Carvedilol (BioDeep_00000001929)

human metabolite blood metabolite Chemicals and Drugs Exogenous Volatile Flavor Compounds

代谢物信息卡片

(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol

化学式: C24H26N2O4 (406.1892476)
中文名称: 卡维地洛
谱图信息: 最多检出来源 Viridiplantae(plant) 4.37%

Reviewed

Last reviewed on 2024-10-11.

Cite this Page

Carvedilol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/carvedilol (retrieved 2024-11-24) (BioDeep RN: BioDeep_00000001929). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

描述信息

Carvedilol is only found in individuals that have used or taken this drug. It is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF).Carvedilol is a racemic mixture in which nonselective beta-adrenoreceptor blocking activity is present in the S(-) enantiomer and alpha-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilols beta-adrenergic receptor blocking ability decreases the heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its alpha adrenergic receptor blocking properties. Carvedilol and its metabolite BM-910228 (a less potent beta blocker, but more potent antioxidant) have been shown to restore the inotropic responsiveness to Ca²⁺ in OH^- free radical-treated myocardium. Carvedilol and its metabolites also prevent OH^- radical-induced decrease in sarcoplasmic reticulum Ca²⁺-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in chronic heart failure by preventing free radical damage.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AG - Alpha and beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D020011 - Protective Agents > D000975 - Antioxidants
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

同义名列表

25 个代谢物同义名

(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol; 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol; Carvedilol hydrochloride; Carvedilol, 14C labeled; Carvedilol, 14C-labeled; Carvedilol, (+-)-isomer; Carvedilol, (-)-isomer; 14C-Labeled carvedilol; Carvedilol, (R)-isomer; Carvedilol, (+)-isomer; Carvedilol, (S)-isomer; Carvedilol, (+); Carvedilol, (-); Carvedilolum; carvedilol; SKF 105517; Dilatrend; Coropres; Eucardic; Artist; Kredex; Querto; Coreg; BM 14190; Carvedilol

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:3441
KEGG: C06875
KEGGdrug: D00255
PubChem: 2585
HMDB: HMDB0015267
Metlin: METLIN1558
DrugBank: DB01136
ChEMBL: CHEMBL723
Wikipedia: Carvedilol
MeSH: Carvedilol
chemspider: 2487
CAS: 107741-96-8
CAS: 72956-09-3
PMhub: MS000001463
NIKKAJI: J33.955E
RefMet: Carvedilol
medchemexpress: HY-B0006
PubChem: 9092
KNApSAcK: 3441

