isotetrandrine (BioDeep_00000261591)

Main id: BioDeep_00000014687

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds natural product


代谢物信息卡片


O,O-Dimethylstepholine

化学式: C38H42N2O6 (622.3042712000001)
中文名称: 异粉防己碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1c2c3c(c(c1OC)OC)Oc1cc4c(cc1OC)CCN([C@H]4Cc1cc(ccc1)Oc1cc(C[C@H]3N(CC2)C)ccc1OC)C
InChI: InChI=1S/C38H42N2O6/c1-39-14-12-25-20-32(42-4)34-22-28(25)29(39)17-23-8-7-9-27(16-23)45-33-19-24(10-11-31(33)41-3)18-30-36-26(13-15-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-11,16,19-22,29-30H,12-15,17-18H2,1-6H3/t29-,30+/m0/s1

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000970 - Antineoplastic Agents

同义名列表

8 个代谢物同义名

Isosinomenine A; isotetrandrine; O,O-Dimethylstepholine; O,O-Dimethylobamegine; (+)-Isotetrandrine; O-Methylberbamine; Isosinomenin A; Isotetrandrine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiawen Song, Yushi Liu, Yurou Guo, Minghao Yuan, Wenxiao Zhong, Jiamei Tang, Yiping Guo, Li Guo. Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review. Inflammopharmacology. 2024 Jun; 32(3):1743-1757. doi: 10.1007/s10787-024-01452-9. [PMID: 38568399]
  • Li Fang, Rong Shen, Yao Lu, Xiangfeng Xu, Fang Huang. Tetrandrine alleviates inflammation and promotes macrophage M2 polarization in gouty arthritis by NF-κB-mediated Lcp1. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):205-211. doi: 10.14715/cmb/2024.70.2.29. [PMID: 38430024]
  • Jie Ling, Xiao Li, Maolin Wang, Chaozheng Zhang, Yilan Liu, Xin Zhang, Changqun Liu, Qing Ren, Yingjie Zeng, Chuanqi Wang, Ying Chen, Chen Sun, Hongyu Chen, Yi Zuo, Xiujun Cao, Yun Deng, Bo Ren, Defang Li, Jun Lu. Novel sulfonyl-substituted tetrandrine derivatives for colon cancer treatment by inducing mitochondrial apoptosis and inhibiting PI3K/AKT/mTOR pathway. Bioorganic chemistry. 2024 Feb; 143(?):107069. doi: 10.1016/j.bioorg.2023.107069. [PMID: 38160477]
  • Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong. Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma. Drug development and industrial pharmacy. 2024 Jan; ?(?):1-15. doi: 10.1080/03639045.2024.2302886. [PMID: 38235554]
  • Na Kou, Yi-Bing Chen, Xian-Wen Li, Dong Xu, Yue Wang, Xin-Ran Dong, Yuan-Lu Cui, Qiangsong Wang. Pulmonary administration of tetrandrine loaded Zinc-Alginate nanogels attenuates pulmonary fibrosis in rats. International journal of pharmaceutics. 2024 Jan; 649(?):123625. doi: 10.1016/j.ijpharm.2023.123625. [PMID: 37984618]
  • Yunyan Chen, Ziwei Zhang, Zhilei Qian, Rui Ma, Minna Luan, Yu Sun. Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil. International journal of nanomedicine. 2024; 19(?):727-742. doi: 10.2147/ijn.s446895. [PMID: 38288265]
  • Zhengyu Fang, Peihong Lin, Rui Gao, Wenjing Yang, Aizhen Zhou, Wenying Yu. Preparation, Characterization, and Anti-Lung Cancer Activity of Tetrandrine-Loaded Stealth Liposomes. International journal of nanomedicine. 2024; 19(?):787-803. doi: 10.2147/ijn.s431599. [PMID: 38293606]
  • Kaitao Wang, Jiapeng Deng, Jialong Yang, An Wang, Minle Ye, Qingyu Chen, Guodong Chen, Dingsheng Lin. Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway. Phytotherapy research : PTR. 2023 Nov; ?(?):. doi: 10.1002/ptr.8058. [PMID: 37909161]
  • Hui Jiang, Chunming Tang, Yuanyuan Wen, Qianqian Zhao, Mingyuan Xu, Jinting Fan, Zhiji Wang, Lifeng Wang, Huae Xu, Gang Chen. Enhanced Antitumor Efficacy of Novel Biomimetic Platelet Membrane-Coated Tetrandrine Nanoparticles in Nonsmall Cell Lung Cancer. Molecular pharmaceutics. 2023 Oct; ?(?):. doi: 10.1021/acs.molpharmaceut.3c00310. [PMID: 37823637]
