4,4'-Dipyridyl disulfide (BioDeep_00000174532)

 

Secondary id: BioDeep_00000016506

human metabolite blood metabolite


代谢物信息卡片


4-(pyridin-4-yldisulfanyl)pyridine

化学式: C10H8N2S2 (220.01288879999998)
中文名称: 4,4＇-二吡啶基二硫
谱图信息: 最多检出来源 Mus musculus(blood) 36.84%

分子结构信息

SMILES: C1=CN=CC=C1SSC2=CC=NC=C2
InChI: InChI=1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H

描述信息

同义名列表

14 个代谢物同义名

4-(pyridin-4-yldisulfanyl)pyridine; 4,4-Dipyridine disulphide; Bis(4-pyridyl) disulphide; 4,4-Dipyridine disulfide; Bis(4-pyridyl) disulfide; Di(4-pyridyl) disulphide; 4,4-DIPYRIDYL disulphide; Di(4-pyridyl) disulfide; 4,4-Dipyridyl disulfide; 4-Pyridyl disulphide; 4,4-Dithiodipyridine; 4-Pyridyl disulfide; 4,4-Dithiopyridine; Aldrithiol-4



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Muriel Arimon, Shuko Takeda, Kathryn L Post, Sarah Svirsky, Bradley T Hyman, Oksana Berezovska. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiology of disease. 2015 Dec; 84(?):109-19. doi: 10.1016/j.nbd.2015.06.013. [PMID: 26102023]
  • Judith Martini, Pedro Cabrales, Ananda K, Seetharama A Acharya, Marcos Intaglietta, Amy G Tsai. Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Critical care (London, England). 2008; 12(2):R54. doi: 10.1186/cc6874. [PMID: 18423033]
  • Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nature chemical biology. 2006 Nov; 2(11):596-607. doi: 10.1038/nchembio821. [PMID: 16998480]
  • Albena T Dinkova-Kostova, W David Holtzclaw, Nobunao Wakabayashi. Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. Biochemistry. 2005 May; 44(18):6889-99. doi: 10.1021/bi047434h. [PMID: 15865434]
  • Christian K Riener, Gerald Kada, Hermann J Gruber. Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine. Analytical and bioanalytical chemistry. 2002 Jul; 373(4-5):266-76. doi: 10.1007/s00216-002-1347-2. [PMID: 12110978]
  • J M Tremblay, H Li, L R Yarbrough, G M Helmkamp. Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity. Biochemistry. 2001 Aug; 40(31):9151-8. doi: 10.1021/bi0107896. [PMID: 11478882]
  • J I Kourie. Hydrogen peroxide inhibits chloride channels of the sarcoplasmic reticulum of skeletal muscle. The Journal of membrane biology. 1999 Nov; 172(1):25-36. doi: 10.1007/s002329900580. [PMID: 10552011]
  • K R Eager, A F Dulhunty. Cardiac ryanodine receptor activity is altered by oxidizing reagents in either the luminal or cytoplasmic solution. The Journal of membrane biology. 1999 Feb; 167(3):205-14. doi: 10.1007/s002329900484. [PMID: 9929372]
  • K R Eager, A F Dulhunty. Activation of the cardiac ryanodine receptor by sulfhydryl oxidation is modified by Mg2+ and ATP. The Journal of membrane biology. 1998 May; 163(1):9-18. doi: 10.1007/s002329900365. [PMID: 9569245]
  • S Cai, R Sauvé. Effects of thiol-modifying agents on a K(Ca2+) channel of intermediate conductance in bovine aortic endothelial cells. The Journal of membrane biology. 1997 Jul; 158(2):147-58. doi: 10.1007/s002329900252. [PMID: 9230092]
  • K R Eager, L D Roden, A F Dulhunty. Actions of sulfhydryl reagents on single ryanodine receptor Ca(2+)-release channels from sheep myocardium. The American journal of physiology. 1997 Jun; 272(6 Pt 1):C1908-18. doi: 10.1152/ajpcell.1997.272.6.c1908. [PMID: 9227420]
  • J I Kourie. A redox O2 sensor modulates the SR Ca2+ countercurrent through voltage- and Ca(2+)-dependent Cl- channels. The American journal of physiology. 1997 Jan; 272(1 Pt 1):C324-32. doi: 10.1152/ajpcell.1997.272.1.c324. [PMID: 9038839]
  • M Le, G E Means. A procedure for the determination of monothiols in the presence of dithiothreitol--an improved assay for the reduction of disulfides. Analytical biochemistry. 1995 Aug; 229(2):264-71. doi: 10.1006/abio.1995.1411. [PMID: 7485981]
  • A Andersson, A Isaksson, L Brattström, B Hultberg. Homocysteine and other thiols determined in plasma by HPLC and thiol-specific postcolumn derivatization. Clinical chemistry. 1993 Aug; 39(8):1590-7. doi: . [PMID: 8353942]
  • S Nagura, T Kawasaki, T Taguchi, M Kasai. Calcium release from isolated sarcoplasmic reticulum due to 4,4'-dithiodipyridine. Journal of biochemistry. 1988 Sep; 104(3):461-5. doi: 10.1093/oxfordjournals.jbchem.a122490. [PMID: 2853704]
  • P B Armstrong, J P Quigley. Limulus alpha 2-macroglobulin. First evidence in an invertebrate for a protein containing an internal thiol ester bond. The Biochemical journal. 1987 Dec; 248(3):703-7. doi: 10.1042/bj2480703. [PMID: 2449170]
  • K Kelemenics, I Jókay, I Földes. Effect of heparin on the reactivity of SH-groups in the macrophage membrane. Acta physiologica Hungarica. 1986; 68(2):199-210. doi: NULL. [PMID: 2435108]
  • K B Augustinsson, H Eriksson, Y Faijersson. A new approach to determining cholinesterase activities in samples of whole blood. Clinica chimica acta; international journal of clinical chemistry. 1978 Oct; 89(2):239-52. doi: 10.1016/0009-8981(78)90322-4. [PMID: 709874]
  • Y S Chen, W L Hubbell. Reactions of the sulfhydryl groups of membrane-bound bovine rhodopsin. Membrane biochemistry. 1978; 1(1-2):107-30. doi: 10.3109/09687687809064162. [PMID: 41159]