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jaroslaw Szponar, Agnieszka Gorska, Marta Ostrowska-Lesko, Agnieszka Korga-Plewko, Michal Tchorz, Erwin Ciechanski, Anna Dabrowska, Ewa Poleszak, Franciszek Burdan, Jaroslaw Dudka, Marek Murias, Slawomir Mandziuk. Assessment of the Impact of Carvedilol Administered Together with Dexrazoxan and Doxorubicin on Liver Structure and Function, Iron Metabolism, and Myocardial Redox System in Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042219. [PMID: 38396896]
Mila Kovačević, Alenka Zvonar Pobirk, Ilija German Ilić. The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Feb; 193(?):106582. doi: 10.1016/j.ejps.2023.106582. [PMID: 37709174]
Bingqiong Wang, Jialing Zhou, Xiaoning Wu, Yameng Sun, Lei Li, Ping Li, Minghui Li, Wei Jiang, Mingyi Xu, Bo Feng, Xiaoyuan Xu, Jilin Cheng, Wen Xie, Tao Han, Xiaozhong Wang, Hai Li, Hongxin Piao, Xinyu Zhao, Shuyan Chen, Tongtong Meng, Qiushuang Guan, Fandong Meng, Yuanyuan Kong, Xiaojuan Ou, Jidong Jia, Hong You. Carvedilol plus NUCs for compensated HBV-cirrhosis patients under virological suppression: a randomised, open-label trial. The American journal of gastroenterology. 2023 Nov; ?(?):. doi: 10.14309/ajg.0000000000002569. [PMID: 37929952]
Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis. Drugs in R&D. 2023 Aug; ?(?):. doi: 10.1007/s40268-023-00435-5. [PMID: 37556093]
Qi Song, Song Li. Identification of Plant Co-regulatory Modules Using CoReg. Methods in molecular biology (Clifton, N.J.). 2023; 2594(?):217-223. doi: 10.1007/978-1-0716-2815-7_16. [PMID: 36264499]
Marcella Pavan, Priscila Yamamoto, Rodrigo Moreira da Silva, Wilson Salgado Junior, José Dos Santos, Rafael Kemp, Ajith Sankarankutty, Natália de Moraes, Cristiane de Gaitani. Chemometric optimization of salting-out assisted liquid-liquid extraction (SALLE) combined with LC-MS/MS for the analysis of carvedilol enantiomers in human plasma: Application to clinical pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Aug; 1205(?):123338. doi: 10.1016/j.jchromb.2022.123338. [PMID: 35724550]
Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury. Drug and chemical toxicology. 2022 Jul; 45(4):1558-1564. doi: 10.1080/01480545.2020.1846551. [PMID: 33198524]
Mehmet Tolga Kafadar, Mehmet Ali Gök. Effects of Carvedilol on liver ischemia-reperfusion injury in rats. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2022 Jul; 28(7):885-893. doi: 10.14744/tjtes.2021.57824. [PMID: 35775675]
S Balasurya, Mohammad K Okla, Ibrahim A Alaraidh, Walid Soufan, Abdullah A Al-Ghamdi, Syed R Ahamad, Mostafa A Abdel-Maksoud, Hamada AbdElgawad, Lija L Raju, Ajith M Thomas, S Sudheer Khan. Photodegradation of 5-flurouracil, carvedilol, para-chlorophenol and methimazole with 3D MnWO4 nanoflower modified Ag2WO4 nanorods: A non-genotoxic nanomaterial for water treatment. Chemosphere. 2022 Jun; 297(?):134130. doi: 10.1016/j.chemosphere.2022.134130. [PMID: 35257704]
Xian-Tao Li. Beneficial effects of carvedilol modulating potassium channels on the control of glucose. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113057. doi: 10.1016/j.biopha.2022.113057. [PMID: 35658228]
Rasha M S M Mohamed, Enssaf Ahmad Ahmad, Bothina H F Omran, Amr T Sakr, Islam A A E-H Ibrahim, Mona F Mahmoud, Mostafa E El-Naggar. Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway. Life sciences. 2022 Mar; 293(?):120304. doi: 10.1016/j.lfs.2022.120304. [PMID: 35016879]
Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):413-423. doi: 10.1161/hypertensionaha.121.18026. [PMID: 34879704]
Md Abdullah Shamim, Steven Yeung, Ayaz Shahid, Mengbing Chen, Jeffrey Wang, Preshita Desai, Cyrus Parsa, Robert Orlando, Frank L Meyskens, Kristen M Kelly, Bradley T Andresen, Ying Huang. Topical carvedilol delivery prevents UV-induced skin cancer with negligible systemic absorption. International journal of pharmaceutics. 2022 Jan; 611(?):121302. doi: 10.1016/j.ijpharm.2021.121302. [PMID: 34793935]
Michael Rode, Kolja Nenoff, Kerstin Wirkner, Katrin Horn, Andrej Teren, Ralf Regenthal, Markus Loeffler, Joachim Thiery, Achim Aigner, Janne Pott, Holger Kirsten, Markus Scholz. Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers. PloS one. 2022; 17(4):e0266897. doi: 10.1371/journal.pone.0266897. [PMID: 35446883]