  • Yi Li, Song He, Youdan Zhao, Hongzhan Jiang, Zhi Lyu. Unraveling the mechanism of tetrandrine combined with Buyang Huanwu Decoction against silicosis using network pharmacology and molecular docking analyses. Medicine. 2023 Aug; 102(32):e34716. doi: 10.1097/md.0000000000034716. [PMID: 37565873]
  • Min Wang, Kai Liu, Zhongming Zhou, Huizhuan Geng. miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine. Histology and histopathology. 2023 Aug; ?(?):18657. doi: 10.14670/hh-18-657. [PMID: 37702425]
  • Ting Liu, Kangdi Li, Zhenxing Zhang, Jinghui Peng, Jingzhao Yang, Betty Yuen Kwan Law, Xin Liu, Wenhua Li. Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway. The American journal of Chinese medicine. 2023 Jan; ?(?):1-20. doi: 10.1142/s0192415x23500222. [PMID: 36692485]
  • Wanli Xue, Rui Sun, Zheng Hao, Zhenzhen Xing, Hongjie Cheng, Lei Shao. Tetrandrine inhibits migration and invasion of BGC-823 and MKN-45 cells by regulating PI3K/AKT/mTOR signaling pathway. Chemical biology & drug design. 2023 Jan; ?(?):. doi: 10.1111/cbdd.14202. [PMID: 36593659]
  • Simeng Chu, Yujie Lu, Wenjuan Liu, Xiaoyao Ma, Jiamin Peng, Xiaoying Wang, Min Jiang, Gang Bai. Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154325. doi: 10.1016/j.phymed.2022.154325. [PMID: 35820303]
  • Jia-Wen Song, Yu-Shi Liu, Yu-Rou Guo, Wen-Xiao Zhong, Yi-Ping Guo, Li Guo. Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126858. [PMID: 35743311]
  • Jiao Guan, Liming Wang, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu. UHPLC-MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):458-464. doi: 10.1093/chromsci/bmab116. [PMID: 34734235]
  • Hyo-Seon Lee, Dae Hwan Kim, In-Seon Lee, Ji-Hyun Park, Gregory Martin, Stephen Safe, Keuk-Jun Kim, Joung-Hee Kim, Byung Ik Jang, Syng-Ook Lee. Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095280. [PMID: 35563670]
  • Fang Shi, Lei Ni, Ye-Mei Gao. Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis. Immunological investigations. 2022 Apr; 51(3):465-479. doi: 10.1080/08820139.2020.1837864. [PMID: 33140671]
  • Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen. Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+ Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice. Frontiers in immunology. 2022; 13(?):800283. doi: 10.3389/fimmu.2022.800283. [PMID: 35464441]
  • Lichan Mao, Yin Ding, Dongrong Yu, Jiazhen Yin, Jin Yu. Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway. Analytical cellular pathology (Amsterdam). 2022; 2022(?):7534181. doi: 10.1155/2022/7534181. [PMID: 36247873]
  • Jui-Feng Lin, Yen-Shuo Liu, Yu-Chuen Huang, Chih-Wen Chi, Cheng-Chia Tsai, Tung-Hu Tsai, Yu-Jen Chen. Borneol and Tetrandrine Modulate the Blood-Brain Barrier and Blood-Tumor Barrier to Improve the Therapeutic Efficacy of 5-Fluorouracil in Brain Metastasis. Integrative cancer therapies. 2022 Jan; 21(?):15347354221077682. doi: 10.1177/15347354221077682. [PMID: 35168384]
  • Yin Ding, Xuanli Tang, Yuhui Wang, Dongrong Yu, Caifeng Zhu, Jin Yu. Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade. BMC complementary medicine and therapies. 2021 Dec; 21(1):296. doi: 10.1186/s12906-021-03469-x. [PMID: 34906112]
  • Nan Wang, Shengdong Yang, Tao Tan, Yanran Huang, Yangmei Chen, Chaoqun Dong, Jin Chen, Xiaoji Luo. Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways. Bioengineered. 2021 12; 12(1):5870-5882. doi: 10.1080/21655979.2021.1967034. [PMID: 34477474]
  • Xin-Yu Lu, Zhong-Ze Wang, Si-Cheng Wan, Er-Hu Zhao, Hong-Juan Cui. [Effects of tetrandrine on proliferation, migration, and invasion of glioblastoma cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Dec; 46(24):6520-6529. doi: 10.19540/j.cnki.cjcmm.20210824.703. [PMID: 34994145]
