1ST169198 (BioDeep_00000229853)

 

Secondary id: BioDeep_00000182005, BioDeep_00000259434

PANOMIX_OTCML-2023


代谢物信息卡片


1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, 2,3,6,7,7A,8,13,13A,13B,13C-DECAHYDRO-, 4-OXIDE, (4R,7AS,13AR,13BR,13CS)-

化学式: C15H22N2O2 (262.1681192)
中文名称: 氧化槐果碱, 氧卡地平
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 62.35%

分子结构信息

SMILES: C1CC2CN3C(CC=CC3=O)C4C2[N+](C1)(CCC4)[O-]
InChI: InChI=1S/C15H22N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-,17+/m0/s1

描述信息

Matridin-15-one, 13,14-didehydro-, 1-oxide is a natural product found in Sophora viciifolia, Sophora alopecuroides, and other organisms with data available.
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC)[2].
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC)[2].

同义名列表

14 个代谢物同义名

1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, 2,3,6,7,7A,8,13,13A,13B,13C-DECAHYDRO-, 4-OXIDE, (4R,7AS,13AR,13BR,13CS)-; 1H,5H,10H-Dipyrido(2,1-f:3,2,1-ij)(1,6)naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, 4-oxide, (7aS,13aR,13bR,13cS)-; (1R,2R,9S,13R,17S)-13-oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one; Matridin-15-one, 13,14-didehydro-, 1-oxide; 13,14-DIDEHYDROMATRIDIN-15-ONE 1-OXIDE; MATRIDINE-13-ENE-15-ONE 1-OXIDE; (+)-SOPHOCARPINE N-OXIDE; Sophocarpine N-oxide; (+)-oxysophocarpine; UNII-58BVU7200M; Oxysophocarpine; sophocarpidine; 58BVU7200M; 1ST169198



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chao Liu, Rui Wang, Xia Jiao, Junfeng Zhang, Changbo Zhang, Zhenbiao Wang. Oxysophocarpine suppresses TRAF6 level to ameliorate oxidative stress and inflammatory factors secretion in mice with dextran sulphate sodium (DSS) induced-ulcerative colitis. Microbial pathogenesis. 2023 Sep; 182(?):106244. doi: 10.1016/j.micpath.2023.106244. [PMID: 37423495]
  • Wenbing Zhi, Shengnan Jiang, Zongren Xu, Yuye An, Jing Chen, Ye Li, Yang Liu, Hong Zhang. Oxysophocarpine inhibits airway inflammation and mucus hypersecretion through JNK/AP-1 pathway in vivo and in vitro. Fitoterapia. 2022 Oct; 162(?):105278. doi: 10.1016/j.fitote.2022.105278. [PMID: 35970410]
  • Qiang Wang, Junnan Xu, Xiang Li, Dawei Zhang, Yong Han, Xu Zhang. Comprehensive two-dimensional PC-3 prostate cancer cell membrane chromatography for screening anti-tumor components from Radix Sophorae flavescentis. Journal of separation science. 2017 Jul; 40(13):2688-2693. doi: 10.1002/jssc.201700208. [PMID: 28432774]
  • Jia-Xin Chen, Hong-Hui Shen, Ming Niu, Yu-Ming Guo, Xiao-Qiong Liu, Yan-Zhong Han, Ya-Ming Zhang, Yan-Ling Zhao, Bing-Ke Bai, Wen-Jun Zhou, Xiao-He Xiao. Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6. Virus research. 2016 Apr; 215(?):104-13. doi: 10.1016/j.virusres.2015.12.005. [PMID: 26685094]
  • Feng-Chun Zhao, Kai-Yang Wan, Xiao-Qian Liu, Qi-Wei Zhang, Hui-Min Gao, Zhi-Min Wang. [Rapid determination of the multi-marker ingredients in Heterosmilacis Japonicae Rhizoma and Sophorae Flavescentis Radix with near-infrared diffused reflection spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2014 Oct; 34(10):2652-6. doi: . [PMID: 25739202]
  • Jing Chen, Shu-Mei Wang, Jiang Meng, Fei Sun, Sheng-Wang Liang. [Simultaneous quantitative analysis of five alkaloids in Sophora flavescens by multi-components assay by single marker]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 May; 38(9):1406-10. doi: ". [PMID: 23944078]
  • Noriko Funaya, Jun Haginaka. Matrine- and oxymatrine-imprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-type alkaloids from Sophora flavescens Aiton. Journal of chromatography. A. 2012 Jul; 1248(?):18-23. doi: 10.1016/j.chroma.2012.05.081. [PMID: 22695694]
  • Xiao-juan Wang, Hong-zhu Deng, Bin Jiang, Hui Yao. The natural plant product sophocarpine ameliorates dextran sodium sulfate-induced colitis in mice by regulating cytokine balance. International journal of colorectal disease. 2012 May; 27(5):575-81. doi: 10.1007/s00384-011-1352-z. [PMID: 22083209]
  • Lei Zhang, Wentao Liu, Ruowen Zhang, Zhiwei Wang, Zhenduo Shen, Xiaohui Chen, Kaishun Bi. Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):892-8. doi: 10.1016/j.jpba.2008.03.019. [PMID: 18479880]
  • Lei Zhang, Zhi-Wei Wang, Jian-Wei Lian, Hao Zhou, Xiao-Hui Chen, Kai-Shun Bi. [Simultaneous determination of matrine, oxysophocarpin and oxymatrine in rat plasma by HPLC-MS and its application in the pharmacokinetic study]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Aug; 43(8):843-7. doi: . [PMID: 18956778]
  • Cheng Peng, Jin-Hong Hu, Quan-Gang Zhu, Ji-Yong Liu, Zhuo Qin, Jing Wang. [Studies on cutaneous permeation in vitro of Kushen recipe gel]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(18):1870-4. doi: ". [PMID: 18051892]
  • L Zhang, G Li, P J Houghton, S Jackson, P R Twentyman. [Alkaloids in Sophora alopecuroides seed and relevant tests for activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1997 Dec; 22(12):740-3, 764. doi: ". [PMID: 11243172]
  • X Wang, J Li, L Wei, S Omiya. [Alkaloid constituents in the seeds of Sophora viciifolia Hance]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1995 Mar; 20(3):168-9, 192. doi: ". [PMID: 7646780]
  • J F Cui, G D Zhang, M Z Wang. [HPLC and TLC-densitometry determination of alkaloidal constituents in Sophora flavescens and Sophora lopecuroides]. Yao xue xue bao = Acta pharmaceutica Sinica. 1985 Jan; 20(1):59-66. doi: ". [PMID: 4024951]