2-Deoxyglucose (BioDeep_00000055101)
Main id: BioDeep_00000004153
human metabolite PANOMIX_OTCML-2023 Endogenous natural product BioNovoGene_Lab2019
代谢物信息卡片
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
化学式: C6H12O5 (164.0685)
中文名称: 2-脱氧-D-葡萄糖, D-2-脱氧葡萄糖
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C=O)C(C(C(CO)O)O)O
InChI: InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
描述信息
2-Deoxyglucose is classified as a member of the fatty alcohols. Fatty alcohols are aliphatic alcohols consisting of a chain of a least six carbon atoms. 2-Deoxyglucose is considered to be soluble (in water) and acidic.
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- PubChem: 108223
- HMDB: HMDB0062477
- DrugBank: DB08831
- ChEMBL: CHEMBL2074932
- Wikipedia: Deoxyglucose
- MeSH: Deoxyglucose
- chemspider: 97292
- CAS: 154-17-6
- CAS: 61-58-5
- LOTUS: LTS0026475
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-123
- KEGG: C00586
- PubChem: 3865
- KNApSAcK: 15866
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Inner Membrane Transport:
Adenosine triphosphate + Water + Zinc ⟶ Adenosine diphosphate + Hydrogen Ion + Phosphate + Zinc - Inner Membrane Transport:
Adenosine triphosphate + Water + Zinc ⟶ Adenosine diphosphate + Hydrogen Ion + Phosphate + Zinc
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0026475
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: LTS0026475
- 1827580 - Streptomyces nigra: 10.3389/FMICB.2018.01587
- 1827580 - Streptomyces nigra: LTS0026475
- 2062 - Streptomycetaceae: LTS0026475
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yang Yang, Hai-Ling Wang, Rui-Tong Cheng, Pei-Rong Zheng, Hui-Peng Sun, Zhi-Wen Liu, Heng Yuan, Xue-Yi Liu, Wen-Yun Gao, Heng Li. Determination of α-Dicarbonyl compounds in traditional Chinese herbal medicines.
Fitoterapia.
2024 Jun; 175(?):105928. doi:
10.1016/j.fitote.2024.105928. [PMID: 38548027] - Xiao Liang, Siling Tang, Yajing Song, Dandan Li, Li Zhang, Shuhui Wang, Yancang Duan, Huilan Du. Effect of 2-deoxyglucose-mediated inhibition of glycolysis on migration and invasion of HTR-8/SVneo trophoblast cells.
Journal of reproductive immunology.
2023 Jul; 159(?):104123. doi:
10.1016/j.jri.2023.104123. [PMID: 37487312] - Lili Tian, Majid Mufaqam Syed-Abdul, Priska Stahel, Gary F Lewis. Enteral glucose, absorbed and metabolized, potently enhances mesenteric lymph flow in chow- and high-fat-fed rats.
American journal of physiology. Gastrointestinal and liver physiology.
2022 Oct; 323(4):G331-G340. doi:
10.1152/ajpgi.00095.2022. [PMID: 35916412] - Lulu Wei, Ranran Wang, Junaid Wazir, Kai Lin, Shiyu Song, Li Li, Wenyuan Pu, Chen Zhao, Yong Wang, Zhonglan Su, Hongwei Wang. 2-Deoxy-D-glucose Alleviates Cancer Cachexia-Induced Muscle Wasting by Enhancing Ketone Metabolism and Inhibiting the Cori Cycle.
Cells.
2022 09; 11(19):. doi:
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Biotechnology letters.
2022 Jul; 44(7):831-843. doi:
10.1007/s10529-022-03259-6. [PMID: 35608787] - Marta Migała, Justyna Chałubińska-Fendler, Marzenna Zielińska. 1,5-Anhydroglucitol as a Marker of Acute Hyperglycemia in Cardiovascular Events.
The review of diabetic studies : RDS.
2022 06; 18(2):68-75. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2022 Jun; 119(25):e2123265119. doi:
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Clinical and translational medicine.
2022 06; 12(6):e883. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jun; 1200(?):123277. doi:
10.1016/j.jchromb.2022.123277. [PMID: 35533424] - Catrin Herpich, Bastian Kochlik, Daniela Weber, Christiane Ott, Tilman Grune, Kristina Norman, Jana Raupbach. Fasting Concentrations and Postprandial Response of 1,2-Dicarbonyl Compounds 3-Deoxyglucosone, Glyoxal, and Methylglyoxal Are Not Increased in Healthy Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2022 05; 77(5):934-940. doi:
10.1093/gerona/glab331. [PMID: 34726231] - Jolanta Kowalczyk-Bołtuć, Krzysztof Wiórkowski, Jerzy Bełtowski. Effect of Exogenous Hydrogen Sulfide and Polysulfide Donors on Insulin Sensitivity of the Adipose Tissue.