  • Hong Wang, Lu Chen, Shaoxia Wang, Xiaoxuan Tian, Lusha Zhang, Huiying Li, Chunxiao Li, Yuejin Xue, Qianyi Wang, Leyu Fang, Wenjie Yang, Wei Sun, Yuze Leng, Mengyao Li, Xiumei Gao. Tetrandrine promotes angiogenesis via transcriptional regulation of VEGF-A. Vascular pharmacology. 2021 12; 141(?):106920. doi: 10.1016/j.vph.2021.106920. [PMID: 34592429]
  • Ching-Lung Liao, Yi-Shih Ma, Te-Chun Hsia, Yu-Cheng Chou, Jin-Cherng Lien, Shu-Fen Peng, Chao-Lin Kuo, Fei-Ting Hsu. Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237105. [PMID: 34885686]
  • Defang Ren, Yu Fu, Li Wang, Jianqin Liu, Xia Zhong, Jiyuan Yuan, Chaoli Jiang, Honglian Wang, Zhi Li. Tetrandrine ameliorated Alzheimer's disease through suppressing microglial inflammatory activation and neurotoxicity in the 5XFAD mouse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Sep; 90(?):153627. doi: 10.1016/j.phymed.2021.153627. [PMID: 34247115]
  • Pingliang Li, Jian Zou, Yanhan Dong, Jintao Jiang, Wenxing Liang, Delong Li. Tetrandrine, a Potent Antifungal Agent, Inhibits Mycelial Growth and Virulence of Botrytis cinerea. Phytopathology. 2021 Jul; 111(7):1152-1157. doi: 10.1094/phyto-10-20-0446-r. [PMID: 33289404]
  • Xue-Tao Li, Ming Jing, Fu-Yi Cai, Xue-Min Yao, Liang Kong, Xiao-Bo Wang. Enhanced antitumour efficiency of R8GD-modified epirubicin plus tetrandrine liposomes in treatment of gastric cancer via inhibiting tumour metastasis. Journal of liposome research. 2021 Jun; 31(2):145-157. doi: 10.1080/08982104.2020.1748647. [PMID: 32223361]
  • Bingyu Sun, Yongqiang Liu, Danhua He, Jinke Li, Jiawei Wang, Wulin Wen, Ming Hong. Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis. Journal of Zhejiang University. Science. B. 2021 Mar; 22(3):190-203. doi: 10.1631/jzus.b2000497. [PMID: 33719224]
  • Wencheng Xu, Junichi Kusano, Shuhe Chen, Ryusei Yamamoto, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Seiichi Hayashi, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Absolute configuration of tetrandrine and isotetrandrine influences their anti-proliferation effects in human T cells via different regulation of NF-κB. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021 Jan; 76(1-2):21-25. doi: 10.1515/znc-2020-0064. [PMID: 33119545]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases. Pharmacology & therapeutics. 2021 01; 217(?):107659. doi: 10.1016/j.pharmthera.2020.107659. [PMID: 32800789]
  • Yuntao Wang, Wei Yue, Haiyan Lang, Xiaoqing Ding, Xinyi Chen, Haiyan Chen. Resuming Sensitivity of Tamoxifen-Resistant Breast Cancer Cells to Tamoxifen by Tetrandrine. Integrative cancer therapies. 2021 Jan; 20(?):1534735421996822. doi: 10.1177/1534735421996822. [PMID: 33660534]
  • Wenqian Shang, Jing Zhang, Haibo Song, Shunfei Zhu, Aimin Zhang, Yushuang Hua, Shujun Han, Yan Fu. Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology. Drug design, development and therapy. 2021; 15(?):2907-2919. doi: 10.2147/dddt.s307670. [PMID: 34262258]
  • Xiang-Peng Kong, Hai-Qin Ren, Etta Y L Liu, Ka-Wing Leung, Shu-Chen Guo, Ran Duan, Tina T X Dong, Karl W K Tsim. The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245914. [PMID: 33327436]
  • Xiu-Ying Li, Jian-Hua Wang, Li-Yan Gu, Xue-Min Yao, Fu-Yi Cai, Ming Jing, Xue-Tao Li, Rui-Jun Ju. Dual variable of drug loaded micelles in both particle and electrical charge on gastric cancer treatment. Journal of drug targeting. 2020 12; 28(10):1071-1084. doi: 10.1080/1061186x.2020.1777419. [PMID: 32484364]
