Nicotinamide N-oxide (BioDeep_00000026945)
Secondary id: BioDeep_00000472805, BioDeep_00001874317
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C6H6N2O2 (138.0429256)
中文名称: 烟碱-N-氧化物
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.39%
分子结构信息
SMILES: C1=CC(=C[N+](=C1)[O-])C(=O)N
InChI: InChI=1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9)
描述信息
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyses the reduction of nicotinamide N-oxide to nicotinamide in liver is xanthine oxidase. [HMDB]
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyses the reduction of nicotinamide N-oxide to nicotinamide in liver is xanthine oxidase.
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
同义名列表
11 个代谢物同义名
1-oxo-1Λ⁵-pyridine-3-carboximidate; 3-carbamoylpyridin-1-ium-1-olate; 3-pyridinecarboxamide, 1-oxide; 1-Oxide-3-pyridinecarboxamide; 1-Oxide-(8ci)-nicotinamide; Nicotinamide N1-oxide; Nicotinamide-N-oxide; 1-Oxide-nicotinamide; Nicotinamide 1-oxide; Nicotinamide N-oxide; 1-Oxy-nicotinamide
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:89640
- PubChem: 72661
- HMDB: HMDB0002730
- ChEMBL: CHEMBL3542327
- foodb: FDB023057
- chemspider: 65522
- CAS: 1986-81-8
- PMhub: MS000239523
- RefMet: Nicotinamide N-oxide
- medchemexpress: HY-101407
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Akihiro Maeta, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata. Simultaneous measurement of nicotinamide and its catabolites, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide, in mice urine.
Bioscience, biotechnology, and biochemistry.
2014; 78(8):1306-9. doi:
10.1080/09168451.2014.918495
. [PMID: 25130730] - Alexander Michael Real, Shangyu Hong, Pavlos Pissios. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Mar; 41(3):550-3. doi:
10.1124/dmd.112.049734
. [PMID: 23418369] - Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
Molecular bioSystems.
2010 May; 6(5):909-21. doi:
10.1039/b914182k
. [PMID: 20567778] - R M Menon, M H Adams, M A González, D S Tolbert, J H Leu, E A Cefali. Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.
International journal of clinical pharmacology and therapeutics.
2007 Aug; 45(8):448-54. doi:
10.5414/cpp45448
. [PMID: 17725178] - Rajeev M Menon, Mario A González, Marijke H Adams, Dwain S Tolbert, Jocelyn H Leu, Eugenio A Cefali. Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites.
Journal of clinical pharmacology.
2007 Jun; 47(6):681-8. doi:
10.1177/0091270007300264
. [PMID: 17463214] - Mark W Ruddock, David G Hirst. Metabolites of the radiosensitizer nicotinamide are unlikely to contribute to the degree of emesis observed with the parent drug.
Oncology research.
2007; 16(12):569-74. doi:
10.3727/000000007783629990
. [PMID: 18351131] - Tsutomu Fukuwatari, Hideko Wada, Ryuzo Sasaki, Katsumi Shibata. Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
Bioscience, biotechnology, and biochemistry.
2004 Jan; 68(1):44-50. doi:
10.1271/bbb.68.44
. [PMID: 14745162] - J Bernier, M R Stratford, J Denekamp, M F Dennis, S Bieri, F Hagen, O Kocagöncü, M Bolla, A Rojas. Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
1998 Aug; 48(2):123-33. doi:
10.1016/s0167-8140(98)00048-6
. [PMID: 9783883] - M R Stratford, M F Dennis. Pharmacokinetics and biochemistry studies on nicotinamide in the mouse.
Cancer chemotherapy and pharmacology.
1994; 34(5):399-404. doi:
10.1007/bf00685564
. [PMID: 8070006] - K Shibata, H Kakehi, H Matsuo. Niacin catabolism in rodents.
Journal of nutritional science and vitaminology.
1990 Apr; 36(2):87-98. doi:
10.3177/jnsv.36.87
. [PMID: 2143779]