Biomolecules.
2022 04; 12(5):. doi:
10.3390/biom12050646. [PMID: 35625574] - Irati Aiestaran-Zelaia, María Jesús Sánchez-Guisado, Marina Villar-Fernandez, Mikel Azkargorta, Lucia Fadon-Padilla, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Pedro Ramos-Cabrer, Antonella Spinazzola, Félix Elortza, Jésus Ruíz-Cabello, Ian J Holt. 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart.
Scientific reports.
2022 04; 12(1):6890. doi:
10.1038/s41598-022-10168-1. [PMID: 35478201] - Anant Narayan Bhatt, Abhishek Kumar, Yogesh Rai, Neeraj Kumari, Dhiviya Vedagiri, Krishnan H Harshan, Vijayakumar Chinnadurai, Sudhir Chandna. Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions.
Life sciences.
2022 Apr; 295(?):120411. doi:
10.1016/j.lfs.2022.120411. [PMID: 35181310] - Ikuno Uehara, Mitsuko Kajita, Atsuko Tanimura, Shigeaki Hida, Munehiko Onda, Zenya Naito, Shinsuke Taki, Nobuyuki Tanaka. 2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation.
Pharmacology research & perspectives.
2022 04; 10(2):e00940. doi:
10.1002/prp2.940. [PMID: 35212163] - Yasanandana S Wijayasinghe, Meenakshi P Bhansali, Maheshkumar R Borkar, Ganesh U Chaturbhuj, Brian S Muntean, Ronald E Viola, Pravin R Bhansali. A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials.
Journal of medicinal chemistry.
2022 03; 65(5):3706-3728. doi:
10.1021/acs.jmedchem.1c01737. [PMID: 35192360] - Junyi Qian, Cheng Chen, Xiaohang Wang, Yuanyuan Tan, Jiao Yang, Yuexing Yuan, Juan Chen, Haijian Guo, Bei Wang, Zilin Sun, Yao Wang. HbA1c combined with glycated albumin or 1,5-anhydroglucitol improves the efficiency of diabetes screening in a Chinese population.
Diabetic medicine : a journal of the British Diabetic Association.
2022 03; 39(3):e14685. doi:
10.1111/dme.14685. [PMID: 34473869] - Kim Maasen, Simone J P M Eussen, Jean L J M Scheijen, Carla J H van der Kallen, Pieter C Dagnelie, Antoon Opperhuizen, Coen D A Stehouwer, Marleen M J van Greevenbroek, Casper G Schalkwijk. Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study.
The American journal of clinical nutrition.
2022 01; 115(1):34-44. doi:
10.1093/ajcn/nqab329. [PMID: 34625788] - Shahnaz Majeed, Mohammed Danish, Norul Aini Zakariya, Rokiah Hashim, Mohammed Tahir Ansari, Saad Alkahtani, Md Saquib Hasnain. In Vitro Evaluation of Antibacterial, Antioxidant, and Antidiabetic Activities and Glucose Uptake through 2-NBDG by Hep-2 Liver Cancer Cells Treated with Green Synthesized Silver Nanoparticles.
Oxidative medicine and cellular longevity.
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10.1155/2022/1646687. [PMID: 35620573] - Christopher S Wilson, Blair T Stocks, Emilee M Hoopes, Jillian P Rhoads, Kelsey L McNew, Amy S Major, Daniel J Moore. Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight.
2021 10; 6(19):. doi:
10.1172/jci.insight.143245. [PMID: 34403367] - Enrique A Mesri, Theodore J Lampidis. 2-Deoxy-d-glucose exploits increased glucose metabolism in cancer and viral-infected cells: Relevance to its use in India against SARS-CoV-2.
IUBMB life.
2021 10; 73(10):1198-1204. doi:
10.1002/iub.2546. [PMID: 34418270] - M Piazza, N M J Hanssen, F Persson, J L Scheijen, M P H van de Waarenburg, M M J van Greevenbroek, P Rossing, P Hovind, C D A Stehouwer, H-H Parving, C G Schalkwijk. Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study.
Diabetic medicine : a journal of the British Diabetic Association.
2021 09; 38(9):e14405. doi:
10.1111/dme.14405. [PMID: 32961617] - Yuexing Yuan, Jinfeng Cheng, Cheng Chen, Yao Wang. Combining serum 1,5-anhydroglucitol with fasting plasma glucose to detect diabetes mellitus in a community-based population with hypertension.
Annals of palliative medicine.
2021 Aug; 10(8):8746-8752. doi:
10.21037/apm-21-1305. [PMID: 34488364] - Lakshi A Dayarathne, Sachithra S Ranaweera, Premkumar Natraj, Priyanka Rajan, Young Jae Lee, Chang Hoon Han. Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes.