  • Jinjing Li, Xin Jin, Lingling Zhang, Yang Yang, Rui Liu, Zheng Li. Comparison of Different Chitosan Lipid Nanoparticles for Improved Ophthalmic Tetrandrine Delivery: Formulation, Characterization, Pharmacokinetic and Molecular Dynamics Simulation. Journal of pharmaceutical sciences. 2020 12; 109(12):3625-3635. doi: 10.1016/j.xphs.2020.09.010. [PMID: 32946897]
  • Fei Luan, Xirui He, Nan Zeng. Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems. The Journal of pharmacy and pharmacology. 2020 Nov; 72(11):1491-1512. doi: 10.1111/jphp.13339. [PMID: 32696989]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Haruki Yamada, Toshihiko Hirano. Methylprednisolone potentiates tetrandrine pharmacodynamics against human T lymphoblastoid leukemia MOLT-4 cells via regulation of NF-κB activation and cell cycle transition. Steroids. 2020 11; 163(?):108714. doi: 10.1016/j.steroids.2020.108714. [PMID: 32818521]
  • Paula M Heister, Robin N Poston. Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19. Pharmacology research & perspectives. 2020 10; 8(5):e00653. doi: 10.1002/prp2.653. [PMID: 32930523]
  • Wencheng Xu, Xiaoqin Wang, Shuhe Chen, Hongguang Wu, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine enhances glucocorticoid receptor translocation possibly via inhibition of P-glycoprotein in daunorubicin-resistant human T lymphoblastoid leukemia cells. European journal of pharmacology. 2020 Aug; 881(?):173232. doi: 10.1016/j.ejphar.2020.173232. [PMID: 32525004]
  • Qishuang Li, Junling Bu, Ying Ma, Jian Yang, Zhimin Hu, Changjiangsheng Lai, Yanqin Xu, Jinfu Tang, Guanghong Cui, Yanan Wang, Yujun Zhao, Baolong Jin, Ye Shen, Juan Guo, Luqi Huang. Characterization of O-methyltransferases involved in the biosynthesis of tetrandrine in Stephania tetrandra. Journal of plant physiology. 2020 Jul; 250(?):153181. doi: 10.1016/j.jplph.2020.153181. [PMID: 32460036]
  • Lihua Zhang, Lulu Pang, Siqing Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Zhu, Xiaomei Zhuang, Weijia Zhi, Xiang Yu, Lina Du, Hongyan Zuo, Yiguang Jin. Intranasal tetrandrine temperature-sensitive in situ hydrogels for the treatment of microwave-induced brain injury. International journal of pharmaceutics. 2020 Jun; 583(?):119384. doi: 10.1016/j.ijpharm.2020.119384. [PMID: 32371003]
  • Wenqiang Su, Yinmei Liang, Zhiping Meng, Xuanyu Chen, Manqi Lu, Xingxing Han, Xiaomin Deng, Qichun Zhang, Huaxu Zhu, Tingming Fu. Inhalation of Tetrandrine-hydroxypropyl-β-cyclodextrin Inclusion Complexes for Pulmonary Fibrosis Treatment. Molecular pharmaceutics. 2020 05; 17(5):1596-1607. doi: 10.1021/acs.molpharmaceut.0c00026. [PMID: 32142292]
  • Sheng-Cao Hu, Jin Yang, Chao Chen, Jun-Rong Song, Wei-Dong Pan. Design, Synthesis of Novel Tetrandrine-14-l-Amino Acid and Tetrandrine-14-l-Amino Acid-Urea Derivatives as Potential Anti-Cancer Agents. Molecules (Basel, Switzerland). 2020 Apr; 25(7):. doi: 10.3390/molecules25071738. [PMID: 32283819]
  • Xiufang Liang, Yunan Xiang, Yanling Li, Ping Feng, Yongping Qin, Xianrong Lai. A rapid method for simultaneous quantification of berberine, berbamine, magnoflorine and berberrubine in mouse serum using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1142(?):122040. doi: 10.1016/j.jchromb.2020.122040. [PMID: 32145638]
  • Ruonan Shuang, Mengdi Wang, Juanling Mao, Jiamei Zou, Yuhui Ping. Pharmacokinetics of 10-hydroxycamptothecin-tetrandrine liposome complexes in rat by a simple and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2020 Feb; 43(3):569-576. doi: 10.1002/jssc.201900347. [PMID: 31701613]