Hoda M S Ahmed, Samar G Mohamed, Wael S Ibrahim, Asmaa M Rezk, Amr A A Mahmoud, Mona F Mahmoud, Islam A A E-H Ibrahim. Acute and chronic metabolic effects of carvedilol in high-fructose, high-fat diet-fed mice: implication of β-arrestin2 pathway. Canadian journal of physiology and pharmacology. 2022 Jan; 100(1):68-77. doi: 10.1139/cjpp-2021-0299. [PMID: 34570983]
Wen Zhang, Guiming Deng, Jia Hu, Ran Yan, Junliu Hu, Jianmin Fan. Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension. Computational and mathematical methods in medicine. 2022; 2022(?):7889024. doi: 10.1155/2022/7889024. [PMID: 35936366]
Rasha M S M Mohamed, Shimaa M Elshazly, Ola E Nafea, Dalia M Abd El Motteleb. Comparative cardioprotective effects of carvedilol versus atenolol in a rat model of cardiorenal syndrome type 4. Naunyn-Schmiedeberg's archives of pharmacology. 2021 10; 394(10):2117-2128. doi: 10.1007/s00210-021-02130-1. [PMID: 34398250]
Sarah A Baraka, Mai F Tolba, Doaa A Elsherbini, Reem N El-Naga, Azza S Awad, Ebtehal El-Demerdash. Rosuvastatin and low-dose carvedilol combination protects against isoprenaline-induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO-1 signalling. Clinical and experimental pharmacology & physiology. 2021 10; 48(10):1358-1370. doi: 10.1111/1440-1681.13535. [PMID: 34081810]
Hope Onohuean, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Safaa Qusti, Eida M Alshammari, Gaber El-Saber Batiha. Covid-19 and development of heart failure: mystery and truth. Naunyn-Schmiedeberg's archives of pharmacology. 2021 10; 394(10):2013-2021. doi: 10.1007/s00210-021-02147-6. [PMID: 34480616]
Georgios N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis, Haralampos Milionis. Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites. Journal of clinical gastroenterology. 2021 09; 55(8):721-729. doi: 10.1097/mcg.0000000000001431. [PMID: 32991355]
Qingtong Wang, Ying Wang, Toni M West, Yongming Liu, Gopireddy R Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K Xiang. Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovascular research. 2021 08; 117(10):2237-2251. doi: 10.1093/cvr/cvaa266. [PMID: 32956449]
Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175137. [PMID: 34500571]
Sanaa A Ahmed, Walaa I Mohammed. Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111594. doi: 10.1016/j.biopha.2021.111594. [PMID: 33878623]
Nahed Mohamed Sallam, Rania Abdel Basset Sanad, Mahgoub Mohamed Ahmed, E L Sayed Khafagy, Mamdouh Ghorab, Shadeed Gad. Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models. Drug delivery and translational research. 2021 06; 11(3):1009-1036. doi: 10.1007/s13346-020-00814-4. [PMID: 32607938]
Syed Mohammed Basheeruddin Asdaq, Obulesu Challa, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, Abdulrahman Hadi Almutiri, Majed Sadun Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113203. [PMID: 34071846]
Julian C Dunkley, Camila I Irion, Keyvan Yousefi, Serene A Shehadeh, Guerline Lambert, Krista John-Williams, Keith A Webster, Jeffrey J Goldberger, Lina A Shehadeh. Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in Col4a3-/- Alport mice. American journal of physiology. Heart and circulatory physiology. 2021 05; 320(5):H1862-H1872. doi: 10.1152/ajpheart.00535.2020. [PMID: 33769915]
Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):704-712. doi: 10.1053/j.ajkd.2020.07.023. [PMID: 33010357]
Abhilash Chandra, Namrata Rao, Divya Srivastava, Prabhaker Mishra. Better peridialytic blood pressure control using carvedilol in end stage renal disease patients on twice weekly maintenance hemodialysis. International urology and nephrology. 2021 May; 53(5):1007-1014. doi: 10.1007/s11255-020-02716-3. [PMID: 33387227]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Peter McGranaghan, Anshul Saxena, Hans-Dirk Düngen, Muni Rubens, Sandeep Appunni, Joseph Salami, Emir Veledar, Philipp Lacour, Florian Blaschke, Danilo Obradovic, Goran Loncar, Elvis Tahirovic, Frank Edelmann, Burkert Pieske, Tobias Daniel Trippel. Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure. Scientific reports. 2021 04; 11(1):8164. doi: 10.1038/s41598-021-87776-w. [PMID: 33854188]
Alireza Farshi, Nooriyeh DalirAkbari, Afshar Zomorrodi, Mohammad Khalili, Mahsa Mahmoudinezhad. A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. Urology journal. 2021 Apr; 18(3):337-342. doi: 10.22037/uj.v18i.5678. [PMID: 33840085]
Ji Eun Choi, Jung Suk Kim, Min-Jong Choi, Kyungho Baek, Mi Ran Woo, Jong Oh Kim, Han-Gon Choi, Sung Giu Jin. Effects of different physicochemical characteristics and supersaturation principle of solidified SNEDDS and surface-modified microspheres on the bioavailability of carvedilol. International journal of pharmaceutics. 2021 Mar; 597(?):120377. doi: 10.1016/j.ijpharm.2021.120377. [PMID: 33581270]