Journal of veterinary science.
2021 Jul; 22(4):e55. doi:
10.4142/jvs.2021.22.e55. [PMID: 34313040] - S Halder, A K Mehta. 2-Deoxy-D-glucose: is this the final cure for COVID-19: or yet another mirage?.
European review for medical and pharmacological sciences.
2021 Jul; 25(13):4448-4450. doi:
10.26355/eurrev_202107_26234. [PMID: 34286486] - Hesham Shamshoum, Filip Vlavcheski, Rebecca E K MacPherson, Evangelia Tsiani. Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2021 Jul; 46(7):819-827. doi:
10.1139/apnm-2020-0592. [PMID: 33471600] - Moataz M Hanafy, Jeremie Z Lindeque, Shohda A El-Maraghy, Abdel-Hamid Z Abdel-Hamid, Nancy N Shahin. Time-based investigation of urinary metabolic markers for Type 2 diabetes: Metabolomics approach for diabetes management.
BioFactors (Oxford, England).
2021 Jul; 47(4):645-657. doi:
10.1002/biof.1731. [PMID: 33836111] - Wiem Haj Ahmed, Nathalie Boulet, Anaïs Briot, Barry J Ryan, Gemma K Kinsella, Jeffrey O'Sullivan, Francisco Les, Josep Mercader-Barceló, Gary T M Henehan, Christian Carpéné. Novel Facet of an Old Dietary Molecule? Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes.
Molecules (Basel, Switzerland).
2021 Jun; 26(13):. doi:
10.3390/molecules26133831. [PMID: 34201708] - Nik Nur Syazni Nik Mohamed Kamal, Fatin Athirah Abdul Aziz, Wen-Nee Tan, Agustine Nengsih Fauzi, Vuanghao Lim. Mechanistic Actions between Garcinia atroviridis Essential Oil and 2 Deoxy-d-glucose in Cultured PANC-1 Human Pancreatic Cancer Cells.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123518. [PMID: 34207699] - Mana Ohigashi, Keiko Osugi, Yoshiki Kusunoki, Kahori Washio, Satoshi Matsutani, Taku Tsunoda, Toshihiro Matsuo, Kosuke Konishi, Tomoyuki Katsuno, Mitsuyoshi Namba, Hidenori Koyama. Association of time in range with hemoglobin A1c, glycated albumin and 1,5-anhydro-d-glucitol.
Journal of diabetes investigation.
2021 Jun; 12(6):940-949. doi:
10.1111/jdi.13437. [PMID: 33058513] - Manju Bala, Prachi Gupta, Sanjeev Gupta, Anita Dua, Elisha Injeti, Ashwani Mittal. Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes.
Journal of pharmacological and toxicological methods.
2021 May; 109(?):107069. doi:
10.1016/j.vascn.2021.107069. [PMID: 33892108] - Chuyi Tan, Jia Gu, Tao Li, Huan Chen, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xiao. Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy.
International journal of molecular medicine.
2021 03; 47(3):. doi:
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Nagoya journal of medical science.
2021 Feb; 83(1):51-61. doi:
10.18999/nagjms.83.1.51. [PMID: 33727737] - C H Jian, A H Zhao, X J Ma, W Lu, W Zhu, Y F Wang, J Zhou, Y Q Bao. [Research on consistency of different measurement methods for saliva 1,5-anhydroglucitol].
Zhonghua yi xue za zhi.
2020 Nov; 100(42):3291-3295. doi:
10.3760/cma.j.cn112137-20200312-00726. [PMID: 33202489] - Amit Verma, Amitava Adhikary, Gayle Woloschak, Bilikere S Dwarakanath, Rao V L Papineni. A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management.
International journal of radiation biology.
2020 11; 96(11):1323-1328. doi:
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The journal of applied laboratory medicine.
2020 11; 5(6):1296-1306. doi:
10.1093/jalm/jfaa066. [PMID: 32529222] - Abdullah Al Mamun, Hisaki Hayashi, Aya Yamamura, Md Junayed Nayeem, Motohiko Sato. Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells.
The journal of physiological sciences : JPS.
2020 Sep; 70(1):44. doi:
10.1186/s12576-020-00773-y. [PMID: 32962633] - Adrian Georg Simon, Laura Kristin Esser, Jörg Ellinger, Vittorio Branchi, Yuri Tolkach, Stefan Müller, Manuel Ritter, Glen Kristiansen, Michael Helmut Muders, Thomas Mayr, Marieta Ioana Toma. Targeting glycolysis with 2-deoxy-D-glucose sensitizes primary cell cultures of renal cell carcinoma to tyrosine kinase inhibitors.