  • Yubo Guo, Beibei Chen, Xiaohua Pei, Dongwei Zhang. Radix Stephaniae Tetrandrine: An Emerging Role for Management of Breast Cancer. Current pharmaceutical design. 2020; 26(1):25-36. doi: 10.2174/1381612826666200110143706. [PMID: 31924150]
  • Yuan Xi, Hai-Jing Zhang, Zu-Guang Ye, Guang-Ping Zhang. [Research development on modern pharmacological effect of tetrandrine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jan; 45(1):20-28. doi: 10.19540/j.cnki.cjcmm.20190830.401. [PMID: 32237407]
  • Jin Yu, Caifeng Zhu, Jiazhen Yin, Dongrong Yu, Feng Wan, Xuanli Tang, Xue Jiang. Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling. Drug design, development and therapy. 2020; 14(?):361-370. doi: 10.2147/dddt.s234262. [PMID: 32095070]
  • Dong Eon Kim, Jung Sun Min, Min Seong Jang, Jun Young Lee, Young Sup Shin, Jong Hwan Song, Hyoung Rae Kim, Seungtaek Kim, Young-Hee Jin, Sunoh Kwon. Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110696. [PMID: 31690059]
  • Bhagya N, Chandrashekar K R. Optimization of column chromatography technique for the isolation of tetrandrine from Cyclea peltata and LC-ESI-MS based quantification and validation of the method. Natural product research. 2019 Oct; 33(19):2873-2877. doi: 10.1080/14786419.2018.1503660. [PMID: 30873865]
  • Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chemico-biological interactions. 2019 Sep; 310(?):108726. doi: 10.1016/j.cbi.2019.108726. [PMID: 31255635]
  • Xuzhao Wang, Yafei Chen, Junwei Li, Shuai Guo, Xiaoe Lin, Hailin Zhang, Yong Zhan, Hailong An. Tetrandrine, a novel inhibitor of ether-à-go-go-1 (Eag1), targeted to cervical cancer development. Journal of cellular physiology. 2019 05; 234(5):7161-7173. doi: 10.1002/jcp.27470. [PMID: 30362536]
  • Louis W C Chow, Ka-Shun Cheng, Fai Leong, Chi-Wai Cheung, Lian-Ru Shiao, Yuk-Man Leung, Kar-Lok Wong. Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production. Naunyn-Schmiedeberg's archives of pharmacology. 2019 04; 392(4):427-436. doi: 10.1007/s00210-018-01601-2. [PMID: 30547225]
  • Xue-Tao Li, Wei Tang, Hong-Jun Xie, Shuang Liu, Xiao-Li Song, Yao Xiao, Xin Wang, Lan Cheng, Gui-Rong Chen. The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma. Journal of liposome research. 2019 Mar; 29(1):21-34. doi: 10.1080/08982104.2017.1408649. [PMID: 29166813]
  • Yugai Jia, Yu Tao, Changjun Lv, Yufeng Xia, Zhifeng Wei, Yue Dai. Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. Cell death & disease. 2019 01; 10(2):38. doi: 10.1038/s41419-018-1286-2. [PMID: 30674869]
  • Haiyan Zhang, Beibei Xie, Zhen Zhang, Xiugui Sheng, Shiqian Zhang. Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo. Drug design, development and therapy. 2019; 13(?):119-127. doi: 10.2147/dddt.s187776. [PMID: 30587932]
  • Yiping Lin, Jingchan Yao, Meiling Wu, Xiaoqian Ying, Mingxing Ding, Yanli Wei, Xiaoyan Fu, Wei Feng, Yunguang Wang. Tetrandrine Ameliorates Airway Remodeling of Chronic Asthma by Interfering TGF-β1/Nrf-2/HO-1 Signaling Pathway-Mediated Oxidative Stress. Canadian respiratory journal. 2019; 2019(?):7930396. doi: 10.1155/2019/7930396. [PMID: 31781316]
  • Yan Yu, Bing Hu, Jianxin Bao, Jessica Mulvany, Eric Bielefeld, Ryan T Harrison, Sarah A Neton, Partha Thirumala, Yingying Chen, Debin Lei, Ziyu Qiu, Qingyin Zheng, Jihao Ren, Maria Cristina Perez-Flores, Ebenezer N Yamoah, Pezhman Salehi. Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma. Journal of the Association for Research in Otolaryngology : JARO. 2018 12; 19(6):653-668. doi: 10.1007/s10162-018-00690-3. [PMID: 30187298]
  • Wei-Chan Lin, Wei-Hsun Wang, Yi-Hsien Lin, Jyh-Der Leu, Shan-Yun Cheng, Yu-Jen Chen, Jeng-Jong Hwang. Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model. Oncology reports. 2018 Sep; 40(3):1390-1400. doi: 10.3892/or.2018.6568. [PMID: 30015952]
  • Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li. Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. Journal of experimental & clinical cancer research : CR. 2018 Jun; 37(1):114. doi: 10.1186/s13046-018-0779-2. [PMID: 29866132]
  • Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia. 1H NMR-based metabolomics approach to investigate the urine samples of collagen-induced arthritis rats and the intervention of tetrandrine. Journal of pharmaceutical and biomedical analysis. 2018 May; 154(?):302-311. doi: 10.1016/j.jpba.2018.03.026. [PMID: 29567573]
  • Guixian Wu, Ting Liu, Han Li, Yafang Li, Dengju Li, Wenhua Li. c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation. Cell death & disease. 2018 05; 9(5):473. doi: 10.1038/s41419-018-0498-9. [PMID: 29700286]
  • Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. Journal of experimental & clinical cancer research : CR. 2018 Jan; 37(1):7. doi: 10.1186/s13046-018-0678-6. [PMID: 29334999]
  • Junjie Lan, Lan Huang, Huayong Lou, Chao Chen, Tangjingjun Liu, Shengcao Hu, Yao Yao, Junrong Song, Jun Luo, Yazhou Liu, Bin Xia, Lei Xia, Xueyi Zeng, Yaacov Ben-David, Weidong Pan. Design and synthesis of novel C14-urea-tetrandrine derivatives with potent anti-cancer activity. European journal of medicinal chemistry. 2018 Jan; 143(?):1968-1980. doi: 10.1016/j.ejmech.2017.11.007. [PMID: 29133049]
  • Guangyi Yang, Chenning Zhang, Pei Hu, Meiling Zhu, Ming Hu, Song Gao. An UPLC-MS/MS method for quantifying tetrandrine and its metabolite berbamine in human blood: Application to a human pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Dec; 1070(?):92-96. doi: 10.1016/j.jchromb.2017.10.048. [PMID: 29100757]
  • Bo Kou, Wei Liu, Xu Xu, Yang Yang, Qiuyue Yi, Fengwei Guo, Jianpeng Li, Jinsong Zhou, Qingshan Kou. Autophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells. Oncology reports. 2017 Nov; 38(5):3137-3143. doi: 10.3892/or.2017.5988. [PMID: 29048631]
  • Kuo-Ching Liu, Ya-Jing Lin, Yung-Ting Hsiao, Meng-Liang Lin, Jiun-Long Yang, Yi-Ping Huang, Yung-Lin Chu, Jing-Gung Chung. Tetrandrine Induces Apoptosis in Human Nasopharyngeal Carcinoma NPC-TW 039 Cells by Endoplasmic Reticulum Stress and Ca2+/Calpain Pathways. Anticancer research. 2017 11; 37(11):6107-6118. doi: 10.21873/anticanres.12059. [PMID: 29061791]
  • Tie-Jun Zhang, Rui-Xia Guo, Xia Li, Yan-Wei Wang, Yong-Jun Li. Tetrandrine cardioprotection in ischemia-reperfusion (I/R) injury via JAK3/STAT3/Hexokinase II. European journal of pharmacology. 2017 Oct; 813(?):153-160. doi: 10.1016/j.ejphar.2017.08.019. [PMID: 28822855]
  • Wencheng Xu, Kehan Meng, Junichi Kusano, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Eiki Ando, Xiaoqin Wang, Yuanchao Tu, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Immunosuppressive efficacy of tetrandrine combined with methylprednisolone against mitogen-activated peripheral blood mononuclear cells of haemodialysis patients. Clinical and experimental pharmacology & physiology. 2017 Sep; 44(9):924-931. doi: 10.1111/1440-1681.12797. [PMID: 28613399]
  • Mingjiang Yao, Bo Yuan, Xiao Wang, Ai Sato, Kana Sakuma, Kurumi Kaneko, Hana Komuro, Ayane Okazaki, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano, Norio Takagi. Synergistic cytotoxic effects of arsenite and tetrandrine in human breast cancer cell line MCF-7. International journal of oncology. 2017 Aug; 51(2):587-598. doi: 10.3892/ijo.2017.4052. [PMID: 28656245]
