Mei Qian. Silencing of FABP3 leads to apoptosis-induced mitochondrial dysfunction and stimulates Wnt signaling in zebrafish.
Molecular medicine reports.
2013 Sep; 8(3):806-12. doi:
10.3892/mmr.2013.1586. [PMID: 23846528] - Pamela S Tietz Bogert, Bing Q Huang, Sergio A Gradilone, Tetyana V Masyuk, Gary L Moulder, Stephen C Ekker, Nicholas F Larusso. The zebrafish as a model to study polycystic liver disease.
Zebrafish.
2013 Jun; 10(2):211-7. doi:
10.1089/zeb.2012.0825. [PMID: 23668934] - Shuping Dou, Miles Smith, Yuzhen Wang, Mary Rusckowski, Guozheng Liu. Intraperitoneal injection is not always a suitable alternative to intravenous injection for radiotherapy.
Cancer biotherapy & radiopharmaceuticals.
2013 May; 28(4):335-42. doi:
10.1089/cbr.2012.1351. [PMID: 23469942] - Fahad Mahmood, Monika Mozere, Anselm A Zdebik, Horia C Stanescu, Jonathan Tobin, Philip L Beales, Robert Kleta, Detlef Bockenhauer, Claire Russell. Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome.
Disease models & mechanisms.
2013 May; 6(3):652-60. doi:
10.1242/dmm.009480. [PMID: 23471908]