Neoline (BioDeep_00000230231)

 

Secondary id: BioDeep_00000171862, BioDeep_00001883954

PANOMIX_OTCML-2023


代谢物信息卡片


11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8,16-triol

化学式: C24H39NO6 (437.2777234)
中文名称: 雪上一枝蒿乙素, 尼奥林
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 4.14%

分子结构信息

SMILES: CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6CC4C5C6O)OC)O)OC)O)COC
InChI: InChI=1S/C24H39NO6/c1-5-25-10-22(11-29-2)7-6-15(26)24-13-8-12-14(30-3)9-23(28,16(13)18(12)27)17(21(24)25)19(31-4)20(22)24/h12-21,26-28H,5-11H2,1-4H3

描述信息

A diterpene alkaloid with formula C24H39NO6 that is isolated from several Aconitum species.
Neoline is a natural product found in Aconitum variegatum, Aconitum karakolicum, and other organisms with data available.
Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].
Neoline,?the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].

同义名列表

11 个代谢物同义名

Neoline; 11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8,16-triol; Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,6-alpha,14-alpha,16-beta)-; 20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14-triol; ethyl-dimethoxy-(methoxymethyl)[?]triol; Dideacetyldelphisine; ACon1_001801; Bullatine-B; Bullatine B; Xuan-Wu 3; Neoline/Bullatine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaocui Li, Weiqing Hou, Tingting Lin, Jiadong Ni, Huawei Qiu, Yu Fu, Zhongxiang Zhao, Caihua Yang, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu, Lijun Zhu. Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations. Journal of ethnopharmacology. 2023 Mar; 303(?):115879. doi: 10.1016/j.jep.2022.115879. [PMID: 36370966]
  • Yoshihiko Nakatani, Kanako Negoro, Miki Yamauchi, Maki Katasho, Kei-Ichiro Ishikura, Anna Iwaki, Kazuyo Tsukada, Marina Yamaguchi, Arata Uehara, Masato Yoshida, Kan'ichiro Ishiuchi, Toshiaki Makino, Masaki Kitajima, Masahiro Ohsawa, Taku Amano. Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. Journal of ethnopharmacology. 2020 Sep; 259(?):112963. doi: 10.1016/j.jep.2020.112963. [PMID: 32439405]
  • Yohei Tanimura, Masato Yoshida, Kan'ichiro Ishiuchi, Masahiro Ohsawa, Toshiaki Makino. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. Journal of ethnopharmacology. 2019 Sep; 241(?):111859. doi: 10.1016/j.jep.2019.111859. [PMID: 30974202]
  • Haolong Liu, Feng Qiu, Haiyu Zhao, Baolin Bian, Lei Wang. Simultaneous high-performance liquid chromatography with tandem mass spectrometry quantification of six bioactive components in rat plasma after oral administration of Yougui pill. Journal of separation science. 2019 May; 42(10):1867-1877. doi: 10.1002/jssc.201800772. [PMID: 30868717]
  • Guangguo Tan, Xin Wang, Kui Liu, Xin Dong, Wenting Liao, Hong Wu. Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. Food & function. 2018 Nov; 9(11):5528-5535. doi: 10.1039/c8fo01217b. [PMID: 30209468]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • Toshiaki Suzuki, Keisuke Miyamoto, Naomi Yokoyama, Mayuko Sugi, Akina Kagioka, Yuka Kitao, Takumi Adachi, Masahiro Ohsawa, Hajime Mizukami, Toshiaki Makino. Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain. Journal of ethnopharmacology. 2016 Jun; 186(?):44-52. doi: 10.1016/j.jep.2016.03.056. [PMID: 27038579]
  • Xiao-hong Gong, Yan Li, Yun-xia Li, An Yuan, Meng-jie Zhao, Ruo-qi Zhang, Dai-wen Zeng, Cheng Peng. Development and Validation of an UPLC-Q-TOF-MS Method for Quantification of Fuziline in Beagle Dog After Intragastric and Intravenous Administration. Journal of chromatographic science. 2016 Mar; 54(3):405-12. doi: 10.1093/chromsci/bmv156. [PMID: 26564737]
  • Xiao-hong Gong, Meng-jie Zhao, An Yuan, Yan Li, Liang Xiong, Cheng Peng, Yun-xia Li. Pharmacokinetics and bioavailability study of neoline in Beagle dogs. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jul; 40(13):2656-60. doi: 10.4268/cjcmm20151331. [PMID: 26697695]
  • Tivadar Kiss, Péter Orvos, Száva Bánsághi, Peter Forgo, Nikoletta Jedlinszki, László Tálosi, Judit Hohmann, Dezső Csupor. Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. Fitoterapia. 2013 Oct; 90(?):85-93. doi: 10.1016/j.fitote.2013.07.010. [PMID: 23876370]
  • Sang Hee Shim, Ju Sun Kim, Sam Sik Kang, Kun Ho Son, KiHwan Bae. Alkaloidal constituents from Aconitum jaluense. Archives of pharmacal research. 2003 Sep; 26(9):709-15. doi: 10.1007/bf02976678. [PMID: 14560917]