  • Wencheng Xu, Kehan Meng, Yuanchao Tu, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Toshihiko Hirano, Haruki Yamada. Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells. European journal of pharmacology. 2017 Jul; 807(?):102-108. doi: 10.1016/j.ejphar.2017.04.007. [PMID: 28408143]
  • Jinming Zhang, Lu Wang, Hon Fai Chan, Wei Xie, Sheng Chen, Chengwei He, Yitao Wang, Meiwan Chen. Co-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated lipid-polymer hybrid nanoparticles overcome multidrug resistance in cancer cells. Scientific reports. 2017 05; 7(?):46057. doi: 10.1038/srep46057. [PMID: 28470171]
  • Junjie Lan, Ning Wang, Lan Huang, Yazhou Liu, Xiaopan Ma, Huayong Lou, Chao Chen, Yibin Feng, Weidong Pan. Design and synthesis of novel tetrandrine derivatives as potential anti-tumor agents against human hepatocellular carcinoma. European journal of medicinal chemistry. 2017 Feb; 127(?):554-566. doi: 10.1016/j.ejmech.2017.01.008. [PMID: 28109948]
  • Shurui Chen, Wei Liu, Ke Wang, Yizeng Fan, Jiaqi Chen, Jianbin Ma, Xinyang Wang, Dalin He, Jin Zeng, Lei Li. Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-κB/MMP-9 signaling. PloS one. 2017; 12(3):e0173725. doi: 10.1371/journal.pone.0173725. [PMID: 28288190]
  • Xiao-Li Song, Shuang Liu, Ying Jiang, Li-Yan Gu, Yao Xiao, Xin Wang, Lan Cheng, Xue-Tao Li. Targeting vincristine plus tetrandrine liposomes modified with DSPE-PEG2000-transferrin in treatment of brain glioma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Jan; 96(?):129-140. doi: 10.1016/j.ejps.2016.09.024. [PMID: 27644895]
  • Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang. Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Dec; 23(14):1821-1829. doi: 10.1016/j.phymed.2016.10.021. [PMID: 27912885]
  • Li-Na Gao, Qi-Shuai Feng, Xin-Fang Zhang, Qiang-Song Wang, Yuan-Lu Cui. Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 09; 34(9):1557-68. doi: 10.1002/jor.23155. [PMID: 26748661]
  • Yusaku Miyamae, Yukina Nishito, Naomi Nakai, Yoko Nagumo, Takeo Usui, Seiji Masuda, Taiho Kambe, Masaya Nagao. Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line. Biochemical and biophysical research communications. 2016 08; 477(1):40-46. doi: 10.1016/j.bbrc.2016.06.018. [PMID: 27270032]
  • Byeong-Churl Jang. Tetrandrine has anti-adipogenic effect on 3T3-L1 preadipocytes through the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3. Biochemical and biophysical research communications. 2016 08; 476(4):481-486. doi: 10.1016/j.bbrc.2016.05.150. [PMID: 27246736]
  • Lidong Wang, Xinxin Ci, Hongming Lv, Xiaosong Wang, F Xiaofeng Qin, Genhong Cheng. Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression. Experimental biology and medicine (Maywood, N.J.). 2016 08; 241(14):1568-76. doi: 10.1177/1535370216647122. [PMID: 27190261]
  • Ting Liu, Xin Liu, Wenhua Li. Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget. 2016 Jun; 7(26):40800-40815. doi: 10.18632/oncotarget.8315. [PMID: 27027348]
  • Hongmei Ma, Li Yao, Ling Pang, Xingwei Li, Qun Yao. Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. Molecular medicine reports. 2016 Jun; 13(6):4814-20. doi: 10.3892/mmr.2016.5132. [PMID: 27082007]
  • N Bhagya, K R Chandrashekar. Tetrandrine--A molecule of wide bioactivity. Phytochemistry. 2016 May; 125(?):5-13. doi: 10.1016/j.phytochem.2016.02.005. [PMID: 26899361]
  • Xue-Tao Li, Wei Tang, Ying Jiang, Xiao-Min Wang, Yan-Hong Wang, Lan Cheng, Xian-Sheng Meng. Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells. Oncotarget. 2016 Apr; 7(17):24604-22. doi: 10.18632/oncotarget.8360. [PMID: 27029055]
