Taurohyodeoxycholic acid (BioDeep_00000419367)
natural product PANOMIX_OTCML-2023 Bile acids PANOMIX LipidSearch
代谢物信息卡片
化学式: C26H45NO6S (499.29674300000005)
中文名称: 牛磺猪去氧胆酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 1.02%
Last reviewed on 2024-07-16.
Cite this Page
Taurohyodeoxycholic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/taurohyodeoxycholic_acid (retrieved
2024-11-26) (BioDeep RN: BioDeep_00000419367). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2CC(C4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C26H45NO6S/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-/m1/s1
描述信息
Taurohyodeoxycholic acid is a bile acid taurine conjugate. It is a conjugate acid of a taurohyodeoxycholate(1-).
Taurohyodeoxycholic acid is the tauroconjugated form of Hyodeoxycholic acid (HDCA, a dihydroxylated natural bile acid). Taurohyodeoxycholic acid induces a biliary phospholipid secretion and suggests a hepatoprotective potential. Taurohyodeoxycholic acid also can promote gallstone dissolution[1][1].
同义名列表
1 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:139138
- PubChem: 119046
- ChEMBL: CHEMBL270516
- MoNA: CCMSLIB00005435491
- MoNA: CCMSLIB00005435492
- MoNA: CCMSLIB00005435493
- MoNA: CCMSLIB00005435581
- MoNA: CCMSLIB00005435582
- MoNA: CCMSLIB00005435583
- MoNA: CCMSLIB00005435584
- MoNA: CCMSLIB00005435585
- MoNA: CCMSLIB00005435586
- MoNA: CCMSLIB00005435587
- RefMet: Taurohyodeoxycholic acid
- CAS: 2958-04-5
- PANOMIX LipidSearch: CA-41
- medchemexpress: HY-114360
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ningning Zheng, Hao Wang, Weize Zhu, Yan Li, Houkai Li. Astraglus polysaccharide attenuates nonalcoholic fatty liver disease through THDCA in high-fat diet-fed mice.
Journal of ethnopharmacology.
2023 Nov; ?(?):117401. doi:
10.1016/j.jep.2023.117401. [PMID: 37967775] - Iván L Csanaky, Andrew J Lickteig, Youcai Zhang, Curtis D Klaassen. Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicology and applied pharmacology.
2020 09; 403(?):115136. doi:
10.1016/j.taap.2020.115136. [PMID: 32679164] - Ying Xu, Ping-Ping Zhong, Yan-Yan Tao. Metabolic profiling of endogenous bile acids: a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats.
Chinese journal of natural medicines.
2018 Apr; 16(4):271-283. doi:
10.1016/s1875-5364(18)30057-8. [PMID: 29703327] - Adnan Adil Hismiogullari, Sahver Ege Hismiogullari, Khalid Rahman. Isolation and biochemical analysis of vesicles from taurohyodeoxycholic acid-infused isolated perfused rat livers.
World journal of gastroenterology.
2013 Oct; 19(37):6228-36. doi:
10.3748/wjg.v19.i37.6228. [PMID: 24115821] - Youcai Zhang, Iván L Csanaky, Xingguo Cheng, Lois D Lehman-McKeeman, Curtis D Klaassen. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):451-62. doi:
10.1093/toxsci/kfs123. [PMID: 22461449] - Jiao He, Jinru Liang, Sha Zhu, Wenna Zhao, Yongmin Zhang, Wenji Sun. Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice.
European journal of pharmacology.
2011 Nov; 670(1):229-35. doi:
10.1016/j.ejphar.2011.08.036. [PMID: 21925164] - F Lanzarotto, S Sosta, A Lanzini. Effect of chronic administration of tauro-hyodeoxycholic acid on biliary bile acid composition and on biliary lipid secretion in humans.
Scandinavian journal of gastroenterology.
2001 Sep; 36(9):981-6. doi:
10.1080/003655201750305521. [PMID: 11521991] - C Song, R A Hiipakka, S Liao. Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs.
Steroids.
2000 Aug; 65(8):423-7. doi:
10.1016/s0039-128x(00)00127-6. [PMID: 10936612] - P Loria, M Bozzoli, M Concari, M E Guicciardi, F Carubbi, M Bertolotti, D Piani, A Nistri, M Angelico, M Romani, N Carulli. Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans.
Hepatology (Baltimore, Md.).
1997 Jun; 25(6):1306-14. doi:
10.1002/hep.510250601. [PMID: 9185744] - P Loria, M Bozzoli, M Angelico, M Bertolotti, F Carubbi, M Concari, L Baiocchi, A Nistri, P Della Guardia, M Romani, N Carulli. Effect of taurohyodeoxycholic acid on biliary lipid secretion in man: preliminary report.
The Italian journal of gastroenterology.
1996 Sep; 28(7):391-2. doi:
". [PMID: 8937941] - M Angelico, L Baiocchi, A Nistri, A Franchitto, P Della Guardia, E Gaudio. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.
Digestive diseases and sciences.
1994 Nov; 39(11):2389-97. doi:
10.1007/bf02087656. [PMID: 7956608] - M De Bernardi di Valserra, A S Tripodi, S Contos, P Mattaboni, R Germogli. Chronic toxicity of taurohyodeoxycholic acid in rats.
Arzneimittel-Forschung.
1993 Aug; 43(8):880-7. doi:
NULL. [PMID: 8216447] - F Feletti, A S Tripodi, M De Bernardi di Valserra, R Germogli. Chronic toxicity of taurohyodeoxycholic acid in dogs.
Arzneimittel-Forschung.
1993 Aug; 43(8):888-93. doi:
NULL. [PMID: 8216448]