Journal of cancer research and clinical oncology.
2020 Sep; 146(9):2255-2265. doi:
10.1007/s00432-020-03278-8. [PMID: 32533404] - Hyungjun Jang, Jusung Oh, Hangil Ki, Min-Gon Kim. Paper-based 1,5-anhydroglucitol quantification using enzyme-based glucose elimination.
The Analyst.
2020 Aug; 145(17):5740-5743. doi:
10.1039/d0an00905a. [PMID: 32686804] - Sakurako Kira, Chikako Ito, Rumi Fujikawa, Munechika Misumi. Association between a biomarker of glucose spikes, 1,5-anhydroglucitol, and cancer mortality.
BMJ open diabetes research & care.
2020 08; 8(1):. doi:
10.1136/bmjdrc-2020-001607. [PMID: 32792354] - Samantha R Soncini, Dakshayini G Chandrashekarappa, David A Augustine, Kenny P Callahan, Allyson F O'Donnell, Martin C Schmidt. Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis.
PLoS genetics.
2020 07; 16(7):e1008484. doi:
10.1371/journal.pgen.1008484. [PMID: 32673313] - Ryoko Asada, Kenji Tazawa, Shinkichi Sato, Nobuhiko Miwa. Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.
Medical gas research.
2020 Jul; 10(3):114-121. doi:
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Food & function.
2020 Jun; 11(6):5105-5114. doi:
10.1039/d0fo00359j. [PMID: 32356551] - Bu Le, Xiaoyun Cheng, Shen Qu. Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats.
Journal of cellular and molecular medicine.
2020 06; 24(12):6773-6780. doi:
10.1111/jcmm.15328. [PMID: 32395890] - Robert Little, Michael J Houghton, Ian M Carr, Martin Wabitsch, Asimina Kerimi, Gary Williamson. The Ability of Quercetin and Ferulic Acid to Lower Stored Fat is Dependent on the Metabolic Background of Human Adipocytes.
Molecular nutrition & food research.
2020 06; 64(12):e2000034. doi:
10.1002/mnfr.202000034. [PMID: 32350998] - Cheng Chen, Xiaohang Wang, Yuanyuan Tan, Jiao Yang, Yuexing Yuan, Juan Chen, Haijian Guo, Bei Wang, Ziling Sun, Yao Wang. Reference intervals for serum 1,5-anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province.
Journal of diabetes.
2020 Jun; 12(6):447-454. doi:
10.1111/1753-0407.13016. [PMID: 31846192] - Chaohui Jian, Aihua Zhao, Xiaojing Ma, Kun Ge, Wei Lu, Wei Zhu, Yufei Wang, Jian Zhou, Wei Jia, Yuqian Bao. Diabetes Screening: Detection and Application of Saliva 1,5-Anhydroglucitol by Liquid Chromatography-Mass Spectrometry.
The Journal of clinical endocrinology and metabolism.
2020 06; 105(6):. doi:
10.1210/clinem/dgaa114. [PMID: 32170297] - Gong Su, Ming-Xi Gao, Gen-Ling Shi, Xi-Xi Dai, Wei-Feng Yao, Tao Zhang, Shao-Wei Zhuang. Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome.
Cardiovascular diabetology.
2020 05; 19(1):71. doi:
10.1186/s12933-020-01045-0. [PMID: 32473648] - Masahiko Tachi, Naoko Yamaguchi, Shoshiro Okada. Thromboxane A2 in the paraventricular hypothalamic nucleus mediates glucoprivation-induced adrenomedullary outflow.
European journal of pharmacology.
2020 May; 875(?):173034. doi:
10.1016/j.ejphar.2020.173034. [PMID: 32097659] - Jin-Pyo An, Eun Jin Park, Byeol Ryu, Ba Wool Lee, Hyo Moon Cho, Thi Phuong Doan, Ha Thanh Tung Pham, Won Keun Oh. Oleanane Triterpenoids from the Leaves of Gymnema inodorum and Their Insulin Mimetic Activities.
Journal of natural products.
2020 04; 83(4):1265-1274. doi:
10.1021/acs.jnatprod.0c00051. [PMID: 32237726] - Asuka Morita, Motoshi Ouchi, Keitaro Satoh, Misao Terada, Hiroe Kon, Hidefumi Wakashin, Keitaro Hayashi, Naohiko Anzai, Kenzo Oba, Akira Shimizu, Tomoe Fujita. Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion.
Experimental animals.
2020 Apr; 69(2):127-134. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Mar; 68(?):153178. doi:
10.1016/j.phymed.2020.153178. [PMID: 32126492] - June Hyuk Jang, Jae Eun Park, Ji Sook Han. Scopoletin increases glucose uptake through activation of PI3K and AMPK signaling pathway and improves insulin sensitivity in 3T3-L1 cells.