  • Chen Shi, Rui Meng, Ke Li. [Preparation and in vitro evaluation of tetrandrine-loaded composite microspheres embedded with PLGA nanoparticles]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Mar; 41(5):838-844. doi: 10.4268/cjcmm20160513. [PMID: 28875636]
  • P Ning, Y Peng, D W Liu, Y H Hu, Y Liu, D M Liu. Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro. Genetics and molecular research : GMR. 2016 Feb; 15(1):. doi: 10.4238/gmr.15017288. [PMID: 26909951]
  • Meiyan Sun, Jie Wang, Yue Zhou, Zijian Wang, Yong Jiang, Miao Li. Isotetrandrine Reduces Astrocyte Cytotoxicity in Neuromyelitis Optica by Blocking the Binding of NMO-IgG to Aquaporin 4. Neuroimmunomodulation. 2016; 23(2):98-108. doi: 10.1159/000444530. [PMID: 27064690]
  • Qi Lv, Xian-Yang Zhu, Yu-Feng Xia, Yue Dai, Zhi-Feng Wei. Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways. Chinese journal of natural medicines. 2015 Nov; 13(11):831-841. doi: 10.1016/s1875-5364(15)30087-x. [PMID: 26614458]
  • Wei Liu, Bo Kou, Zhen-Kun Ma, Xiao-Shuang Tang, Chuan Lv, Min Ye, Jia-Qi Chen, Lei Li, Xin-Yang Wang, Da-Lin He. Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells. Asian journal of andrology. 2015 Sep; 17(5):850-3. doi: 10.4103/1008-682x.142134. [PMID: 25677131]
  • XinGang Lu, RuoXi Zhang, Feng Fu, Jie Shen, Hua Nian, Tao Wu. Simultaneous Determination of Fangchinoline and Tetrandrine in Qi-Fang-Xi-Bi-Granules by RP-HPLC. Journal of chromatographic science. 2015 Sep; 53(8):1328-32. doi: 10.1093/chromsci/bmv016. [PMID: 25754692]
  • Xiaoli Wang, Xiao Liu, Hao Cai, Ke Pei, Gang Cao, Xiaoyan Xu, Fa Shi, Baochang Cai. Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts. Journal of separation science. 2015 May; 38(8):1286-93. doi: 10.1002/jssc.201401384. [PMID: 25645647]
  • Xiaoli Wang, Xiao Liu, Xiaoyan Xu, Tingting Zhu, Fa Shi, Kunming Qin, Baochang Cai. Screening and identification of multiple constituents and their metabolites of Fangji Huangqi Tang in rats by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry basing on coupling data processing techniques. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Mar; 985(?):14-28. doi: 10.1016/j.jchromb.2015.01.021. [PMID: 25656758]
  • Chin-Tsung Ting, Wan-Chun Li, Chang-Yi Chen, Tung-Hu Tsai. Preventive and therapeutic role of traditional Chinese herbal medicine in hepatocellular carcinoma. Journal of the Chinese Medical Association : JCMA. 2015 Mar; 78(3):139-44. doi: 10.1016/j.jcma.2014.09.003. [PMID: 25447209]
  • Jin Lu, Meng Zhang, Hua-xu Zhu, Li-wei Guo, Lin-mei Pan, Ting-ming Fu. [Studies on preparation by SPG membrane emulsification method and in vitro characterization of tetradrine-tashionone II(A)-PLGA composite microspheres]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Mar; 40(6):1091-6. doi: ". [PMID: 26226751]
  • Xi Cao, Jingwen Luo, Tao Gong, Zhi-Rong Zhang, Xun Sun, Yao Fu. Coencapsulated doxorubicin and bromotetrandrine lipid nanoemulsions in reversing multidrug resistance in breast cancer in vitro and in vivo. Molecular pharmaceutics. 2015 Jan; 12(1):274-86. doi: 10.1021/mp500637b. [PMID: 25469833]
  • Qiang-Song Wang, Yuan-Lu Cui, Li-Na Gao, Yong Guo, Rui-Xin Li, Xi-Zheng Zhang. Reduction of the pro-inflammatory response by tetrandrine-loading poly(L-lactic acid) films in vitro and in vivo. Journal of biomedical materials research. Part A. 2014 Nov; 102(11):4098-107. doi: 10.1002/jbm.a.35083. [PMID: 24442958]
  • Jiawei Li, Xiujun Guo, Zhidong Liu, Chukwunweike Ikechukwu Okeke, Nan Li, Hainan Zhao, Mike Okweesi Aggrey, Weisan Pan, Tao Wu. Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies. Drug development and industrial pharmacy. 2014 Jul; 40(7):980-7. doi: 10.3109/03639045.2013.795582. [PMID: 23662696]