pipecolic acid betaine (BioDeep_00000229226)

Main id: BioDeep_00000269914

 

human metabolite PANOMIX_OTCML-2023 PANOMIX-Anthocyanidin


代谢物信息卡片


5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one

化学式: C21H20O10 (432.105642)
中文名称: 阿福豆苷, 山柰素-3-O-鼠李糖苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O[C@@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)C)c1ccc(cc1)O)O)O
InChI: InChI=1S/C28H32O15/c1-10-18(31)21(34)23(36)27(39-10)40-13-7-14(30)17-15(8-13)41-25(11-3-5-12(38-2)6-4-11)26(20(17)33)43-28-24(37)22(35)19(32)16(9-29)42-28/h3-8,10,16,18-19,21-24,27-32,34-37H,9H2,1-2H3/t10?,16?,18-,19?,21-,22?,23?,24?,27?,28-/m0/s1

描述信息

Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].
Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin[1][2][3][4].
Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice[1].

同义名列表

12 个代谢物同义名

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-{[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-{[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}chromen-4-one; kaempferol 3-O-alpha-L-rhamnopyranoside; Kaempferol 3-O-alpha-rhamnoside; kaempherol 3-O-alpha-rhamnoside; kaempferol 3-O-rhamnoside; kaempferol-3-rhamnoside; Pipecolic acid betaine; Afzelin; Kaempferol-3-O-rhamnoside; Afzelin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chaoyang Zhao, Fen Wang, Bolin Tang, Jun Han, Xiang Li, Guo Lian, Xiaolong Li, Shisheng Hao. Anti-inflammatory effects of kaempferol-3-O-rhamnoside on HSV-1 encephalitis in vivo and in vitro. Neuroscience letters. 2021 11; 765(?):136172. doi: 10.1016/j.neulet.2021.136172. [PMID: 34433098]
  • Jue Yang, Jianfei Qiu, Yong Hu, Yongqiang Zhang, Li Chen, Qun Long, Juan Chen, Jingrui Song, Qing Rao, Yanmei Li, Wei Gu, Xiaojiang Hao. A natural small molecule induces megakaryocytic differentiation and suppresses leukemogenesis through activation of PKCδ/ERK1/2 signaling pathway in erythroleukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Oct; 118(?):109265. doi: 10.1016/j.biopha.2019.109265. [PMID: 31545282]
  • Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen. Inter-population and inter-organ distribution of the main polyphenolic compounds of Epilobium angustifolium. Phytochemistry. 2017 Feb; 134(?):54-63. doi: 10.1016/j.phytochem.2016.11.003. [PMID: 27866749]
  • Lalit Kumar Lal Das, Mradul Verma, Mahendra Sahai. Three new acyltyramines from Anisodus luridus Link et Otto (Solanaceae). Natural product research. 2016 Nov; 30(21):2434-41. doi: 10.1080/14786419.2016.1198346. [PMID: 27406583]
  • Milena Masullo, Vincenza Cantone, Antonietta Cerulli, Gianluigi Lauro, Francesco Messano, Gian Luigi Russo, Cosimo Pizza, Giuseppe Bifulco, Sonia Piacente. Giffonins J-P, Highly Hydroxylated Cyclized Diarylheptanoids from the Leaves of Corylus avellana Cultivar 'Tonda di Giffoni'. Journal of natural products. 2015 Dec; 78(12):2975-82. doi: 10.1021/acs.jnatprod.5b00695. [PMID: 26606246]
  • Mi Ja Chung, Ramesh Prasad Pandey, Ji Won Choi, Jae Kyung Sohng, Doo Jin Choi, Yong Il Park. Inhibitory effects of kaempferol-3-O-rhamnoside on ovalbumin-induced lung inflammation in a mouse model of allergic asthma. International immunopharmacology. 2015 Apr; 25(2):302-10. doi: 10.1016/j.intimp.2015.01.031. [PMID: 25698556]
  • So-Mi Yang, So Hyun Han, Bong-Gyu Kim, Joong-Hoon Ahn. Production of kaempferol 3-O-rhamnoside from glucose using engineered Escherichia coli. Journal of industrial microbiology & biotechnology. 2014 Aug; 41(8):1311-8. doi: 10.1007/s10295-014-1465-9. [PMID: 24879482]
  • Jes Gitz Holler, S Brøgger Christensen, Hans-Christian Slotved, Hasse B Rasmussen, Alfonso Gúzman, Carl-Erik Olsen, Bent Petersen, Per Mølgaard. Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees. The Journal of antimicrobial chemotherapy. 2012 May; 67(5):1138-44. doi: 10.1093/jac/dks005. [PMID: 22311936]
  • Simplice Joel Ndendoung Tatsimo, Jean de Dieu Tamokou, Léopold Havyarimana, Dezső Csupor, Peter Forgo, Judit Hohmann, Jules-Roger Kuiate, Pierre Tane. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC research notes. 2012 Mar; 5(?):158. doi: 10.1186/1756-0500-5-158. [PMID: 22433844]