Nutrition research (New York, N.Y.).
2020 02; 74(?):52-61. doi:
10.1016/j.nutres.2019.12.003. [PMID: 31945607] - Lei Chen, Xiujun Lin, Xiaoyun Fan, Yuewei Qian, Qiyan Lv, Hui Teng. Sonchus oleraceus Linn extract enhanced glucose homeostasis through the AMPK/Akt/ GSK-3β signaling pathway in diabetic liver and HepG2 cell culture.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Feb; 136(?):111072. doi:
10.1016/j.fct.2019.111072. [PMID: 31877369] - Mirko Magnone, Laura Emionite, Lucrezia Guida, Tiziana Vigliarolo, Laura Sturla, Sonia Spinelli, Ambra Buschiazzo, Cecilia Marini, Gianmario Sambuceti, Antonio De Flora, Anna Maria Orengo, Vanessa Cossu, Sara Ferrando, Ottavia Barbieri, Elena Zocchi. Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation.
Scientific reports.
2020 01; 10(1):1454. doi:
10.1038/s41598-020-58206-0. [PMID: 31996711] - Paco Romero, Fernando Alférez, Beatriz Establés-Ortiz, María T Lafuente. Insights into the regulation of molecular mechanisms involved in energy shortage in detached citrus fruit.
Scientific reports.
2020 01; 10(1):1109. doi:
10.1038/s41598-019-57012-7. [PMID: 31980654] - Hajira Ramlan, Hanafi Ahmad Damanhuri. Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.
Experimental gerontology.
2020 01; 129(?):110779. doi:
10.1016/j.exger.2019.110779. [PMID: 31705967] - Jin Cai, Liang Zhou, Xiudao Song, Meiqi Yin, Guoqiang Liang, Heng Xu, Lurong Zhang, Guorong Jiang, Fei Huang. Alteration of Intestinal Microbiota in 3-Deoxyglucosone-Induced Prediabetic Rats.
BioMed research international.
2020; 2020(?):8406846. doi:
10.1155/2020/8406846. [PMID: 32908918] - Afreen Khanam, Saheem Ahmad, Arbab Husain, Shahnawaz Rehman, Alvina Farooqui, Mohd Aslam Yusuf. Glycation and Antioxidants: Hand in the Glove of Antiglycation and Natural Antioxidants.
Current protein & peptide science.
2020; 21(9):899-915. doi:
10.2174/1389203721666200210103304. [PMID: 32039678] - Qingqing Lou, Xiaodan Yuan, Shujie Hao, Joshua D Miller, Juan Yan, Panpan Zuo, Jianing Li, Lihong Yang, Hong Li. Effects of Glucose Fluctuation Targeted Intervention on the Prognosis of Patients with Type 2 Diabetes following the First Episode of Cerebral Infarction.
Journal of diabetes research.
2020; 2020(?):2532171. doi:
10.1155/2020/2532171. [PMID: 32090117] - Lingwen Ying, Xiaojing Ma, Yun Shen, Jingyi Lu, Wei Lu, Wei Zhu, Yufei Wang, Yuqian Bao, Jian Zhou. Serum 1,5-Anhydroglucitol to Glycated Albumin Ratio Can Help Early Distinguish Fulminant Type 1 Diabetes Mellitus from Newly Onset Type 1A Diabetes Mellitus.
Journal of diabetes research.
2020; 2020(?):1243630. doi:
10.1155/2020/1243630. [PMID: 32280712] - Huguet V Landa-Galvan, Emmanuel Rios-Castro, Tatiana Romero-Garcia, Angelica Rueda, Jesus Alberto Olivares-Reyes. Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes.
PloS one.
2020; 15(1):e0228115. doi:
10.1371/journal.pone.0228115. [PMID: 31995605] - Hazeline Roche-Hakansson, Goutham Vansarla, Laura R Marks, Anders P Hakansson. The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae.
The Journal of biological chemistry.
2019 12; 294(51):19511-19522. doi:
10.1074/jbc.ra119.009930. [PMID: 31694917] - Saurabh Singh, Sanjay Pandey, Amanpreet Singh Chawla, Anant Narayan Bhatt, Bal Gangadhar Roy, Daman Saluja, Bilikere S Dwarakanath. Dietary 2-deoxy-D-glucose impairs tumour growth and metastasis by inhibiting angiogenesis.
European journal of cancer (Oxford, England : 1990).
2019 12; 123(?):11-24. doi:
10.1016/j.ejca.2019.09.005. [PMID: 31670076] - Shota Machida, Saki Mukai, Rina Kono, Megumi Funato, Hiroaki Saito, Taketo Uchiyama. Synthesis and Comparative Structure-Activity Study of Carbohydrate-Based Phenolic Compounds as α-Glucosidase Inhibitors and Antioxidants.