Tanja Gangnus, Bjoern B Burckhardt. Low-volume LC-MS/MS method for the pharmacokinetic investigation of carvedilol, enalapril and their metabolites in whole blood and plasma: Application to a paediatric clinical trial. Drug testing and analysis. 2021 Mar; 13(3):694-708. doi: 10.1002/dta.2949. [PMID: 33126289]
Najla Locatelli Santos Esteves, Lígia Marquez Andrade, Anna Paula Krawczyk-Santos, Bruno Dos Santos Souza, Ricardo Neves Marreto, Stephânia Fleury Taveira. Development of carvedilol-loaded lipid nanoparticles with compatible lipids and enhanced skin permeation in different skin models. Journal of microencapsulation. 2021 Mar; 38(2):124-133. doi: 10.1080/02652048.2020.1857862. [PMID: 33305646]
Asmaa M Rezk, Islam A A E-H Ibrahim, Mona F Mahmoud, Amr A A Mahmoud. Quercetin and lithium chloride potentiate the protective effects of carvedilol against renal ischemia-reperfusion injury in high-fructose, high-fat diet-fed Swiss albino mice independent of renal lipid signaling. Chemico-biological interactions. 2021 Jan; 333(?):109307. doi: 10.1016/j.cbi.2020.109307. [PMID: 33159969]
Maha Sabry, Seham Mostafa, Laila Rashed, Marwa Abdelgwad, Samaa Kamar, Suzanne Estaphan. Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats. PloS one. 2021; 16(2):e0244650. doi: 10.1371/journal.pone.0244650. [PMID: 33571214]
Hala Salah Abdel-Kawy. Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats. Drug and chemical toxicology. 2021 Jan; 44(1):101-111. doi: 10.1080/01480545.2019.1576718. [PMID: 30810389]
Yuan-Hsi Tseng, Chia-Yen Liu, Chuan-Pin Lee, Meng-Hung Lin, Yao-Hsu Yang. Effect of carvedilol on arteriovenous graft primary patency. Vascular. 2020 Dec; 28(6):765-774. doi: 10.1177/1708538120923886. [PMID: 32408854]
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Reetu Sharma. Network-based approach highlighting interplay among anti-hypertensives: target coding-genes: diseases. Scientific reports. 2020 11; 10(1):20152. doi: 10.1038/s41598-020-76605-1. [PMID: 33214616]
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Osama M Ahmed, Hossam Ebaid, El-Shaymaa El-Nahass, Mahmoud Ragab, Ibrahim M Alhazza. Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak. Biomolecules. 2020 09; 10(9):. doi: 10.3390/biom10091317. [PMID: 32937925]
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Charbel Skayem, Nakhle Ayoub. Carvedilol and COVID-19: A Potential Role in Reducing Infectivity and Infection Severity of SARS-CoV-2. The American journal of the medical sciences. 2020 09; 360(3):300. doi: 10.1016/j.amjms.2020.05.030. [PMID: 32631576]
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Zhouke Tan, Guibao Ke, Junlin Huang, Die Yang, Mingjing Pi, Li Li, Xiaolin Liu, Shaohua Tao, Lvlin Chen, Guobiao Liang, Shuangxin Liu. Effects of Carvedilol on Cardiovascular Events and Mortality in Hemodialysis Patients, A Systematic Review and Meta-Analysis. Iranian journal of kidney diseases. 2020 07; 14(4):256-266. doi: NULL. [PMID: 32655020]
Madhumita Premkumar, Devaraja Rangegowda, Tanmay Vyas, Jelen S Khumuckham, Saggere M Shasthry, Sherin S Thomas, Ritu Goyal, Guresh Kumar, Shiv K Sarin. Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis. Journal of clinical gastroenterology. 2020 07; 54(6):561-568. doi: 10.1097/mcg.0000000000001219. [PMID: 31305281]
Marko Krstić, Luka Manić, Nikola Martić, Dragana Vasiljević, Svetlana Đogo Mračević, Saša Vukmirović, Aleksandar Rašković. Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Jul; 150(?):105343. doi: 10.1016/j.ejps.2020.105343. [PMID: 32376386]
Wael S Ibrahim, Islam A A E-H Ibrahim, Mona F Mahmoud, Amr A A Mahmoud. Carvedilol Diminishes Cardiac Remodeling Induced by High-Fructose/High-Fat Diet in Mice via Enhancing Cardiac β-Arrestin2 Signaling. Journal of cardiovascular pharmacology and therapeutics. 2020 07; 25(4):354-363. doi: 10.1177/1074248420905683. [PMID: 32052660]
Linlin Fang, Yanyan Zhao, Chao Wang, Changyuan Wang, Xu Han, Pengjun Chen, Lizhu Zhao, Jingping Wang, Shuang Li, Zhen Jiang. Preparation of a thiols β-cyclodextrin/gold nanoparticles-coated open tubular column for capillary electrochromatography enantioseparations. Journal of separation science. 2020 Jun; 43(11):2209-2216. doi: 10.1002/jssc.201901323. [PMID: 32160391]
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