  • Daniel R Lewis, Melissa V Ramirez, Nathan D Miller, Prashanthi Vallabhaneni, W Keith Ray, Richard F Helm, Brenda S J Winkel, Gloria K Muday. Auxin and ethylene induce flavonol accumulation through distinct transcriptional networks. Plant physiology. 2011 May; 156(1):144-64. doi: 10.1104/pp.111.172502. [PMID: 21427279]
  • Yu Tang Tung, Wei Chun Chang, Ping Sheng Chen, Tzu Cheng Chang, Shang Tzen Chang. Ultrasound-assisted extraction of phenolic antioxidants from Acacia confusa flowers and buds. Journal of separation science. 2011 Apr; 34(7):844-51. doi: 10.1002/jssc.201000820. [PMID: 21374811]
  • Mei Xiao, Ning Cao, Jing-jing Fan, Yan Shen, Qiang Xu. [Studies on flavonoids from the leaves of Lindera aggregata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Jan; 34(1):62-4. doi: ". [PMID: 21818968]
  • Patricia Rodríguez, Freddy González-Mujica, Jairo Bermúdez, Masahisa Hasegawa. Inhibition of glucose intestinal absorption by kaempferol 3-O-α-rhamnoside purified from Bauhinia megalandra leaves. Fitoterapia. 2010 Dec; 81(8):1220-3. doi: 10.1016/j.fitote.2010.08.007. [PMID: 20727952]
  • Jin-Ho Kang, Guanghui Liu, Feng Shi, A Daniel Jones, Randolph M Beaudry, Gregg A Howe. The tomato odorless-2 mutant is defective in trichome-based production of diverse specialized metabolites and broad-spectrum resistance to insect herbivores. Plant physiology. 2010 Sep; 154(1):262-72. doi: 10.1104/pp.110.160192. [PMID: 20668059]
  • A M Emam, M A Mohamed, Y M Diab, N Y Megally. Isolation and structure elucidation of antioxidant compounds from leaves of Laurus nobilis and Emex spinosus. Drug discoveries & therapeutics. 2010 Jun; 4(3):202-7. doi: ". [PMID: 22491184]
  • Jin-Ho Kang, Feng Shi, A Daniel Jones, M David Marks, Gregg A Howe. Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry. Journal of experimental botany. 2010 Feb; 61(4):1053-64. doi: 10.1093/jxb/erp370. [PMID: 20018901]
  • Li-Min Dai, Chun-Chao Zhao, Hui-zi Jin, Jian Tang, Yun-Heng Shen, Hui-Liang Li, Cai-Yun Peng, Wei-Dong Zhang. A new ferulic acid ester and other constituents from Dracocephalum peregrinum. Archives of pharmacal research. 2008 Oct; 31(10):1325-9. doi: 10.1007/s12272-001-2113-2. [PMID: 18958424]
  • Srijani Ghanta, Anindita Banerjee, Avijit Poddar, Sharmila Chattopadhyay. Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener. Journal of agricultural and food chemistry. 2007 Dec; 55(26):10962-7. doi: 10.1021/jf071892q. [PMID: 18038982]
  • Farid A Badria, Madiha Ameen, Mohamed R Akl. Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 Sep; 62(9-10):656-60. doi: 10.1515/znc-2007-9-1005. [PMID: 18069236]
  • Yan-zhi Li, Zhan-lin Li, Hui-ming Hua, Zheng-gang Li, Ming-sheng Liu. [Studies on flavonoids from stems and leaves of Calophyllum inophyllum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Apr; 32(8):692-4. doi: . [PMID: 17608221]
  • R Kumar, M Ilyas, M Parveen, Shafiullah. A new chromone from Cassia nodosa. Journal of Asian natural products research. 2006 Oct; 8(7):595-8. doi: 10.1080/10286020500179470. [PMID: 17135042]
  • M Haladová, E Eisenreichová, M Mrizová, D Grancai, K Ubik. [Flavonoids--main constituents of the leaves of Holodiscus discolor (Pursh) Maxim]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 2006 Sep; 55(5):242-4. doi: . [PMID: 17128595]
  • Jing-Zhen Deng, Rebekah Marshall, Shannon H Jones, Randall K Johnson, Sidney M Hecht. DNA-damaging agents from Crypteronia paniculata. Journal of natural products. 2002 Dec; 65(12):1930-2. doi: 10.1021/np020285o. [PMID: 12502343]
  • Carola Stingl, Holger Knapp, Peter Winterhalter. 3,4-Dihydroxy-7,8-dihydro-beta-ionone 3-O-beta-D-glucopyranoside and other glycosidic constituents from apple leaves. Natural product letters. 2002 Apr; 16(2):87-93. doi: 10.1080/10575630290019976. [PMID: 11990433]
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