Molecules (Basel, Switzerland).
2019 Nov; 24(23):. doi:
10.3390/molecules24234340. [PMID: 31783621] - Xin-Jie Wang, Hong-Xia Zhang, Heng Li, Ai-Hua Zhu, Wen-Yun Gao. Measurement of α-dicarbonyl compounds in human saliva by pre-column derivatization HPLC.
Clinical chemistry and laboratory medicine.
2019 Nov; 57(12):1915-1922. doi:
10.1515/cclm-2019-0350. [PMID: 31377732] - Saki Shimamoto, Kazuki Nakashima, Ryo Kamimura, Rukana Kohrogi, Hiroki Inoue, Nao Nishikoba, Akira Ohtsuka, Daichi Ijiri. Insulin acutely increases glucose transporter 1 on plasma membranes and glucose uptake in an AKT-dependent manner in chicken adipocytes.
General and comparative endocrinology.
2019 11; 283(?):113232. doi:
10.1016/j.ygcen.2019.113232. [PMID: 31356813] - Amanda J Page, George Hatzinikolas, Andrew D Vincent, Paul Cavuoto, Gary A Wittert. The TRPV1 channel regulates glucose metabolism.
American journal of physiology. Endocrinology and metabolism.
2019 10; 317(4):E667-E676. doi:
10.1152/ajpendo.00102.2019. [PMID: 31408376] - Komal Saraswat, Raushan Kumar, Syed Ibrahim Rizvi. Glycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species.
Rejuvenation research.
2019 Oct; 22(5):377-384. doi:
10.1089/rej.2018.2125. [PMID: 30451072] - Naamwin R Meda, Tatjana Stevanovic, Patrice E Poubelle. Anhydroglucitol-core gallotannins from red maple buds modulate viability of human blood neutrophils.
Toxicology in vitro : an international journal published in association with BIBRA.
2019 Oct; 60(?):76-86. doi:
10.1016/j.tiv.2019.05.010. [PMID: 31100377] - Eleni Demetriou, Harriet E Story, Robin Bofinger, Helen C Hailes, Alethea B Tabor, Xavier Golay. Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents.
The journal of physical chemistry. B.
2019 09; 123(35):7545-7557. doi:
10.1021/acs.jpcb.9b02280. [PMID: 31449408] - Bruna R Martins, Letícia C Gomes, Kátia C Boritza, Mauren I Anghebem-Oliveira, Emanuel M Souza, Suzana N França, Geraldo Picheth, Fabiane G M Rego. Serum 1,5-Anhydroglucitol Concentration as a Biomarker for Type 1 Diabetes in Adults and Children.
Clinical laboratory.
2019 Sep; 65(9):. doi:
10.7754/clin.lab.2019.190141. [PMID: 31532108] - Yuta Tezuka, Izaya Nakaya, Keisuke Nakayama, Masaaki Nakayama, Mayumi Yahata, Jun Soma. Methylglyoxal as a prognostic factor in patients with chronic kidney disease.
Nephrology (Carlton, Vic.).
2019 Sep; 24(9):943-950. doi:
10.1111/nep.13526. [PMID: 30407693] - Namrata Sanjeevi, Leah M Lipsky, Tonja R Nansel. Hyperglycemia and Carotenoid Intake Are Associated with Serum Carotenoids in Youth with Type 1 Diabetes.
Journal of the Academy of Nutrition and Dietetics.
2019 08; 119(8):1340-1348. doi:
10.1016/j.jand.2019.03.009. [PMID: 31101482] - Qiaorui Liu, Xulei Zheng, Zhiwen Liu, Ling Qiu. Vitamin D status is associated with 1,5-anhydro-d-glucitol status in patients with type 2 diabetes mellitus.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Aug; 44(8):857-860. doi:
10.1139/apnm-2018-0719. [PMID: 30633541] - Xue-Wen Li, Meixiang Huang, Kakei Lo, Wei-Li Chen, Ying-Yan He, Yongli Xu, Huizhen Zheng, Haiyan Hu, Jun Wang. Anti-Diabetic Effect of a Shihunine-Rich Extract of Dendrobium loddigesii on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK-GLUT4-PPARα.
Molecules (Basel, Switzerland).
2019 Jul; 24(14):. doi:
10.3390/molecules24142673. [PMID: 31340585] - Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Norihito Takahashi, Hirohisa Endo, Yoshiteru Kato, Manabu Ogita, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Kikuo Isoda, Kazunori Shimada, Satoru Suwa, Hiroyuki Daida. Impact of serum 1,5-anhydro-D-glucitol level on the prediction of severe coronary artery calcification: an intravascular ultrasound study.
