Calicheamicin (BioDeep_00000912267)

Chemicals and Drugs Antibiotics Antitumor activity Toxin Cytotoxicity

代谢物信息卡片

S-[6-[[5-[5-(ethylamino)-4-methoxyoxan-2-yl]oxy-4-hydroxy-6-[[(5E,13Z)-9-hydroxy-12-(methoxycarbonylamino)-13-[2-(methyltrisulfanyl)ethylidene]-11-oxo-2-bicyclo[7.3.1]trideca-1(12),5-dien-3,7-diynyl]oxy]-2-methyloxan-3-yl]amino]oxy-4-hydroxy-2-methyloxan-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methylbenzenecarbothioate

化学式: C55H74IN3O21S4 (1367.2742224)
中文名称: 卡里奇霉素
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-10-09.

Cite this Page

Calicheamicin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/calicheamicin (retrieved 2024-11-23) (BioDeep RN: BioDeep_00000912267). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCNC1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NOC5CC(C(C(O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)OC7C(C(C(C(O7)C)O)OC)O)I)C)O)O
InChI: InChI=1S/C55H74IN3O21S4/c1-12-57-30-24-73-35(22-34(30)68-6)78-48-43(63)40(26(3)75-53(48)77-33-17-15-13-14-16-19-55(67)23-32(61)41(58-54(66)72-10)38(33)29(55)18-20-82-84-81-11)59-80-36-21-31(60)50(28(5)74-36)83-51(65)37-25(2)39(56)46(49(71-9)45(37)69-7)79-52-44(64)47(70-8)42(62)27(4)76-52/h13-14,18,26-28,30-31,33-36,40,42-44,47-48,50,52-53,57,59-60,62-64,67H,12,20-24H2,1-11H3,(H,58,66)/b14-13+,29-18-

描述信息

Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death.

Calicheamicin is a naturally occurring organic compound that belongs to the class of macrocyclic lactones. It is renowned for its potent antitumor activity and was originally isolated from soil as an antibiotic. The compound's distinctive feature is its ability to bind to DNA and induce double-strand DNA breaks, which is a highly effective mechanism for inhibiting the proliferation of tumor cells.
Due to its significant cytotoxicity, Calicheamicin and its derivatives have been the subject of research and development for antitumor drugs. However, the clinical application of Calicheamicin is limited by its strong toxicity. It is often used in combination with other treatments to reduce side effects and enhance its therapeutic efficacy.

D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D000080084 - Calicheamicins

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数据库引用编号

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PubChem: 156963280
MeSH: Calicheamicins

分类词条

大环内酯类抗生素

代谢反应

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