Cardiovascular diabetology.
2019 06; 18(1):69. doi:
10.1186/s12933-019-0878-1. [PMID: 31159826] - Xiudao Song, Guoqiang Liang, Min Shi, Liang Zhou, Fei Wang, Lurong Zhang, Fei Huang, Guorong Jiang. Acute exposure to 3‑deoxyglucosone at high glucose levels impairs insulin secretion from β‑cells by downregulating the sweet taste receptor signaling pathway.
Molecular medicine reports.
2019 Jun; 19(6):5015-5022. doi:
10.3892/mmr.2019.10163. [PMID: 31059088] - Alex Calizzano, Pascale Perret, Marie-Dominique Desruet, Mitra Ahmadi, Ghislaine Reboulet, Loïc Djaileb, Gérald Vanzetto, Daniel Fagret, Gilles Barone-Rochette, Catherine Ghezzi. Safety, Biodistribution, and Dosimetry of 123I-6-Deoxy-6-Iodo-D-Glucose, a Tracer of Glucose Transport, in Healthy and Diabetic Volunteers.
Clinical nuclear medicine.
2019 May; 44(5):386-393. doi:
10.1097/rlu.0000000000002510. [PMID: 30888989] - Agnieszka Korga, Marta Ostrowska, Magdalena Iwan, Mariola Herbet, Jaroslaw Dudka. Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment.
FEBS open bio.
2019 05; 9(5):959-972. doi:
10.1002/2211-5463.12628. [PMID: 30973680] - Tao Zhang, Xinying Zhu, Haichong Wu, Kangfeng Jiang, Gan Zhao, Aftab Shaukat, Ganzhen Deng, Changwei Qiu. Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose.
Journal of cellular and molecular medicine.
2019 05; 23(5):3711-3723. doi:
10.1111/jcmm.14276. [PMID: 30920152] - Jie Zhang, Zi Wang, Huipan Liu, Liang Cai, Yue Feng, Ling Zhou, Hongyuan Wei, Ying Xie, Yue Chen. In vivo and in vitro evaluation of 177Lu-labeled DOTA-2-deoxy-D-glucose in mice. A novel radiopharmaceutical agent for cells imaging and therapy.
Hellenic journal of nuclear medicine.
2019 May; 22(2):103-110. doi:
10.1967/s002449911002. [PMID: 31273351] - Y Horii, Y Fujisaki, R Fuyuki, Y Misonou, K Nagai. Effect of Lactobacillus delbrueckii LAB4 on hepatic and pancreatic sympathetic nerve activity and blood glucose levels in rats.
Beneficial microbes.
2019 Apr; 10(3):293-300. doi:
10.3920/bm2018.0083. [PMID: 30638397] - Stephanie J Loomis, Anna Köttgen, Man Li, Adrienne Tin, Josef Coresh, Eric Boerwinkle, Richard Gibbs, Donna Muzny, James Pankow, Elizabeth Selvin, Priya Duggal. Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study.
Scientific reports.
2019 04; 9(1):5941. doi:
10.1038/s41598-019-42202-0. [PMID: 30976018] - Yuanyuan Bai, Ruihua Yang, Yanan Song, Yuhuan Wang. Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2019 Apr; 127(4):220-225. doi:
10.1055/s-0043-122142. [PMID: 29270924] - Magdalena Szopa, Tomasz Klupa, Maria Kapusta, Bartlomiej Matejko, Damian Ucieklak, Wojciech Glodzik, Barbara Zapala, Cyrus Maurice Sani, Jerzy Hohendorff, Maciej T Malecki, Jan Skupien. A decision algorithm to identify patients with high probability of monogenic diabetes due to HNF1A mutations.
Endocrine.
2019 04; 64(1):75-81. doi:
10.1007/s12020-019-01863-7. [PMID: 30778899] - Xiaoying Lian, Xiaoyuan Wu, Zhongxin Li, Yingjie Zhang, Kangkang Song, Guangyan Cai, Qinggang Li, Shupeng Lin, Xiangmei Chen, Xue-Yuan Bai. The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
British journal of pharmacology.
2019 03; 176(5):711-724. doi:
10.1111/bph.14558. [PMID: 30515768] - Thyparambil Aravindakshan Pramodkumar, Ramamoorthy Jayashri, Kuppan Gokulakrishnan, Kaliyaperumal Velmurugan, Rajendra Pradeepa, Ulagamathesan Venkatesan, Ponnusamy Saravanan, Ram Uma, Ranjit Mohan Anjana, Viswanathan Mohan. 1,5 Anhydroglucitol in gestational diabetes mellitus.
Journal of diabetes and its complications.
2019 03; 33(3):231-235. doi:
10.1016/j.jdiacomp.2018.11.010. [PMID: 30594413] - Xin-Jie Wang, Sheng-Bo Ma, Zhuo-Feng Liu, Heng Li, Wen-Yun Gao. Elevated levels of α-dicarbonyl compounds in the plasma of type II diabetics and their relevance with diabetic nephropathy.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Feb; 1106-1107(?):19-25. doi:
10.1016/j.jchromb.2018.12.027. [PMID: 30639946] - Remy J H Martens, Natascha J H Broers, Bernard Canaud, Maarten H L Christiaans, Tom Cornelis, Adelheid Gauly, Marc M H Hermans, Constantijn J A M Konings, Frank M van der Sande, Jean L J M Scheijen, Frank Stifft, Joris J J M Wirtz, Jeroen P Kooman, Casper G Schalkwijk. Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study.
PloS one.
2019; 14(8):e0221058. doi:
10.1371/journal.pone.0221058. [PMID: 31408493] - Fabio Stossi, Radhika D Dandekar, Hannah Johnson, Philip Lavere, Charles E Foulds, Maureen G Mancini, Michael A Mancini. Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells.
PloS one.
2019; 14(11):e0224405. doi:
10.1371/journal.pone.0224405. [PMID: 31710612] - Fei Wang, Xiudao Song, Liang Zhou, Guoqiang Liang, Fei Huang, Guorong Jiang, Lurong Zhang. The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.
Archives of physiology and biochemistry.
2018 Dec; 124(5):430-435. doi:
10.1080/13813455.2017.1419366. [PMID: 29277113] - Ying Liang, Ikumi Sasaki, Yuki Takeda, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata, Yoshimasa Nakamura. Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation.
Bioscience, biotechnology, and biochemistry.
2018 Dec; 82(12):2130-2139. doi:
10.1080/09168451.2018.1514247. [PMID: 30185113] - Pablo Sánchez-Aguilera, Alexis Diaz-Vegas, Cristián Campos, Oscar Quinteros-Waltemath, Hugo Cerda-Kohler, Genaro Barrientos, Ariel Contreras-Ferrat, Paola Llanos. Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2018 12; 1863(12):1469-1477. doi:
10.1016/j.bbalip.2018.09.005. [PMID: 30254016] - L Zhou, X D Song, H Xu, G Q Liang, F Wang, L R Zhang, F Huang, J Cai, G R Jiang. Exogenous 3-Deoxyglucosone-Induced Carbonyl and Oxidative Stress Causes β-Cells Dysfunction by Impairing Gut Permeability in Rats.
Biochemistry. Biokhimiia.
2018 Nov; 83(11):1358-1368. doi:
10.1134/s0006297918110068. [PMID: 30482147] - Marciane Welter, Kátia C Boritza, Mauren I Anghebem-Oliveira, Railson Henneberg, Aline B Hauser, Fabiane G M Rego, Geraldo Picheth. Reference intervals for serum 1,5-anhydroglucitol in children, adolescents, adults, and pregnant women.
Clinica chimica acta; international journal of clinical chemistry.
2018 Nov; 486(?):54-58. doi:
10.1016/j.cca.2018.07.018. [PMID: 30017617] - Manasa Kongot, Neeraj Dohare, Vishal Singh, Dinesh S Reddy, Nitin Kumar Singhal, Rajan Patel, Amit Kumar. A novel biocompatible NiII tethered moiety as a glucose uptake agent and a hit against methicillin-resistant Staphylococcus aureus.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):335-349. doi:
10.1016/j.ejps.2018.07.008. [PMID: 29981891] - Audrey Berthe, Marie Zaffino, Claire Muller, François Foulquier, Marine Houdou, Céline Schulz, Frédéric Bost, Elia De Fay, Sabine Mazerbourg, Stéphane Flament. Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells.
Breast cancer research and treatment.
2018 Oct; 171(3):581-591. doi:
10.1007/s10549-018-4874-z. [PMID: 29971627] - Benjamin Szwergold. A Hypothesis: Moderate Consumption of Alcohol Contributes to Lower Prevalence of Type 2 Diabetes Due to the Scavenging of Alpha-Dicarbonyls by Dietary Polyphenols.
Rejuvenation research.
2018 Oct; 21(5):389-404. doi:
10.1089/rej.2017.1974. [PMID: 28891383] - Tae Woo Jung, Sung Hoon Lee, Hyoung-Chun Kim, Joon Seok Bang, A M Abd El-Aty, Ahmet Hacımüftüoğlu, Yong Kyoo Shin, Ji Hoon Jeong. METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice.
Experimental & molecular medicine.
2018 09; 50(9):1-11. doi:
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